期刊
PLASMA PROCESSES AND POLYMERS
卷 13, 期 12, 页码 1179-1188出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppap.201600090
关键词
atmospheric pressure plasma jet; Jurkat T cells; kINPen; plasma oncology; reactive oxygen and nitrogen species; redox signaling; THP-1 monocytes
资金
- German Federal Ministry of Education and Research [03Z22DN11, 13N13960]
- Ministry of Education, Science and Culture [AU 15 001]
Targeting cancer cells with cold physical plasma emerged as a promising application in plasma medicine. To understand its mode of action with regard to cellular redox-regulation, two leukemia cell lines (Jurkat and THP-1 cells) were plasma-treated and their gene expression was compared. Transcriptomics revealed strikingly similar expression levels of activator protein 1 family members, and of a particular set of genes associated with apoptosis, DNA repair, and antioxidant defense. Interestingly, important constitutively expressed antioxidant transcripts were differently expressed in both cell types which suggest them to be crucial for the Jurkat's high and the THP-1 cells' low sensitivity to plasma. Utilizing these targets as biological read outs may help rendering plasmas more effective against different types of cancers.
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