Article
Obstetrics & Gynecology
Hanna Huebner, Kirsten Heussner, Matthias Ruebner, Matthias Schmid, Jennifer Nadal, Joachim Woelfle, Andrea Hartner, Carlos Menendez-Castro, Manfred Rauh, Matthias W. Beckmann, Sven Kehl, Fabian B. Fahlbusch
Summary: This study compared the direct and indirect enzymatic activity of 11 β-HSD2 in placentas of women who had spontaneous births and cesarean sections. The ratio of cortisol to cortisone correlated with the direct microsomal enzymatic turnover, while mode of delivery had a strong influence on tissue steroids. HSD11B2 expression correlated with indirect and direct cortisol turnover rates in C-section placentas only, with significantly increased levels of CRH, cortisol, and cortisone following spontaneous birth.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Pharmacology & Pharmacy
Cristina Gomez, Zerin Alimajstorovic, Nantia Othonos, Denise V. Winter, Sarah White, Gareth G. Lavery, Jeremy W. Tomlinson, Alexandra J. Sinclair, Alex Odermatt
Summary: This study compares the abilities of GUDCA/G7oxoLCA ratio and urinary (5α-THF+THF)/THE ratio to detect pharmacological 11 beta-HSD1 inhibition in humans. Results suggest that GUDCA/G7oxoLCA ratio is a more reliable biomarker for 11 beta-HSD1 inhibition.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Rosemary A. Dineen, Julie Martin-Grace, Khalid Mohamed Saeed Ahmed, Angela E. Taylor, Fozia Shaheen, Lina Schiffer, Lorna C. Gilligan, Gareth G. Lavery, Isolda Frizelle, Anjuli Gunness, Aoife Garrahy, Anne Marie Hannon, Paal Methlie, Sverre Husebye Eystein, Paul M. Stewart, Jeremy W. Tomlinson, James M. Hawley, Brian G. Keevil, Michael W. O'Reilly, Diarmuid Smith, John McDermott, Marie-Louise Healy, Amar Agha, Agnieszka Pazderska, James Gibney, Lucy-Ann Behan, Chris J. Thompson, Wiebke Arlt, Mark Sherlock
Summary: This study compared the effects of immediate release hydrocortisone (IR-HC) and dual-release hydrocortisone (DR-HC) on patients with adrenal insufficiency (AI) and found that IR-HC treatment led to abnormal cortisol metabolism, while DR-HC treatment could improve this condition.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Justine M. Webster, Michael S. Sagmeister, Chloe G. Fenton, Alex P. Seabright, Yu-Chiang Lai, Simon W. Jones, Andrew Filer, Mark S. Cooper, Gareth G. Lavery, Karim Raza, Ramon Langen, Rowan S. Hardy
Summary: Glucocorticoids are important anti-inflammatory therapies, but their use is limited due to metabolic adverse effects like muscle wasting. The enzyme 11 beta-HSD1 plays a role in modulating glucocorticoid responses in muscle. Knocking out 11 beta-HSD1 prevented muscle atrophy associated with glucocorticoid therapy in a model of chronic inflammation, suggesting a potential strategy to refine the safety of glucocorticoids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Martina Blaschke, Regine Koepp, Frank Streit, Johannes Beismann, Georg Manthey, Mark-Tilmann Seitz, Angelique Kragl, Heide Siggelkow
Summary: The enzyme 11 beta-HSD1 plays a key role in pre-receptor glucocorticoid metabolism, with increased expression leading to adipogenic differentiation in human mesenchymal progenitor cells. Inhibition experiments confirmed the enzyme's specificity for cortisol synthesis and adipogenic differentiation, potentially explaining the link between increased 11 beta-HSD1 expression, higher cortisol levels, and reduced bone quality in old age or in situations of supra-physiological glucocorticoid exposure.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Chemistry, Analytical
Tiantian Fu, Bingyi Yao, Yuanqing Guo, Yuanjin Zhang, Shengbo Huang, Xin Wang
Summary: Chlorpromazine, a widely used drug in clinic with sedative and antiemetic effects, was analyzed by LC-MS/MS to study its metabolism. The method successfully quantified the metabolites of chlorpromazine in different microsomal enzymes, including 7-hydroxychlorpromazine, N-monodesmethylchlorpromazine, and chlorpromazine sulfoxide. The method was validated in rat liver microsomes and partially verified in human liver and placenta microsomes, showing good accuracy, precision, extraction recovery, and no matrix effect.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Medical Laboratory Technology
E. G. W. M. Lentjes, H. N. Bui, L. R. Ruhaak, I. P. Kema, K. L. M. Coene, J. M. W. Van den Ouweland
Summary: LC-MS/MS methods have been increasingly used in hospital laboratories over the past decade. This switch from immunoassays to LC-MS/MS methods was driven by the promise of improved sensitivity and specificity, better standardization, and better between-laboratory comparison. However, it remains uncertain whether these expectations have been met.
CLINICA CHIMICA ACTA
(2023)
Review
Medicine, General & Internal
Jonathan Seckl
Summary: 11 beta-HSDs are enzymes that convert active 11-hydroxy glucocorticoids to their inert 11-keto forms. 11 beta-HSD2 inactivates glucocorticoids and has important roles in the kidney and developing foetal brain. In contrast, 11 beta-HSD1 amplifies active glucocorticoid levels in the brain and is associated with age-related cognitive decline.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Yuki Nouchi, Eiji Munetsuna, Hiroya Yamada, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Miyuki Ikeya, Itsuki Kageyama, Takuya Wakasugi, Atsushi Teshigawara, Yuji Hattori, Yoshiki Tsuboi, Hiroaki Ishikawa, Koji Suzuki, Koji Ohashi
Summary: This study aimed to elucidate the molecular mechanism by which maternal high-fructose corn syrup (HFCS) intake increases circulating GC levels in rat offspring. By giving female Sprague Dawley rats HFCS solution, it was found that HFCS led to a decrease in activity of GC-metabolizing enzyme 11 beta-Hsd2 and an increase in renal miR-27a expression. These findings suggest that the elevation of circulating GC levels in offspring induced by maternal HFCS consumption may be explained by a decrease in 11 beta-Hsd2 activity via renal miR-27a expression.
Article
Environmental Sciences
Shaowei Wang, Jingyi Zheng, Yang Zhu, Yiyan Wang, Huitao Li, Ren-shan Ge
Summary: The study found that most BPA analogues are more potent inhibitors of human and rat 11 beta-HSD1 enzymes, with structure-dependent and species-dependent inhibition.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Pharmacology & Pharmacy
Michael Weingartner, Simon Stucheli, Denise Kratschmar, Julia Birk, Petra Klusonova, Karen E. Chapman, Gareth G. Lavery, Alex Odermatt
Summary: The study found that the plasma ratio of UDC-Tau to 7oxoLC-Tau can serve as a biomarker for decreased 11 beta-HSD1 oxoreduction activity in different mouse models. Enzyme product to substrate ratios were more reliable markers of 11 beta-HSD1 activity than absolute levels due to large inter-individual variations in bile acid concentrations. The persistence of oxoreduction activity in the face of cofactor loss indicates the existence of an alternative NADPH source in the endoplasmic reticulum.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Agronomy
Marzia Pezzolato, Elena Biasibetti, Marilena Gili, Cristiana Maurella, Alessandro Benedetto, Marianna Marturella, Federica Ostorero, Giancarlo Bozzo, Claudio Bellino, Antonio D'angelo, Flaminia Valentini, Francesca Roberti, Maurizio Fiori, Paolo Stacchini, Elena Bozzetta
Summary: The aim of this study was to verify if veal calves housed under controlled conditions still have physiological levels of natural steroid hormones and if this affects the normal histological pattern of growth promoters in target organs.
Article
Endocrinology & Metabolism
Nicola Wheelan, Jonathan R. Seckl, Joyce L. W. Yau
Summary: This study investigates how a deficiency of 11β-HSD1 and aging modulates fear conditioning and PTSD-like memory in mice. The results indicate that a deficiency of 11β-HSD1 protects young adult mice against amnesia for the conditioning context and hypermnesia for a salient tone, but only prevents contextual amnesia in aged mice.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Chemistry, Analytical
D. Luque-Cordoba, F. Priego-Capote
Summary: Steroidogenesis is a crucial process in maintaining physiological levels of steroids in the body, and its deficiency can lead to various pathologies. A research has developed a high-throughput and fully automated method for quantifying multiple steroids in human serum, achieving high sensitivity and selectivity. This method was tested on human serum samples and showed satisfactory results in line with physiological ranges reported in literature.
Review
Endocrinology & Metabolism
Claire S. Martin, Mark S. Cooper, Rowan S. Hardy
Summary: The role of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) enzymes in the metabolism of endogenous and therapeutic glucocorticoids (GCs) is crucial for bone metabolism and bone cell function. Targeting this system may offer new strategies for managing and treating various bone diseases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Meeting Abstract
Oncology
R. Erber, A. Hartmann, P. Fasching, R. Stoehr, M. W. Beckmann, M. Zentgraf, M. Ruebner, H. Huebner, J. Fischer, E. Guerini Rocco, G. Viale, A. Cayre, F. Penault-Llorca, T. Caniego Casa, J. Palacios Calvo, P. Jank, C. Denkert, L. Khoury, T. Mairinger, F. Ferrazzi
ANNALS OF ONCOLOGY
(2020)
Article
Genetics & Heredity
Haoyu Zhan, Thomas U. Ahearn, Julie Lecarpentier, Daniel Barnes, Jonathan Beesley, Guanghao Qi, Xia Jiang, Tracy A. O'Mara, Ni Zhao, Manjeet K. Bolla, Alison M. Dunning, Joe Dennis, Qin Wang, Zumuruda Abu Ful, Kristiina Aittomaki, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J. Aronson, Banu K. Arun, Paul L. Auer, Jacopo Azzollini, Daniel Barrowdale, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Katarzyna Bialkowska, Ana Blanco, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Bernardo Bonanni, Davide Bondavalli, Ake Borg, Hiltrud Brauch, Hermann Brenner, Ignacio Briceno, Annegien Broeks, Sara Y. Brucker, Thomas Bruening, Barbara Burwinkel, Saundra S. Buys, Helen Byers, Trinidad Caldes, Maria A. Caligo, Mariarosaria Calvello, Daniele Campa, Jose E. Castelao, Jenny Chang-Claude, Stephen J. Chanock, Melissa Christiaens, Hans Christiansen, Wendy K. Chung, Kathleen B. M. Claes, Christine L. Clarke, Sten Cornelissen, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Peter Devilee, Orland Diez, Susan M. Domchek, Thilo Doerk, Miriam Dwek, Diana M. Eccles, Arif B. Ekici, D. Gareth Evans, Peter A. Fasching, Jonine Figueroa, Lenka Foretova, Florentia Fostira, Eitan Friedman, Debra Frost, Manuela Gago-Dominguez, Susan M. Gapstur, Judy Garber, Jose A. Garcia-Saenz, Mia M. Gaudet, Simon A. Gayther, Graham G. Giles, Andrew K. Godwin, Mark S. Goldberg, David E. Goldgar, Anna Gonzalez-Neira, Mark H. Greene, Jacek Gronwald, Pascal Guenel, Lothar Haeberle, Eric Hahnen, Christopher A. Haiman, Christopher R. Hake, Per Hall, Ute Hamann, Elaine F. Harkness, Bernadette A. M. Heemskerk-Gerritsen, Peter Hillemanns, Frans B. L. Hogervorst, Bernd Holleczek, Antoinette Hollestelle, Maartje J. Hooning, Robert N. Hoover, John L. Hopper, Anthony Howell, Hanna Huebner, Peter J. Hulick, Evgeny N. Imyanitov, Claudine Isaacs, Louise Izatt, Agnes Jager, Milena Jakimovska, Anna Jakubowska, Paul James, Ramunas Janavicius, Wolfgang Janni, Esther M. John, Michael E. Jones, Audrey Jung, Rudolf Kaaks, Pooja Middha Kapoor, Beth Y. Karlan, Renske Keeman, Sofia Khan, Elza Khusnutdinova, Cari M. Kitahara, Yon-Dschun Ko, Irene Konstantopoulou, Linetta B. Koppert, Stella Koutros, Vessela N. Kristensen, Anne-Vibeke Laenkholm, Diether Lambrechts, Susanna C. Larsson, Pierre Laurent-Puig, Conxi Lazaro, Emilija Lazarova, Flavio Lejbkowicz, Goska Leslie, Fabienne Lesueur, Annika Lindblom, Jolanta Lissowska, Wing-Yee Lo, Jennifer T. Loud, Jan Lubinski, Alicja Lukomska, Robert J. MacInnis, Arto Mannermaa, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Maria Elena Martinez, Laura Matricardi, Lesley McGuffog, Catriona McLean, Noura Mebirouk, Alfons Meindl, Usha Menon, Austin Miller, Elvira Mingazheva, Marco Montagna, Anna Marie Mulligan, Claire Mulot, Taru A. Muranen, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Patrick Neven, William G. Newman, Finn C. Nielsens, Liene Nikitina-Zake, Jesse Nodora, Kenneth Offit, Edith Olah, Olufunmilayo Olopade, Hakan Olsson, Nick Orr, Laura Papi, Janos Papp, Tjoung-Won Park-Simon, Michael T. Parsons, Bernard Peissel, Ana Peixoto, Beth Peshkin, Paolo Peterlongo, Julian Peto, Kelly-Anne Phillips, Marion Piedmonte, Dijana Plaseska-Karanfilska, Karolina Prajzendanc, Ross Prentice, Darya Prokofyeva, Brigitte Rack, Paolo Radice, Susan J. Ramus, Johanna Rantala, Muhammad U. Rashid, Gad Rennert, Hedy S. Rennert, Harvey A. Risch, Atocha Romero, Matti A. Rookus, Matthias Ruebner, Thomas Ruediger, Emmanouil Saloustros, Sarah Sampson, Dale P. Sandler, Elinor J. Sawyer, Maren T. Scheuner, Rita K. Schmutzler, Andreas Schneeweiss, Minouk J. Schoemaker, Ben Schoettker, Peter Schuermann, Leigha Senter, Priyanka Sharma, Mark E. Sherman, Xiao-Ou Shu, Christian F. Singer, Snezhana Smichkoska, Penny Soucy, Melissa C. Southey, John J. Spinelli, Jennifer Stone, Dominique Stoppa-Lyonnet, Anthony J. Swerdlow, Csilla Szabo, Rulla M. Tamimi, William J. Tapper, Jack A. Taylor, Manuel R. Teixeira, MaryBeth Terry, Mads Thomassen, Darcy L. Thull, Marc Tischkowitz, Amanda E. Toland, Rob A. E. M. Tollenaar, Ian Tomlinson, Diana Torres, Melissa A. Troester, Therese Truong, Nadine Tung, Michael Untch, Celine M. Vachon, Ans M. W. van den Ouweland, Lizet E. van der Kolk, Elke M. van Veen, Elizabeth J. vanRensburg, Ana Vega, Barbara Wappenschmidt, Clarice R. Weinberg, Jeffrey N. Weitzel, Hans Wildiers, Robert Winqvist, Alicja Wolk, Xiaohong R. Yang, Drakoulis Yannoukakos, Wei Zheng, Kristin K. Zorn, Roger L. Milne, Peter Kraft, Jacques Simard, Paul D. P. Pharoah, Kyriaki Michailidou, Antonis C. Antoniou, Marjanka K. Schmidt, Georgia Chenevix-Trench, Douglas F. Easton, Nilanjan Chatterjee, Montserrat Garcia-Closas
Article
Obstetrics & Gynecology
Hanna Huebner, Kirsten Heussner, Matthias Ruebner, Matthias Schmid, Jennifer Nadal, Joachim Woelfle, Andrea Hartner, Carlos Menendez-Castro, Manfred Rauh, Matthias W. Beckmann, Sven Kehl, Fabian B. Fahlbusch
Summary: This study compared the direct and indirect enzymatic activity of 11 β-HSD2 in placentas of women who had spontaneous births and cesarean sections. The ratio of cortisol to cortisone correlated with the direct microsomal enzymatic turnover, while mode of delivery had a strong influence on tissue steroids. HSD11B2 expression correlated with indirect and direct cortisol turnover rates in C-section placentas only, with significantly increased levels of CRH, cortisol, and cortisone following spontaneous birth.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Obstetrics & Gynecology
Jutta Pretscher, Matthias Ruebner, Arif B. Ekici, Melanie Roedl, Hanna Huebner, Judith Schwitulla, Adriana Titzmann, Charlotte Hartwig, Matthias W. Beckmann, Peter A. Fasching, Michael O. Schneider, Eva Schwenke
Summary: This study identified a significant association between one SNP in the progesterone receptor and preeclampsia, suggesting a potential genetic link to the onset of preeclampsia. Further research is needed to explore the role and causal relationship of genetic variations in the development of preeclampsia.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Hematology
Shrey Kohli, Kunal Kumar Singh, Anubhuti Gupta, Paulina Markmeyer, Franziska Lochmann, Dheerendra Gupta, Rajiv Rana, Ahmed Elwakiel, Hanna Huebner, Matthias Ruebner, Berend Isermann
Summary: The study revealed a unidirectional interaction between placental inflammasome activation and reduced placental TM expression, and demonstrated that soluble TM treatment or placental TM restoration can alleviate PE-like symptoms.
Article
Multidisciplinary Sciences
Franziska M. Wuerfel, Hanna Huebner, Lothar Haeberle, Paul Gass, Alexander Hein, Sebastian M. Jud, Carolin C. Hack, Marius Wunderle, Ruediger Schulz-Wendtland, Ramona Erber, Arndt Hartmann, Arif B. Ekici, Matthias W. Beckmann, Peter A. Fasching, Matthias Ruebner
SCIENTIFIC REPORTS
(2020)
Article
Reproductive Biology
Barbara Denkl, Nada Cordasic, Hanna Huebner, Carlos Menendez-Castro, Marius Schmidt, Alexander Mocker, Joachim Woelfle, Andrea Hartner, Fabian B. Fahlbusch
Summary: The study investigates the roles of placental UPR and oxidative stress in IUGR and PE, finding that placental ER stress is not induced in rat and mouse models, while oxidative stress is significantly increased in female IUGR rat placentas.
BIOLOGY OF REPRODUCTION
(2021)
Article
Oncology
Peter A. Fasching, Siddhartha Yadav, Chunling Hu, Marius Wunderle, Lothar Haeberle, Steven N. Hart, Matthias Ruebner, Eric C. Polley, Kun Y. Lee, Rohan D. Gnanaolivu, Peyman Hadji, Hanna Huebner, Hans Tesch, Johannes Ettl, Friedrich Overkamp, Michael P. Lux, Arif B. Ekici, Bernhard Volz, Sabrina Uhrig, Diana Lueftner, Markus Wallwiener, Volkmar Mueller, Erik Belleville, Michael Untch, Hans-Christian Kolberg, Matthias W. Beckmann, Andre Reis, Arndt Hartmann, Wolfgang Janni, Pauline Wimberger, Florin-Andrei Taran, Tanja N. Fehm, Diethelm Wallwiener, Sara Y. Brucker, Andreas Schneeweiss, Andreas D. Hartkopf, Fergus J. Couch
Summary: Among patients with metastatic breast cancer, around 10.4% carry germline mutations in established breast cancer predisposition genes such as BRCA1 and BRCA2. While these mutations may impact tumor characteristics, they do not significantly affect progression-free survival or overall survival in patients with metastatic breast cancer.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Paulina Markmeyer, Franziska Lochmann, Kunal Kumar Singh, Anubhuti Gupta, Ruaa Younis, Khurrum Shahzad, Ronald Biemann, Hanna Huebner, Matthias Ruebner, Berend Isermann, Shrey Kohli
Summary: Research indicates that procoagulant extracellular vesicles (EV) can affect trophoblast morphology and differentiation by inducing a thrombo-inflammatory pathway, leading to an increase in giant trophoblast and spongiotrophoblast cells. These effects are related to platelet activation and NLRP3 inflammasome, with inflammasome activation in humans showing negative correlation with trophoblast differentiation marker GCM1 and positive correlation with blood pressure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Hanna Huebner, Hannah Lubrich, Simon Blum, Sophia Antoniadis, Johannes Lermann, Arif Ekici, Peter A. Fasching, Matthias W. Beckmann, Matthias Ruebner, Stefanie Burghaus
Summary: The study compared two extraction methods for isolating and quantifying ccfDNA from endometriosis patients, with the Maxwell method showing significantly higher yield and the QIAamp method showing higher ccfDNA integrity. Both methods are suitable for downstream applications in non-invasive detection and analysis of somatic mutations within endometriosis tissue.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Oncology
Ramona Erber, Arndt Hartmann, Peter Andreas Fasching, Matthias Ruebner, Robert Stohr, Matthias Wilhelm Beckmann, Miriam Zentgraf, Verena Popp, Jodi Weidler, Iris Simon, Steffi Becker, Hanna Huebner, Josephine Fischer, Elena Guerini Rocco, Giuseppe Viale, Anne Cayre, Frederique Penault-Llorca, Tamara Caniego Casas, Belen Perez-Mies, Jose Palacios, Paul Jank, Carsten Denkert, Lina Khoury, Thomas Mairinger, Fulvia Ferrazzi
Summary: This study compared the performance of the mRNA-based STRAT4 method with the gold standard of immunohistochemistry, finding that ESR1 and ERBB2 mRNA results were entirely consistent, while PGR and MKI67 results showed some inconsistencies.
Article
Oncology
Ramona Erber, Sareetha Kailayangiri, Hanna Huebner, Matthias Ruebner, Arndt Hartmann, Lothar Haeberle, Julia Meyer, Simon Voelkl, Andreas Mackensen, Laura Landgraf, Carol Geppert, Ruediger Schulz-Wendtland, Matthias W. Beckmann, Peter A. Fasching, Nicole Farwick, Claudia Rossig, Paul Gass
Summary: The study found that GD2 is expressed in more than 50% of breast cancer cases, with the highest frequency in hormone receptor-positive tumors. However, GD2 expression was not significantly associated with patient outcome.
Article
Oncology
Hanna Huebner, Lothar Haeberle, Volkmar Mueller, Iris Schrader, Ralf Lorenz, Helmut Forstbauer, Visnja Fink, Fabienne Schochter, Inga Bekes, Sven Mahner, Julia Jueckstock, Naiba Nabieva, Andreas Schneeweiss, Hans Tesch, Sara Y. Brucker, Jens-Uwe Blohmer, Tanja N. Fehm, Georg Heinrich, Mahdi Rezai, Matthias W. Beckmann, Peter A. Fasching, Wolfgang Janni, Brigitte Rack
Summary: CA27.29 (MUC1) is a well-known biomarker for predicting prognosis and treatment efficacy in breast cancer, mainly evaluated in the preoperative setting. This study suggests that both pre- and post-chemotherapy CA27.29 values do not provide additional prognostic information, but pre-chemotherapy CA27.29 may help identify a group with unfavorable prognosis among node-positive patients.
Article
Chemistry, Analytical
Johanna Gleichauf, Lukas Hennemann, Fabian B. B. Fahlbusch, Oliver Hofmann, Christine Niebler, Alexander Koelpin
Summary: The monitoring of vital signs and improving patient comfort in neonatal intensive care is important. Non-contact methods are being researched to resolve the discomfort caused by skin contact in preterm neonates. We propose a novel approach using fusion data of thermal and RGB cameras for neonatal face detection. Our results show high precision and increased data efficiency, contributing to the development of non-contact monitoring for preterm neonates.
Article
Obstetrics & Gynecology
Carla E. Schulmeyer, Simon Bader, Hanna Huebner, Matthias Ruebner, Peter A. Fasching
Summary: Next generation sequencing (NGS) technology has revolutionized genomic research by allowing rapid sequencing of the entire human genome within a day. It is widely used in genetic, microbiological, and oncological research, but has not yet been fully integrated into clinical routine. In obstetrics and gynecology, NGS is particularly valuable for noninvasive prenatal testing (NIPT), reproductive medicine, and oncology.
