Article
Clinical Neurology
Salomon Cohen-Cohen, Ahmed Helal, Ziying Yin, Matthew K. Ball, Richard L. Ehman, Jamie J. Van Gompel, John Huston
Summary: This study confirms that MRE is a reliable tool for predicting pituitary adenoma consistency. Preoperative knowledge of tumor consistency could potentially aid in surgical planning, counseling about potential surgical risks, and estimating the length of operative time.
JOURNAL OF NEUROSURGERY
(2022)
Article
Oncology
Linqi Zhang, Xi Long, Mayidili Nijiati, Tianhui Zhang, Mengsi Li, Ying Deng, Sichi Kuang, Yuanqiang Xiao, Jie Zhu, Bingjun He, Jingbiao Chen, Phillip Rossman, Kevin J. Glaser, Sudhakar K. Venkatesh, Richard L. Ehman, Jin Wang
Summary: The study showed that using 3D MRE can help predict aggressiveness in EC, particularly in predicting tumor grade, FIGO stage, and depth of myometrial invasion.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ling Long, Meiling Liu, Xijia Deng, Meimei Cao, Jing Zhang, Xiaosong Lan, Jiuquan Zhang
Summary: The value of tomoelastography in determining the underlying origins of uterine adenocarcinoma was prospectively evaluated. MRI and tomoelastography examination were performed on 64 patients with confirmed adenocarcinomas. The study found that cervical adenocarcinomas and endometrial adenocarcinomas have different biomechanical features. Tomoelastography can provide additional diagnostic value for distinguishing between the two diseases.
MAGNETIC RESONANCE IMAGING
(2023)
Article
Endocrinology & Metabolism
Kerstin Lagerstrand, Nicholas Gaedes, Stig Eriksson, Dan Farahmand, Erica De Coursey, Gudmundur Johansson, Lars Jonsson, Thomas Skoglund
Summary: The study demonstrated that preoperative virtual Magnetic Resonance Elastography (vMRE) can successfully evaluate tissue stiffness in patients with pituitary adenomas (PA), particularly in displaying focal regions of heterogeneous tumors that may affect surgical outcomes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuan Le, Jun Chen, Phillip J. Rossman, Bradley Bolster Jr, Stephan Kannengiesser, Armando Manduca, Kevin J. Glaser, Yi Sui, John Huston III, Ziying Yin, Richard L. Ehman
Summary: In this study, a novel MR elastography technique called wavelet MRE was demonstrated. This technique allows for broadband motion sensitivity and reconstruction of true tissue displacement using a simple inverse transform. The results of simulations, phantom tests, and human brain testing showed that wavelet MRE accurately estimated motion and produced consistent results.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Engineering, Biomedical
Lisa Smith, Vidar Skulberg, Lili Zhang, Ivar Sjaastad, Emil Espe
Summary: Cardiac magnetic resonance elastography (MRE) is a useful technique for assessing myocardial stiffness in vivo. In this study, small animal cardiac MRE was explored using phantoms with known underlying stiffness. The results showed that MRE can differentiate between different stiffnesses in small cardiac phantoms, although the stiffness measurements were influenced by geometrical effects when the wavelength was longer than half the size of the heart. The Local Frequency Estimate (LFE) inversion algorithm was found to be the most sensitive to changes in stiffness.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Megan Co, Huiming Dong, Daniel J. Boulter, Xuan Nguyen, Safdar N. Khan, Brian Raterman, Brett Klamer, Arunark Kolipaka, Benjamin A. Walter
Summary: This study validated the use of a spin-echo echo-planar imaging (SE-EPI) sequence for magnetic resonance elastography (MRE) of the intervertebral disc (IVD). The results showed that the SE-EPI sequence can effectively assess the shear properties of the IVD, with good correlation to the standard gradient recalled echo (GRE) sequence, and it also reduces scan times.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Clinical Neurology
T. Takamura, U. Motosugi, M. Ogiwara, Y. Sasaki, K. J. Glaser, R. L. Ehman, H. Kinouchi, H. Onishi
Summary: In managing meningiomas, tumor consistency can be predicted by stiffness, while relative MTT may be correlated with tumor stiffness and differentiate among different histologic subtypes of meningioma.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Jing Guo, Lynn Jeanette Savic, Karl Herbert Hillebrandt, Ingolf Sack
Summary: The mechanical characteristics of cancer, including high solid stress and heterogeneous changes in tissue properties, play important roles in tumor progression and metastasis. Magnetic resonance elastography is an emerging imaging technology that can characterize the biomechanical properties of tumors and provide novel in vivo imaging markers. This review article presents recent technical developments, basic results, and clinical applications of magnetic resonance elastography in patients with malignant tumors.
INVESTIGATIVE RADIOLOGY
(2023)
Article
Oncology
Yi-Lin Luo, Fang Gu, Hai-Qing Fan, Jin-Hui Du, Yue Yu, Li-Kun Liu, Xin Liao
Summary: This study explored the diagnostic value of an ectopic posterior pituitary hyperintense signal (EPPHS) in diagnosing pituitary macroadenoma. The formation of EPPHS may be related to injuries to the pituitary stalk.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Emin Gultekin, Christoph Wetz, Juergen Braun, Dominik Geisel, Christian Furth, Bernd Hamm, Ingolf Sack, Stephan R. Marticorena Garcia
Summary: Magnetic resonance elastography (MRE) with tomoelastography postprocessing shows good diagnostic performance in differentiating pancreatic neuroendocrine tumors (PNETs) from healthy pancreatic tissue and correlates PNET stiffness with PET derived asphericity, indicating its potential for assessing PNET hardness and predicting aggressiveness.
Article
Virology
Mayu Higuchi, Nobuharu Tamaki, Masayuki Kurosaki, Kento Inada, Sakura Kirino, Koji Yamashita, Yuka Hayakawa, Shuhei Sekiguchi, Leona Osawa, Kenta Takaura, Chiaki Maeyashiki, Shun Kaneko, Yutaka Yasui, Kaoru Tsuchiya, Hiroyuki Nakanishi, Jun Itakura, Nobuyuki Enomoto, Namiki Izumi
Summary: Most patients achieved sustained virological response (SVR) with direct-acting antivirals (DAA) therapy, but some patients, especially those with advanced fibrosis, did not show improvement in liver stiffness after achieving SVR. Despite obtaining SVR, improvement in liver stiffness could not be obtained in some cases.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Engineering, Biomedical
Runke Wang, Yu Chen, Ruokun Li, Suhao Qiu, Zhiyong Zhang, Fuhua Yan, Yuan Feng
Summary: This study introduces a method for fast MRE that can provide a more accurate estimation of shear modulus in the brain. Experimental results show that the proposed method can achieve high-quality images in a shorter scanning time and outperforms traditional methods in terms of reconstruction performance. This research is of great significance for improving the imaging speed and quality of MRE.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Engineering, Biomedical
Dilyana B. Mangarova, Gergely Bertalan, Jakob Jordan, Julia Brangsch, Avan Kader, Jana Moeckel, Lisa C. Adams, Ingolf Sack, Matthias Taupitz, Bernd Hamm, Juergen Braun, Marcus R. Makowski
Summary: This study demonstrates the use of microscopic multifrequency magnetic resonance elastography to measure the stiffness of abdominal aortic aneurysms with a resolution of 40 microns. The results show that changes in stiffness are closely related to extracellular matrix remodeling. This technique has the potential to provide detailed characterization of AAAs and quantify pathological remodeling of the extracellular matrix.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Lorne W. Hofstetter, Henrik Odeen, Bradley D. Bolster, Douglas A. Christensen, Allison Payne, Dennis L. Parker
Summary: This study presents a novel MR shear wave elastography technique that combines transient acoustic radiation force impulses with sinusoidal-shaped MR displacement encoding. An analytic expression for calculating shear wave speed in a heterogeneous medium was derived, and the feasibility of using this technique was confirmed experimentally. The study demonstrated the accuracy of the method in measuring shear wave speed values in different mediums, showing potential applications in clinical settings.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Orthopedics
Janet M. Denbeigh, Mario Hevesi, Carlo A. Paggi, Zachary T. Resch, Leila Bagheri, Kristin Mara, Arvin Arani, Chenghao Zhang, A. Noelle Larson, Daniel B. F. Saris, Aaron J. Krych, Andre J. van Wijnen
Summary: The study found that physiological storage at 37 degrees Celsius improves chondrocyte viability and metabolism, and maintains collagen expression compared to storage at 22 degrees Celsius, suggesting potential for optimizing short-term fresh OCA storage for improved clinical outcomes.
Article
Biophysics
Dinesh K. Deelchand, Adam Berrington, Ralph Noeske, James M. Joers, Arvin Arani, Joseph Gillen, Michael Schar, Jon-Fredrik Nielsen, Scott Peltier, Navid Seraji-Bozorgzad, Karl Landheer, Christoph Juchem, Brian J. Soher, Douglas C. Noll, Kejal Kantarci, Eva M. Ratai, Thomas H. Mareci, Peter B. Barker, Guelin Oz
Summary: The study developed a short-echo sLASER sequence that could be executed on different platforms within a B-1 limit of 15 μT, demonstrating good reproducibility across vendors.
NMR IN BIOMEDICINE
(2021)
Article
Medicine, Research & Experimental
Luis A. Antezana, Matthew L. Carlson, Ernest M. Hoffman, Roberto A. Cueva, Jamie J. Van Gompel
Article
Radiology, Nuclear Medicine & Medical Imaging
Yi Sui, Arvin Arani, Joshua D. Trzasko, Matthew C. Murphy, Phillip J. Rossman, Kevin J. Glaser, Kiaran P. McGee, Armando Manduca, Richard L. Ehman, Philip A. Araoz, John Huston
Summary: The new TURBINE-MRE sequence demonstrated feasibility in acquiring desired 3D wave-field data and stiffness maps in a phantom and in-vivo brains. The stiffness measured with both methods had a strong linear relationship, showing comparable results between TURBINE-MRE and standard SE-EPI-MRE. This pilot study encourages further exploration of TURBINE-MRE for functional MRE, free-breathing abdominal MRE, and cardiac MRE applications.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Neurosciences
Petrice M. Cogswell, Heather J. Wiste, Matthew L. Senjem, Jeffrey L. Gunter, Stephen D. Weigand, Christopher G. Schwarz, Arvin Arani, Terry M. Therneau, Val J. Lowe, David S. Knopman, Hugo Botha, Jonathan Graff-Radford, David T. Jones, Kejal Kantarci, Prashanthi Vemuri, Bradley F. Boeve, Michelle M. Mielke, Ronald C. Petersen, Clifford R. Jack
Summary: This study investigates the associations between QSM and established markers of Alzheimer's disease. It found that increased susceptibility in deep and inferior gray nuclei is related to aging, cognitive impairment, amyloid deposition, and off-target binding of the tau ligand. Associations were also seen between susceptibility and amyloid PET, tau PET, and cortical gray matter volume in the medial temporal lobe. Additionally, iron content was found to be insufficient in the cortex for reliable detection using QSM.
Review
Radiology, Nuclear Medicine & Medical Imaging
Arvin Arani, Armando Manduca, Richard L. Ehman, John Huston
Summary: MRI elastography is a non-invasive imaging technique for measuring the mechanical properties of the living human brain, with potential clinical applications in various neurological conditions. This review provides an overview of the measurements obtained with brain MRE, tools used for these measurements, and promising biomarkers for future clinical use.
BRITISH JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bing Hu, Ying Deng, Jingbiao Chen, Sichi Kuang, Wenjie Tang, Bingjun He, Linqi Zhang, Yuanqiang Xiao, Jun Chen, Phillip Rossman, Arvin Arani, Ziying Yin, Kevin J. Glaser, Meng Yin, Sudhakar K. Venkatesh, Richard L. Ehman, Jin Wang
Summary: This study aimed to assess the relationship between MRE stiffness of PCa and LNM extent. Results showed that PCa MRE stiffness and maximum diameter were independent predictors of LNM, and their combination could provide higher sensitivity and specificity than the Briganti 2019 nomogram for predicting LNM.
ABDOMINAL RADIOLOGY
(2021)
Article
Clinical Neurology
Qin Chen, Bradley F. Boeve, Arvin Forghanian-Arani, Matthew L. Senjem, Clifford R. Jack, Scott A. Przybelski, Timothy G. Lesnick, Walter K. Kremers, Julie A. Fields, Christopher G. Schwarz, Jeffrey L. Gunter, Joshua D. Trzasko, Jonathan Graff-Radford, Rodolfo Savica, David S. Knopman, Dennis W. Dickson, Tanis J. Ferman, Neill Graff-Radford, Ronald C. Petersen, Kejal Kantarci
Summary: QSM measurement revealed higher magnetic susceptibility in the substantia nigra in patients with probable dementia with Lewy bodies (pDLB), with no association between parkinsonism severity and mean susceptibility in the substantia nigra. The trend of increasing susceptibility from controls to iRBD and MCI-LB, and to pDLB indicates early iron deposition in the substantia nigra in the prodromal stage of DLB.
JOURNAL OF NEUROIMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Arvin Arani, Christopher G. Schwarz, Heather J. Wiste, Stephen D. Weigand, Petrice M. Cogswell, Matthew C. Murphy, Joshua D. Trzasko, Jeffrey L. Gunter, Matthew L. Senjem, Kiaran P. McGee, Yunhong Shu, Matt A. Bernstein, John Huston, Clifford R. Jack
Summary: The study investigated the systematic differences in localized regions of left-right image intensity asymmetry (LRIA) on MRI scans and the potential diagnostic uncertainty caused by this artifact. Using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, the study found that LRIA affected the diagnostic accuracy of IR-SPGR, MP-RAGE, and LT-FSE-IR sequences. The study highlights the importance of considering LRIA when interpreting MRI images.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ying Deng, Zhuoya Yi, Tianhui Zhang, Bing Hu, Linqi Zhang, Kritisha Rajlawot, Sichi Kuang, Bingjun He, Arvin Arani, Jun Chen, Meng Yin, Phillip Rossman, Kevin J. Glaser, Sudhakar K. Venkatesh, Richard L. Ehman, Jin Wang
Summary: This study demonstrated the feasibility and diagnostic value of high-frequency magnetic resonance elastography (MRE) for evaluating prostatic disease in patients with lower urinary tract symptoms (LUTS). The image quality of prostate MRE using a modified driver was better at higher frequencies (60-150 Hz), showing potential usefulness in evaluating prostate diseases, especially at higher frequencies. Further research with a larger population may be warranted in the future.
ABDOMINAL RADIOLOGY
(2022)
Article
Oncology
Sukwoo Hong, Nadia Laack, Anita Mahajan, Erin K. O'Brien, Janalee K. Stokken, Jeffrey R. Janus, Garret Choby, Jamie J. Van Gompel
Summary: The introduction of a multidisciplinary team has shown to effectively treat clival chordoma, resulting in higher tumor resection rate, lower recurrence rate, and reduced post-operative complications. After 2013, the endoscopic approach became more commonly used, leading to greater tumor resections and lower incidence of new cranial nerve deficits.
Article
Oncology
Garrett Ni, Carlos D. Pinheiro-Neto, Ehiremen Iyoha, Jamie J. Van Gompel, Michael J. Link, Maria Peris-Celda, Eric J. Moore, Janalee K. Stokken, Mauricio Gamez, Garret Choby
Summary: This study examines patient outcomes after recurrence of esthesioneuroblastoma and describes patterns of salvage therapeutic interventions. The 5-year overall survival after recurrence was found to be 63% and the 5-year progression-free survival was 56%. The time to develop a secondary recurrence was shorter than the time to develop the first recurrence, and patients with secondary recurrences were older at the time of their primary tumor diagnosis.
Article
Neurosciences
Christopher G. Schwarz, Walter K. Kremers, Arvin Arani, Marios Savvides, Robert I. Reid, Jeffrey L. Gunter, Matthew L. Senjem, Petrice M. Cogswell, Prashanthi Vemuri, Kejal Kantarci, David S. Knopman, Ronald C. Petersen, Clifford R. Jack
Summary: It is now known that research brain MRI, CT, and PET images may be re-identified using face recognition, but applying face-deidentification software can reduce this risk. The re-identification potential and effects of de-facing are unknown for certain research MRI sequences. In this study, the re-identification rates were examined for different MRI sequences, and it was found that high-quality de-facing software can greatly reduce the risk of re-identification for identifiable MRI sequences.
Article
Oncology
Simona Serioli, Mariagrazia Nizzola, Pedro Plou, Alessandro De Bonis, Jenna Meyer, Luciano C. P. C. Leonel, Andrea A. Tooley, Lilly H. Wagner, Elizabeth A. Bradley, Jamie J. Van Gompel, Maria Elena Benini, Iacopo Dallan, Maria Peris-Celda
Summary: This study aims to provide a detailed description of the anatomy to understand the potential and limitations of transorbital approaches (TOAs). Measurements of the orbit region and surrounding areas were performed on CT scans and dry skulls, and dissection was done on specimens to illustrate the TOA. Three clinical cases were presented to highlight the surgical applications.
Article
Neuroimaging
Neha Atulkumar Singh, Arvin Arani, Jonathan Graff-Radford, Matthew L. Senjem, Peter R. Martin, Mary M. Machulda, Christopher G. Schwarz, Yunhong Shu, Petrice M. Cogswell, David S. Knopman, Ronald C. Petersen, Val J. Lowe, Clifford R. Jack Jr, Keith A. Josephs, Jennifer L. Whitwell
Summary: This study used QSM to detect iron distribution in the brain and found differences in iron deposition patterns between typical AD and atypical AD (such as LPA and PCA). The results demonstrate the potential of QSM in studying iron deposition in these patients.
NEUROIMAGE-CLINICAL
(2022)