Article
Pharmacology & Pharmacy
Yunzhao Yang, Zhongyuan Xia, Cheng Xu, Chunchun Zhai, Xi Yu, Siqi Li
Summary: Ciprofol protects the heart against ISO-induced myocardial infarction by reducing cardiac oxidative stress, the inflammatory response, and cardiomyocyte apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Abdullah F. AlAsmari, Adel Alghamdi, Nemat Ali, Muath A. Almeaikl, Hassan M. Hakami, Meshal K. Alyousef, Mohammed AlSwayyed, Metab Alharbi, Faleh Alqahtani, Fawaz Alasmari, Nasser Alsaleh
Summary: This study investigated the toxic effect of Venetoclax (VTX) on the heart and found that VTX treatment resulted in cardiac damages, with major changes in histopathology, elevated cardiac enzymes and hypertrophic gene markers. Additionally, increased oxidative stress, inflammatory markers, and apoptosis were observed, along with a decline in the levels of Bcl-2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wei Zhou, Yang Fu, Jin-Song Xu
Summary: Sophocarpine (SOP) can alleviate isoproterenol (ISO)-induced kidney injury by inhibiting inflammation, apoptosis, oxidative stress, and fibrosis. Its mechanisms of action involve the suppression of TLR-4/NF-κB and TGF-β1/Smad3 signaling pathways and activation of the Nrf2/HO-1 signaling pathway.
Article
Environmental Sciences
Maha S. Lokman, Hussam A. Althagafi, Fahad Alharthi, Ola A. Habotta, Arwa A. Hassan, Mohamed A. Elhefny, Hassan Al Sberi, Abdulrahman Theyab, Ahmad Hasan Mufti, Alaa Alhazmi, Yousef M. Hawsawi, Asmaa F. Khafaga, Mahmoud S. Gewaily, Khalaf F. Alsharif, Ashraf Albrakati, Rami B. Kassab
Summary: This study aimed to evaluate the protective effect of Quercetin against 5-FU-induced cardiotoxicity. The results suggested that Quercetin has potent antioxidant, anti-inflammatory, and anti-apoptotic effects, which can ameliorate the cardiotoxic effects of 5-FU.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Anouar Feriani, Meriam Tir, Waleed Aldahmash, Kais Mnafgui, Alimi Hichem, Ana Maria Gomez-Caravaca, Maria Del Mar Contreras, Amani Taamalli, Saleh Alwasel, Antonio Segura-Carretero, Nizar Tlili, Abdel Halim Harrath
Summary: The aim of this study was to investigate the cardiopreventive effect of the methanolic extract of S. molle L. (MESM) on isoproterenol-induced infarction in rats. The results showed that MESM exhibited cardioprotective effects by normalizing cardiac risk parameters, reducing oxidative stress, inhibiting apoptosis, reducing DNA fragmentation and infarct size, and inhibiting fibrosis in myocardial tissue.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Cell Biology
Yanyu Lu, Qianqian Min, Xiaoyan Zhao, Li Li, Guojun Zhao, Jianzeng Dong
Summary: Eupatilin has various biological activities, including anticancer, anti-inflammatory, antioxidant, neuroprotective, anti-allergic, and cardioprotective effects. This study aimed to investigate the protective effects of eupatilin on doxorubicin-induced cardiotoxicity. The results demonstrated that eupatilin attenuated inflammation, oxidative stress, and cardiomyocyte apoptosis, and improved doxorubicin-induced cardiac dysfunction by activating the PI3K-AKT signaling pathway. This study provides the first evidence for the therapeutic potential of eupatilin in doxorubicin-induced cardiotoxicity.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Toxicology
Zheng-Cai Du, Zhong-Shang Xia, Yan-Feng Huang, Yi Peng, Bing-Bing Cao, Chun-Qi Li, Yun-Fei Liang, Fang-Hui Zhao, Ming-Zhe Zhang, Zhang-Mei Chen, Xiao-Tao Hou, Er-Wei Hao, Jia-Gang Deng
Summary: Momordica cochinchinensis is an indigenous South Asian edible fruit, and its seeds have been used in traditional Chinese medicine for its antioxidant, anti-ulcer, and potential anticancer properties. Recent studies suggest that Momordica cochinchinensis seed extract may induce cardiotoxicity through pathways involved in inflammation, oxidative stress, and apoptosis.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Environmental Sciences
Qiang Luo, Shuqiong Tang, Xiaoping Xiao, You Wei, Bo Cheng, Yong Huang, Keyuan Zhong, Guiyou Tian, Huiqiang Lu
Summary: In this study, the toxicity of benomyl to zebrafish was evaluated, showing high toxicity and inducing oxidative stress and apoptosis. These findings provide important insights into the safe use of benomyl.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
A. O. Hamouda, A. R. Abdel-Hamed, D. M. Abo-Elmatty, N. F. Khedr, M. H. Ghattas
Summary: The combination of Pentoxifylline (PTX) and Kaempferol (KP) has a significant therapeutic effect against non-alcoholic steatohepatitis (NASH), with decreased oxidative stress, lipogenesis, proinflammatory cytokines, and modulation of histopathological manifestation. This effect is achieved by regulating apoptosis and necroptosis pathways, as well as by decreasing levels of LDL-C, total cholesterol, triglycerides, glutathione peroxidase (GPx), superoxide dismutase (SOD), malondialdehyde (MDA), glucose, insulin, and HOMA-IR, while increasing the expression of AMP-activated protein kinase (AMPK) and reducing the expression of peroxisome proliferator-activated receptor (PPAR), phosphorylated mixed lineage kinase-like protein (pMLKL), and sterol regulatory element binding protein 1 (SREBP1).
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Environmental Sciences
Quan Mo, Muhammad Fakhar-e-Alam Kulyar, Yanmei Ding, Yan Zhang, Huachun Pan, Jiakui Li
Summary: This study examines the toxic effects of long-term exposure to Thiram on the heart of broilers and finds that Thiram may cause cardiotoxicity by interfering with taurine and hypotaurine metabolism, pyrimidine metabolism, and glycerolipid metabolism. This study is of great importance for understanding the molecular mechanism of cardiotoxicity caused by Thiram.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Basma G. Eid, Nagla Abd El-Aziz El-Shitany, Thikryat Neamatallah
Summary: The study demonstrated that trimetazidine has a prophylactic effect against adriamycin-induced cardiac toxicity, potentially through increasing antioxidant levels, inhibiting inflammation, and programmed cell death.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Heba M. Obeidat, Osama Y. Althunibat, Manal A. Alfwuaires, Saleem H. Aladaileh, Abdulmohsen Algefare, Afaf F. Almuqati, Fawaz Alasmari, Hammad Khalifeh Aldal'in, Abdulkareem A. Alanezi, Bader Alsuwayt, Mohammad H. Abukhalil
Summary: This study demonstrates that (+)-taxifolin (TAX) has a significant protective effect against isoproterenol (ISO)-induced acute myocardial injury, reducing oxidative tissue damage and inflammation response by activating the Nrf2/HO-1 signaling pathway and attenuating apoptosis.
Article
Biochemistry & Molecular Biology
Mengjie Xiao, Yufeng Tang, Jie Wang, Guangping Lu, Jianlou Niu, Jie Wang, Jiahao Li, Qingbo Liu, Zhaoyun Wang, Zhifeng Huang, Yuanfang Guo, Ting Gao, Xiaohui Zhang, Shouwei Yue, Junlian Gu
Summary: This study suggests that FGF1 may be a potential therapeutic agent against ADR-induced cardiotoxicity. Treatment with FGF1 & DEG; HBS can prevent ADR-induced cardiac dysfunction and associated inflammation, fibrosis, and hypertrophy. The protective effects of FGF1 & DEG; HBS are mediated through the inhibition of apoptosis and oxidative stress in cardiomyocytes.
Article
Biochemistry & Molecular Biology
Jie A. Wang, Yufeng Tang, Jingjing Zhang, Jie B. Wang, Mengjie Xiao, Guangping Lu, Jiahao Li, Qingbo Liu, Yuanfang Guo, Junlian Gu
Summary: In this study, the researchers investigated the role of the interaction between SIRT1 and SESN2 in DOX-induced cardiomyopathy. They found that SIRT1 deficiency aggravated cardiac damage, while the activation of SIRT1 had protective effects. Further studies revealed that SIRT1 reduced oxidative damage and apoptosis by attenuating the interaction between SESN2 and MDM2, thereby protecting the heart from DOX-induced toxicity.
Review
Medicine, Research & Experimental
Yuxin Du, Laurie J. Demillard, Jun Ren
Summary: Cerebrovascular diseases such as stroke can lead to cardiac complications through mechanisms such as catecholamine surges, which increase the risk of heart damage.
Article
Biochemistry & Molecular Biology
Yogeeta O. Agrawal, Umesh B. Mahajan, Vinit V. Agnihotri, Mayur S. Nilange, Hitendra S. Mahajan, Charu Sharma, Shreesh Ojha, Chandragouda R. Patil, Sameer N. Goyal
Summary: Ezetimibe was successfully encapsulated into nanostructured lipid carriers using high pressure homogenization technique, showing promising pharmaceutical properties and significant therapeutic effects on hyperlipidemia in rats. The Ezetimibe nanostructured lipid carriers demonstrated superiority in terms of bioavailability enhancement and reduced side effects.
Article
Pharmacology & Pharmacy
Niraj Kumar Jha, Charu Sharma, Hebaallah Mamdouh Hashiesh, Seenipandi Arunachalam, M. F. Nagoor Meeran, Hayate Javed, Chandragouda R. Patil, Sameer N. Goyal, Shreesh Ojha
Summary: Beta-caryophyllene (BCP) as a selective functional agonist on CB2 receptors, exhibits anti-inflammatory, antiviral, and immunomodulatory properties. It is considered a promising therapeutic candidate for COVID-19 due to its tissue protective properties, modulation of signaling pathways, and inhibitory effects on inflammatory mediators. Further preclinical and clinical studies are warranted to explore its potential as an immunomodulator, anti-inflammatory agent, and antiviral compound.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Hebaallah Mamdouh Hashiesh, Charu Sharma, Sameer N. Goyal, Bassem Sadek, Niraj Kumar Jha, Juma Al Kaabi, Shreesh Ojha
Summary: BCP is a natural compound with selective agonist properties that activate CB2R and have various pharmacological effects. BCP shows protective effects in the heart, liver, nervous system, kidneys, gastrointestinal tract, cancer, with antioxidant, anti-inflammatory, and immunomodulatory actions.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Agriculture, Multidisciplinary
M. F. Nagoor Meeran, Sheikh Azimullah, Hebaallah Hashiesh Mamoudh, Charu Sharma, Sanjay Kumar, Sameer N. Goyal, Shreesh Ojha
Summary: This study evaluated the cardioprotective effects of nerolidol against chronic cardiotoxicity induced by doxorubicin in rats. Nerolidol demonstrated significant protection against doxorubicin-induced cardiac dysfunction, oxidative stress, and inflammation, possibly through its potent antioxidant properties.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Hebaallah Mamdouh Hashiesh, Charu Sharma, Sameer N. Goyal, Niraj Kumar Jha, Shreesh Ojha
Summary: The CB2-selective agonist JWH133 has shown therapeutic potential in treating pain, inflammation, and cancer while avoiding adverse effects on the central nervous system. By modulating immune and inflammatory signaling pathways, JWH133 may be a promising agent for the treatment of various diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Pharmacology & Pharmacy
Charu Sharma, Niraj Kumar Jha, M. F. Nagoor Meeran, Chandragouda R. Patil, Sameer N. Goyal, Shreesh Ojha
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Seenipandi Arunachalam, M. F. Nagoor Meeran, Sheikh Azimullah, Charu Sharma, Sameer N. Goyal, Shreesh Ojha
Summary: This study investigated the cardioprotective effects of nerolidol in a rat model of doxorubicin-induced acute cardiotoxicity, highlighting its antioxidant, anti-inflammatory, and antiapoptotic activities through modulation of cellular signaling pathways.
Article
Neurosciences
Kamakshi Mehta, Deepak Prabhakar Bhagwat, Devraj, Palika Sehgal, Garima Mittal, Kapil Suchal
Summary: This study demonstrates the neuroprotective role of negundoside in reducing behavioral dysfunction and oxidative damage induced by global cerebral ischemia and reperfusion injury.
PSYCHOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Vinit Agnihotri, Yogeeta Agrawal, Sameer Goyal, Charu Sharma, Shreesh Ojha
Summary: This review demonstrates the pathological changes that should be taken into account when targeting the pulmonary endothelial vasculature, especially with regard to inhaled particle deposition in the alveolar vasculature and characteristic formulations.
Review
Neurosciences
Saptamita Paul Choudhury, Sarika Bano, Srijon Sen, Kapil Suchal, Saroj Kumar, Fredrik Nikolajeff, Sanjay Kumar Dey, Vaibhav Sharma
Summary: Parkinson's disease is a neurological disorder characterized by reduced dopamine levels and alpha-synuclein playing a central role. Ion-channels and gap-junctions are also important in influencing brain metabolism during PD. Targeting these structures may provide new therapeutic interventions for the disease.
NPJ PARKINSONS DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Tulshidas S. Patil, Nayan A. Gujarathi, Abhijeet A. Aher, Hemal E. Pachpande, Charu Sharma, Shreesh Ojha, Sameer N. Goyal, Yogeeta O. Agrawal
Summary: Psoriasis is a disease characterized by abnormal differentiation and excessive proliferation of epidermal keratinocytes, severely impacting patients' quality of life. Current treatment options provide only temporary relief with various adverse effects. Nanostructured lipid carriers (NLCs) have emerged as promising nanocarriers for psoriasis treatment due to their superior physicochemical properties. This manuscript provides an overview of psoriasis, its pathophysiology, existing treatment options, and limitations, highlighting the advantages, rationale, and mechanism of NLCs for psoriasis treatment. It also presents various NLC nanoformulations and relevant patents for psoriasis treatment, along with regulatory considerations. NLCs exhibit sustained drug release, the ability to incorporate hydrophobic and hydrophilic drugs, improved skin hydration, penetration, retention, and bioavailability, reduced staining potential, and decreased side effects compared to conventional ointments, indicating a bright future for NLC nanoformulations in psoriasis treatment. However, academic-industry collaboration and stricter regulatory controls are needed for the commercialization of NLC nanoformulations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Sumit S. Rathod, Yogeeta O. Agrawal, Kartik T. Nakhate, M. F. Nagoor Meeran, Shreesh Ojha, Sameer N. Goyal
Summary: Neuroinflammation is a complex biological process that originates as a protective response in the brain. The distribution of CB1 and CB2 cannabinoid receptors across different brain regions may play important roles in regulating neuroinflammatory processes.
Article
Pharmacology & Pharmacy
Neena Katoch, Ankit Bhardwaj, Kapil Suchal, Sangeeta Sharma
Summary: The study aims to determine the optimal range of phenytoin and valproate levels and identify the critical drug levels below which the risk of breakthrough seizures increases in the North Indian population. Lower mean levels were observed in cases compared to controls, with a negative correlation of drug levels with age and weight. The study suggests a wide level/dose ratio in controls, especially in the valproate group, indicating the need for further prospective studies with larger sample sizes and genetic studies.
JOURNAL OF PHARMACOLOGY & PHARMACOTHERAPEUTICS
(2021)
Article
Tropical Medicine
Aarti S. Kale, Avinash R. Wadkar, Umesh B. Mahajan, Lalit A. Birari, Sateesh Belemkar, Sameer N. Goyal, Shreesh Ojha, Sanjay J. Surana, Chandragouda R. Patil, Kalpesh R. Patil
Summary: Aloin effectively alleviates chronic constriction injury (CCI)-induced neuropathic pain in rats by reducing mechanical and thermal allodynia, improving motor nerve conduction velocity, decreasing oxidative stress, lowering pro-inflammatory cytokine levels, and restoring the histoarchitecture of compressed sciatic nerve.
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
(2021)
Review
Multidisciplinary Sciences
M. F. Nagoor Meeran, Hayate Javed, Charu Sharma, Sameer N. Goyal, Sanjay Kumar, Niraj Kumar Jha, Shreesh Ojha
Summary: This study discusses the potential of Echinacea as a candidate immunomodulatory, anti-inflammatory, and antiviral agent for COVID-19. Highlighting its pharmacological effects and molecular mechanisms, it emphasizes the importance of its role in regulating the immune-inflammatory axis and in mitigating the severity and progression of the disease.
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.