Scopolamine: a journey from the field to clinics

Total Synthesis of (±)-Scopolamine: Challenges of the Tropane Ring

(2016) Pierre-Antoine Nocquet et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Non-statistical13C Fractionation Distinguishes Co-incident and Divergent Steps in the Biosynthesis of the Alkaloids Nicotine and Tropine

(2016) Katarzyna M. Romek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alkaloid production and capacity for methyljasmonate induction by hairy roots of two species in Tribe Anthocercideae, family Solanaceae

(2015) Suzanne M. Ryan et al.   FUNCTIONAL PLANT BIOLOGY

Efficient biosynthesis of rare natural product scopolamine using E. coli cells expressing a S14P/K97A mutant of hyoscyamine 6β-hydroxylase AaH6H

(2015) Yue-De Cao et al.   JOURNAL OF BIOTECHNOLOGY

Effect of Scopolamine Butylbromide on Clozapine-induced Hypersalivation in Schizophrenic Patients: A Case Series

(2015) Ippei Takeuchi et al.   Clinical Psychopharmacology and Neuroscience

In Vitro Acaricidal Activity ofAtropa belladonnaand Its Components, Scopolamine and Atropine, againstRhipicephalus(Boophilus)microplus

(2014) R. Godara et al.   TheScientificWorldJOURNAL

Production of tropane alkaloids in Hyoscyamus niger (black henbane) hairy roots grown in bubble-column and spray bioreactors

(2013) Zbigniew Jaremicz et al.   BIOTECHNOLOGY LETTERS

Scopolamine as an Antidepressant

(2013) Robert J. Jaffe et al.   CLINICAL NEUROPHARMACOLOGY

Atropa acuminata Royle Ex Lindl. blunts production of pro-inflammatory mediators eicosanoids., leukotrienes, cytokines in vitro and in vivo models of acute inflammatory responses

(2013) Albeena Nisar et al.   JOURNAL OF ETHNOPHARMACOLOGY

Enhancing the production of tropane alkaloids in transgenic Anisodus acutangulus hairy root cultures by over-expressing tropinone reductase I and hyoscyamine-6β-hydroxylase

(2012) Guoyin Kai et al.   Molecular BioSystems

Production of tropane alkaloids in diploid and tetraploid plants and in vitro hairy root cultures of Egyptian henbane (Hyoscyamus muticus L.)

(2012) Esmail Dehghan et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Functional identification of hyoscyamine 6β-hydroxylase from Anisodus acutangulus and overproduction of scopolamine in genetically-engineered Escherichia coli

(2011) Guoyin Kai et al.   BIOTECHNOLOGY LETTERS

Co-expression of AaPMT and AaTRI effectively enhances the yields of tropane alkaloids in Anisodus acutangulus hairy roots

(2011) Guoyin Kai et al.   BMC BIOTECHNOLOGY

Alkaloids in the human food chain - Natural occurrence and possible adverse effects

(2011) Irina I. Koleva et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Management of drooling in disabled patients with scopolamine patches

(2010) Abigail Mato et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Transdermal scopolamine for the prevention of postoperative nausea and vomiting: A systematic review and meta-analysis

(2010) Christian C. Apfel et al.   CLINICAL THERAPEUTICS

The use of subcutaneous scopolamine as a palliative treatment in Parkinson’s disease

(2010) Laura Mónica Pérez et al.   PALLIATIVE MEDICINE

Scopolamine, anisodamine and hyoscyamine production by Brugmansia candida hairy root cultures in bioreactors

(2010) Alejandra Beatriz Cardillo et al.   PROCESS BIOCHEMISTRY

Anticholinergic syndrome following an unintentional overdose of scopolamine

(2010) Corallo   Therapeutics and Clinical Risk Management

Pediatric plant exposures in Germany, 1998–2004

(2009) Jörg Pietsch et al.   CLINICAL TOXICOLOGY

Analysis of toxic alkaloids in body samples

(2009) Jochen Beyer et al.   FORENSIC SCIENCE INTERNATIONAL

Atropine, Hyoscine Butylbromide, or Scopolamine Are Equally Effective for the Treatment of Death Rattle in Terminal Care

(2009) Hans Wildiers et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Alkaloid Biosynthesis: Metabolism and Trafficking

(2008) Jörg Ziegler et al.   Annual Review of Plant Biology

Hyoscine butylbromide – a review on its parenteral use in acute abdominal spasm and as an aid in abdominal diagnostic and therapeutic procedures

(2008) Guido N. Tytgat   CURRENT MEDICAL RESEARCH AND OPINION

Expression of Brugmansia candida Hyoscyamine 6beta-Hydroxylase gene in Saccharomyces cerevisiae and its potential use as biocatalyst

(2008) Alejandra B Cardillo et al.   Microbial Cell Factories

Application of Metabolic Engineering to the Production of Scopolamine

(2008) Javier Palazón et al.   MOLECULES