Article
Agriculture, Multidisciplinary
Xiaojing Fan, Dan Kong, Shan He, Junzheng Chen, Yue Jiang, Zhiqing Ma, Juntao Feng, He Yan
Summary: Asarum heterotropoides extracts contain various active components, with phenanthrene derivatives being the main active ingredients. The new compound aristoloxazine C shows excellent antibacterial activity, especially against phytopathogenic bacteria, making it a potential template for new bactericides or antimicrobial targets.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Plant Sciences
Shachi Singh, Mukesh Kumar, Seema Dwivedi, Anjali Yadav, Sarika Sharma
Summary: In this study, a rapid and effective metabolomic method was used to screen the chemical characterization of all parts of B. prionitis, including leaf, root, stem, and inflorescence. Bioactive iridoid glycosides and phenolic compounds were identified in all parts, with root showing the highest antioxidant and antibacterial activity. Some of the identified compounds were positively correlated with the tested biological activity. Principal component analysis of the chemical profiles revealed variability in compound distribution.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Ehesan U. Sharif, Pei Shi, George A. O'Doherty
Summary: Two unnatural regioisomeric glycosylated Gilvocarcin analogues were proposed as model compounds to study the biosynthetic origin of Gilvocarcins and the proposed O- to C-glycoside migration in the evolution of Angucycline antibiotics. The analogue with weak antibiotic activity compared to Gilvocarcin M was synthesized using a regio-divergent synthetic pathway with a Mitsunobu-like invertive cyclictolization reaction to install the carbasugar motif.
ISRAEL JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Applied
Jie Bai, Si-yao Wang, Kang Pan, Hua-jun Luo, Kun Zou, Hui Wang
Summary: A new sesquiterpene glycoside, ligulariatinside A, and nine known compounds were isolated from the roots of Ligularia veitchiana. The structures of these compounds were determined through comprehensive analysis. Some of these compounds showed antibacterial activity against Vibrio anguillarum.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Liang Liu, Qi-Meng Yin, Qi-Jun Dai, Xuan-Yuan Chen, Xi-Qing Chen, Jian-Bin Wang, Han-Qing Pang, Xian-Wen Zhang
Summary: A previously undescribed biphenanthrene and five known phenanthrenes were isolated from Liparis nervosa, a medicinal plant of the Orchidaceae family. These compounds showed cytotoxic activities against human lung cancer cells.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Yue-Dong Yue, Zhi-Nan Xiang, Jia-Chun Chen
Summary: A new phenolic glycoside and a new megastigmane glycoside were isolated from Alangium chinense roots, along with twelve known compounds. In vitro anti-inflammatory activity of these compounds was evaluated, with compound 1 showing stronger activity than Triptolide.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Esteban Araya-Hermosilla, Paola Parlanti, Mauro Gemmi, Virgilio Mattoli, Sebastiano Di Pietro, Dalila Iacopini, Carlotta Granchi, Barbara Turchi, Filippo Fratini, Valeria Di Bussolo, Filippo Minutolo, Francesco Picchioni, Andrea Pucci
Summary: The study focuses on designing germicidal polymeric coatings by incorporating quaternary ammonium and sugar groups onto the polymer backbone, demonstrating their effective disinfection properties. The functional polymers coated on cellulose substrates exhibit excellent antibacterial performance, and they show good retention after water treatment at neutral pH.
Article
Chemistry, Multidisciplinary
Meihang Chen, Xun Zhang, Hairong Luo, Zengyan Zhou, Meiyun Chen, Wenneng Wu, Daowang Lu
Summary: Fifteen novel pyrimidine derivatives with glycoside scaffolds were synthesized and screened for their in vitro antifungal and antibacterial activities. Compounds 4l, 4m, and 4o showed better in vitro antifungal activity against P. infestans compared to dimethomorph.
Article
Food Science & Technology
Yangliu Liu, Panpan Han, Yingmin Jia, Zhou Chen, Siting Li, Aijin Ma
Summary: This study established an antibacterial activity database and investigated the application of brevilaterins, antibacterial lipopeptides from Brevibacillus laterosporus S62-9, in food. The results showed that brevilaterins exhibited broad-spectrum inhibitory and bactericidal activity, particularly against Gram-positive bacteria and spoilage bacteria in grain products. In addition, brevilaterins effectively inhibited and killed multiple antibiotic-resistant bacteria and did not readily develop resistance. The study also found that brevilaterins interacted with sodium dodecyl sulfate and soybean phospholipid. There was no significant difference in activity between brevilaterin B and brevilaterin C.
Article
Plant Sciences
Hans Jacquemyn, Tim Pankhurst, Peter S. Jones, Rein Brys, Michael J. Hutchings
Summary: This article provides information on the biology of Liparis loeselii and its ecological characteristics. The species has a wide distribution but has declined in most areas due to habitat destruction and desiccation. It is primarily found in inland fens and coastal dune slacks in Britain, but can also be found in other wet habitats. The species is sensitive to nutrient concentrations, low pH, and drought, and is susceptible to predation under drought conditions. It reproduces through selfing and is the focus of conservation efforts due to its decline.
JOURNAL OF ECOLOGY
(2023)
Article
Chemistry, Applied
Youran Liu, Li Yang, Jianzhong Wang, Donglin Chen
Summary: Two new lignans (phillyroside A and phillyroside B) and three new phenylethanoid glycosides (forsythoside K, forsythoside L, and forsythol L) were isolated from the aerial parts of Forsythia suspensa. The structures of these compounds were determined using spectroscopic analyses. The in vitro antioxidant activity of the five new compounds was evaluated. Compounds 4 and 5 showed significant antioxidant activity in DPPH and ABTS experiments.
NATURAL PRODUCT RESEARCH
(2023)
Article
Polymer Science
Maolan Zhang, Yuanliang Wang, Guoming Zeng, Shuang Yang, Xiaoling Liao, Da Sun
Summary: The piperazine polymers PE and PEM exhibited good antibacterial activity against E. coli, particularly under acidic conditions. The mechanism of action involves PE forming holes on the bacterial surface by reacting with peptidoglycans, while PEM adsorbs and shrinks bacteria to create bactericidal effects. These findings suggest the potential biomedical applications of PE and PEM.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Kesar Singh, R. N. Yadava, Ritu Yadav
Summary: A novel flavone glycoside was isolated from Cynotis axillaris Schult. and its structure and antimicrobial activity were characterized.
CHEMISTRY & BIODIVERSITY
(2023)
Review
Food Science & Technology
Yin Zhou, Xinxin Chen, Tingting Chen, Xiaoqiang Chen
Summary: This review examines the relationships between the sources, structural properties, and antibacterial activity of plant polysaccharides. The structural features of plant polysaccharides are closely tied to their antibacterial activity, and they can exert antibacterial effects through various mechanisms. This review will guide future applications of plant polysaccharides.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Geochemistry & Geophysics
Qi Hu, Shaohai Hu, Shuaiqi Liu, Shuwen Xu, Yu-Dong Zhang
Summary: Deep learning-based ship detection methods have achieved great success in SAR images, but still face challenges from imaging mechanism interference, speckle noise, and clutter. Existing algorithms often overlook pixel-level information. To improve detection accuracy, we propose a novel ship detection method based on FINet, which integrates object-level and pixel-level information.
IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
(2022)
Article
Microbiology
Mingxing Tian, Yi Yin, Zhengmin Lian, Zichen Li, Meiying Song, Hai Hu, Xiang Guan, Chan Ding, Shaohui Wang, Tao Li, Jingjing Qi, Shengqing Yu
VETERINARY MICROBIOLOGY
(2020)
Article
Agriculture, Multidisciplinary
Liu Li-li, Fei Chen-zhong, Dong Hui, Zhang Ke-yu, Fu Jian-jun, Li Tao, Xue Fei-qun
JOURNAL OF INTEGRATIVE AGRICULTURE
(2020)
Article
Immunology
Mingxing Tian, Meiying Song, Yi Yin, Zhengmin Lian, Zichen Li, Hai Hu, Xiang Guan, Yumei Cai, Chan Ding, Shaohui Wang, Tao Li, Jingjing Qi, Shengqing Yu
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2020)
Article
Microbiology
Zhimin Cheng, Zichen Li, Yi Yin, Zhengmin Lian, Hosny Ahmed Abdelgawad, Hai Hu, Xiang Guan, Dong Zuo, Yumei Cai, Chan Ding, Shaohui Wang, Tao Li, Jingjing Qi, Mingxing Tian, Shengqing Yu
Summary: The A19 strain of Brucella vaccine shows effective attenuation of virulence and reduced invasiveness in host cells, providing a potential strategy for controlling brucellosis.
VETERINARY MICROBIOLOGY
(2021)
Article
Infectious Diseases
Yanan Zhao, Lingli Liu, Shaohui Wang, Mingxing Tian, Jingjing Qi, Tao Li, Shengqing Yu
Summary: This study reported the draft genome sequence of a multidrug-resistant Klebsiella quasipneumoniae subsp. similipneumoniae strain isolated from a pig farm in China, revealing the presence of 12 important antibiotic resistance genes in its genome. The findings will be valuable for understanding antibiotic resistance and pathogenic mechanisms in Klebsiella quasipneumoniae.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
Article
Chemistry, Organic
Tuanli Yao, Jiazhe Hui, Tao Liu, Tao Li
Summary: A palladium-catalyzed multicomponent reaction has been developed for the synthesis of o-alkylated arylacrylates and stilbenes through tandem intramolecular Heck cyclization/aryne dicarbofunctionalization, providing a straightforward method for accessing these compounds.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Microbiology
Tao Li, Yan Lu, Hua Zhang, Lei Wang, Ross C. Beier, Yajie Jin, Wenjing Wang, Huanrong Li, Xiaolin Hou
Summary: Aloe-emodin demonstrates promising antimicrobial activity against Gram-positive bacteria, particularly Staphylococcus epidermidis. Its mechanism of action involves disrupting cell morphology and selective membrane permeability, affecting protein synthesis and biofilm formation.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Veterinary Sciences
Chenglin Tao, Zhengfei Yi, Yaodong Zhang, Yao Wang, Hong Zhu, Dosseh Jean Apotre Afayibo, Tao Li, Mingxing Tian, Jingjing Qi, Chan Ding, Song Gao, Shaohui Wang, Shengqing Yu
Summary: Improper use of antibiotics has led to the rise of multidrug-resistant bacteria, posing a major health threat. Bacterial biofilms also contribute to antibiotic resistance. Phage therapy with SHWT1, a lytic phage against multidrug-resistant Salmonella, showed promising results in vitro and in vivo, suggesting its potential as a therapeutic agent against salmonellosis caused by resistant strains.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Microbiology
Jingjing Qi, Yu Wang, Haoran Li, Yuanbing Shang, Song Gao, Chan Ding, Xiaohan Liu, Shaohui Wang, Tao Li, Mingxing Tian, Shengqing Yu
Summary: Mycoplasma synoviae infection causes significant economic losses to the poultry industry. The enzyme MSPdhD is not only involved in energy metabolism and redox balance, but also plays a role in cytoadherence and pathogenesis of M. synoviae. Rabbit anti-rMSPdhD serum has a strong bactericidal activity and can inhibit the adhesion of M. synoviae to host cells.
VETERINARY MICROBIOLOGY
(2022)
Article
Immunology
Suhua Xin, Hong Zhu, Chenglin Tao, Beibei Zhang, Lan Yao, Yaodong Zhang, Dosseh Jean Apotre Afayibo, Tao Li, Mingxing Tian, Jingjing Qi, Chan Ding, Shengqing Yu, Shaohui Wang
Summary: The TaqMan multiplex real-time PCR assay developed in this study proved to be highly specific and reliable for simultaneous detection and differentiation of S. Pullorum, S. Gallinarum, S. Enteritidis, and S. Typhimurium. The assay demonstrated analytical sensitivity down to three colony-forming units (CFUs) for the four Salmonella serovars and a detection limit of 500 CFU/g in artificially contaminated samples, improving to 10 CFU/g after pre-enrichment. When applied to clinical poultry samples, the multiplex real-time PCR assay yielded comparable results to traditional bacteriological examination, indicating its promising potential for clinical diagnostics and epidemiological studies of Salmonella in chicken farms and poultry products.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Kangwen Xu, Limin Wang, Dan Xiong, Hongjun Chen, Xinru Tong, Xiaolong Shao, Tao Li, Guoliang Qian
Summary: The Wsp and DSF systems are two important signaling systems that mediate bacterial communications, and they control biofilm formation through regulating c-di-GMP. The Wsp system regulates biofilm formation via WspR-mediated c-di-GMP signaling, while the DSF system does not depend on RpfG's enzymatic activity. The WspR-RpfG complex acts as a molecular linker connecting the Wsp and DSF systems, enabling the Wsp system to dynamically integrate the DSF system and regulate biofilm formation.
NPJ BIOFILMS AND MICROBIOMES
(2022)
Article
Chemistry, Multidisciplinary
Tuanli Yao, Shuaijing Zhao, Tao Liu, Yuting Wu, Yanhui Ma, Tao Li, Xiangyang Qin
Summary: The first transition-metal-free regioselective synthesis of 2,3-diarylindenones via tandem annulation of 2-alkynylbenzaldehydes with phenols is reported. Two different reaction modes controlled by electronic effects and temperature can selectively produce either non-rearranged or rearranged indenones.
CHEMICAL COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Jinxing Liao, Danyu Shen, Long Lin, Hongjun Chen, Yajie Jin, Shan-Ho Chou, Xiao-Quan Yu, Tao Li, Guoliang Qian
Summary: This study presents a new quorum-quenching strategy to inhibit bacterial infections by directly acquiring bacterial genes/proteins to block AHL signaling. By artificially expressing a typical AHL synthase gene in an antifungal bacterium, effective proteins that inhibit AHL synthesis were identified, leading to the discovery of a novel quorum-quenching protein, LqqP.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Veterinary Sciences
Yaodong Zhang, Yao Wang, Hong Zhu, Zhengfei Yi, Dosseh Jean Apotre Afayibo, Chenglin Tao, Tao Li, Mingxing Tian, Jingjing Qi, Chan Ding, Shengqing Yu, Shaohui Wang
Summary: The inactivation of the DctR gene in APEC resulted in decreased biofilm formation, reduced adherence capacity, and other negative effects, which were restored through genetic complementation. Additionally, DctR positively regulates the expression of ETT2 in APEC, influencing the virulence of the pathogen.
VETERINARY RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Tuanli Yao, Bo Wang, Beige Ren, Xiangyang Qin, Tao Li
Summary: The first palladium-catalyzed Ugi-type multicomponent reaction for the synthesis of N-acyl anthranilamides has been developed, providing efficient access to structurally diverse compounds from readily available starting materials. The utility of this method has been demonstrated by late stage functionalization of two commercial drugs: Flurbiprofen and Loxoprofen.
CHEMICAL COMMUNICATIONS
(2021)
Article
Plant Sciences
Yi Zhu, Junlin Wang, Lu Tang, Yuxin Shang, Weiyi Zhao, Wei Zhang, Ping Hai, Yongbiao Zheng, Wenbo Li, Yanfang Su
Summary: One new iridoid glucoside and two new lignan glycosides, along with three known compounds, were isolated from the whole plants of Lancea tibetica. The structures were determined by spectroscopic methods and X-ray crystallographic analysis. One of the new iridoid glucosides and the known compounds exhibited moderate antioxidant activity.
PHYTOCHEMISTRY LETTERS
(2024)
Article
Plant Sciences
Yi Deng, Minghua Chen, Junming Yi, Yuguo Zheng
Summary: This study successfully designed and synthesized a series of quinazolinone derivatives containing purine molecules, and found that some compounds exhibited strong antiviral activity against tobacco mosaic virus. The findings have important implications for further development of antiviral drugs.
PHYTOCHEMISTRY LETTERS
(2024)
