期刊
PHYTOCHEMISTRY
卷 132, 期 -, 页码 109-114出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2016.10.005
关键词
Leptolyngbya sp.; Marine cyanobacteria; Total synthesis; Polyketide; Yoshinone A
资金
- Keio Gijuku Academic Development Funds
- Grants-in-Aid for Scientific Research [15K16555] Funding Source: KAKEN
In 2014, the gamma-pyrone-containing polyketide, yoshinone A, was isolated from the marine cyanobacterium Leptolyngbya sp. and its structure was determined. Yoshinone A inhibited differentiation of 3T3-L1 cells into adipocytes, with an EC50 value of 420 nM without any cytotoxicity, and therefore is expected to be a lead compound for obesity drugs. To establish its absolute configuration, and to provide sufficient amounts for further research, the total synthesis of yoshinone A was achieved through synthesis of its two possible diastereomers. (C) 2016 Elsevier Ltd. All rights reserved.
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