Review
Chemistry, Inorganic & Nuclear
Seoyoon Song, Deborah Lee, Lucia C. Dalle Ore, Sungjun Kwak, Lifeng Kang, Hyung Kyo Kim, Noah Malmstadt, Sun Min Kim, Tae-Joon Jeon
Summary: This paper introduces the latest advancements in photoactivable liposomes in drug delivery, highlighting their advantages in precise control over drug release and targeted delivery, as well as the fine control over release kinetics achieved through the manipulation of light-responsive components. Additionally, the paper emphasizes the design considerations of physicochemical properties and light-related constituents.
COORDINATION CHEMISTRY REVIEWS
(2024)
Article
Materials Science, Biomaterials
Shanzhou Huang, Zuyi Ma, Chengjun Sun, Qi Zhou, Zhenchong Li, Shujie Wang, Qian Yan, Chunsheng Liu, Baohua Hou, Chuanzhao Zhang
Summary: In this study, a local injectable hydrogel delivery system was used to construct a platform for synergistic chemo-photothermal therapy for multi-drug resistant hepatocellular carcinoma. The prepared hydrogel had injectable properties and stable photothermal conversion, and could release therapeutic agents on demand for up to 14 days. The platform showed promising results in improving the antitumor efficacy for multi-drug resistant cancer.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Biotechnology & Applied Microbiology
Di Meng, Jinlin Song, Yin Yi, Jihong Li, Ting Zhang, Yu Shu, Xiaohong Wu
Summary: This study aimed to prepare naringin (Ng) liposomes to reduce the burst release of Ng and improve new bone formation. The nanosized Ng liposomes with a high encapsulation efficiency were successfully synthesized and the burst release was dramatically reduced from 74.4% to 23.7% by adding SAIB. In vivo experiment showed that the new bone formation rate in the animals receiving Ng-lipo/SAIB was significantly higher compared with the control group. These results suggest that Ng-lipo/SAIB hybrid depots could serve as candidate materials for drug delivery in bone regeneration applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Zhuoyao Ni, Jiajie Hu, Hui Zhu, Yazhuo Shang, Daijie Chen, Yinghong Chen, Honglai Liu
Summary: The study introduced a dual-antibacterial platform using sodium alginate and carboxymethyl chitosan as the framework for Near-Infrared controlled pharmacotherapy and photothermal therapy of drug-resistant bacteria, showing excellent antibacterial capacity and biocompatibility.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Polymer Science
Bingbing Zhao, Yuting Yan, Junmei Zhang, Enping Chen, Ke Wang, Changshun Zhao, Yinan Zhong, Dechun Huang, Zhiqin Cui, Dawei Deng, Congying Gu, Wei Chen
Summary: A novel zwitterionic triblock copolymer was designed and synthesized, showing well-defined structure and controlled molecular weight; the copolymer could self-assemble into polymersomes with good biocompatibility and cell transmembrane ability; cytochrome c-loaded polymersomes exhibited potent cancer inhibitory activity and apoptosis-inducing ability against HeLa cells.
Article
Medicine, Research & Experimental
Xiangjun Chen, Huayu He, Xinyu Guo, Mingyi Hou, Xinzhong Zhang, Shengnan Li, Changrong Wang, Guodong Zhao, Wenting Li, Xiuping Zhang, Wei Hong
Summary: This study developed highly effective pH-responsive and biodegradable nanoparticles that can deliver drugs to tumor sites through the enhanced permeability and retention effect. The nanoparticles showed a switchable charge and excellent drug loading efficiency. In vitro and in vivo experiments demonstrated the effectiveness and safety of this drug delivery system, resulting in a significant inhibition of tumor growth.
MOLECULAR PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Monica C. Garcia, Jose Manuel Calderon-Montano, Manuela Rueda, Marcela Longhi, Antonio M. Rabasco, Miguel Lopez-Lazaro, Francisco Prieto-Dapena, Maria Luisa Gonzalez-Rodriguez
Summary: This study reports the development of pH/thermo-sensitive liposomes using nucleolipids and modified with gold nanoparticles. The results demonstrate that these liposomes can efficiently release anticancer drugs and exhibit significant toxicity against cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Materials Science, Biomaterials
Zejie Yu, Yi Wang, Miaomiao Cai, Jiachang Chen, Qirong Zou, Quli Fan, Lei Zhang
Summary: A novel detection strategy for dynamic monitoring of drug release was developed using gold nano-triangular sheets. The pronounced spectral shifts in their LSPR scattering spectra can be used to assess drug loading and release and release kinetics.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Max L. Wang, Christian F. Chamberlayne, Haixia Xu, Mohammad Mofidfar, Spyridon Baltsavias, Justin P. Annes, Richard N. Zare, Amin Arbabian
Summary: On-demand drug delivery systems combined with wireless implants can control drug release, reducing dosage and side effects. Researchers designed a release system based on a modified electroresponsive polypyrrole nanoparticulate film for negatively charged compounds. They also developed an ultrasonically powered mm-sized implant to electronically control the on-demand drug delivery system in vivo. The feasibility of wireless, controllable drug release was demonstrated through in vitro and in vivo characterization using fluorescein as a model drug.
Article
Instruments & Instrumentation
Ilaria Andreana, Valeria Bincoletto, Paola Milla, Franco Dosio, Barbara Stella, Silvia Arpicco
Summary: Pentamidine is an antimicrobial drug that has potential applications in the treatment of various diseases. However, systemic administration can lead to severe side effects. Nanocarriers have been proposed as a way to reduce these side effects.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Kasula Nagaraja, Kummara Madhusudana Rao, Duddekunta Hemalatha, Sunmi Zo, Sung Soo Han, K. S. V. Krishna Rao
Summary: In this study, hydrogels based on natural Strychnos potatorum L. polysaccharide were successfully fabricated and subsequently used as templates for the green synthesis of silver nanoparticles. The hydrogels exhibited dual responsiveness and antibacterial activity, making them suitable for drug release and cancer treatment applications.
Article
Chemistry, Physical
Jiuyu Cui, Jun Huang, Yonggan Yan, Wenqian Chen, Jie Wen, Xunwei Wu, Jikai Liu, Hanlian Liu, Chuanzhen Huang
Summary: A Fe3O4-loaded photothermal microneedle patch (Fe3O4@MN) has been developed for controlled drug delivery, achieving enhanced drug release efficiency. The Fe3O4@MN has sufficient mechanical strength to penetrate the skin, and its temperature can rapidly increase under NIR irradiation. In vitro experiments showed high drug release rates and increased penetration depth compared to a patch without Fe3O4 nanoparticles, indicating the potential application of the synthesized microneedle patch for transdermal drug delivery.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Review
Chemistry, Analytical
Xue Bai, Zara Smith, Yuheng Wang, Sam Butterworth, Annalisa Tirella
Summary: Although nanomedicine has been extensively studied for cancer treatment, only a few nanomedicines are currently approved and in use, limiting its clinical applications. The lack of control over the release pattern of therapeutics is identified as a key research gap. Different strategies for the design and manufacturing of nanomedicines are being investigated to improve the control over therapeutic release. Smart sustained release nanoparticles have shown promise in safely delivering therapeutics with different kinetic profiles for cancer treatment.
Article
Chemistry, Multidisciplinary
Amr A. Abd-Elghany, Ebtesam A. Mohamad
Summary: This study evaluated the photoprotective effects of ellagic acid (EA) extracted from pomegranate on human fibroblast skin cells and its ability to protect collagen from UV-induced damage. The results showed that encapsulated EA in chitosan-coated niosomes improved cell survival and regulated the expression of genes associated with skin aging.
Review
Chemistry, Multidisciplinary
Eman Jaradat, Edward Weaver, Adam Meziane, Dimitrios A. Lamprou
Summary: In conventional drug administration, drug molecules may not effectively reach the pathological site, so nanoparticles (NPs) as drug carriers have potential. NPs have a large surface area and quantum properties. Traditional methods for manufacturing NPs have limitations and new methods need to be investigated.
Article
Chemistry, Multidisciplinary
Anupam Das, Chandan Adhikari, Debasis Nayak, Anjan Chakraborty
Article
Chemistry, Physical
Chandan Adhikari, Anjan Chakraborty
Article
Chemistry, Multidisciplinary
Anupam Das, Chandan Adhikari, Anjan Chakraborty
Article
Chemistry, Physical
Nishu Kanwa, Soumya Kanti De, Chandan Adhikari, Anjan Chakraborty
JOURNAL OF PHYSICAL CHEMISTRY B
(2017)
Article
Chemistry, Physical
Anupam Das, Chandan Adhikari, Anjan Chakraborty
JOURNAL OF PHYSICAL CHEMISTRY B
(2017)
Article
Pharmacology & Pharmacy
Chandan Adhikari, Anurag Mishra, Debasis Nayak, Anjan Chakraborty
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2018)
Article
Pharmacology & Pharmacy
Chandan Adhikari, Anurag Mishra, Debasis Nayak, Anjan Chakraborty
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2018)
Article
Biophysics
Namhyun Choi, Hajun Dang, Anupam Das, Myeong Seong Sim, Il Yup Chung, Jaebum Choo
BIOSENSORS & BIOELECTRONICS
(2020)
Article
Biophysics
Hao Chen, Sung-Gyu Park, Namhyun Choi, Joung-Il Moon, Hajun Dang, Anupam Das, Seunghun Lee, Do-Geun Kim, Lingxin Chen, Jaebum Choo
BIOSENSORS & BIOELECTRONICS
(2020)
Article
Spectroscopy
Anupam Das, Namhyun Choi, Joung-Il Moon, Jaebum Choo
Summary: This study presents a rapid and sensitive method for determining the total iron-binding capacity of transferrin in human serum using surface-enhanced Raman scattering (SERS) spectroscopy. Metal-organic framework (MOF)-gold nanoparticle (AuNP) complexes were utilized as the SERS substrate to enhance the Raman signals of reporter molecules, allowing for quantitative estimation of Tf concentration. The SERS-based analysis using MOF-AuNPs shows potential for diagnosing iron deficiency in human serum with a detection limit of 0.51 mu M.
JOURNAL OF RAMAN SPECTROSCOPY
(2021)
Review
Polymer Science
Chandan Adhikari
Summary: Polymeric nanoparticles have significant applications in drug delivery, medical diagnostics, and nanomedicine, with recent developments in combining inorganic nanoparticles with polymers for enhanced properties. Their versatility and potential for tunable applications make them highly appealing for various fields of science and engineering.
POLYMER-PLASTICS TECHNOLOGY AND MATERIALS
(2021)
Article
Biophysics
Anupam Das, Kihyun Kim, Sung-Gyu Park, Namhyun Choi, Jaebum Choo
Summary: A surface-enhanced Raman scattering (SERS)-based immunoassay platform was developed for rapid diagnosis of scrub typhus and murine typhus in South Korea, with high sensitivity and lower limits of detection compared to ELISA. The platform utilizes a microarray device and Raman spectroscopy to detect biomarkers of the two diseases, enabling direct diagnosis in the field when combined with portable Raman spectrophotometers.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Chemistry, Multidisciplinary
Hao Chen, Anupam Das, Liyan Bi, Namhyun Choi, Joung-Il Moon, Yixuan Wu, Sohyun Park, Jaebum Choo
Article
Chemistry, Medicinal
Shinde Vidyacharan, Chandan Adhikari, Vagolu Siva Krishna, Rudraraju Srilakshmi Reshma, Dharmarajan Sriram, Duddu S. Sharada
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2017)