Article
Medicine, General & Internal
Ahsan Alam, Emilie Cornec-Le Gall, Ronald D. Perrone
Summary: This article describes autosomal dominant polycystic kidney disease, its signs and symptoms, diagnosis, and treatment options.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Pharmacology & Pharmacy
Guangying Shao, Shuai Zhu, Baoxue Yang
Summary: ADPKD is a common hereditary kidney disease characterized by progressively enlarged cysts that destroy renal function, potentially leading to ESRD. Herbal medicines have shown potential in inhibiting cyst development and ADPKD progression, providing new insights for clinical therapeutic strategies.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Claudio Ponticelli, Gabriella Moroni, Francesco Reggiani
Summary: Autosomal-Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder caused by mutations in PKD1 or PKD2 genes. The involvement of autophagy in ADPKD remains a subject of investigation, with potential implications on cyst formation and fibrosis. Autophagy inducers have shown promising results in preclinical studies and may provide a potential avenue for future investigations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Lauren Pickel, Ioan-Andrei Iliuta, James Scholey, York Pei, Hoon-Ki Sung
Summary: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive growth of renal cysts and loss of functional nephrons. Evidence suggests that dietary interventions such as caloric restriction, intermittent fasting, and ketogenic diets have the potential to slow disease progression and confer metabolic benefits.
ADVANCES IN NUTRITION
(2022)
Article
Biology
Maria Rombolotti, Fabio Sangalli, Domenico Cerullo, Andrea Remuzzi, Ettore Lanzarone
Summary: This study proposes a method for kidney and cyst segmentation in micro-CT images of mice with Autosomal Dominant Polycystic Kidney Disease and normal mice using fully convolutional networks. Different network architectures are compared and evaluated based on Intersection over Union and Dice coefficients. The results show that the U-Net with a batch normalization layer after each pair of 3 x 3 convolutions, and the U-Net with convolutional layers replaced by inception blocks perform the best.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Johannes Leierer, Paul Perco, Benedikt Hofer, Susanne Eder, Alexander Dzien, Julia Kerschbaum, Michael Rudnicki, Gert Mayer
Summary: Changes in protein concentrations in the body fluids of ADPKD patients mainly involve dysregulation of various molecular processes, including markers such as EGF, APLN, VEGFA, and AGT. These markers are significantly correlated with renal function and disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Matthew B. Lanktree, Amirreza Haghighi, Ighli di Bari, Xuewen Song, York Pei
Summary: Autosomal dominant polycystic kidney disease is mainly caused by mutations in PKD1 and PKD2 genes, but may also be caused by mutations in other endoplasmic reticulum protein biosynthetic pathway genes or somatic mosaicism. Genetic testing aids in diagnosis and prognosis, but screening for PKD1 mutations is challenging, and conventional Sanger sequencing is limited in elucidating the causes of atypical polycystic kidney disease.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Gastroenterology & Hepatology
Bernhard Schlevogt, Vincent Schlieper, Jana Krader, Rita Schroeter, Thomas Wagner, Matthias Weiand, Andree Zibert, Hartmut H. Schmidt, Carsten Bergmann, Pavel Nedvetsky, Michael P. Krahn
Summary: In this study, a variant in the SEC61A1 gene was identified to be associated with the development of polycystic liver disease. The mutant SEC61A1 protein was shown to undergo enhanced proteasomal degradation, resulting in impaired synthesis of polycystin-2.
LIVER INTERNATIONAL
(2023)
Article
Urology & Nephrology
Cortney N. Steele, Ester S. Oh, Wei Wang, Heather Farmer-Bailey, Berenice Y. Gitomer, Michel Chonchol, Kristen L. Nowak
Summary: Cerebrovascular dysfunction, characterized by increased brain pulsatile flow, reduced cerebrovascular reactivity, and cerebral hypoperfusion, precedes the onset of dementia and is linked to cognitive dysfunction. Patients with autosomal dominant polycystic kidney disease (ADPKD) have a higher risk of dementia and are more likely to develop intracranial aneurysms, but cerebrovascular function in ADPKD patients has not been previously characterized.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Kyongtae T. Bae, Cheng Tao, Robert Feldman, Alan S. L. Yu, Vicente E. Torres, Ronald D. Perrone, Arlene B. Chapman, Godela Brosnahan, Theodore I. Steinman, William E. Braun, Michal Mrug, William M. Bennett, Peter C. Harris, Avantika Srivastava, Douglas P. Landsittel, Kaleab Z. Abebe
Summary: This study aimed to evaluate the associations of polycystic liver progression with other disease progression variables and classify liver progression on the basis of patient's age, height-adjusted liver cystic volume, and height-adjusted liver volume. The use of height-adjusted liver cystic volume showed greater separations in volumetric progression of polycystic liver disease.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Adriana Gregory, Fouad T. Chebib, Bhavya Poudyal, Heather L. Holmes, Alan S. L. Yu, Douglas P. Landsittel, Kyongtae T. Bae, Arlene B. Chapman, Rahbari-Oskoui Frederic, Michal Mrug, William M. Bennett, Peter C. Harris, Bradley J. Erickson, Vicente E. Torres, Timothy L. Kline
Summary: New image-derived biomarkers are needed to improve the management of autosomal dominant polycystic kidney disease. A new technique to individually segment cysts and quantify biometric parameters has been developed. Total cyst number and cyst parenchyma surface area showed superior prediction of kidney function decline and disease stages compared to the measurement of total kidney volume.
KIDNEY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Jessica T. T. Camargo, Camilo A. Gonzalez, Lina Herrera, Nancy Yomayusa-Gonzalez, Milciades Ibanez, Ana M. M. Valbuena-Garcia, Lizbeth Acuna-Merchan
Summary: This study investigated the prevalence, geographical location, and ethnic groups of ADPKD patients undergoing dialysis or kidney transplant in Colombia between 2015 and 2019. The prevalence of ADPKD was lower compared to Europe and the US, and further genetic prevalence studies may be needed in some states with higher prevalence.
Review
Medicine, General & Internal
Jing Xu, Cheng Xue, Xiaodong Wang, Lei Zhang, Changlin Mei, Zhiguo Mao
Summary: ADPKD, the most common inherited kidney disease worldwide, is mainly influenced by genes PKD1 and PKD2. Epigenetic modifications, particularly chromatin methylation and histone modifications, play a significant role in the development and progression of ADPKD. More research is needed to better understand and potentially treat the methylation abnormalities in ADPKD.
FRONTIERS IN MEDICINE
(2022)
Article
Urology & Nephrology
Youngwoo Kim, Cheng Tao, Hyungchan Kim, Geum-Yoon Oh, Jeongbeom Ko, Kyongtae T. Bae
Summary: A fully automated segmentation method was developed to measure TKV in ADPKD patients. This method accurately segments the kidney regions while excluding exophytic cysts and has a similar accuracy to that of manual methods.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Genetics & Heredity
Yasuo Suzuki, Kan Katayama, Ryosuke Saiki, Yosuke Hirabayashi, Tomohiro Murata, Eiji Ishikawa, Masaaki Ito, Kaoru Dohi
Summary: This study analyzed the genes of 50 ADPKD patients and identified mutations in PKD1, PKD2, and GANAB genes, which can assist in diagnosis and treatment of the disease.
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
J. Kim, Y. Kim, Z. Yang, B. Hong, M. Kuo, W. Han, S. Yamamoto, N. Jamshidi
Article
Radiology, Nuclear Medicine & Medical Imaging
Shota Yamamoto, Wonshik Han, Youngwoo Kim, Liutao Du, Neema Jamshidi, Danshan Huang, Jong Hyo Kim, Michael D. Kuo
Article
Radiology, Nuclear Medicine & Medical Imaging
Eunyoung Kang, Eung-Jik Lee, Mijung Jang, Sun Mi Kim, Youngwoo Kim, Minsoo Chun, Joo Ho Tai, Wonshik Han, Sung-Won Kim, Jong Hyo Kim
AMERICAN JOURNAL OF ROENTGENOLOGY
(2016)
Article
Urology & Nephrology
Youngwoo Kim, Yinghui Ge, Cheng Tao, Jianbing Zhu, Arlene B. Chapman, Vicente E. Torres, Alan S. L. Yu, Michal Mrug, William M. Bennett, Michael F. Flessner, Doug P. Landsittel, Kyongtae T. Bae
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Youngwoo Kim, Alessandro Furlan, Amir A. Borhani, Kyongtae T. Bae
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2018)
Article
Engineering, Electrical & Electronic
Ilkoo Ahn, Youngwoo Kim, Changick Kim
Article
Radiology, Nuclear Medicine & Medical Imaging
Youngwoo Kim, Byung Woo Hong, Seung Ja Kim, Jong Hyo Kim
Article
Ophthalmology
Jinho Lee, Youngwoo Kim, Jong Hyo Kim, Ki Ho Park
JOURNAL OF GLAUCOMA
(2019)
Article
Engineering, Manufacturing
Hyeon Beom Kim, Soo Wan Kim, Jeong Beom Ko, Young Jin Yang, Geum Yoon Oh, Young Woo Kim, Hyung Chan Kim
Summary: This study investigates sugar behavior during extrusion process to address limitations in 3D printed candy manufacturing. Optimal parameters for nozzle movement speed, extrusion speed, and pattern spacing were derived for reproducible 3D models. The research demonstrates the feasibility of producing personalized custom shapes with high reproducibility in the future.
JOURNAL OF MANUFACTURING PROCESSES
(2021)
Article
Urology & Nephrology
Youngwoo Kim, Cheng Tao, Hyungchan Kim, Geum-Yoon Oh, Jeongbeom Ko, Kyongtae T. Bae
Summary: A fully automated segmentation method was developed to measure TKV in ADPKD patients. This method accurately segments the kidney regions while excluding exophytic cysts and has a similar accuracy to that of manual methods.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Chemistry, Analytical
Soo-Wan Kim, Geum-Yoon Oh, Kang-In Lee, Young-Jin Yang, Jeong-Beom Ko, Young-Woo Kim, Young-Sun Hong
Summary: In this study, a highly sensitive and flexible capacitive pressure sensor with an aligned airgap structure was developed. The sensor exhibits a wide range of working pressures, quick response time, and is applicable in wearable electronic devices and medical assistive devices.
Article
Computer Science, Information Systems
Min Ho Kwak, Youngwoo Kim, Kangin Lee, Jae Young Choi
Summary: This letter introduces a new lightweight deep learning object detector called LW-YOLOv4-tiny, which incorporates the convolution block feature addition module (CBFAM). LW-YOLOv4-tiny achieves smaller model size, reduced computation requirement, and faster speed compared to the latest version of YOLOv4-tiny. It also achieves high mean average precision (mAP) on the MSCOCO2017 and PASCAL VOC2012 benchmarks.
IEICE TRANSACTIONS ON INFORMATION AND SYSTEMS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
J. Zhu, Z. Wang, Y. Kim, S. K. Bae, C. Tao, J. Gong, K. T. Bae
CLINICAL RADIOLOGY
(2017)