期刊
CHEMPHYSCHEM
卷 17, 期 12, 页码 1840-1845出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cphc.201500726
关键词
cytotoxicity; disulfide bonds; glutathione; mesoporous silica nanoparticles; sulfonatocalixarenes
资金
- National Natural Science Foundation of China [51473061, 21272093]
- Fundamental Research Funds for the Central Universities [JCKY-QKJC05]
- JLU Cultivation Fund for the National Science Fund for Distinguished Young Scholars
Mesoporous silica nanoparticles (MSNs) have been functionalized with supramolecular switches, composed of cleavable disulfide bond-containing alkylammonium stalks encircled by water-soluble sulfonatocalix[4,6]arenes, to result in smart mechanized MSNs. Cargo can be encased tightly in the nanopores of these mechanized MSNs in their closed state, but are released efficiently either in response to L-glutathione (GSH), by cleaving the disulfide bonds in the stalks, or in response to pH variation, by turning on the calixarene-based supramolecular switches. The higher concentration of GSH in cancer cell cytosol and the relatively lower pH value of cancer cell lysosome can simultaneously activate the mechanized MSNs, enabling them to release the pre-loaded cargo in place. This sufficient use of the different environment of cancer cells and normal healthy cells can enhance the targeting effect of delivery vehicles and effectively lower the side effects of delivered anti-cancer drugs. In vitro cytotoxicity tests suggest good biocompatibility and low toxicity of these newly developed drug-delivery systems.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据