Article
Clinical Neurology
Stephen Zicha, Randall J. Bateman, Leslie M. Shaw, Henrik Zetterberg, Anthony W. Bannon, Wesley A. Horton, Mike Baratta, Hartmuth C. Kolb, Iwona Dobler, Yulia Mordashova, Ziad S. Saad, David L. Raunig, Emmanouil (Manos) Spanakis, Yan Li, Suzanne E. Schindler, Kyle Ferber, Carrie E. Rubel, Robert L. Martone, Christopher J. Weber, Rebecca M. Edelmayer, Emily A. Meyers, James G. Bollinger, Erin G. Rosenbaugh, William Z. Potter
Summary: This study evaluated the performance of six plasma A beta assays in predicting amyloid positivity compared to age and APOE genotype. The results showed that three of the assays significantly improved the prediction accuracy, and plasma A beta 42/40 predicted amyloid PET status better than A beta 42 or A beta 40 alone.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemistry & Molecular Biology
Lei Gu, Zhefeng Guo
Summary: The formation of A beta oligomers and fibrils is crucial in Alzheimer's disease pathogenesis. A beta 42 and A beta 40 interact with each other influencing their aggregation, and A beta 40 has been shown to reduce plaque pathology in mouse models. The study suggests that A beta 42 and A beta 40 can form mixed oligomers with direct molecular interactions.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Li Wang, Kilho Eom, Taeyun Kwon
Summary: The study found that in the initial stage of aggregation process for both Aβ40 and Aβ42, multiple particles are formed which later self-assemble to form amyloid fibrils of different shapes. Different aggregation pathways of Aβ isoforms lead to amyloid fibrils with contrasting structures.
Article
Clinical Neurology
Haoshen Shi, Yosef Koronyo, Dieu-Trang Fuchs, Julia Sheyn, Ousman Jallow, Krishna Mandalia, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Andrei A. Kramerov, Alexander V. Ljubimov, Debra Hawes, Carol A. Miller, Keith L. Black, Roxana O. Carare, Maya Koronyo-Hamaoui
Summary: This study found that vascular amyloid beta (Aβ) protein deposits were detected in retinas of mild cognitively impaired (MCI) and Alzheimer's disease (AD) patients, and these deposits were linked to disease status. The study also revealed that the components of retinal vascular tight junctions (TJs) and Aβ expression were correlated with neuropathology. The severe decreases in retinal vascular zonula occludens-1 (ZO-1) and claudin-5 were identified in MCI and AD patients, which correlated with arteriolar Aβ(40) deposition and cerebral pathology and cognitive deficits.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Youssra K. K. Al-Hilaly, Connor Hurt, Janet E. E. Rickard, Charles R. R. Harrington, John M. D. Storey, Claude M. M. Wischik, Louise C. C. Serpell, Ansgar B. B. Siemer
Summary: Aggregation of the tau protein into fibrillar cross-beta aggregates is a characteristic of neurodegenerative diseases like Alzheimer's disease. A recent study found that a tau fragment called dGAE can form filaments in vitro, providing a promising model for studying AD tau filaments. Solid-state NMR was used to characterize the tau filaments and it was found that filaments assembled under non-reducing conditions are more dynamic and less ordered than those assembled in the presence of a reducing agent.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Jinhyeong Jang, Chan Beum Park
Summary: A study has found that linnaeite mineral can dissociate Alzheimer's beta-amyloid oligomers under near-infrared light irradiation, suggesting its potential as a drug for reducing AD pathology.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Clinical Neurology
Mariagiovanna Cozza, Lucia Amadori, Virginia Boccardi
Summary: Cerebral Amyloid Angiopathy (CAA) is a neurological disorder characterized by the deposition of amyloid plaques in the walls of cerebral blood vessels. This article provides insights into its pathogenesis, diagnosis, and treatment options. Accurate diagnosis of CAA is crucial for its management, and experimental treatments targeting amyloid beta clearance and anti-inflammatory approaches offer hope for future therapeutic advancements.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Atamjit Singh, Karanvir Singh, Jashandeep Kaur, Ramanpreet Kaur, Aman Sharma, Jasleen Kaur, Uttam Kaur, Renu Chadha, Preet Mohinder Singh Bedi
Summary: Alzheimer's disease, the most prevalent form of dementia worldwide, currently lacks effective treatment options. This review focuses on the pathogenesis of the disease and the development of 1,2,3-triazole containing derivatives as potential anti-Alzheimer's agents. The review provides insight into established targets of the disease and discusses the design, structure-activity relationships, and pharmacological outcomes of multifunctional anti-Alzheimer's agents containing 1,2,3-triazole. It serves as a baseline for future research groups working on Alzheimer's drug development.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Huiqin Zhang, Wei Wei, Ming Zhao, Lina Ma, Xuefan Jiang, Hui Pei, Yu Cao, Hao Li
Summary: Extracellular neuritic plaques and intracellular neurofibrillary tangles, composed of amyloid-beta and phosphorylated tau protein respectively, are hallmark proteins of Alzheimer's disease. The interactions between these proteins have been extensively studied, with A beta accelerating tau phosphorylation, tau mediating A beta toxicity, and potential synergistic effects on microglial cells and astrocytes. Understanding these interactions may lead to new interventions against Alzheimer's disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Akiko Amano, Nobuo Sanjo, Wataru Araki, Yasutaka Anraku, Makoto Nakakido, Etsuro Matsubara, Takami Tomiyama, Tetsuya Nagata, Kouhei Tsumoto, Kazunori Kataoka, Takanori Yokota
Summary: Researchers developed polymeric nanomicelles capable of passing through the blood-brain barrier to deliver specific antibodies to the brain. The administration of 6H4 antibody fragments in polymeric nanomicelles for 10 weeks significantly reduced the amounts of toxic A beta species in the brain and inhibited the formation of A beta plaques. Behavioral analysis also showed an improvement in spatial reference memory in mice with Alzheimer's disease.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Geriatrics & Gerontology
Yuan Gao, Yang Sun, Sadequl Islam, Tomohisa Nakamura, Taisuke Tomita, Kun Zou, Makoto Michikawa
Summary: Alzheimer's disease (AD) is associated with the accumulation of amyloid beta-protein 1-42 (A beta 42) in the brain. Angiotensin-converting enzyme (ACE) can convert neurotoxic A beta 42 to neuroprotective A beta 40 in a glycosylation-dependent manner. Mutations in the PSEN1 gene are the main cause of familial AD and lead to an increased A beta 42/40 ratio, but the mechanism behind this is still unclear.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Vasilios C. Constantinides, George P. Paraskevas, Fotini Boufidou, Mara Bourbouli, Efstratios-Stylianos Pyrgelis, Leonidas Stefanis, Elisabeth Kapaki
Summary: Alzheimer's disease dementia (ADD) may resemble behavioral variant frontotemporal dementia (bvFTD) and corticobasal syndrome (CBS), which are associated with frontotemporal lobar degeneration with tau proteinopathy or FTLD with TDP-43 proteinopathy. CSF biomarkers tau and amyloid beta are useful in AD pathology diagnosis. This study compared the diagnostic accuracy of different biomarker ratios and composite markers in distinguishing ADD from FTD and differentiating AD pathology from non-AD pathologies.
Article
Clinical Neurology
Shorena Janelidze, Sebastian Palmqvist, Antoine Leuzy, Erik Stomrud, Inge M. W. Verberk, Henrik Zetterberg, Nicholas J. Ashton, Pedro Pesini, Leticia Sarasa, Jose Antonio Allue, Charlotte E. Teunissen, Jeffrey L. Dage, Kaj Blennow, Niklas Mattsson-Carlgren, Oskar Hansson
Summary: The combination of blood Aβ 42 / Aβ 40 and p-tau217 showed relatively high accuracy in discriminating Aβ status, with p-tau217 demonstrating the strongest associations with Aβ pathology in MCI but not in CU.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Min Zhu, Longfei Jia, Jianping Jia
Summary: The study identified miR-96-5p as the upstream miRNA for ABCA1, and inhibition of miR-96-5p in AD models could reduce A beta(42)/A beta(40) ratios by upregulating the expression of ABCA1, indicating an important role of miR-96-5p in regulating A beta content.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Daniel L. Kober, Melissa D. Stuchell-Brereton, Colin E. Kluender, Hunter B. Dean, Michael R. Strickland, Deborah F. Steinberg, Samantha S. Nelson, Berevan Baban, David M. Holtzman, Carl Frieden, Jennifer Alexander-Brett, Erik D. Roberson, Yuhua Song, Tom J. Brett
Summary: The study using comprehensive biolayer interferometry analysis revealed that TREM2 binds apoE through a protein-mediated mechanism, with slight affinity differences among isoforms; TREM2 and sTREM2 can directly bind mAβ42 and potently inhibit Aβ42 polymerization, suggesting a potential role in preventing AD pathogenesis.
ALZHEIMERS & DEMENTIA
(2021)
Review
Chemistry, Multidisciplinary
Rajiv K. Kar, Anne-Frances Miller, Maria-Andrea Mroginski
Summary: Flavins play a central role in electron bifurcation, signaling, and various enzymatic reactions, allowing organisms to drive demanding reactions based on low-grade chemical fuel. Understanding the fundamental electronic structure principles of flavins is crucial for incorporating their capabilities into designed materials and devices.
WILEY INTERDISCIPLINARY REVIEWS-COMPUTATIONAL MOLECULAR SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ipsita Chakraborty, Rajiv K. Kar, Dibakar Sarkar, Sourav Kumar, Nakul C. Maiti, Atin Kumar Mandal, Anirban Bhunia
Summary: The dynamics of solvents play a significant role in the fibrillation of amyloidogenic systems, and can be effectively studied through NMR methods. Validation with MD simulations has shown the pivotal role of solvent environment in linking aggregation properties of amyloid systems. Time-dependent modulation of solvent dynamics probed with NMR can provide insights into amyloidogenesis and toxicity profiles.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Biochemical Research Methods
Humaira Ilyas, Mariena J. A. van der Plas, Monica Agnoletti, Sourav Kumar, Atin Kumar Mandal, Hanudatta S. Atreya, Anirban Bhunia, Martin Malmsten
Summary: The study investigated how PEGylation affects the interaction of host defense peptides with bacterial lipopolysaccharide and the suppression of LPS-induced cell activation. The results showed that PEGylation did not compromise the anti-inflammatory effects of the peptides and even improved the suppression of LPS-induced cell activation.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Kamal D. Patel, Sk Abdul Mohid, Arkajyoti Dutta, Shalini Arichthota, Anirban Bhunia, Devyani Haldar, Vijayalekshmi Sarojini
Summary: This study developed a novel substrate-based sirtuin inhibitor that successfully penetrated bacterial cell membranes and inhibited bacterial transcription activity, showing excellent antibacterial potency against both Gram-negative and Gram-positive pathogens. These peptides also demonstrated the ability to inhibit biofilm formation, disrupt preformed biofilms, and showed selectivity towards bacterial membranes, suggesting potential therapeutic applications for antimicrobial treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Saumik Sen, Rajiv K. Kar, Veniamin A. Borin, Igor Schapiro
Summary: The photoisomerization of retinal is a crucial primary event in the rhodopsin protein family, highly optimized in the protein for ultrafast, selective, and efficient reactions. Space saving mechanisms based on the rotation of multiple double bonds have been proposed to elucidate the highly complex process inside the protein.
WILEY INTERDISCIPLINARY REVIEWS-COMPUTATIONAL MOLECULAR SCIENCE
(2022)
Editorial Material
Chemistry, Multidisciplinary
Maria Luisa Mangoni, Anirban Bhunia, Bruno Botta, Francesca Ghirga
FRONTIERS IN CHEMISTRY
(2021)
Review
Cell Biology
Akanksha Gandhi, Rupesh Kariyat, Amaravadhi Harikishore, Marzieh Ayati, Anirban Bhunia, Nirakar Sahoo
Summary: Plants and insect herbivores engage in a relentless battle, with plants evolving strategies to detect and defend against herbivores through physical, structural, and chemical barriers. Plants perceive herbivory through mechanical and chemical means, with ion channels acting as first responders in defense signaling pathways. Recent studies have focused on early plant defense signaling in response to herbivory, highlighting the crucial role of ion channels.
Article
Biochemistry & Molecular Biology
Kanti Kusum Yadav, Monalisha Ojha, Ranit Pariary, Manoranjan Arakha, Anirban Bhunia, Suman Jha
Summary: The study explores the effects of surface potential and functional groups on the fibrillation of bovine insulin using zinc oxide nanoparticles. It is found that zinc oxide nanoparticles with positive surface potential enhance insulin fibrillation, but the addition of amino acids as surface functional groups mitigates this effect. The change in interfacial functional groups also reverses the interface-mediated destabilization of insulin conformation. The interaction between the amino acid functional groups and key amyloidogenic sequences of insulin is believed to stabilize the conformation and reduce fibrillation and cytotoxicity.
Review
Biochemistry & Molecular Biology
Surajit Bhattacharjya, Sk Abdul Mohid, Anirban Bhunia
Summary: Antimicrobial peptides (AMPs) are effective therapeutic modalities against drug-resistant Gram-negative bacteria. This review article discusses the 3-D structures and mode of actions of several potent AMPs, as well as studies on human peptide LL37 and de novo-designed peptides. The challenges in clinical trials of AMPs are also summarized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Rajiv K. Kar
Summary: Hybrid quantum mechanics/molecular mechanics (QM/MM) is one of the most reliable approaches for accurately modeling and studying the complex pharmaceutical discovery system. Classical mechanics has significantly accelerated the drug discovery process in the past decade. However, the current challenge is the large pool of false positives, which require extensive validation. Hybrid QM/MM is an effective solution for accurately studying ligand binding, structural mechanisms, free energy evaluation, and spectroscopic characterization. This article highlights the methodological details relevant to cost-effective hybrid QM/MM methods. This approach, combined with traditional pharmacoinformatics methods, could be a reliable strategy to balance the cost and accuracy of the calculations.
DRUG DISCOVERY TODAY
(2023)
Article
Biochemistry & Molecular Biology
Hans-Christian Siebert, Thomas Eckert, Anirban Bhunia, Nele Klatte, Marzieh Mohri, Simone Siebert, Anna Kozarova, John W. Hudson, Ruiyan Zhang, Ning Zhang, Lan Li, Konstantinos Gousias, Dimitrios Kanakis, Mingdi Yan, Jesus Jimenez-Barbero, Tibor Kozar, Nikolay E. Nifantiev, Christian Vollmer, Timo Brandenburger, Detlef Kindgen-Milles, Thomas Haak, Athanasios K. Petridis
Summary: The global outbreak of SARS-CoV-2/COVID-19 has provided an opportunity and challenge to accumulate a large amount of biomedical data and test new concepts and strategies to combat the pandemic. This study correlated clinical biomedical data with structural biology and biophysical data to evaluate new diagnostic and therapeutic approaches against SARS-CoV-2. The methods used were effective in identifying potential peptide sequences and carbohydrate moieties to protect the blood-brain barrier and develop new therapeutic approaches against long-COVID symptoms.
Article
Biology
Rishab Panda, Pritam K. Panda, Janarthanan Krishnamoorthy, Rajiv K. Kar
Summary: This study reveals key factors hidden in protein networks that are linked to experimental photocycle kinetics, providing important clues for designing synthetic LOV constructs with desirable photocycle efficiency.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Rajan Singh, Shweta Tiwari, Jyotirekha Jena, Rajiv K. Kar
Summary: This article introduces a laboratory experiment for material characterization of low-dimensional graphene-based materials in the biomedical field. The experiment includes sample preparation and characterization using various spectroscopic techniques. These experiments are highly essential for developing students' practical skills and motivating innovative problem-solving.
JOURNAL OF CHEMICAL EDUCATION
(2023)
Article
Chemistry, Multidisciplinary
Ranit Pariary, Sandip Dolui, Gourav Shome, Sk Abdul Mohid, Achintya Saha, Bhisma N. Ratha, Amaravadhi Harikishore, Kuladip Jana, Atin K. Mandal, Anirban Bhunia, Nakul C. Maiti
Summary: Our studies demonstrate that Coomassie Brilliant Blue G-250 shows promise as a chemical chaperone for stabilising the alpha-helical native human insulin conformers, preventing their aggregation and increasing insulin secretion. This multipolar effect, along with its non-toxic nature, could be valuable for the development of highly bioactive, targeted, and biostable therapeutic insulin.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Ashim Paul, Sourav Kumar, Sujan Kalita, Sourav Kalita, Dibakar Sarkar, Anirban Bhunia, Anupam Bandyopadhyay, Amal Chandra Mondal, Bhubaneswar Mandal
Summary: Synthetic antibodies show great promise in combating diseases and biomedical applications, but designing a therapeutic synthetic antibody to prevent amyloid-beta aggregation remains challenging. A novel synthetic paratope, SP1, has been reported to prevent A beta aggregation, reverse amyloid fibrils, and reduce neurotoxicity in human cells. This new paratope engineering module may lead to cost-effective molecular probes for combating protein misfolding-related diseases.
Article
Chemistry, Physical
Sergey Yu. Ketkov, Sheng-Yuan Tzeng, Elena A. Rychagova, Anton N. Lukoyanov, Wen-Bih Tzeng
Summary: Metallocenes, including methylcobaltocene, play important roles in various fields of chemistry. The ionization energy and vibrational structure of (Cp ')(Cp)Co can be influenced by introducing methyl substituents. The mass-analyzed threshold ionization spectrum and DFT calculations provide accurate information about the properties and transformations of (Cp ')(Cp)Co.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Review
Chemistry, Physical
Qifeng Mu, Jian Hu
Summary: Polymer mechanochemistry has experienced a renaissance due to the rapid development of mechanophores and principles governing mechanochemical transduction or material strengthening. It has not only provided fundamental guidelines for converting mechanical energy into chemical output, but also found applications in engineering and smart devices.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Da Hye Yang, Francesco Ricci, Fredrik L. Nordstrom, Na Li
Summary: Through systematic evaluation of the oiling-out behavior of procaine, we identified both stable and metastable liquid-liquid phase separation, and established phase diagrams to assist in rational selection of crystallization strategies.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Vikki Anand Varma, Simmie Jaglan, Mohd Yasir Khan, Sujin B. Babu
Summary: Designing engineering structures like nanocages, shells, and containers through self-assembly of colloids is a challenging problem. This work proposes a simple model for the subunit, which leads to the formation of monodispersed spherical cages or containers. The model with only one control parameter can be used to design cages with the desired radius.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Hainan Jiang, Yaolong He, Xiaolin Li, Zhiyao Jin, Huijie Yu, Dawei Li
Summary: The cycling lifespan and coulombic efficiency of lithium-ion batteries are crucial for high C-rate applications. The Li-ion concentration plays a crucial role in determining the mechanical integrity and structural stability of electrodes. This study focuses on graphite as the working electrode and establishes an experimental system to investigate the mechanical properties of composite graphite electrode at different C-rates. Considering the effect of Li-ion concentration in stress analysis is found to be significant.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Zhiye Wang, Yunchuan Li, Mingjun Sun
Summary: This study investigates the influence of intramolecular pi-pi interactions on the electronic transport capabilities of molecules. By designing and analyzing three pi-conjugated molecules, the researchers observe that different pi-conjugated structures have varying effects on electron transport. The findings provide a theoretical foundation for designing single-molecule electronic devices with multiple electron channels based on intramolecular pi-pi interactions.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Yuandong Xu, Haoyang Feng, Chaoyang Dong, Yuqing Yang, Meng Zhou, Yajun Wei, Hui Guo, Yaqing Wei, Jishan Su, Yingying Ben, Xia Zhang
Summary: Hollow MoS2 cubes and spheres were successfully synthesized using a one-step hydrothermal method with the hard template method. The hollow MoS2 cubes exhibited higher specific capacitance and energy density compared to the hollow MoS2 spheres. The symmetrical supercapacitors assembled with these hollow structures showed good performance and high capacity retention after multiple cycles. These findings suggest that controlling the pore structure and surface characteristics of MoS2 is crucial for enhancing its electrochemical properties.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Ainhoa Oliden-Sanchez, Rebeca Sola-Llano, Joaquin Perez-Pariente, Luis Gomez-Hortiguela, Virginia Martinez-Martinez
Summary: The combination of photoactive molecules and inorganic structures is important for the development of advanced materials in optics. In this study, bulky dyes were successfully encapsulated in a zeolitic framework, resulting in emission throughout the visible spectrum.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Miaomiao Zhang, Cunyuan Pei, Qiqi Xiang, Lintao Liu, Zhongxu Dai, Huijuan Ma, Shibing Ni
Summary: The design of a solid electrolyte interphase (SEI) plays a crucial role in improving the electrochemical performance of anode materials. In this study, lithium difluoro(oxalate)borate (LiDFOB) is used as an electrolyte additive to form a protective SEI film on Li3VO4 (LVO) anodes. The addition of LiDFOB results in a dense, uniform, stable, and LiF-richer SEI, which enhances the Li-ion storage kinetics. The generated SEI also prevents further decomposition of the electrolyte and maintains the morphology of LVO anodes during charge/discharge processes. This work demonstrates the effectiveness of LiDFOB as a multi-functional additive for LiPF6 electrolytes and provides insights into SEI construction for high-performance LVO anodes.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
B. V. Andryushechkin, T. V. Pavlova, V. M. Shevlyuga
Summary: The atomic structure of the Ag(111)-p(4 x 4)-O phase was reexamined and two phases with the same periodicity were discovered. It was demonstrated that the accepted Ag6 model is incompatible with high-resolution oxygen-sensitive STM images.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
S. L. Romo-Avila, D. Marquez-Ruiz, R. A. Guirado-Lopez
Summary: In this study, we used density functional theory (DFT) calculations to investigate the interaction between model graphene oxide (GO) nanostructures and chlorine monoxide ClO. We aimed to understand the role of this highly oxidizing species in breaking C-C bonds and forming significant holes on GO sheets. Our results showed that C-C bonds in a single graphene oxide sheet can be broken through a simple mechanism involving the dissociation of two chemically attached ClO molecules. The formation of carbonyl groups and holes on the GO surface was also observed. This study provides important insights into the degradation of carbon nanotubes and the stability of GO during the myeloperoxidase (MPO) catalytic cycle.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Alberto Garcia-Fernandez, Birgit Kammlander, Stefania Riva, Hakan Rensmo, Ute B. Cappel
Summary: In this study, the X-ray stability of five different lead halide perovskite compositions (MAPbI3, MAPbCl3, MAPbBr3, FAPbBr3, CsPbBr3) was investigated using photoelectron spectroscopy. Different degradation mechanisms and resistance to X-ray were observed depending on the crystal composition. Overall, perovskite compositions based on the MA+ cation were found to be less stable than those based on FA+ or Cs+. Metallic lead formation was most easily observed in the chloride perovskite, followed by bromide, and very little in MAPbI3. Multiple degradation processes were identified for the bromide compositions, including ion migration, formation of volatile and solid products, as well as metallic lead. CsBr was formed as a solid degradation product on the surface of CsPbBr3.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Timofei Rostilov, Vadim Ziborov, Alexander Dolgoborodov, Mikhail Kuskov
Summary: The shock-loading behavior of nanomaterials is investigated in this study. It is found that shock compaction waves exhibit a distinct two-step structure, with the formation of faster precursor waves that travel ahead of the main compaction waves. The complexity of the shock Hugoniot curve of the tested nanomaterial is described, and the effect of initial porosity on the compressed states is demonstrated.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Sergey S. Nikitin, Alexander D. Koryakov, Elizaveta A. Antipinskaya, Alexey A. Markov, Mikhail V. Patrakeev
Summary: The stability of La1/3Sr2/3Fe1-xMnxO3-delta, a perovskite-type oxide, under reducing conditions is dependent on the manganese content. Increasing the manganese content leads to a decrease in stability. The behavior of iron and manganese in the oxide shows distinct differences, which can be attributed to the difference in the enthalpy of oxidation reactions. Additionally, the change in the La/Sr ratio affects the concentration of iron and manganese ions.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Mosayeb Naseri, Shirin Amirian, Mehrdad Faraji, Mohammad Abdur Rashid, Maicon Pierre Lourenco, Venkataraman Thangadurai, D. R. Salahub
Summary: Inspired by the successful transfer of freestanding ultrathin films of SrTiO3 and BiFeO3, this study assessed the structural stability and investigated the electronic, optical, and thermoelectric properties of a group of two-dimensional perovskite-type materials called perovskenes. The findings revealed that these materials are wide bandgap semiconductors with potential application in UV shielding. Moreover, they exhibit better electrical and thermal conductivity at high temperatures, enabling efficient power generation in thermoelectric devices.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)