Review
Endocrinology & Metabolism
Xue-Ling Xu, Zheng-Yuan Huang, Kun Yu, Jun Li, Xiang-Wei Fu, Shou-Long Deng
Summary: This review focuses on the role of ER alpha and ER beta in polycystic ovary syndrome (PCOS), ovarian cancer, and premature ovarian failure (POF), as well as the major challenges of existing therapies. It provides a reference for the treatment of estrogen target tissue ovarian diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Fan Hu, Weifeng Liang, Linke Zhang, Huan Wang, Zimu Li, Yifeng Zhou
Summary: The study found that both BPA and BPS exposure in mice can negatively impact emotion and social interaction, and high-dose exposure can lead to abnormal local neuronal activation. Although BPS has less adverse effects on mice at low doses compared to BPA, there are still risks associated with prolonged high-volume exposure.
Article
Environmental Sciences
Xue Wen, Man Zhu, Zehua Li, Tao Li, Xuewen Xu
Summary: This study explores the effects of BPA on wound repair and finds that dietary intake of BPA delays wound healing, while wound application of BPA accelerates skin regeneration. This is because BPA up-regulates the expression of ERβ in the wound area, and enhances the function of fibroblasts to promote wound repair. For diabetic patients, application of BPA on wounds significantly speeds up wound healing without significant adverse effects on ovarian hormone levels.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Food Science & Technology
Baocai Xie, Dengke Pan, Huan Liu, Min Liu, Xiaochen Shi, Xinyi Chu, Junfeng Lu, Mengqing Zhu, Bo Xia, Jiangwei Wu
Summary: Diosmetin treatment can reduce body weight and fat mass, improve glucose tolerance and insulin resistance by increasing energy expenditure through enhancing thermogenesis and browning of adipose tissue. Mechanistically, diosmetin acts as an agonist for estrogen receptors (ERs) to elevate their expression in adipose tissue, and the presence of ERs is essential for the metabolic benefits of diosmetin.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Endocrinology & Metabolism
Aylin Del Moral-Morales, Juan Carlos Gonzalez-Orozco, Ana Maria Hernandez-Vega, Karina Hernandez-Ortega, Karla Mariana Pena-Gutierrez, Ignacio Camacho-Arroyo
Summary: A study found that in human Glioblastomas (GBM), the pro-oncogenic actions of 17 beta-estradiol (E2) are mediated by EZH2, which promotes proliferation, migration, and invasion of GBM cells. Although E2 does not modify EZH2 expression, gene silencing and pharmacological inhibition of EZH2 can block these pro-oncogenic actions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Kun Yu, Zheng-Yuan Huang, Xue-Ling Xu, Jun Li, Xiang-Wei Fu, Shou-Long Deng
Summary: This article discusses the role of estrogen in the female endometrium and its regulatory role through nuclear and membrane-associated receptors. The importance of ERs in maintaining endometrial function is emphasized, and references for treating endometrial diseases are provided.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Peng Chen, Bo Li, Ling Ou-Yang
Summary: Estrogen receptors play crucial roles in regulating various physiological processes in humans. Abnormal signaling of these receptors can lead to a wide range of disorders. This review provides an overview of ER alpha, ER beta, and GPER1, highlighting their functions in both health and disease. Additionally, it discusses the potential clinical applications and challenges associated with these receptors.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Shunli Jiang, Guanlin Yang, Shuang Zhou, Xu Zhang, Cheng Peng, Qing Lu
Summary: The study revealed a positive association between bisphenol A (BPA) exposure and hypertension risk, with specific genotypes in ESR1/2, CAT, and eNOS potentially increasing susceptibility to the hypertensive effects of BPA.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Genetics & Heredity
Linn Amanda Syding, Agnieszka Kubik-Zahorodna, David Pajuelo Reguera, Petr Nickl, Bohdana Hruskova, Michaela Kralikova, Jana Kopkanova, Vendula Novosadova, Petr Kasparek, Jan Prochazka, Jan Rozman, Rostislav Turecek, Radislav Sedlacek
Summary: Stress responses can lead to pathological conditions if there is prolonged secretion of glucocorticoids or inappropriate behavioral responses. In this study, we found that Gabra5 deficiency, which is linked to anxiety disorders, is associated with decreased anxiety and stress response. However, this phenotype was not observed in traditional anxiety behavior tests.
Article
Endocrinology & Metabolism
Dandan Song, Huan He, Rajitha Indukuri, Zhiqiang Huang, Lina Stepanauskaite, Indranil Sinha, Lars-Arne Haldosen, Chunyan Zhao, Cecilia Williams
Summary: This study investigates the differences between estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) in regulating cell proliferation and migration. The results show that ERα and ERβ have opposite effects on cell proliferation and different impacts on migration. Furthermore, they regulate distinct sets of target genes, providing valuable insights into the mechanisms of these two different ER isoforms.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Ran Ji, Mengqiao Cui, Dongyu Zhou, Xiaoyuan Pan, Yuqi Xie, Xiling Wu, Xin Liang, Hongxing Zhang, Weiyi Song
Summary: BPA exposure during adulthood can lead to sex-specific anxiety-like behaviors in mice, particularly in males. The hyperactivity of glutamatergic neurons in the paraventricular thalamus appears to be a key factor contributing to this anxiety. The down-regulation of alpha-1D adrenergic receptor in the PVT may also play a role in BPA-induced anxiety.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Chemistry, Multidisciplinary
Varsha Panwar, Stanzin Lzaod, Tanmay Dutta
Summary: Laccases from extremophilic bacteria, such as Brevibacillus agri, have shown potential in industrial applications due to their ability to withstand extreme conditions and their cost-effective production. This study confirms the similarity between the thermostable laccase LacT from B. agri and the CotA laccase from Bacillus amyloliquefaciens. The researchers also investigate the structure and stability of LacT and demonstrate its potential for the bioremediation of phenolic compounds.
Article
Geriatrics & Gerontology
Ruixue Zhou, Zhisheng Wang, Bojun Zhou, Zixin Yu, Chongyun Wu, Jun Hou, Ken Cheng, Timon Chengyi Liu
Summary: This study aimed to investigate whether aerobic exercise exerts mood-modulating effects through an estrogen signaling mechanism. The experiment consisted of two parts – comparing different modeling methods to identify the most suitable depression-like phenotype for further study, and treating animals with the most obvious depression-like phenotype in different ways, such as placebo treatment, estradiol replacement therapy, aerobic training, or estrogen receptor antagonist treatment. The results showed that aerobic exercise had antidepressant effects comparable to estrogen, and these effects may be mediated by estrogen receptors. Additionally, a gradual decrease in ovarian hormone levels may underlie chronic restraint stress-induced depression.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Bassem Refaat, Akhmed Aslam, Shakir Idris, Ahmed H. Almalki, Mofareh Y. Alkhaldi, Hassan A. Asiri, Riyad A. Almaimani, Abdulrahman Mujalli, Faisal Minshawi, Sara A. Alamri, Mona I. AlHussain, Badee A. Baltow, Mansour H. Alqasmi, Ghaiyda T. Basfar, Ohoud M. Alosaimi, Ibrahim A. Muhayya
Summary: This study reveals that the expression of estrogen and androgen receptors in colorectal cancer tissues is correlated with tumor characteristics, and hormonal therapy may serve as an alternative treatment strategy for colorectal cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Isabela Ribeiro Madalena, Guido Artemio Maranon-Vasquez, Marjorie Ayumi Omori, Emerson Tavares de Sousa, Heitor Albergoni da Silveira, Jorge Esquiche Leon, Flares Baratto-Filho, Sandra Yasuyo Fukada Alves, Maria Bernadete Sasso Stuani, Paulo Nelson-Filho, Christian Kirschneck, Erika Calvano Kuechler
Summary: The aim of this study was to assess the effects of estrogen deficiency on tooth eruption rate (TER) and gene expression of estrogen receptor alpha and beta (ER alpha and ER beta) in a rat model. The results showed that estrogen deficiency decreased TER in teeth under impeded condition and increased gene expression of ER beta in the odontogenic region of teeth with continuous formation.
CLINICAL ORAL INVESTIGATIONS
(2023)