Article
Plant Sciences
Ryutaro Tokutsu, Konomi Fujimura-Kamada, Tomohito Yamasaki, Keisuke Okajima, Jun Minagawa
Summary: Photosynthesis in chloroplasts is crucial for photoautotrophic growth, while non-photochemical quenching (NPQ) helps prevent the generation of reactive oxygen species under excess light. In the green alga Chlamydomonas reinhardtii, UV light activates NPQ-dependent photoprotection more rapidly than visible light, leading to faster gene expression and protein accumulation related to photoprotection. The action spectrum of UV-dependent induction of photoprotective factors suggests that C. reinhardtii senses longer-wavelength UV compared to the dicot plant Arabidopsis, indicating a unique UV response in green algae.
Article
Environmental Sciences
Qing-Yuan Zhong, Bing Lin, Yin-Ting Chen, Yin-Ping Huang, Wei-Peng Feng, Ying Wu, Gui-Hong Long, Yun-Nan Zou, Yu Liu, Bao-Qin Lin, Nian-Li Sang, Janis Ya-Xian Zhan
Summary: Male mice are more prone to skin tumor development induced by UV radiation compared to female mice, and they are more sensitive to UV irradiation, leading to greater oxidative stress and inflammatory damage.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kavita Vats, Oleg Kruglov, Alicia Mizes, Svetlana N. Samovich, Andrew A. Amoscato, Vladimir A. Tyurin, Yulia Y. Tyurina, Valerian E. Kagan, Yuri L. Bunimovich
Summary: This research indicates that UVB-induced skin inflammation is primarily mediated by ferroptosis in epidermal keratinocytes, rather than apoptosis or pyroptosis. Inhibition of ferroptosis can prevent inflammation and has implications for the prevention and treatment of various skin diseases induced by UVB.
Article
Immunology
Benita C. Y. Tse, Rachael A. Ireland, Jun Yup Lee, Felix Marsh-Wakefield, Lai Fong Kok, Anthony S. Don, Scott N. Byrne
Summary: Studies have shown that UV radiation disrupts T cell recirculation by manipulating the S1P pathway, which leads to immune suppression.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xia Chen, Junling Yang, Minghui Li, Shuang Zhu, Maoru Zhao, Cao Yang, Bo Liu, Hui Gao, Ao Lu, Lingling Ge, Lingyue Mo, Zhanjun Gu, Haiwei Xu
Summary: This study found that fullerenols have a protective effect on UVB-induced cornea damage, reducing the injured area and cell death while increasing cell proliferation. Fullerenols alleviate UVB-induced corneal injury by scavenging free radicals, repairing mitochondrial dysfunction and DNA lesions.
Article
Biochemistry & Molecular Biology
Yujie Ouyang, Jing Chen, Ling Jiang, Yumeng Li, Yibo Hu, Si Li, Jinhua Huang, Qinghai Zeng
Summary: The study reveals that ciRS-7 triggers melanogenesis in melanocytes through regulation of the miR-7/STAT3 and AKT/FGF2 paracrine axis in keratinocytes and fibroblasts. This mechanism may play a critical role in the development of pigmented skin diseases.
DNA AND CELL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Md Abdullah Shamim, Steven Yeung, Ayaz Shahid, Mengbing Chen, Jeffrey Wang, Preshita Desai, Cyrus Parsa, Robert Orlando, Frank L. Meyskens, Kristen M. Kelly, Bradley T. Andresen, Ying Huang
Summary: This study characterized a topical delivery system based on transfersome (T-CAR) for preventing UV-induced skin cancer. The T-CAR gel showed promising results in reducing skin edema, tumor incidence, and expression of cancer-related markers without significant systemic effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Hye Rim Park, Jae Kwang Kim, Jae Kyoung Lee, Beom Rak Choi, Sae Kwang Ku, Kyung Hwan Jegal
Summary: An unripe apple extract (UAE) has been found to have beneficial effects on wrinkle improvement, skin moisturizing, skin inflammation, and antioxidant activities in UVB-irradiated hairless mice. UAE prevented UVB-induced wrinkle formation and skin water loss, reduced skin edema, neutrophil infiltration, and pro-inflammatory cytokine production, while increasing anti-inflammatory cytokine levels. Additionally, UAE exhibited anti-oxidative stress properties by increasing glutathione content and inhibiting lipid peroxidation and superoxide anion production.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Ewan Eadie, Paul O'Mahoney, Louise Finlayson, Isla Rose Mary Barnard, Sally Helen Ibbotson, Kenneth Wood
Summary: This study compares the DNA damage caused by far-UVC and sunlight exposure in different climatic conditions, revealing that sunlight exposure poses greater risk for DNA damage compared to far-UVC. It should be noted that the photochemical reactions and consequences of high-energy far-UVC photons absorbed by the stratum corneum remain unknown.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Young Kyu Kim, Ju Young Lee, Han Na Suh
Summary: Through mouse models, it was found that lipopolysaccharide and ovalbumin can increase immune cell infiltration in tissues, activate NF-kappa B, increase cytokine levels in serum, and stimulate JAK2/STAT3 signaling, promoting tissue regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Mariam Zewail, Passent M. E. Gaafar, Nancy Abdel Hamid Abou Youssef, Merhan E. E. Ali, Mai F. F. Ragab, Miranda F. F. Kamal, Mohamed H. H. Noureldin, Haidy Abbas
Summary: The interest in bioactive compounds from natural sources has led to the development of the skin care industry. Spirulina, a microalga rich in nutrients and phytochemicals, has antioxidant, immunomodulatory, and anti-inflammatory activities. Spirulina-loaded bilosomes were designed as a novel drug delivery system for skin care, with good characteristics and safety profile.
Article
Plant Sciences
Marie-Laure Martin, Marjorie Pervent, Ilana Lambert, Stefano Colella, Mathilde Tancelin, Dany Severac, Gilles Clement, Pascal Tillard, Florian Frugier, Marc Lepetit
Summary: In mature symbiotic root nodules, rhizobia fix atmospheric dinitrogen to provide ammonium for plant nitrogen demand. The symbiosis is adjusted to the plant's nitrogen demand through systemic N signaling, controlling nodule development. Nodule expansion is stimulated under N deficit, while nodule senescence is activated under N satiety. Drought has a negative impact on nodules. In this study, split-root systems were used to characterize the systemic responses of symbiotic plants to localized osmotic stress. The application of PEG inhibited the symbiotic dinitrogen fixation activity of locally treated nodules, leading to nitrogen limitation. The localized PEG treatment triggered systemic signaling, stimulating nodule development and enhancing sucrose allocation. Transcriptomic reprogramming associated with PEG and N deficit signaling shared many target transcripts. These findings suggest that systemic N signaling plays a role in the adaptation of symbiotic plants to local variations in their edaphic environment.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Medicine, General & Internal
Seok-Hoon Lee, Nam-Seok Joo
Summary: This study aimed to investigate the effect of NBUVB-LED exposure on serum 25(OH)D concentrations. The results indicated that NBUVB-LED exposure might increase serum 25(OH)D levels. However, further research is needed to validate these findings.
Article
Immunology
Han Liu, Xiaopu Guo, Tangwei Yi, Yihan Zhu, Xinyi Ren, Renxian Guo, Yi Dai, Shaohui Liang
Summary: The tree frog Hyla annectans in the southwestern plateau area of China may possess novel peptides with anti-inflammatory and antioxidant properties, which can protect the skin from UV-induced damage by modulating stress signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Hye-Sun Lim, Kyeongno Yoon, Dong Hun Lee, Yong-Seok Lee, Jin Ho Chung, Gunhyuk Park
Summary: We have discovered that 20-hydroxyecdysone (20E), a steroid prohormone secreted by insects, can inhibit skin aging induced by UVB radiation. By inhibiting aldosterone synthase and reducing corticosterone levels, 20E reduces stress and protects against the decrease in collagen levels caused by UV radiation, making it a potential candidate for preventing skin aging.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Dermatology
Cezary Skobowiat, Andrzej T. Slominski
EXPERIMENTAL DERMATOLOGY
(2016)
Article
Oncology
Cezary Skobowiat, Allen S. W. Oak, Tae-Kang Kim, Chuan He Yang, Lawrence M. Pfeffer, Robert C. Tuckey, Andrzej T. Slominski
Meeting Abstract
Dermatology
A. Slominski, T. Kim, I. Semak, T. Sweatman, C. Skobowiat, J. Slekelee, Z. Lin, A. Post-Lethwaite, W. Li, D. Tobin
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2017)
Article
Endocrinology & Metabolism
Kushal Gandhi, Cun Li, Nadezhda German, Cezary Skobowiat, Maira Carrillo, Raja Reddy Kallem, Eneko Larumbe, Stacy Martinez, Marcel Chuecos, Gary Ventolini, Peter Nathanielsz, Natalia Schlabritz-Loutsevitch
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2018)
Article
Endocrinology & Metabolism
Cezary Skobowiat, Anna A. Brozyna, Zorica Janjetovic, Saowanee Jeayeng, Allen S. W. Oak, Tae-Kang Kim, Uraiwan Panich, Russel J. Reiter, Andrzej T. Slominski
JOURNAL OF PINEAL RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Andrzej T. Slominski, Anna A. Brozyna, Cezary Skobowiat, Michal A. Zmijewski, Tae-Kang Kim, Zorica Janjetovic, Allen S. Oak, Wojciech Jozwicki, Anton M. Jetten, Rebecca S. Mason, Craig Elmets, We Li, Robert M. Hoffman, Robert C. Tuckey
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2018)
Article
Dermatology
Timothy Falla, Katie Rodan, Kathy Fields, Robert Bianchini, Cullin Mahon, Cezary Skobowiat
JOURNAL OF COSMETIC DERMATOLOGY
(2020)
Article
Endocrinology & Metabolism
Andrzej T. Slominski, Tae-Kang Kim, Konrad Kleszczynski, Igor Semak, Zorica Janjetovic, Trevor Sweatman, Cezary Skobowiat, Jeffery D. Steketee, Zongtao Lin, Arnold Postlethwaite, Wei Li, Russel J. Reiter, Desmond J. Tobin
JOURNAL OF PINEAL RESEARCH
(2020)
Article
Dermatology
T. W. Fischer, A. Bergmann, N. Kruse, K. Kleszczynski, C. Skobowiat, A. T. Slominski, R. Paus
Summary: This study demonstrates that CRH induces complex intrafollicular HPA response and non-HPA-related stress response in human AGA HFs, which can be effectively antagonized by caffeine. Additionally, caffeine enhances the expression of inositol trisphosphate receptor, newly detected in human HFs, supporting the hypothesis that stress can impair human hair physiology and induce hair loss, and caffeine may prevent stress-induced hair damage and loss.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Meeting Abstract
Dermatology
C. Skobowiat, O. Dueva-Koganov, C. Crane, C. Mahon, R. Bianchini, K. Rodan, K. Fields, T. Falla
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Meeting Abstract
Dermatology
O. Dueva-Koganov, C. Crane, T. Oswald, C. Skobowiat, R. Bianchini, C. Mahon, T. Falla
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Article
Dermatology
Seemal Desai, Eloisa Ayres, Hana Bak, Megan Manco, Stephen Lynch, Susana Raab, Ana Du, DesTenee Green, Cezary Skobowiat, Janet Wangari-Talbot, Qian Zheng
JOURNAL OF DRUGS IN DERMATOLOGY
(2019)
Meeting Abstract
Obstetrics & Gynecology
Marcel Chuecos, Cun Li, Stacy Martinez, Kushal Gandhi, Cezary Skobowiat, Maira Carrillo, Moss Hampton, Suraparaju Raju, Gary Ventolini, Peter Nathanielsz, Natalia Shlabritz-Loutsevitch
REPRODUCTIVE SCIENCES
(2017)
Meeting Abstract
Dermatology
C. Skobowiat, J. S. Craw, R. Bianchini, K. Fields, K. Rodan, T. Falla
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)