期刊
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
卷 15, 期 12, 页码 1567-1578出版社
SPRINGERNATURE
DOI: 10.1039/c6pp00340k
关键词
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资金
- National Natural Science Foundation of China [20972036, 21272048, 21471041]
- Natural Science Foundation of Heilongjiang Province [B20913]
- Program for Scientific Technological Innovation Team Construction in the Universities of Heilongjiang Province [211TD010]
- Scientific Research Fund of Heilongjiang Provincial Education Department [12531194]
- Natural Science Youth Foundation of Heilongjiang Province [QC2016011]
- Innovation Fund for Graduate Students of Harbin Normal University
Magnetic iron oxide modified pyropheophorbide-a fluorescence nanoparticles, Fe3O4@SiO2@APTES@PPa (FSAP), were designed as magnetically targeted photodynamic antineoplastic agents and prepared through continuous covalent chemical modification on the surface of Fe3O4 nanoparticles. The properties of the intermediates and the final product were comprehensively characterized by transmission electron microscopy, powder X-ray diffraction analysis, Fourier transform infrared spectroscopy, vibrating sample magnetometry, zeta potential measurement, ultraviolet-visible absorption spectroscopy, fluorescence emission spectroscopy, and thermogravimetric analysis. In this work, we demonstrated the in vitro photodynamic therapy (PDT) of FSAP against ovarian cancer (SKOV-3) cells, which indicated that FSAP could be taken up successfully and showed low dark toxicity without irradiation, but remarkable phototoxicity after irradiation. Meanwhile, FSAP had showed good biocompatibility and low dark toxicity against normal cells in the biological experiments on mouse normal fibroblast cell lines (L929 cells). In addition, in the photochemical process of FSAP mediated photodynamic therapy, the Type-II photo-oxygenation process (generated singlet oxygen) played an important role in the induction of cell damage.
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