Article
Dermatology
Hua Jiang, Qiong Ma, Jing Dong, Xin Ye
Summary: This meta-analysis found that liposomal bupivacaine wound infiltration does not reduce postoperative morphine consumption and does not provide additional benefits in pain-related outcomes. Current evidence does not support the routine use of liposomal bupivacaine for wound infiltration following surgical procedures.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Nutrition & Dietetics
Tays Amanda Felisberto Goncalves, Viviane Silva Lima, Arthur Jose Pontes Oliveira de Almeida, Alinne Villar de Arruda, Ana Caroline Meneses Ferreira Veras, Thais Trajano Lima, Evyllen Myllena Cardoso Soares, Adhonias Correia dos Santos, Maria Eduarda Costa de Vasconcelos, Mathania Silva de Almeida Feitosa, Robson Cavalcante Veras, Isac Almeida de Medeiros
Summary: This study demonstrated the regulatory effects of carvacrol on endothelial repair in spontaneously hypertensive rats. Results showed that carvacrol promoted the migration and proliferation of endothelial progenitor cells, increased eNOS expression and activity, reduced reactive oxygen species production and cellular senescence, and improved vascular function.
Article
Multidisciplinary Sciences
Nunzia Caporarello, Jisu Lee, Tho X. Pham, Dakota L. Jones, Jiazhen Guan, Patrick A. Link, Jeffrey A. Meridew, Grace Marden, Takashi Yamashita, Collin A. Osborne, Aditya Bhagwate, Steven K. Huang, Roberto F. Nicosia, Daniel J. Tschumperlin, Maria Trojanowska, Giovanni Ligresti
Summary: Vascular dysfunction plays a significant role in aging and chronic diseases, but its involvement in lung repair and fibrosis remains unclear. In this study, the authors identified the endothelial transcription factor ERG as a mediator of vascular repair, whose function declines in aged lungs, resulting in sustained fibrosis. These findings highlight the importance of understanding the mechanisms underlying vascular dysfunction in lung fibrosis and provide potential targets for therapeutic interventions.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Mohammad Shamsul Ola
Summary: The study suggests that high glucose does not increase ROS levels in cultured retinal cells; instead, it appears to have a mitigating effect on oxidative stress induced by low or normal blood glucose conditions.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Dermatology
Jinhui Weng, Zhoujun Cheng, Shupeng Li
Summary: This study aimed to evaluate the effectiveness of dexmedetomidine as an adjuvant to local wound infiltration anaesthesia in reducing surgical site wound pain in patients undergoing laparoscopic cholecystectomy. The results showed that dexmedetomidine significantly reduced surgical site wound pain at 1 h, 4 h, 12 h, and 24 h postoperatively in laparoscopic cholecystectomy patients.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Engineering, Biomedical
Maqsood Ali, Si Hyun Kwak, Byong-Taek Lee, Hwan Jun Choi
Summary: By using an optimized bead system encapsulating VEGF, wound healing can be promoted, vascularization can be increased, and cell expression markers can be enhanced.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Review
Biochemistry & Molecular Biology
Yijia Mao, Lingkai Meng, Huayi Liu, Yuting Lu, Kuo Yang, Guangze Ouyang, Yanran Ban, Shuang Chen
Summary: This review summarizes recent research on the influence of traditional Chinese medicine (TCM) on vascular endothelial growth factor (VEGF). It is found that many Chinese medicines and recipes have a regulatory effect on VEGF, providing new treatment ideas and theoretical basis for TCM as a complementary and alternative therapy.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Multidisciplinary Sciences
Zhiyang Li, Heng Zhang, Yujie Sun, Zhuangzhuang Feng, Bijia Cui, Jingxia Han, Yinan Li, Huijuan Liu, Tao Sun
Summary: Angiogenesis plays a crucial role in embryologic development, growth, and tissue repair, but dysregulation of this process is a hallmark of various pathologies, including cancer. Existing methods for evaluating cell vascular formation are often limited to static analysis, leading to bias. Researchers have developed code scripts to study the dynamic angiogenesis process, allowing for the screening of drugs that can affect various parameters of vascular formation. Animal experiments have confirmed the efficacy of these drugs in inhibiting blood vessel formation, providing a new perspective for angiogenesis research and drug development.
Review
Immunology
Zachary Lamplugh, Yi Fan
Summary: Immunotherapy shows promise in cancer treatment, but solid tumor T cell-based immunotherapy faces challenges due to lack of universal tumor-specific antigens and an immunosuppressive tumor microenvironment. The vascular microenvironment plays a crucial role in inducing immune-hostile conditions and resistance to immunotherapy in tumors.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anna T. Hofmann, Paul Slezak, Sabine Neumann, James Ferguson, Heinz Redl, Rainer Mittermayr
Summary: In this study, the dose-dependent effects of rhVEGF(165) in fibrin sealant on ischemic and non-ischemic wounds were investigated. Lower doses of VEGF were found to promote angiogenesis and wound healing, and the use of fibrin sealant alone accelerated wound closure.
Article
Biochemistry & Molecular Biology
Walker D. Short, Emily Steen, Aditya Kaul, Xinyi Wang, Oluyinka O. Olutoye, Hima V. Vangapandu, Natalie Templeman, Alexander J. Blum, Chad M. Moles, Daria A. Narmoneva, Timothy M. Crombleholme, Manish J. Butte, Paul L. Bollyky, Sundeep G. Keswani, Swathi Balaji
Summary: This study found that overexpression of IL-10 in dermal wounds recruits EPCs, increases vascular structures, and accelerates re-epithelialization.
Review
Food Science & Technology
Joseph Festa, Aamir Hussain, Zakia Al-Hareth, Harprit Singh, Mariasole Da Boit
Summary: Anthocyanins, a type of flavonoid polyphenols, have been studied for their potential in improving cardiovascular health and preventing endothelial dysfunction. However, their poor bioavailability raises questions about the role of their metabolites in the observed biological activity. Recent studies have used different models and concentrations to better understand the mechanisms of action of these compounds. The review highlights the need for further research on improving the bioavailability of the metabolites and exploring the effects of metabolites in mixtures.
Review
Biochemistry & Molecular Biology
Xi Guo, Hong Yi, Tin Chiu Li, Yu Wang, Huilin Wang, Xiaoyan Chen
Summary: VEGF is a well-known angiogenic factor that plays a critical role in embryo implantation by enhancing embryo development and facilitating interactions between the embryo and endometrium. Changes in VEGF expression are correlated with reproductive failure, including recurrent implantation failure and recurrent miscarriage. This study aimed to clarify the role of VEGF in embryo implantation by reviewing recent literature and exploring its effects and underlying mechanisms.
Review
Biochemistry & Molecular Biology
Yukihito Higashi
Summary: Oxidative stress and chronic inflammation play a crucial role in the development of atherosclerosis, as vascular endothelial dysfunction leads to its progression and forms a vicious cycle with oxidative stress and inflammation.
Article
Oncology
Yanfen Cui, Hui Liu, Zhaosong Wang, He Zhang, Jianfei Tian, Zhiyong Wang, Weijie Song, Hui Guo, Liming Liu, Ruinan Tian, Xiaoyan Zuo, Sixin Ren, Fei Zhang, Ruifang Niu
Summary: High fructose intake is associated with increased risk of multiple cancers. Fructose can enhance the biological function of vascular endothelial cells (VECs) and promote angiogenesis by activating the Akt and Src signaling pathways. It can also upregulate production of reactive oxygen species (ROS) in colorectal cancer cells, indirectly enhancing the function of VECs. These findings have been validated in clinical colorectal cancer tissues and mouse models.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Cell Biology
Ali Emre Atici, Sevil Arabaci Tamer, Hilal Nisva Levent, Irem Peker Eyuboglu, Feriha Ercan, Mustafa Akkiprik, Berrak C. Yegen
Summary: NPW has a beneficial effect against oxidative damage and inflammation induced by sepsis, with notable protection on renal and hepatic function. NPW treatment reduced levels of inflammatory markers, alleviated tissue damage, and improved antioxidant status.
Article
Medicine, Research & Experimental
Sevil Arabaci Tamer, Turkan Koyuncuoglu, Ayca Karagoz Koroglu, Dilek Akakin, Meral Yuksel, Berrak C. Yegen
Summary: This study found that Nesfatin-1 has neuroprotective effects and can alleviate oxidative damage and memory dysfunction caused by epilepsy. It acts by inhibiting reactive nitrogen species and increasing antioxidant capacity.
Article
Transplantation
Neslihan Tezcan, Zarife Nigar Ozdemir-Kumral, Naziye Ozkan Yenal, Ozlem T. Cilingir-Kaya, Aysin Tulunay Virlan, Dilek Ozbeyli, Sule Cetinel, Berrak C. Yegen, Mehmet Koc
Summary: The study demonstrates that NES-1 has renoprotective effects and can ameliorate renal fibrosis induced by unilateral ureteral obstruction. The mechanism may involve inhibition of neutrophil infiltration, reduction of oxidative stress, and inflammation. These findings suggest that NES-1 may play a regulatory role in protecting the kidneys against obstruction-induced renal injury.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Cell Biology
Sevil Arabaci Tamer, Tulin Altinoluk, Miray Emran, Seda Korkmaz, Rozerin Goze Yuksel, Zeynep Baykal, Zehra Sena Dur, Hilal Nisva Levent, Muruvvet Abbak Ural, Meral Yuksel, Ozge Cevik, Feriha Ercan, Alper Yildirim, Berrak C. Yegen
Summary: This study aimed to evaluate the effects of hormone replacement, melatonin, exercise, or their combination on oxidative damage and functional status of ovariectomized rats, and to determine whether the SIRT1 signaling pathway is involved. The results showed that melatonin treatment, either alone or in combination with hormone replacement therapy, upregulated SIRT1 expression and alleviated oxidative injury and inflammation in the hearts and aortas of ovariectomized rats.
Article
Pharmacology & Pharmacy
Ayca Yildiz Pekoz, Ozlem Akbal Dagistan, Hanan Fael, Meltem Culha, Aybige Erturk, Nur Sena Basarir, Gokben Sahin, Muge Serhatli, Gamze Cakirca, Saban Tekin, Leyla Semiha Sen, Mustafa Sevim, Lutfiye Mulazimoglu Durmusoglu, Berrak C. Yegen
Summary: This study developed and characterized an inhalation solution of favipiravir at a concentration of 2 mg/mL for the treatment of patients with COVID-19. The solution showed superior stability in phosphate buffer saline (PBS) and demonstrated minimum toxicity and sufficient antiviral activity at a concentration of 2 mg/mL. The study suggests that the favipiravir solution prepared with PBS could be a suitable and promising inhalation formulation for pulmonary delivery in the treatment of COVID-19 patients.
Article
Gastroenterology & Hepatology
Sevil Arabaci Tamer, Selin Akbulut, Oemer Erdogan, Oezge Cevik, Feriha Ercan, Berrak C. Yegen
Summary: This study suggests that the novel peptide neuropeptide W (NPW) has potential preventive and therapeutic effects on colitis-associated oxidative injury. It achieves its effects by upregulating colonic blood flow, inhibiting COX-2 protein expression, and suppressing pro-inflammatory cytokine production.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Medicine, Research & Experimental
Sevil Arabaci Tamer, Selin Akbulut, Irem Peker Eyuboglu, Omer Erdogan, Ozge Cevik, Mustafa Akkiprik, Dilek Akakin, Berrak C. Yegen
Summary: The present study demonstrated that peripherally administered NPW has gastroprotective effects by regulating gastric blood flow, suppressing oxidant damage and inflammation, and modulating COX-induced gastroprotection. The expression of NPW is closely related to the occurrence and development of stress-induced ulcers.
Article
Pharmacology & Pharmacy
Ozlem Akbal-Dagistan, Mustafa Sevim, Leyla Semiha Sen, Nur Sena Basarir, Meltem Culha, Aybige Erturk, Hanan Fael, Engin Kaptan, Serap Sancar, Lutfiye Mulazimoglu Durmusoglu, Berrak C. Yegen, Ayca Yildiz-Pekoz
Summary: The study showed that delivering favipiravir via soft-mist inhaler did not have any deleterious effects on lung, liver, and kidney tissues of healthy rats, while achieving a high local concentration of the drug.
Article
Critical Care Medicine
Pinar Kuru Bektasoglu, Turkan Koyuncuoglu, Dilan Ozaydin, Cansu Kandemir, Dilek Akakin, Meral Yuksel, Bora Gurer, Erhan Celikoglu, Berrak C. Yegen
Summary: This study aimed to investigate the antioxidant and neuroprotective effects of Dexpanthenol in traumatic brain injury (TBI). The results showed that Dexpanthenol reduced oxidative damage, suppressed apoptosis by stimulating antioxidant systems, and alleviated brain damage caused by TBI.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Neurosciences
Sevil Arabaci Tamer, Berrak C. Yegen
Summary: The study investigated the role of peripherally administered neuropeptide W (NPW) in the modulation of gastric emptying. It was found that NPW delayed liquid emptying from the stomach, and this effect was reversed by CCK receptor antagonists or denervation of small diameter afferents. Moreover, NPW inhibited antrum contractility in the organ bath. These findings suggest that peripherally administered NPW regulates gastric motility through small diameter afferent neurons and CCK receptors, contributing to its central regulatory role in food intake and energy balance.
NEUROSCIENCE LETTERS
(2023)
Meeting Abstract
Physiology
Z. N. Ozdemir-Kumral, T. Akgun, C. Hasim, E. Ulusoy, F. Yuksel, M. K. Kalpakcioglu, T. Okumus, Z. Uslu, D. Akakin, Z. Goren, M. Yuksel, A. Yildirim, B. Yegen
Meeting Abstract
Physiology
L. S. Sen, K. S. Mermer, M. M. Kahraman, A. E. Toraman, E. Tiftikci, M. Harlak, M. S. Recai, Z. N. Akkurt, M. Yuksel, F. Ercan, B. C. Yegen
Meeting Abstract
Physiology
M. Sevim, T. Altinoluk, M. M. Kahraman, T. Akgun, A. Sahin, H. N. Ozekici, A. Fil, B. Yildiz, B. Yuceturk, E. N. Lale, B. Yegen, A. Yildirim
Meeting Abstract
Physiology
M. M. Kahraman, K. S. Mermer, M. B. Aksoy, L. Ozden, B. M. Sakalli, A. Uludag, Y. Varol, A. Yildirim, B. C. Yegen
Meeting Abstract
Gastroenterology & Hepatology
Leyla S. SEN, Tulin Altinoluk, Betul Esra Ipek, Selin Akbulut, Ozlem Tugce Cilingir-Kaya, Feriha Ercan, Meral Yuksel, Cumhur Yegen, Berrak C. Yegen
Article
Biochemistry & Molecular Biology
Giovanni Pacini, Bo Ahren
Summary: Tirzepatide stimulates both insulin secretion and glucose effectiveness, with stimulation of glucose effectiveness being the prominent process to reduce glucose.
Article
Biochemistry & Molecular Biology
Si -yu Wang, Yu-zhe Zhang, Xiao-han Liu, Xue-ci Guo, Xiao-fang Wang, Feng-tong Han, Yao Zhang, Chang -lin Wang
Summary: In the formalin pain test, the EM-2 analogs EM-2-Me, EM-2-Et, and EM-2-Bu showed significant analgesic effects with reduced tolerance and gastrointestinal side effects. These effects were mediated through central opioid mechanisms, with EM-2-Me possibly involving dynorphin A release and EM-2-Bu directly activating multiple opioid receptors.
