Article
Medicine, General & Internal
Thomas Puehler, Christine Friedrich, Georg Lutter, Maike Kornhuber, Mohamed Salem, Jan Schoettler, Markus Ernst, Mohammed Saad, Hatim Seoudy, Derk Frank, Felix Schoeneich, Jochen Cremer, Assad Haneya
Summary: The study analyzed the impact of UPE complication on short- and long-term outcomes in MIMVS patients. UPE incidence was found to be associated with factors such as intraoperative renal and left ventricular function, pulmonary hypertension, transfusion, and aortic clamp time. During long-term follow-up, comparable survival rates were observed between UPE and non-UPE patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pediatrics
Ilaria Amodeo, Matteo Di Nardo, Genny Raffaeli, Shady Kamel, Francesco Macchini, Antonio Amodeo, Fabio Mosca, Giacomo Cavallaro
Summary: Neonatal ECMO is a life-saving procedure for critically ill infants with potentially reversible conditions. Pulmonary diseases are the main neonatal diagnosis with a high survival rate, while cardiac ECMO has a lower survival rate mainly due to congenital heart defects. Advances in knowledge and technology aim to push the boundaries of neonatal ECMO towards more premature and complex infants in order to improve overall patient outcomes.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Cardiac & Cardiovascular Systems
Thomas Jack, Julia Carlens, Franziska Diekmann, Hosan Hasan, Philippe Chouvarine, Nicolaus Schwerk, Carsten Mueller, Ivonne Wieland, Igor Tudorache, Gregor Warnecke, Murat Avsar, Alexander Horke, Fabio Ius, Dmitry Bobylev, Georg Hansmann
Summary: A prospective observational study at Hannover Medical School showed that lung transplantation (LuTx) in children with end-stage pulmonary arterial hypertension (PAH) resulted in excellent midterm outcomes with 100% survival at 2 years post-LuTx. Postoperative VA-ECMO support facilitated early extubation and contributed to sustained biventricular reverse-remodeling and improved systolic function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Moritz Benjamin Immohr, Sophie Margaretha Eschlboeck, Philipp Rellecke, Hannan Dalyanoglu, Igor Tudorache, Udo Boeken, Payam Akhyari, Alexander Albert, Artur Lichtenberg, Hug Aubin
Summary: ECLS therapy for refractory circulatory failure patients who survive the first 30 days shows favorable outcomes in subsequent survival and functional recovery, indicating the potential for patient recovery even after long periods of mechanical support.
Article
Cardiac & Cardiovascular Systems
Moritz Benjamin Immohr, Sophie Margaretha Eschlboeck, Philipp Rellecke, Hannan Dalyanoglu, Igor Tudorache, Udo Boeken, Payam Akhyari, Alexander Albert, Artur Lichtenberg, Hug Aubin
Summary: Patients treated with ECLS for therapy-refractory circulatory failure have favorable outcomes in terms of survival and functional recovery after 30 days, indicating the potential of ECLS therapy for patient recovery.
Article
Endocrinology & Metabolism
Beata Pyrzak, Malgorzata Ruminska, Ewelina Witkowska-Sedek, Anna Kucharska
Summary: Maternal Graves' disease can cause various thyroid dysfunctions in newborns, including hyperthyroidism and hypothyroidism. This study found that transient hyperthyroidism was the most common thyroid dysfunction in newborns with neonatal hyperthyroidism, but central hypothyroidism can also occur.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Lovisa Hellgren, Ulrika Birberg Thornberg, Kersti Samuelsson, Richard Levi, Anestis Divanoglou, Ida Blystad
Summary: A study in Sweden investigated the long-term effects of COVID-19 on brain MRI and neurocognitive function in high-risk patients, finding that most patients had abnormal MRI findings or impaired neurocognitive function, along with reported fatigue.
Article
Biology
Samuel Genzor, Pavol Pobeha, Martin Simek, Petr Jakubec, Jan Mizera, Martin Vykopal, Milan Sova, Jakub Vanek, Jan Prasko
Summary: Patients with severe COVID-19 who underwent ECMO therapy for over one year were followed-up, and the results showed that most patients had good recovery and did not experience permanent disability in terms of their quality of life.
Article
Surgery
Natalie Liu, Jacob A. Greenberg, Yiwei Xu, Amber L. Shada, Luke M. Funk, Anne O. Lidor
Summary: Phone follow-up after outpatient inguinal hernia repair is found to be as safe and effective as in-person follow-up, with similar rates of adverse outcomes. It can be implemented as an alternative for patients and help decrease healthcare utilization.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Letter
Medicine, General & Internal
Michal Canetti, Noam Barda, Mayan Gilboa, Victoria Indenbaum, Keren Asraf, Tal Gonen, Yael Weiss-Ottolenghi, Sharon Amit, Ram Doolman, Ella Mendelson, Laurence S. Freedman, Yitshak Kreiss, Yaniv Lustig, Gili Regev-Yochay
Summary: A fourth dose of the BNT162b2 vaccine resulted in a smaller improvement in immunity compared to a third dose, and this improvement disappeared completely after 13 weeks.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Pediatrics
Jennifer A. Hoffmann, Polina Krass, Jonathan Rodean, Naomi S. Bardach, Rachel Cafferty, Tumaini R. Coker, Gretchen J. Cutler, Matthew Hall, Rustin B. Morse, Katherine A. Nash, Kavita Parikh, Bonnie T. Zima
Summary: This retrospective study analyzed the outpatient mental health follow-up cases of 28,551 children aged 6 to 17 years after their emergency department visits. The study found that only 31.2% and 55.8% of children had outpatient mental health visits within 7 and 30 days, respectively. Children without prior outpatient mental health care had the highest risk of poor access to care, and timely follow-up within 5 days significantly reduced the risk of return visits.
Article
Critical Care Medicine
Andrea Stadlbauer, Alois Philipp, Sebastian Blecha, Matthias Lubnow, Dirk Lunz, Jing Li, Armando Terrazas, Christof Schmid, Tobias J. Lange, Daniele Camboni
Summary: European guidelines recommend considering extracorporeal life support for acute high-risk pulmonary embolism (PE) since 2019. A study of 119 patients found a survival rate of 45.4% after ECMO treatment, with acceptable QoL, a retirement rate of 45.4%, and some exercise limitations and psychological issues.
ANNALS OF INTENSIVE CARE
(2021)
Article
Medicine, General & Internal
Gregg W. Stone, William T. Abraham, JoAnn Lindenfeld, Saibal Kar, Paul A. Grayburn, D. Scott Lim, Jacob M. Mishell, Brian Whisenant, Michael Rinaldi, Samir R. Kapadia, Vivek Rajagopal, Ian J. Sarembock, Andreas Brieke, Steven O. Marx, David J. Cohen, Federico M. Asch, Michael J. Mack, COAPT Investigators
Summary: Data from a 5-year follow-up of outcomes after transcatheter edge-to-edge repair of severe mitral regurgitation in patients with heart failure demonstrate that this procedure, in addition to medical therapy, leads to lower rates of hospitalization for heart failure and all-cause mortality compared to medical therapy alone.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Pediatrics
Qi Zhou, Yun Cao, Lan Zhang, Nurya Erejep, Wen-Long Xiu, Jing-Yun Shi, Rui Cheng, Wen-Hao Zhou, Shoo K. Lee
Summary: This study aimed to survey hospitals participating in the Chinese Neonatal Network (CHNN) to determine the status of neonatal follow-up programs (NFUPs), including available resources, enrollment criteria, neurodevelopmental assessments, and duration of follow-up. The survey revealed significant variation in eligibility criteria, duration of follow-up, types of assessments, staffing, training, and facilities available for NFUPs in China. Coordination and standardization are urgently needed.
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Surgery
Danielle Abbitt, Kevin Choy, Rose Castle, Heather Carmichael, Teresa S. Jones, Krzystof J. Wikiel, Carlton C. Barnett, John T. Moore, Thomas N. Robinson, Edward L. Jones
Summary: This study retrospectively reviewed the data of patients who underwent cholecystectomy at a level 1A VA Medical Center from August 2019 to August 2021. The findings showed that telehealth follow-up after cholecystectomy is safe and effective in Veterans, with no differences in outcomes compared to in-person follow-up.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Cardiac & Cardiovascular Systems
Mirjana Cvetkovic, Giovanni Chiarini, Mirko Belliato, Thijs Delnoij, Paolo Zanatta, Fabio Silvio Taccone, Dinis Dos Reis Miranda, Mark Davidson, Nashwa Matta, Carl Davis, Hanneke IJsselstijn, Matthieu Schmidt, Lars Mikael Broman, Dirk W. Donker, Dirk Vlasselaers, Piero David, Matteo Di Nardo, Ralf M. Muellenbach, Thomas Mueller, Nicholas A. Barrett, Roberto Lorusso, Jan Belohlavek, Aparna Hoskote
Summary: Neuromonitoring and neurocognitive/neurodevelopmental follow-up are critically important during and after ECMO. However, there is significant variability in practice across Europe, and only a minority of centers have structured longitudinal follow-up programs. Guidelines and minimum standards should be developed to inform local protocols.
Article
Gastroenterology & Hepatology
Chantal A. ten Kate, Anne-Fleur R. L. van Hal, Nicole S. Erler, Michail Doukas, Suzan Nikkessen, John Vlot, Hanneke IJsselstijn, Bas P. L. Wijnhoven, Rene M. H. Wijnen, Manon C. W. Spaander
Summary: This study provides recommendations on the appropriate starting age and intervals of endoscopic surveillance in adults with esophageal atresia. The findings suggest that endoscopic screening can be started at 20 years of age and a surveillance interval of 10 years may be safe for patients up to the age of 40. Endoscopic surveillance may also be necessary for patients who have undergone curative esophageal cancer treatment.
DISEASES OF THE ESOPHAGUS
(2022)
Article
Oncology
Chantal A. ten Kate, Annelies de Klein, Bianca M. de Graaf, Michail Doukas, Antti Koivusalo, Mikko P. Pakarinen, Robert van der Helm, Tom Brands, Hanneke IJsselstijn, Yolande van Bever, Rene M. H. Wijnen, Manon C. W. Spaander, Erwin Brosens
Summary: This study investigated the increased prevalence of Barrett's esophagus in adults with esophageal atresia. The findings suggest a genetic susceptibility and increased induction of inflammatory processes in these patients. Further research is needed to explore this hypothesis and potentially select high-risk patients for targeted screening and surveillance.
Article
Pediatrics
Harald Ehrhardt, Thomas Desplanches, Arno F. J. van Heijst, Liis Toome, Alan Fenton, Heloise Torchin, Alexandra Nuytten, Jan Mazela, Jennifer Zeitlin, Rolf F. Maier
Summary: For premature infants, the mode of delivery is not associated with the incidence of BPD and is not suitable for all women who are considering vaginal delivery. Cesarean section does not reduce the risk of BPD.
Article
Pediatrics
Yerel Ilik, Hanneke IJsselstijn, Saskia J. Gischler, Annabel Van Gils-Frijters, Johannes M. Schnater, Andre B. Rietman
Summary: This study evaluated the association between self- and parental proxy-reported pediatric cognitive functioning and behavior rating, as well as their correlation with neuropsychological assessments. The findings showed that proxy-reported pediatric cognitive functioning revealed cognitive problems more often than behavior rating in school-aged children who had survived neonatal critical illness. Proxy-reported pediatric cognitive functioning can support clinical decision-making regarding the need for extensive neuropsychological assessments.
Article
Pediatrics
Unn Inger Moinichen, Audun Mikkelsen, Ragnhild Gunderson, Thomas Johan Kibsgard, Lars Morkrid, Hanneke IJsselstijn, Ragnhild Emblem
Summary: This study investigated the impact of scoliosis and musculoskeletal abnormalities on adolescents with esophageal atresia (EA). The results showed that 12% of patients had significant scoliosis, 18% had vertebral anomalies, and musculoskeletal abnormalities were detected in 22-78% of the patients. Scoliosis was associated with reduced physical activity, while musculoskeletal abnormalities were related to decreased physical activity and impaired motor skills.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Pediatrics
Audun Mikkelsen, Unn Inger Moinichen, Henrik Mikael Reims, Krzysztof Grzyb, Lars Aabakken, Lars Morkrid, Hanneke IJsselstijn, Ragnhild Emblem
Summary: This study found that questionnaires and interviews alone were not reliable screening tools, but combining dysphagia scores from interviews with non-invasive test results can predict the risk of esophageal metaplasia.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Gastroenterology & Hepatology
Chantal A. ten Kate, Nadine M. Teunissen, Joost van Rosmalen, Lieke S. Kamphuis, Michiel P. van Wijk, Maja Joosten, E. Sofie van Tuyll van Serooskerken, Rene Wijnen, Hanneke IJsselstijn, Andre B. Rietman, Manon C. W. Spaander
Summary: This study developed and validated a specific questionnaire (SQEA) to assess health-related quality of life in adults with esophageal atresia. The questionnaire showed good feasibility, reliability, and validity. It is able to discriminate disease burden and serves as an interesting signaling tool for clinicians to identify more severely affected patients.
DISEASES OF THE ESOPHAGUS
(2023)
Article
Clinical Neurology
Raquel Costa, Adrien M. Aubert, Anna-Veera Seppanen, Ulrika Aden, Iemke Sarrechia, Michael Zemlin, Marina Cuttini, Mairi Mannamaa, Veronique Pierrat, Arno van Heijst, Henrique Barros, Jennifer Zeitlin, Samantha Johnson
Summary: This study aimed to assess the accuracy of parent-reported gross motor impairment (GMI) at age 2 in predicting significant movement difficulties at age 5 in extremely preterm children. The results showed that parent reports of GMI at age 2 accurately classified movement difficulties at age 5 in most children. However, there were some cases where children with movement difficulties at age 5 were not identified at age 2.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Clinical Neurology
Adrien M. Aubert, Raquel Costa, Samantha Johnson, Ulrika Aden, Veronique Pierrat, Marina Cuttini, Mairi Mannamaa, Iemke Sarrechia, Jo F. Lebeer, Arno F. F. Van Heijst, Rolf F. Maier, Mariane Sentenac, Jennifer Zeitlin
Summary: This study aimed to measure the association between cerebral palsy (CP) and non-CP-related movement difficulties and health-related quality of life (HRQoL) among 5-year-old children born extremely preterm. The results showed that children with CP and non-CP-related movement difficulties had lower HRQoL compared to children without movement difficulties. The decrease in HRQoL was more pronounced at lower centiles for children with non-CP-related movement difficulties.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Pediatrics
Isabel I. Sreeram, Johannes M. Schnater, Joost van Rosmalen, Suzan C. M. Cochius-den Otter, Nina C. J. Peters, Robbert J. Rottier, Saskia J. Gischler, Rene M. H. Wijnen, Hanneke IJsselstijn, Andre B. Rietman
Summary: This study longitudinally assessed the self-reported health status and quality of life in 8- and 12-year-old survivors of congenital diaphragmatic hernia (CDH). It was found that boys' self-reported health status declined between the ages of 8 and 12, while quality of life remained stable. These findings highlight the importance of ongoing somatic and psychological assessments for CDH survivors in adolescence and adulthood.
Article
Medicine, General & Internal
Casper M. Kersten, Sergei M. Hermelijn, Louis W. J. Dossche, Nagarajan Muthialu, Paul D. Losty, Maarten Schurink, Andre B. Rietman, Marten J. Poley, Joost van Rosmalen, Tabitha P. L. Zanen van den Adel, Pierluigi Ciet, Jan von der Thusen, Erwin Brosens, Hanneke Ijsselstijn, Harm A. W. M. Tiddens, Rene M. H. Wijnen, J. Marco Schnater
Summary: The CONNECT consortium has established a core outcome set for the management of asymptomatic CPAM, which includes respiratory insufficiency, surgical complications, mass effect, and multifocal disease. The CONNECT trial aims to compare conservative and surgical management to develop evidence-based practice.
Article
Medicine, General & Internal
Federica Pederiva, Steven S. Rothenberg, Nigel Hall, Hanneke Ijsselstijn, Kenneth K. Y. Wong, Jan von der Thuesen, Pierluigi Ciet, Reuven Achiron, Adamo Pio d'Adamo, J. Marco Schnater
Summary: This article introduces the etiology, diagnosis, and treatment of congenital lung malformations (CLMs), and focuses on the impact of this disease on patients' quality of life.
NATURE REVIEWS DISEASE PRIMERS
(2023)
Article
Pediatrics
Louis W. J. Dossche, Casper M. Kersten, Tabitha van den Adel, Rene M. H. Wijnen, Saskia J. Gischler, Hanneke IJsselstijn, Andre B. Rietman, J. M. Schnater
Summary: This study investigates whether children who have undergone resection of a congenital lung abnormality are at a higher risk for neurodevelopmental impairments compared to the general population. The findings suggest that while there are some impairments in sustained attention, visuospatial memory, and motor development, overall neurodevelopmental outcomes in these children are normal. Therefore, testing for neurodevelopmental impairments should only be conducted if associated morbidities are present or if caregivers express doubts about daily functioning.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Sophie de Munck, Suzan C. M. Cochius-den Otter, J. Marco Schnater, Joost van Rosmalen, Nina C. J. Peters, Annabel P. J. M. van Gils-Frijters, Neeltje E. M. van Haren, Saskia J. Gischler, Hanneke IJsselstijn, Andre B. Rietman
Summary: This study evaluated neurocognitive deficits in children with congenital diaphragmatic hernia (CDH) and found that the tested 5-year-old children had normal neuropsychological outcomes on average. However, the severity of the disease in this cohort may have influenced the results.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
