Article
Critical Care Medicine
Rui-Sheng Wang, Shi Huang, Stephen W. Waldo, Edward Hess, Madhura Gokhale, Shelsey W. Johnson, Katarina Zeder, Gaurav Choudhary, Jane A. Leopold, William M. Oldham, Gabor Kovacs, Matthew S. Freiberg, Ryan J. Tedford, Bradley A. Maron, Evan L. Brittain
Summary: This study aims to identify clinical markers and therapeutic targets that inform survival in patients with pulmonary hypertension (PH). The results suggest that elevated pulmonary arterial compliance (PAC) greater than 3.0 ml/mmHg is associated with improved survival, especially in patients with precapillary PH.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Veterinary Sciences
Masayuki Enokizono, Ahmed S. Mandour, Syunta Komeda, Seijirow Goya, Aki Takeuchi, Konosuke Katoh, Akira Yairo, Zeki Yilmaz, Kazumi Shimada, Ryou Tanaka
Summary: This study compared the early cardiovascular effects of intramuscular and intravenous administration of injectable pimobendan in dogs. The results indicated that the cardiovascular effects of intramuscular administration were similar to those of intravenous administration.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Avelina Lee, Iryna Lebedyeva, Wenbo Zhi, Vani Senthil, Herjot Cheema, Michael W. Brands, Weston Bush, Nevin A. Lambert, Madeline Snipes, Darren D. Browning
Summary: Phosphodiesterase-5 inhibitors (PDE5i) are being studied for their potential in preventing colon cancer. However, their side-effects and interactions with other drugs have been a concern. By modifying the prototypical PDE5i sildenafil, we developed a new analog called malonyl-sildenafil which exhibited reduced lipophilicity and showed promising effects on colon epithelium. This analog suppressed proliferation in the colon epithelium, providing a novel approach to developing a first-in-class drug for colon cancer chemoprevention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Abraham Tettey, Yujie Jiang, Xiaohui Li, Ying Li
Summary: Pulmonary arterial hypertension (PAH) is a severe disease with high mortality even under treatment. Research has shown that the nitric oxide pathway plays a key role in PAH pathophysiology, with many drugs targeting this pathway. Novel compounds targeting on NO pathway hold great potential for future therapy, and understanding interactions with other pathways could lead to new drug discoveries for better clinical outcomes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Yiwen Zhang, Chun-Han Lo, Edward L. Giovannucci
Summary: This study found no evidence of an association between PDE5 inhibitor use and risk of conventional and serrated precursors of colorectal cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Hematology
Cassondra Cramer-Bour, Amy Parker Ruhl, Seyed Mehdi Nouraie, Robert O. Emeh, Nicole F. Ruopp, Swee Lay Thein, Nargues A. Weir, Elizabeth S. Klings
Summary: This study retrospectively reviewed 36 patients with SCD-PH treated with PDE5-I therapy, showing a significant improvement in symptoms as assessed by NYHA Class with long-term tolerability of PDE5-I therapy.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2021)
Article
Respiratory System
Timothy J. W. Dawes, Colm McCabe, Konstantinos Dimopoulos, Iain Stewart, Simon Bax, Carl Harries, Chinthaka B. Samaranayake, Aleksander Kempny, Philip L. Molyneaux, Samuel Seitler, Thomas Semple, Wei Li, Peter M. George, Vasileios Kouranos, Felix Chua, Elisabetta A. Renzoni, Maria Kokosi, Gisli Jenkins, Athol U. Wells, Stephen J. Wort, Laura C. Price
Summary: This study investigated the potential benefit of phosphodiesterase 5 inhibitors (PDE5i) in improving survival for patients with interstitial lung disease-associated pulmonary hypertension (ILD-PH). The results showed that patients treated with PDE5i had longer survival compared to untreated patients, with a particularly significant difference when right ventricular function was normal at presentation. These findings suggest that PDE5i treatment in ILD-PH should be further studied through a prospective randomized trial.
Article
Public, Environmental & Occupational Health
Behzad Abbasi, Nathan M. Shaw, Jason L. Lui, Nizar Hakam, Behnam Nabavizadeh, Benjamin N. Breyer
Summary: The use of PDE5i drugs shows a weaker disproportionality signal for priapism events compared to intracavernousal drugs. The highest reporting odds ratio (ROR) for all PDE5i agents is observed in the 12-17 years age group (9.49, 95% CI: 3.76-19.93), followed by the 2-11 years group (4.31, 95% CI: 1.57-9.4).
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Review
Cardiac & Cardiovascular Systems
Sumon Roy, Robert A. Kloner, Fadi N. Salloum, Ion S. Jovin
Summary: The coexistence of cardiovascular disease and erectile dysfunction is common, possibly due to underlying endothelial dysfunction. The effects of phosphodiesterase-5 (PDE5) inhibitors on the cardiovascular system remain unclear, despite their well-established role in erectile dysfunction therapy. Preclinical studies suggest potential clinical applications for PDE5 inhibitors in cardioprotection, but attempts to translate these findings to clinical trials have faced challenges.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Review
Cardiac & Cardiovascular Systems
Matthew J. J. Morrisette, Steven P. P. Dunn
Summary: The review aims to define the mechanism of drug-drug interaction between PDE-5 inhibitors and organic nitrates, as well as its clinical impact and recommended management in different clinical scenarios. Studies have shown that this interaction can cause significant hypotension during episodic PDE-5 use and acute nitrate administration, particularly in cardiovascular emergencies. Despite contraindication, some patients have been observed to chronically co-administer long-acting nitrates and PDE-5 inhibitors without adverse effects. Acute nitrate therapy should be avoided when PDE-5 exposure is present, and the risk of lower-intensity daily PDE-5 administration needs further investigation.
CURRENT CARDIOLOGY REPORTS
(2023)
Review
Cardiac & Cardiovascular Systems
Fen Cao, Kun Wu, Yong-zhi Zhu, Jun-jun Jiang, Gui Zhang, Jun Liu, Ping Xiao, Yang Tian, Wei Zhang, Sheng Zhang, Feng Hou, Zhong-wu Bao
Summary: Based on the analysis of 27 randomized controlled trials, it was found that endothelin receptor antagonists (ERAs) were more effective than Prostaglandins (ProsA) in shortening the duration of mechanical ventilation, while ProsA were better than phosphodiesterase type 5 inhibitors (PDE-5i) in shortening the duration of mechanical ventilation and ICU stay. PDE-5i generated more benefits in decreasing the occurrence of pulmonary hypertension (PH) crisis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Yu-Yang Liu, Yi-Yang Qu, Shang Wang, Ci-Jun Luo, Hong-Ling Qiu, Hui-Ting Li, Ping Yuan, Lan Wang, Jin-Ling Li, Rong Jiang, Rui Zhang
Summary: This study evaluated the efficacy and safety of switching from phosphodiesterase-5 inhibitors (PDE-5is) to riociguat in patients with pulmonary arterial hypertension (PAH). The results showed that riociguat was more effective than PDE-5is in improving hemodynamic parameters, 6-minute walking distance (6MWD), World Health Organization functional class (WHO-FC), and cardiac index (CI). No adverse events were observed during the switch.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Surgery
Kari J. Nelson, Pamela Antiquera, J. Stuart Nelson, Kristen M. Kelly, Nadine Abi-Jaoudeh
Summary: Sildenafil has shown benefit in treating some patients with complicated or refractory lymphatic malformations, leading to significant improvement in clinical symptoms.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Erika L. Poitras, Stephen L. Gust, Paul M. Kerr, Frances Plane
Summary: Nitric oxide activates enzyme soluble guanylate cyclase to produce cGMP, which plays a key role in regulating intracellular calcium levels. PDE5 inhibitors like sildenafil prolong cGMP availability, making them first-line treatments for erectile dysfunction and approved for pulmonary arterial hypertension. Inhaled NO is currently used for neonatal persistent pulmonary hypertension, but alternative approaches are needed for unresponsive cases.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Wenxing Dong, Zhe Zhang, Mingming Chu, Peng Gu, Min Hu, Lulu Liu, Jingbin Huang, Rong Zhang
Summary: This study evaluated the cost-effectiveness of adding selexipag to the combined treatment of macitentan and tadalafil in patients with pulmonary arterial hypertension (PAH) in China. The results showed that adding selexipag increased costs but also improved quality-adjusted life years (QALYs), although the cost-effectiveness ratio was higher than the willingness-to-pay (WTP) threshold. The sensitivity analysis indicated that the results were most sensitive to mortality rates, discount rate, and the cost of selexipag.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Obstetrics & Gynecology
Candace C. Style, Amy R. Mehollin-Ray, Mariatu A. Verla, Patricio E. Lau, Stephanie M. Cruz, Jimmy Espinoza, Timothy C. Lee, Caraciolo J. Fernandes, Sundeep G. Keswani, Oluyinka O. Olutoye
FETAL DIAGNOSIS AND THERAPY
(2020)
Article
Obstetrics & Gynecology
Mariatu A. Verla, Candace C. Style, Amy R. Mehollin-Ray, Sara C. Fallon, Adam M. Vogel, Caraciolo J. Fernandes, Chioma A. Ikedionwu, Timothy C. Lee, Sundeep G. Keswani, Oluyinka O. Olutoye
FETAL DIAGNOSIS AND THERAPY
(2020)
Article
Cardiac & Cardiovascular Systems
Jasmeet Kataria-Hale, Caraciolo J. Fernandes, Michael E. Speer
Editorial Material
Obstetrics & Gynecology
K. Suresh Gautham, Caraciolo J. Fernandes
JOURNAL OF PERINATOLOGY
(2020)
Editorial Material
Medicine, General & Internal
Faeq Al-Mudares, Caraciolo J. Fernandes
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Review
Pediatrics
Jenifer Cuestas, Pablo Lohmann, Joseph L. Hagan, Adam M. Vogel, Caraciolo J. Fernandes, Joseph A. Garcia-Prats
Summary: This study retrospectively reviewed diagnoses and outcomes of neonates with PH treated with ECMO over the past 35 years. It found high mortality rates for neonates with PH requiring ECMO, which have generally decreased but continue to increase for those with PH secondary to renal dysplasia.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Pediatrics
Faeq Al-Mudares, Caraciolo J. Fernandes
Summary: Pulmonary interstitial emphysema (PIE) is a pathological state that typically occurs in infants who require mechanical ventilation. This case report describes a baby with unilateral PIE, who was conservatively treated with positional therapy and showed significant improvement within 4 days and near complete resolution within 10 days.
PEDIATRIC PULMONOLOGY
(2021)
Editorial Material
Peripheral Vascular Disease
Russell A. Kesman, Amy R. Mehollin-Ray, Regina Lantin-Hermoso, John Colquitt, Caraciolo J. Fernandes, Muralidhar H. Premkumar
Summary: Central venous access is essential in the care of critically ill neonates, but can lead to complications such as infection and thrombosis. Accidental arterial cannulation of a venous catheter is a rare but dangerous complication. Physical and radiological findings can raise suspicion, diagnostic tools are needed for confirmation, and strategies should be implemented to prevent potential complications.
JOURNAL OF VASCULAR ACCESS
(2022)
Article
Medicine, Research & Experimental
Simen Vergote, Felix De Bie, Jan Bosteels, Holly Hedrick, James Duffy, Beverley Power, Alexandra Benachi, Paolo De Coppi, Caraciolo Fernandes, Kevin Lally, Irwin Reiss, Jan Deprest
Summary: This article aims to describe the methodology for defining a COS for perinatal and neonatal outcomes of fetuses and newborns with congenital diaphragmatic hernia and to draft a dissemination and implementation plan. The methodology described in the COMET Initiative Handbook will be used. An international steering group will be established to guide the development of the COS. The literature is being systematically reviewed to identify all potential relevant pre- and neonatal outcomes previously used in studies on perinatal interventions for CDH.
Article
Obstetrics & Gynecology
Roopali Donepudi, Michael A. Belfort, Alireza A. Shamshirsaz, Timothy C. Lee, Sundeep G. Keswani, Alice King, Nancy A. Ayres, Caraciolo J. Fernandes, Magdalena Sanz-Cortes, Ahmed A. Nassr, Andres F. Espinoza, Candace C. Style, Jimmy Espinoza
Summary: This study found that FETO is associated with resolution of PH by hospital discharge in fetuses with moderate left-sided CDH according to O/E-LHR criteria, with no significant differences in other outcomes.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Pediatrics
Mariatu A. Verla, Candace C. Style, Timothy C. Lee, Alicia D. Menchaca, Patricio E. Lau, Amy R. Mehollin-Ray, Caraciolo J. Fernandes, Sundeep G. Keswani, Oluyinka O. Olutoye
Summary: The study aimed to develop a quantifiable approach to identify a dome shape of the repaired diaphragm using post-operative chest radiograph and to determine if a dome-shaped prosthetic patch repair is associated with a decreased rate of CDH recurrence. The results showed that a dome-shaped repair may reduce recurrence following prosthetic patch repair of congenital diaphragmatic hernia.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Oncology
Shreya Agarwal, Berkley Kingman Anderson, Priya Mahajan, Caraciolo J. Fernandes, Judith F. Margolin, Ionela Iacobas
Summary: Chylothorax can be a presenting symptom of complex lymphatic anomaly in children and is often treated with octreotide. However, sirolimus has shown efficacy in complex vascular malformations and may also be effective in pediatric lymphatic effusions. A retrospective study at Texas Children's Hospital found that sirolimus can be an effective therapy for chylothorax in infants, with a shorter duration of chest tube requirement compared to previous treatments. Further multi-institutional studies are needed to validate these findings.
PEDIATRIC BLOOD & CANCER
(2022)
Editorial Material
Pediatrics
Ann Blake, Caraciolo J. Fernandes
PEDIATRICS IN REVIEW
(2022)
Review
Pediatrics
Srirupa Hari Gopal, Neil Patel, Caraciolo J. Fernandes
Summary: Congenital diaphragmatic hernia (CDH) is a rare congenital anomaly with complex pathophysiology. The use of PGE1 infusion as a management strategy for CDH-related pulmonary hypertension has shown promising results in optimizing cardiac function and blood flow.
FRONTIERS IN PEDIATRICS
(2022)
Article
Education, Scientific Disciplines
Gregory C. Valentine, Melissa H. Althouse, Caraciolo J. Fernandes
JOURNAL OF MEDICAL EDUCATION AND CURRICULAR DEVELOPMENT
(2020)
