Article
Pediatrics
Esra Ekinci, Stefanie Desmet, Liesbet Van Heirstraeten, Colette Mertens, Ine Wouters, Philippe Beutels, Jan Verhaegen, Surbhi Malhotra-Kumar, Heidi Theeten
Summary: A study in Belgium found similar rates of pneumococcal carriage and density in young children with AOM and healthy children in daycare centers. Certain serotypes not included in PCV vaccines were more frequently carried in children with AOM, suggesting a potential relationship between these serotypes and AOM.
FRONTIERS IN PEDIATRICS
(2021)
Article
Biotechnology & Applied Microbiology
Gabriel Carrasquilla, Alexandra Porras-Ramirez, Sandra Martinez, Rodrigo DeAntonio, Raghavendra Devadiga, Carla Talarico, Diana C. Caceres, Maria M. Castrejon, Patricia Juliao
Summary: After the introduction of pneumococcal conjugate vaccines (PCVs) in Colombia, overall reductions in disease outcomes were observed in most cities and nationwide. However, in some cities, there was an increase in the incidence of otitis media despite the decrease in pneumonia incidence.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Review
Biotechnology & Applied Microbiology
Adriana Guzman-Holst, Eliana de Barros, Pilar Rubio, Rodrigo DeAntonio, Otavio Cintra, Ariane Abreu
Summary: The systematic review examines the impact of the PHiD-CV vaccine in Brazil after 10 years of use, finding positive effects on pediatric pneumococcal disease, pneumonia, and otitis media. Increased vaccination coverage is necessary for sustained population impact.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Immunology
Nader Shaikh, Alejandro Hoberman, Jack L. L. Paradise, Howard E. E. Rockette, Marcia Kurs-Lasky, Judith M. M. Martin
Summary: Through two separate clinical trials, we found that young children aged 6-23 months without nasopharyngeal colonization of either Streptococcus pneumoniae or Haemophilus influenzae may not need or can have a shortened duration of antibiotic treatment.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Pediatrics
Oren Ziv, Dana Adelson, Reem Sadeh, Sofia Kordeluk, Sabri El-Saied, Eugene Leibovitz, Mordechai Kraus, Daniel Kaplan
Summary: This retrospective cohort study showed that immunization with pneumococcal conjugate vaccines (PCV) significantly reduced the occurrence of recurrent acute otitis media (rAOM) in infants following an early episode of acute otitis media (AOM).
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Immunology
Sophie Warren, Myrto Barmpouni, Vasiliki Kossyvaki, George Gourzoulidis, Johnna Perdrizet
Summary: Greece introduced PCV13 in 2010, resulting in a decrease in pneumococcal disease caused by vaccine serotypes. However, non-vaccine serotypes increased. PCV15 and PCV20 were developed to improve serotype coverage. A decision-analytic model was used to forecast the outcomes of switching to PCV15 or PCV20 in Greece.
Article
Immunology
Xueqing Wu, Shanshan Zhao, Yan Jiang, Xi Xiang, Lihong Ge, Qiong Chen, Yanfei Wang, Jorge E. Vidal, Yunsong Yu
Summary: This study evaluated the impact of interrupted PCV availability on pneumococcal pneumonia and genetic variation of Streptococcus pneumoniae. The findings showed that interrupted PCV availability affected the prevalence of pneumococcal disease and pneumococcal genome variation.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Immunology
Janine Paynter, Anna S. Howe, Emma Best, Helen Petousis-Harris
Summary: This study used New Zealand's linkable, administrative health data to examine the comparative risk of otitis media (OM) and pneumonia hospitalisations among children receiving three different pneumococcal conjugate vaccines (PCV). The results showed that PCV10 was associated with a reduced risk for OM compared with PCV7. There were no significant differences between PCV10 and PCV13 in risk of hospitalisation with either otitis media or all-cause pneumonia amongst the transition 2 cohort. In the 18-month follow-up after transition 3, PCV13 was associated with a marginally higher risk of all-cause pneumonia and otitis media compared to PCV10.
Article
Biochemical Research Methods
Gowrisankar Rajam, Kate L. Hicks, Joseph M. Antonello, Yuhua Zhang, Sarah Irey, Julia Kelly, Stephanie Cooper, Leonard J. Rubinstein
Summary: In this study, an innovative multiplex immuno-molecular assay was developed and validated to screen and detect 15-valent pneumococcal conjugate vaccine (PCV15) vaccine serotypes in acute otitis media (AOM) clinical samples. The assay involved two-step testing using PCR and immunological methods. The results demonstrated the feasibility of combining molecular and immunological assays for diagnosing AOM caused by Streptococcus pneumoniae.
JOURNAL OF IMMUNOLOGICAL METHODS
(2023)
Article
Immunology
Haruka Maeda, Bhim Gopal Dhoubhadel, Eiichiro Sando, Motoi Suzuki, Akitsugu Furumoto, Norichika Asoh, Makito Yaegashi, Masahiro Aoshima, Masayuki Ishida, Sugihiro Hamaguchi, Yoshihito Otsuka, Konosuke Morimoto
Summary: The introduction of pediatric pneumococcal conjugate vaccines (PCVs) in Japan has reduced pneumococcal pneumonia and invasive disease caused by PCV-covered serotypes among children and adults. However, the long-term impact of PCV use in children on adult pneumococcal pneumonia in Japan remains unclear.
Article
Immunology
Ravinder Kaur, Minh Pham, Karl O. A. Yu, Michael E. Pichichero
Summary: The study found that antibiotic susceptibility of Streptococcus pneumoniae strains isolated from children improved initially after the introduction of PCV13, but began to decrease from 2013 onwards due to the emergence of new serotypes not included in PCV13. These new strains exhibit reduced susceptibility to multiple commonly used antibiotics, compared to the pre-PCV13 era.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Maria Morales-Suarez-Varela, Diana Toledo, Maria Amelia Fernandez-Sierra, Maria Liebana, Gerardo Rubiera, Gema Navarro, Concepcion Prados, Judith Chamarro, Isabel Peraita-Costa, Angela Dominguez
Summary: This retrospective cohort study found that individuals who were vaccinated against pneumococcal disease had a lower risk of developing SARS-CoV-2 pneumonia compared to those who were not vaccinated. The study also identified certain high-risk groups for developing SARS-CoV-2 pneumonia, such as individuals with obesity, diabetes, and respiratory diseases, who could potentially benefit from vaccination and monitoring.
Article
Immunology
Matus Macaj, Lubica Perdochova, Janka Jakubikova
Summary: Data from Slovakia reveals that the pneumococcal serotypes and their antimicrobial resistance have changed in young children with acute otitis media (AOM) after the introduction of three commercially available pneumococcal conjugate vaccines (PCVs) (PCV7, PCV13, PCV10). The use of PCV13 has the greatest impact on AOM.
Article
Microbiology
Cristina Gavrilovici, Elena-Lia Spoiala, Ingrith-Crenguta Miron, Iuliana Magdalena Starcea, Codruta Olimpiada Iliescu Halitchi, Irina Nicoleta Zetu, Vasile Valeriu Lupu, Carmen Panzaru
Summary: Acute otitis media (AOM) remains a major reason for antibiotic use in children, despite the availability of pneumococcal conjugate vaccines. A study conducted in a pediatric emergency hospital in Romania found that Streptococcus pneumoniae and Haemophilus influenzae were the most common bacteria associated with AOM. Alarmingly, a high proportion of the Streptococcus pneumoniae strains were resistant to multiple drugs. This highlights the importance of addressing antimicrobial resistance to minimize the negative impact on healthcare costs.
Article
Immunology
Julia L. Raboba, Vonintsoa L. Rahajamanana, Emilson P. R. Andriatahirintsoa, Ainamalala C. Razafindrakoto, Andry M. Andrianarivelo, Marcellin Nimpa Mengouo, Yolande Vuo Masembe, Goitom G. Weldegebriel, Linda de Gouveia, Jason M. Mwenda, Annick L. Robinson
Summary: The study assessed the impact of PCV10 on pneumococcal serotypes in children under 5 years in Madagascar. It found that the introduction of PCV10 led to a decrease in meningitis caused by S. pneumoniae and PCV10 vaccine serotypes. The research results show that PCV10 vaccine lowered the incidence of meningitis.
JOURNAL OF INFECTIOUS DISEASES
(2021)
