Article
Multidisciplinary Sciences
Hui Sun, Yufeng Wang, Shentao Wang, Yikui Xie, Kun Sun, Shuai Li, Weitong Cui, Kai Wang
Summary: This article investigated the correlation between the expression patterns of collagen family genes and gastric cancer progression using bioinformatics analyses. It was found that many collagen family genes were overexpressed in gastric cancer tissues, especially in the early T stages, highlighting the significance of collagens in tumor enlargement of gastric cancer.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Haonan Guo, Hui Tang, Yang Zhao, Qianwen Zhao, Xianliang Hou, Lei Ren
Summary: This study aimed to construct a prognostic stratification system for gastric cancer (GC) using tumour invasion-related genes to more accurately predict the clinical prognosis of GC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Wenshuo Yang, Xiaohan Cui, Danping Sun, Guorui Sun, Zhibo Yan, Meng Wei, Zuoyang Wang, Wenbin Yu
Summary: POU5F1 plays a crucial role in maintaining cancer stem cell-like properties in gastric cancer cells. Overexpression of POU5F1 is associated with a poor prognosis in gastric cancer patients. POU5F1 enhances the proliferation, migration, and invasion of gastric cancer cells by triggering Epithelial-mesenchymal transition (EMT) and activating the NF-kappa B pathway. ATRA, a therapeutic agent, inhibits the expression of POU5F1 and effectively impedes the proliferation, migration, and invasion of gastric cancer cells.
CELL DEATH & DISEASE
(2023)
Article
Immunology
Songna Wang, Yuan Fu, Kudelaidi Kuerban, Jiayang Liu, Xuan Huang, Danjie Pan, Huaning Chen, Yizhun Zhu, Li Ye
Summary: DDR1 is highly expressed and significantly associated with poor prognosis in gastric cancer. It may play a role in invasion, metastasis, and immune infiltration of gastric cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Anatomy & Morphology
Xiangwen Zhang, Jiaming Xue, Huiliang Yang, Tingting Zhou, Guo Zu
Summary: TNFAIP6 plays an important role in the prognosis of gastric cancer patients, with higher expression levels associated with tumor invasion depth, lymph node metastasis, TNM stage, and poorer overall survival. Knockdown of TNFAIP6 inhibited proliferation, invasion, and metastasis of gastric cancer cells in vitro.
Article
Biochemistry & Molecular Biology
Linfeng Mao, Weijie Yuan, Kaimei Cai, Chen Lai, Changhao Huang, Yi Xu, Shangwei Zhong, Chen Yang, Ran Wang, Pengwei Zeng, Heyuan Huang, Zhikang Chen, Zihua Chen
Summary: EphA2, YES1, and ANXA2 form a signaling axis that promotes gastric cancer invasion and metastasis. Overexpression of YES1 increases invasion and migration of gastric cancer cells, while knockdown of ANXA2 decreases these processes.
Article
Oncology
Dandong Luo, Yue-e Wen, Huaxian Chen, Zijian Deng, Jiabo Zheng, Shi Chen, Junsheng Peng, Lei Lian
Summary: This study found that the presence of perineural invasion (PNI) is associated with worse survival in patients with stage II gastric cancer undergoing curative resection. Additionally, adjuvant chemotherapy (AC) was shown to be an independent protective factor for improving survival.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Pathology
Seokhwi Kim, Won Jung Bae, Ji Mi Ahn, Jin-Hyung Heo, Kyoung-Mee Kim, Kyeong Woon Choi, Chang Ohk Sung, Dakeun Lee
Summary: The study identified unique miRNA expression profiles that can predict metastasis in intramucosal carcinomas (IMCs), with most miRNAs showing stepwise increased or decreased expression. A machine-learning algorithm could distinguish metastatic IMC from nonmetastatic IMC, and gene ontology and pathway analysis revealed enrichment of key signaling pathways. Furthermore, immunohistochemical staining indicated differential expression of pathway components between metastatic and nonmetastatic IMC.
Article
Medicine, General & Internal
Chunsheng Li, Mingchuan Wang, Xianbin Cheng, Yang Jiang, Huijie Xiao
Summary: This study retrospectively analyzed 350 patients with gastric cancer and found that perineural invasion (PNI) is an independent marker of poor prognosis in gastric cancer, correlated with T staging, lymph node metastasis, and lymphovascular invasion.
Article
Oncology
Fengxiang Zhang, Huaxian Chen, Dandong Luo, Zhizhong Xiong, Xianzhe Li, Shi Yin, Longyang Jin, Shi Chen, Junsheng Peng, Lei Lian
Summary: Lymphovascular invasion (LVI) and perineural invasion (PNI) are associated with poorer prognosis in gastric cancer (GC). This study aimed to investigate their prognostic value in curative resected GC patients. The incidence of LVI/PNI was significantly higher in GC patients compared to colorectal cancer patients (50.54% vs. 21.91%, p < 0.001). LVI/PNI was closely associated with disease progression and served as an independent risk factor for lymph node metastasis and overall survival in GC.
Article
Biology
Jingxuan Xu, Jingjing Song, Xinxin Chen, Yingpeng Huang, Tao You, Ce Zhu, Xian Shen, Yaping Zhao
Summary: This study identified a 12-miRNA signature associated with genomic instability for predicting gastric cancer prognosis. The researchers constructed a miRNA signature scheme based on the TCGA dataset and analyzed the potential biological pathways associated with genomic instability-related miRNAs. Additionally, miR-100-5p and miR-145-3p were found to promote gastric cancer cell growth, invasion, and migration.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Anatomy & Morphology
Yu Chen, Biling Wang, Zihao Zhao, Ming Li, Fei Wang
Summary: Overexpression of PRSS2 in gastric cancer is associated with poor prognosis and can serve as a potential biomarker for assessing the prognosis of gastric cancer. Knockdown of PRSS2 reduces the proliferation, migration, and invasion of GC cells.
Article
Cell Biology
Mi-Jeong Kim, Yoon Min, Soo-Kyung Jeong, Juhee Son, Ji Young Kim, Ji Su Lee, Duk-Hwan Kim, Joo Sang Lee, Eunyoung Chun, Ki-Young Lee
Summary: The study reveals that USP15 is significantly downregulated in lung cancer patients, and its knockout leads to increased migration, invasion, and autophagy induction in lung cancer cells. USP15 interacts with BECN1 and deubiquitinates it, thereby attenuating autophagy induction. Additionally, the expression of USP15 is associated with the upregulation of certain oncogenes and downregulation of tumor suppressor genes in lung cancer patients.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Xiaohao Zheng, Yunzi Wu, Li Zheng, Liyan Xue, Zhichao Jiang, Chenfeng Wang, Yibin Xie
Summary: The study revealed the association between risk factors and long-term prognosis in patients with stage II gastric cancer after radical gastrectomy. Demographic, clinical, and pathological information of 247 patients were collected and analyzed, showing that age, nerve invasion, and surgical approach were independent prognostic factors for stage II gastric cancer patients. These factors were identified through various statistical analyses and subgroup interactions, indicating their importance in predicting disease-specific survival outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
Dailong Li, Wanqiang Li, Yaqi Pang, Siqi Liu, Lu Xu, Xinhua Xu
Summary: This study using meta-analysis showed that lymphovascular invasion is an independent risk factor affecting the prognosis of stage I gastric cancer, and it is significantly associated with overall survival and relapse-free survival.
Article
Pathology
Xiaobo Zhang, Chen Wang, Danhua Shen
Summary: This study investigated the Clinicopathological features and FH mutation in FH-dUL. FH-dUL is rare and the combination of predictive Clinicopathological evaluation, FH and 2SC IHC test, and molecular test were helpful for the screening of FH-dUL or even HLRCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Gaurav Dubey, Mithilesh Singh, Himmat Singh, Mohit Agarwal, Shailendra Singh Chandel, Anurag Mishra, Ravindra Pal Singh, Neelima Kukreti
Summary: SnoRNAs play a crucial role in autoimmune diseases, influencing gene expression, immune cell development, and immune regulation. They have the potential to be biomarkers or therapeutic targets for disease management. However, further research is needed to elucidate their precise molecular mechanisms.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
P. Suhaj, D. Do, T. Olejar, R. Pichova, O. Lang, R. Matej
Summary: Pancreatic polypeptide cell hyperplasia (PPY-H) is a multiplication of neuroendocrine cells producing pancreatic polypeptide (PPY). The development and role of PPY-H still need to be further elucidated. This study analyzed 12 cases of PPY-H accompanying pancreatic neuroendocrine neoplasias (NEN) and found that gastrointestinal symptoms may be more related to PPY-H rather than NEN hormonal production. Strong SSTR2 expression in PPY-H suggests the potential utility of radiotracers in clinical diagnostics, but further studies are needed.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ruyun Zhang, Xiaofei Liao, Bin Zhang, Xiaohong Huang, Guanjie Qin, Xiangyun Kong, Yuan Xie, Yunyan Mo, Jinxuan Dai, Chunqiao Gan, Zan Luo, Jingyan Lu, Wei Jiang
Summary: This study found that patients with high COV+TIL score had worse prognosis in nasopharyngeal carcinoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Waleed Hassan Almalki
Summary: Understanding the molecular pathways behind cardiovascular illnesses is crucial. Recent studies have revealed the role of Xist RNA in cardiovascular diseases, including epigenetic changes, gene expression, cellular identity, and sex chromosomal inactivation. Dysregulation of Xist RNA expression is associated with conditions such as atherosclerosis, hypertrophy, and cardiac fibrosis.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Yanxin Dong, Boshi Fan, Mingyang Li, Jiale Zhang, Shun Xie, Shouyin Dia, Qingge Jia, Taiqian Gong
Summary: Tescalcin (TESC) is upregulated in esophageal squamous carcinoma (ESCC) and is associated with poor prognosis, tumor infiltration, staging, and lymph node metastasis. TESC promotes proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) progression in ESCC, as well as activates the AKT pathway. TESC may serve as a prognostic factor and provide a new therapeutic strategy for ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ozge Sukruoglu Erdogan, Demet Akdeniz Odemis, Zubeyde Yalniz Kayim, Orkun Gurbuz, Seref Bugra Tuncer, Seda Kilic, Betul Celik, Samuray Tuncer, Sema Buyukkapu Bay, Rejin Kebudi, Hulya Yazici
Summary: This study found that methylation of the RB1 gene promoter does not influence the hereditary transmission of familial retinoblastoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Syam Mohan, Mohammed Ageeli Hakami, Hamad Ghaleb Dailah, Asaad Khalid, Asim Najmi, Khalid Zoghebi, Maryam A. Halawi, Thaifallah Munahi Alotaibi
Summary: Cancer is a complex disease caused by multiple factors, and miR-155 plays a significant role as a regulator of the NF-kappa B signaling pathway, contributing to cancer development and progression.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
