☆ 4.2 Review

Peptide vaccination therapy: Towards the next generation

PATHOLOGY INTERNATIONAL (2016)

期刊

PATHOLOGY INTERNATIONAL

卷 66, 期 10, 页码 547-553

出版社

WILEY-BLACKWELL

DOI: 10.1111/pin.12438

关键词

antibody recognizing HLA/peptide complex; cancer stem cell antigen; carcinoma; clinical trial; memory T stem cell; peptide vaccination; sarcoma

类别

Pathology

资金

JSPS KAKENHI [16H05451]
Takeda Science Foundation
Cell Science Research Foundation
Grants-in-Aid for Scientific Research [16H05451] Funding Source: KAKEN

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Protocol

Reagent

摘要

The aim of peptide vaccination therapy is to stimulate and activate peptide-specific T cells to reject tumor cells. This strategy has been promoted by the discovery of tumor-associated antigens recognized by T cells. Peptide vaccination therapy can induce immune responses in some cancer patients but the objective clinical response rates are still low. To improve of the efficacy of peptide vaccination therapy: (i) cancer stem cell antigens specifically expressed in carcinoma/sarcoma stem-like cells but not in normal cells are needed; (ii) peptide vaccination therapy should be performed in the earlier stages; and (iii) memory T stem cells should be regulated to maintain long-lasting immune responses to the peptide vaccination.

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