Article
Clinical Neurology
Eleonora Del Prete, Emmanuelle Schmitt, Sara Meoni, Valerie Fraix, Anna Castrioto, Pierre Pelissier, Roberto Ceravolo, Elena Moro
Summary: This study investigates the relationship between motor fluctuations (MFs) and neuropsychiatric fluctuations (NMFs) in Parkinson's disease (PD). The findings suggest that NMFs only temporarily match the OFF MFs in PD patients. The study emphasizes the need to further investigate the associations between non-motor and motor symptoms in PD patients to better manage NMFs.
NEUROLOGICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Yan Qu, Tingting Zhang, Yunyan Duo, Liling Chen, Xiaohong Li
Summary: This study aims to investigate the value of the Parkinson's KinetiGraph (PKG) in identifying and quantitatively assessing motor complications in the Chinese PD population and its correlation with clinical assessments. The study found that PKG has a significant correlation with clinical assessment, high sensitivity, and high specificity, providing an objective and quantitative method for identifying and assessing motor complications in Parkinson's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Clinical Neurology
C. Warren Olanow, Werner Poewe, Olivier Rascol, Fabrizio Stocchi
Summary: Levodopa is the most effective therapy for Parkinson's disease, but chronic treatment can lead to OFF episodes, causing disability and emotional issues for patients. There are currently three on-demand therapies available for OFF episodes, including subcutaneous injection of apomorphine, sublingual apomorphine film, and inhaled levodopa.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Regina Katzenschlager, Werner Poewe, Olivier Rascol, Claudia Trenkwalder, Guenther Deuschl, K. Ray Chaudhuri, Tove Henriksen, Teus van Laar, Donna Lockhart, Harry Staines, Andrew Lees
Summary: The TOLEDO study showed that apomorphine infusion is an effective and safe treatment for reducing motor fluctuations in Parkinson's disease patients. Long-term use of APO led to sustained reductions in OFF time and improvements in ON time without troublesome dyskinesia, allowing for significant decreases in oral PD medication.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Jose Fidel Baizabal-Carvallo, Marlene Alonso-Juarez, Robert Fekete
Summary: In this study, therapeutic decontamination of the intestines showed significant benefit in improving motor fluctuations and dyskinesia in Parkinson's disease patients. Blinded evaluation of videos revealed marked to moderate improvement in dyskinesia in 57% of cases, while about 80% of patients perceived moderate to robust improvement during follow-up. Further research is needed to confirm and clarify the mechanism of improvement observed in these patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Adam Fry, Dharampreet Singh, Louis Manganas, Marc L. Gordon, Christopher Christodoulou, Hoi-Chung Leung, Guy J. Schwartz
Summary: This study found a high incidence of temporal lobe epileptiform discharges in Parkinson's disease patients with visual hallucinations compared to those without. This finding suggests a possible association with a epileptogenic focus in the visual cortex and highlights the potential use of antiepileptic drugs in treatment-refractory patients, similar to Charles Bonnet syndrome, temporal lobe epilepsy, and migraine with visual aura.
FRONTIERS IN NEUROLOGY
(2022)
Article
Health Care Sciences & Services
Sara Redensek, Tanja Blagus, Maja Trost, Vita Dolzan
Summary: Genetic variability of serotonergic genes is associated with motor complications and psychiatric adverse events caused by dopaminergic treatment in Parkinson's disease (PD), suggesting an important role of the serotonergic pathway in PD pathogenesis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Stuart H. Isaacson, Daniel Kremens, Yasar Torres-Yaghi, Fabrizio Stocchi, Angelo Antonini
Summary: This article reviews the contribution of delays in time to ON to total daily OFF time in Parkinson's disease patients and emphasizes the importance of measuring and adequately addressing delays in time to ON.
PARKINSONISM & RELATED DISORDERS
(2023)
Review
Medicine, General & Internal
Robert A. Hauser, Peter A. LeWitt, Cynthia L. Comella
Summary: Levodopa is the most effective symptomatic treatment for Parkinson's disease, but many patients experience intermittent OFF periods where symptoms return. These periods are largely due to shortened clinical benefit from oral levodopa, as well as impaired absorption and other factors. On-demand therapies have expanded to address these OFF periods, providing rapid and reliable relief as alternatives to traditional medication regimens.
POSTGRADUATE MEDICINE
(2021)
Article
Clinical Neurology
Olivier Rascol, Lars Toenges, Tina DeVries, Mark Jaros, Adrian Quartel, David Jacobs
Summary: The study shows that IR/ER amantadine is effective in reducing LID, but the results vary in different doses and trials. However, despite some adverse events, it still has the potential to be an effective medication in the treatment of LID.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Medicine, General & Internal
Valeria Conti, Viviana Izzo, Maria Claudia Russillo, Marina Picillo, Marianna Amboni, Cesa L. M. Scaglione, Alessandra Nicoletti, Ilaria Cani, Calogero E. Cicero, Emanuela De Bellis, Bruno Charlier, Valentina Giudice, Gerardina Somma, Graziamaria Corbi, Paolo Barone, Amelia Filippelli, Maria Teresa Pellecchia
Summary: This study revealed gender differences in LD pharmacokinetics in PD patients at their first-ever intake of LD. Women had significantly higher AUC and Cmax than men. Gender and BMI were significant predictors of AUC, while only gender predicted Cmax, and only BMI predicted t(1/2), especially in women.
FRONTIERS IN MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Maxwell J. Wagner, Charles P. Daniel, Connor J. Plaisance, Grant E. Borne, Shahab Ahmadzadeh, Sahar Shekoohi, Alan D. Kaye
Summary: Parkinson's disease is characterized by dopamine depletion in the basal ganglia, leading to symptoms such as bradykinesia, gait abnormalities, and cognitive impairment. Apomorphine is used to reverse acute "off" periods during the disease course and restore function in patients. This review provides a concise article discussing the history, pharmacokinetics, mechanism of action, and utilization of apomorphine as a treatment for Parkinson's disease.
EXPERT OPINION ON EMERGING DRUGS
(2023)
Article
Clinical Neurology
Francesca Morgante, Valentina Oppo, Margherita Fabbri, Enrica Olivola, Chiara Sorbera, Rosa De Micco, Giovanna Chiara Ielo, Fabiana Colucci, Salvatore Bonvegna, Alessio Novelli, Nicola Modugno, Mariachiara Sensi, Maurizio Zibetti, Leonardo Lopiano, Alessandro Tessitore, Manuela Pilleri, Roberto Cilia, Antonio E. Elia, Roberto Eleopra, Lucia Ricciardi, Giovanni Cossu
Summary: The study showed that LCIG infusion can be effective for late elderly Parkinson's disease patients, with no significant differences in quality of life, motor and non-motor symptoms severity, side effects, and dropout rates compared to younger patients.
JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Robert A. Hauser, Judy Lytle, Andrea E. Formella, Caroline M. Tanner
Summary: Maintaining consistent levodopa benefits while controlling dyskinesia can be difficult. A recent study evaluated the efficacy of an extended-release amantadine formulation as an adjunct to levodopa for the treatment of OFF episodes. The results showed significant reductions in OFF time in both the overall population and subgroups with different baseline OFF times.
NPJ PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Maria Diez-Cirarda, Alberto Cabrera-Zubizarreta, Ane Murueta-Goyena, Antonio P. Strafella, Rocio Del Pino, Marian Acera, Olaia Lucas-Jimenez, Naroa Ibarretxe-Bilbao, Beatriz Tijero, Juan Carlos Gomez-Esteban, Inigo Gabilondo
Summary: Visual hallucinations (VH) are present in up to 75% of Parkinson's disease (PD) patients. However, their neural bases and participation of the visual system in VH are not well-understood in PD. This study found specific functional and structural abnormalities within the visual system in PD patients with VH, which could potentially serve as biomarkers for VH in PD.
JOURNAL OF NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sanne K. Meles, Remco J. Renken, Annette Janzen, David Vadasz, Marco Pagani, Dario Arnaldi, Silvia Morbelli, Flavio Nobili, Geert Mayer, Klaus L. Leenders, Wolfgang H. Oertel
JOURNAL OF NUCLEAR MEDICINE
(2018)
Article
Neurosciences
Thialda T. Vlagsma, Annelien A. Duits, Hilde T. Dijkstra, Teus van Laar, Jacoba M. Spikman
NEUROPSYCHOLOGICAL REHABILITATION
(2020)
Article
Clinical Neurology
Jeffrey M. Boertien, Sygrid van der Zee, Asterios Chrysou, Marleen J. J. Gerritsen, Nomdo M. Jansonius, Jacoba M. Spikman, Teus van Laar
Article
Clinical Neurology
Gloria Marti-Andres, Liza van Bommel, Sanne K. Meles, Mario Riverol, Rafael Valenti, Rosalie Kogan, Remco J. Renken, Vita Gurvits, Teus van Laar, Marco Pagani, Elena Prieto, M. Rosario Luquin, Klaus L. Leenders, Javier Arbizu
MOVEMENT DISORDERS
(2020)
Letter
Clinical Neurology
Robbert W. K. Borgemeester, Gilles F. H. Diercks, Teus van Laar
Summary: This study aimed to provide clinical evidence for existing treatments of subcutaneous nodules after subcutaneous infusion of apomorphine, using a biopsy-controlled prospective crossover design of four treatments. We demonstrated that dilution of apomorphine significantly improved patient satisfaction, while subcutaneous hydrocortisone reduced nodule size, however with no differences in the histopathology.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Sygrid van der Zee, Prabesh Kanel, Marleen J. J. Gerritsen, Jeffrey M. Boertien, Anne C. Slomp, Martijn L. T. M. Muller, Nicolaas Bohnen, Jacoba M. Spikman, Teus van Laar
Summary: This study assessed the cholinergic innervation status in early-stage Parkinson's disease (PD) patients and found that cholinergic innervation changes were associated with cognitive impairment. Regardless of cognitive status, patients showed cholinergic denervation in the posterior cortical regions. Cognitively intact patients exhibited higher cholinergic activity in the cerebellar, frontal, and subcortical regions, suggesting compensatory cholinergic upregulation in early-stage PD. Limited or failing cholinergic upregulation may play an important role in early cognitive impairment in PD.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Joyce B. Weersink, Natasha M. Maurits, Teus van Laar, Bauke M. de Jong
Summary: Enhanced arm swing can improve gait difficulties in Parkinson's Disease by restoring SMA function, leading to increased step length and walking speed. Healthy individuals exhibit similar gait characteristics to Parkinson's patients when walking without arm swing.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Onanong Phokaewvarangkul, Chanawat Anan, Aukkritthiwat Phimpha, K. Ray Chaudhuri, Teus van Laar, Roongroj Bhidayasiri
Summary: CSAI therapy showed positive outcomes in Thai PD patients, but the majority of patients discontinued the treatment during the follow-up period. Identifying predictors of discontinuation at the initiation of CSAI may help in long-term management strategies.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Muhammad Nazmuddin, Jan-Willem Van Dalen, Ronald J. H. Borra, Gilles N. Stormezand, Harm Jan van der Horn, Sygrid van der Zee, Jeffrey Boertien, Teus van Laar
Summary: The study found a loss of microstructural integrity of the NBM-WM tract in PIGD-PD patients, indicating that the loss of cholinergic projections in this PD subtype already presents in de novo PD patients. Furthermore, significant correlations between the severity of gait and posture issues and NBM-WM FA and MD were identified.
PARKINSONISM & RELATED DISORDERS
(2021)
Review
Clinical Neurology
Naomi Kremer, Teus van Laar, Stefan F. Lange, Sijmen Statius Muller, Sacha La Bastide-van Gemert, D. L. Marinus Oterdoom, Gea Drost, J. Marc C. van Dijk
Summary: Deep brain stimulation (DBS) is an effective treatment for Parkinson's disease, but the optimal surgical accuracy has not been determined. Based on current literature, DBS electrodes placed within a 2mm range of the target do not need repositioning. Further research is needed to establish an indisputable upper cut-off value for surgical accuracy.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Psychology
Maraike A. Coenen, Hendriekje Eggink, Martje E. van Egmond, D. L. Marinus Oterdoom, J. Marc C. van Dijk, Teus van Laar, Jacoba M. Spikman, Marina A. J. Tijssen
Summary: Deep brain stimulation (DBS) of the internal globus pallidus (GPi) has been recognized as a treatment for medication-refractory dystonia. This study compares cognition before and after GPi DBS and finds that the impact of DBS on cognitive functioning is limited, with some domains yet to be investigated.
JOURNAL OF NEUROPSYCHOLOGY
(2023)
Review
Clinical Neurology
Harmen R. Moes, Tove Henriksen, Jaroslaw Slawek, Onanong Phokaewvarangkul, Erik Buskens, Teus van Laar
Summary: This article provides an overview of the screening and selection tools developed over the past 25 years for identifying eligible Parkinson's disease patients for device-aided therapies (DATs). It describes the target therapies, development methods, validation data, and clinical use of the available screening tools. The historical background and potential utility of these tools are also discussed, along with the challenges of development and validation, considering population differences and resource availability.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Psychology
Anne Carien Slomp, Sygrid van Der Zee, Jeffrey M. Boertien, Marleen J. J. Gerritsen, Teus van Laar, Jacoba M. Spikman
Summary: Facial emotion recognition is important for social cognition and behavior regulation. This study compared facial emotion recognition in de novo Parkinson's disease (PD) patients and healthy controls (HC) at the time of diagnosis and its association with social behavioral problems. The results showed that PD patients had impaired facial emotion recognition compared to HC, and lower recognition was correlated with self-reported apathy and proxy-reported social-behavioral problems. These findings highlight the importance of including social cognition measures in the neuropsychological assessment of early PD.
JOURNAL OF NEUROPSYCHOLOGY
(2023)
Letter
Clinical Neurology
Harmen R. Moes, Jolien M. ten Kate, Erik Buskens, Teus van Laar
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Sygrid van der Zee, Martijn L. T. M. Muller, Prabesh Kanel, Teus van Laar, Nicolaas I. Bohnen
Summary: This study investigated the relationship between cognitive functioning and regional cholinergic innervation in patients with PD, utilizing [F-18]Fluoroethoxybenzovesamicol positron emission tomography imaging. The results showed partial overlapping topography across cognitive domains, with most robust correlations in the domains of memory, attention, and executive functioning. The findings confirm and expand on previous observations of cholinergic system involvement in cognitive functioning in PD, reflecting a combination of disease-specific and aging effects.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)