Article
Psychiatry
Miaomiao Hou, Xiaowei Mao, Xiaojun Hou, Kunpeng Li
Summary: Our study found a mild-to-moderate level of stigma in patients with PD. Tremor-dominant subtype, longer disease duration, younger age, severe motor symptoms, and depression are predictors of stigma in PD.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Xue-ning Li, Da-peng Hao, Mei-jie Qu, Meng Zhang, An-bang Ma, Xu-dong Pan, Ai-jun Ma
Summary: By combining plasma FAM19A5 and MRI-based radiomics, the study successfully developed a predictive tool for PD and PDD, which showed excellent accuracy in clinical settings.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Francis P. Grenn, Anni Moore, Sara Bandres-Ciga, Lynne Krohn, Cornelis Blauwendraat
Summary: Genetic risk factors may be shared between different neurodegenerative diseases, with the ANG gene encoding angiogenin playing a neuroprotective role in both Parkinson's disease and amyotrophic lateral sclerosis. However, this study did not find a significant association between ANG variants and Parkinson's disease risk, contrary to previous findings.
NEUROBIOLOGY OF AGING
(2021)
Article
Clinical Neurology
Andrea Quattrone, Camilla Calomino, Alessia Sarica, Maria Eugenia Caligiuri, Maria Giovanna Bianco, Basilio Vescio, Pier Paolo Arcuri, Jolanda Buonocore, Marida De Maria, Maria Grazia Vaccaro, Aldo Quattrone
Summary: This study identified the bilateral inferior frontal gyrus (IFG) and superior temporal gyrus (STG) as regions associated with postural instability in Parkinson's disease (PD) patients. Voxel-based morphometry (VBM) analysis showed reduced grey matter volume in fronto-temporal areas in unsteady PD patients, and this reduction was selectively associated with the postural instability score.
JOURNAL OF NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ghasem Hajianfar, Samira Kalayinia, Mahdi Hosseinzadeh, Sara Samanian, Majid Maleki, Vesna Sossi, Arman Rahmim, Mohammad R. Salmanpour
Summary: The study aimed to predict genetic mutations in Parkinson's disease (PD) using hybrid machine learning systems (HMLS) with imaging and non-imaging data. The results demonstrated that combining medical information with SPECT-based imaging features, and optimal utilization of HMLS, can produce excellent prediction of the mutation status in PD patients.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2023)
Article
Neurosciences
Gong-Jun Ji, Tingting Liu, Ying Li, Pingping Liu, Jinmei Sun, Xingui Chen, Yanghua Tian, Xianwen Chen, Louisa Dahmani, Hesheng Liu, Kai Wang, Panpan Hu
Summary: Accelerated rTMS was found to significantly improve symptoms in patients with Parkinson's disease, with a swift and long-lasting treatment response. Imaging analyses revealed an increase in volume of the left globus pallidus (GP) after cTBS treatment, indicating a potential modulation of the motor circuitry involving the SMA-GP pathway for alleviating motor symptoms of PD.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Qian Zeng, Hongxu Pan, Yuwen Zhao, Yige Wang, Qian Xu, Jieqiong Tan, Xinxiang Yan, Jinchen Li, Beisha Tang, Jifeng Guo
Summary: Sex has been found to be an important factor in the development of Parkinson's disease (PD). In this study, researchers conducted whole-exome sequencing on PD patients in a Chinese population and found rare variants in the TAF1 gene that may be associated with PD. Further genetic and functional analyses are needed to confirm these findings.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Daniele Belvisi, Andrea Fabbrini, Maria Ilenia De Bartolo, Matteo Costanzo, Nicoletta Manzo, Giovanni Fabbrini, Giovanni Defazio, Antonella Conte, Alfredo Berardelli
Summary: The study aimed to identify the pathophysiological substrate of Parkinson's disease subtypes using neurophysiological techniques. Two clinical clusters were identified, with one having milder symptoms and the other having a combination of severe motor and nonmotor manifestations. Differences in motor system dysfunction were observed between the subtypes, while sensory function and sensorimotor integration mechanisms did not differ.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Konstantin Senkevich, Mariia Beletskaia, Aliza Dworkind, Eric Yu, Jamil Ahmad, Jennifer A. Ruskey, Farnaz Asayesh, Dan Spiegelman, Stanley Fahn, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupre, Lior Greenbaum, Sharon Hassin-Baer, Ilya Nagornov, Alexandr Tyurin, Irina Miliukhina, Alla Timofeeva, Anton Emelyanov, Jean-Francois Trempe, Ekaterina Zakharova, Roy N. Alcalay, Sofya Pchelina, Ziv Gan-Or
Summary: This study investigated the association between rare ARSA variants and Parkinson's disease (PD) in a large cohort. The results showed evidence of associations between functional and loss-of-function ARSA variants and PD. However, further replications in larger cohorts are needed to confirm these findings.
MOVEMENT DISORDERS
(2023)
Article
Geriatrics & Gerontology
Bernabe I. Bustos, Sara Bandres-Ciga, J. Raphael Gibbs, Dimitri Krainc, Niccolo E. Mencacci, Ziv Gan-Or, Steven J. Lubbe
Summary: In European descent case-control cohorts, there is a lack of evidence for the association of rare damaging nonsynonymous NUS1 variants with Parkinson's disease, indicating that the previously observed association may be driven by extremely rare population-specific variants.
NEUROBIOLOGY OF AGING
(2021)
Article
Computer Science, Artificial Intelligence
Karishma D'Sa, James R. Evans, Gurvir S. Virdi, Giulia Vecchi, Alexander Adam, Ottavia Bertolli, James Fleming, Hojong Chang, Craig Leighton, Mathew H. Horrocks, Dilan Athauda, Minee L. Choi, Sonia Gandhi
Summary: This study applies machine learning models to predict the presence and primary mechanistic subtypes of Parkinson's disease in human neurons. The accuracy of these models confirms their potential for mechanistic stratification and precision medicine in the future.
NATURE MACHINE INTELLIGENCE
(2023)
Article
Clinical Neurology
Konstantin Senkevich, Cornelia E. Zorca, Aliza Dworkind, Uladzislau Rudakou, Emma Somerville, Eric Yu, Alexey Ermolaev, Daria Nikanorova, Jamil Ahmad, Jennifer A. Ruskey, Farnaz Asayesh, Da Spiegelman, Stanley Fahn, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupre, Lior Greenbaum, Sharon Hassin-Baer, Francis P. Grenn, Ming Sum Ruby Chiang, S. Pablo Sardi, Benoit Vanderperre, Cornelis Blauwendraat, Jean-Francois Trempe, Edward A. Fon, Thomas M. Durcan, Roy N. Alcalay, Ziv Gan-Or
Summary: Senkevich et al. provide evidence that GALC is the gene associated with Parkinson's disease at the chromosome 14 locus and suggest that the association of variants at the GALC locus may be driven by their effect of increasing galactosylceramidase expression and activity. The study highlights the role of lysosome in Parkinson's disease pathogenesis.
Article
Mathematics
Hung Viet Nguyen, Haewon Byeon
Summary: This study used epidemiologic data of Parkinson's disease dementia patients to predict depression using a LIME-based stacking ensemble model. The best combination of the model is ET + LGBM + RF + LR, which can help medical professionals identify and treat patients earlier.
Article
Clinical Neurology
Lucia Ricciardi, Petra Fischer, Abteen Mostofi, Gerd Tinkhauser, Flavie Torrecillos, Fahd Baig, Mark J. Edwards, Erlick A. C. Pereira, Francesca Morgante, Peter Brown
Summary: The study found a link between trait impulsivity and alpha power in patients with Parkinson's disease (PD), regardless of the presence or severity of impulsive compulsive behavior disorders (ICB). Electrode contact pairs with the highest alpha power tended to be more ventral, while those with the highest beta power localized to the dorsolateral motor subthalamic nucleus (STN).
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Ruwei Ou, Qianqian Wei, Yanbing Hou, Lingyu Zhang, Kuncheng Liu, Xiangwei Kong, Shuying Li, Lan Wang, Xianran Xu, Xiaojing Gu, Junyu Lin, Zheng Jiang, Jiao Liu, Wei Song, Bei Cao, Huifang Shang
Summary: Patients with early-onset Parkinson's disease (EOPD) have a higher prevalence of suicidal ideation (SI) and depression, with risk factors including depression, non-smoking, and lower education level.
JOURNAL OF NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Lina Ma, Zhe Tang, Li Zhang, Fei Sun, Yun Li, Piu Chan
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2018)
Article
Medicine, Research & Experimental
Xingmei Wei, Yongxin Li, Qian-jie Fu, Yue Gong, Biao Chen, Jingyuan Chen, Ying Shi, Qiaotong Su, Danmo Cui, Ting Liu
Article
Neurosciences
Zhihui Li, Xingjun Chen, Tao Wang, Ying Gao, Fei Li, Long Chen, Jin Xue, Yan He, Yan Li, Wei Guo, Wu Zheng, Liping Zhang, Fenfen Ye, Xiangpeng Ren, Yue Feng, Piu Chan, Jiang-Fan Chen
BIOLOGICAL PSYCHIATRY
(2018)
Article
Clinical Neurology
Shu-yang Yu, Chen-jie Cao, Li-jun Zuo, Ze-jie Chen, Teng-hong Lian, Fang Wang, Yang Hu, Ying-shan Piao, Li-xia Li, Peng Guo, Li Liu, Qiu-jin Yu, Rui-dan Wang, Piu Chan, Sheng-di Chen, Xiao-min Wang, Wei Zhang
Article
Clinical Neurology
Liang Sun, Piu Chan
CLINICAL NEUROLOGY AND NEUROSURGERY
(2018)
Article
Clinical Neurology
Qian Jia, Linlin Gao, Jiarong Zhang, Tao Wu, Piu Chan
JOURNAL OF NEURORADIOLOGY
(2018)
Article
Biochemical Research Methods
Shengwei Xu, Yu Zhang, Song Zhang, Guihua Xiao, Mixia Wang, Yilin Song, Fei Gao, Ziyue Li, Ping Zhuang, Piu Chan, Guoxian Tao, Feng Yue, Xinxia Cai
JOURNAL OF NEUROSCIENCE METHODS
(2018)
Article
Geriatrics & Gerontology
L. Ma, J. Wang, Z. Tang, P. Chan
JOURNAL OF NUTRITION HEALTH & AGING
(2018)
Article
Acoustics
Ying Shi, Jingyuan Chen, Yue Gong, Biao Chen, Yongxin Li, John J. Galvin, Qian-Jie Fu
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2018)
Article
Clinical Neurology
Shu-Ying Liu, Daryl J. Wile, Jessie Fanglu Fu, Jason Valerio, Elham Shahinfard, Siobhan McCormick, Rostom Mabrouk, Nasim Vafai, Jess McKenzie, Nicole Neilson, Alexandra Perez-Soriano, Julieta E. Arena, Mariya Cherkasova, Piu Chan, Jing Zhang, Cyrus P. Zabetian, Jan O. Aasly, Zbigniew K. Wszolek, Martin J. McKeown, Michael J. Adam, Thomas J. Ruth, Michael Schulzer, Vesna Sossi, A. Jon Stoessl
Article
Clinical Neurology
Tuanzhi Chen, Yan Fan, Xianbo Zhuang, Depeng Feng, Yanxiu Chen, Piu Chan, Yifeng Du
NEUROLOGICAL RESEARCH
(2018)
Article
Neurosciences
Wei Mao, Chunsong Zhao, Hui Ding, Kuo Liang, Jinhua Xue, Piu Chan, Yanning Cai
NEUROSCIENCE LETTERS
(2018)
Article
Clinical Neurology
Ruihui Weng, Xiaobo Wei, Bin Yu, Shuzhen Zhu, Xiaohua Yang, Fen Xie, Mahui Zhang, Ying Jiang, Zhong-Ping Feng, Hong-Shuo Sun, Ying Xia, Kunlin Jin, Piu Chan, Qing Wang, Xiaoya Gao
PARKINSONISM & RELATED DISORDERS
(2018)
Article
Nanoscience & Nanotechnology
Song Zhang, Yilin Song, Mixia Wang, Guihua Xiao, Fei Gao, Ziyue Li, Guoxian Tao, Ping Zhuang, Feng Yue, Piu Chan, Xinxia Cai
MICROSYSTEMS & NANOENGINEERING
(2018)
Article
Cell Biology
Si Wang, Boqiang Hu, Zhichao Ding, Yujiao Dang, Jun Wu, Di Li, Xiaoling Liu, Bailong Xiao, Weiqi Zhang, Ruotong Ren, Jinghui Lei, Huifang Hu, Chang Chen, Piu Chan, Dong Li, Jing Qu, Fuchou Tang, Guang-Hui Liu
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)