Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei

PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress

(2014) Giuditta Illuzzi et al.   NUCLEIC ACIDS RESEARCH

Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities

(2013) Amos A Fatokun et al.   BRITISH JOURNAL OF PHARMACOLOGY

Poly(ADP-ribose): PARadigms and PARadoxes

(2013) Alexander Bürkle et al.   MOLECULAR ASPECTS OF MEDICINE

Poly(ADP-ribose) signaling in cell death

(2013) László Virág et al.   MOLECULAR ASPECTS OF MEDICINE

50Years of poly(ADP-ribosyl)ation

(2013) László Virág   MOLECULAR ASPECTS OF MEDICINE

Trypanosoma bruceiharbours a divergent XPB helicase paralogue that is specialized in nucleotide excision repair and conserved among kinetoplastid organisms

(2013) Nitika Badjatia et al.   MOLECULAR MICROBIOLOGY

Host Cell Poly(ADP-Ribose) Glycohydrolase Is Crucial for Trypanosoma cruzi Infection Cycle

(2013) Salomé C. Vilchez Larrea et al.   PLoS One

Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors

(2013) Teemu Haikarainen et al.   ACS Medicinal Chemistry Letters

Inhibition of poly(ADP-ribose) Polymerase Interferes with Trypanosoma cruzi Infection and Proliferation of the Parasite

(2012) Salomé C. Vilchez Larrea et al.   PLoS One

Presenting your structures: theCCP4mgmolecular-graphics software

(2011) S. McNicholas et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome

(2011) S. Alsford et al.   GENOME RESEARCH

Poly(ADP-ribose) polymerase plays a differential role in DNA damage-response and cell death pathways in Trypanosoma cruzi

(2010) Salomé C. Vilchez Larrea et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Structural Basis for the Interaction between Tankyrase-2 and a Potent Wnt-Signaling Inhibitor

(2010) Tobias Karlberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets

(2010) Raga Krishnakumar et al.   MOLECULAR CELL

ALINE: a WYSIWYG protein-sequence alignment editor for publication-quality alignments

(2009) Charles Simon Bond et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)

(2009) Julie Miyashiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dual role of poly(ADP-ribose) glycohydrolase in the regulation of cell death in oxidatively stressed A549 cells

(2009) Katalin Erdélyi et al.   FASEB JOURNAL

Radiation-induced mitotic catastrophe in PARG-deficient cells

(2009) J.-C. Ame et al.   JOURNAL OF CELL SCIENCE

Structural Basis for Inhibitor Specificity in Human Poly(ADP-ribose) Polymerase-3†

(2009) Lari Lehtiö et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

(2009) Gerardo Priotto et al.   LANCET

Novel alkoxybenzamide inhibitors of poly(ADP-ribose) polymerase

(2008) Keith A. Menear et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mismatch repair in Trypanosoma brucei: Heterologous expression of MSH2 from Trypanosoma cruzi provides new insights into the response to oxidative damage

(2008) Alice Machado-Silva et al.   GENE

Discovery of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the Treatment of Cancer

(2008) Thomas D. Penning et al.   JOURNAL OF MEDICINAL CHEMISTRY

TcPARP: A DNA damage-dependent poly(ADP-ribose) polymerase from Trypanosoma cruzi

(2007) Silvia H. Fernández Villamil et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY