Strategies for new and improved vaccines against ticks and tick-borne diseases

Cattle tick vaccine researchers join forces in CATVAC

(2016) Theo Schetters et al.   Parasites & Vectors

Anaplasma phagocytophilum Uses Common Strategies for Infection of Ticks and Vertebrate Hosts

(2016) José de la Fuente et al.   TRENDS IN MICROBIOLOGY

Sialomes and Mialomes: A Systems-Biology View of Tick Tissues and Tick–Host Interactions

(2016) Jindřich Chmelař et al.   TRENDS IN PARASITOLOGY

Tick iron and heme metabolism – New target for an anti-tick intervention

(2016) Ondrej Hajdusek et al.   Ticks and Tick-Borne Diseases

Genomic insights into the Ixodes scapularis tick vector of Lyme disease

(2016) Monika Gulia-Nuss et al.   Nature Communications

In Vitro Mode of Action and Anti-thrombotic Activity of Boophilin, a Multifunctional Kunitz Protease Inhibitor from the Midgut of a Tick Vector of Babesiosis, Rhipicephalus microplus

(2016) Teresa C. Assumpção et al.   PLoS Neglected Tropical Diseases

Acquisition of exogenous haem is essential for tick reproduction

(2016) Jan Perner et al.   eLife

Survival and innovation: The role of mutational robustness in evolution

(2015) Mario A. Fares   BIOCHIMIE

Integration of Ixodes ricinus genome sequencing with transcriptome and proteome annotation of the naïve midgut

(2015) Wibke J. Cramaro et al.   BMC GENOMICS

Variation among Bm86 sequences in Rhipicephalus (Boophilus) microplus ticks collected from cattle across Thailand

(2015) S. Kaewmongkol et al.   EXPERIMENTAL AND APPLIED ACAROLOGY

Tick vaccines: current status and future directions

(2015) José de la Fuente et al.   Expert Review of Vaccines

The mitochondrial genome of a Texas outbreak strain of the cattle tick, Rhipicephalus (Boophilus) microplus, derived from whole genome sequencing Pacific Biosciences and Illumina reads

(2015) John K. McCooke et al.   GENE

De novo sequencing, assembly and analysis of salivary gland transcriptome of Haemaphysalis flava and identification of sialoprotein genes

(2015) Xing-Li Xu et al.   INFECTION GENETICS AND EVOLUTION

Integrated Metabolomics, Transcriptomics and Proteomics Identifies Metabolic Pathways Affected byAnaplasma phagocytophilumInfection in Tick Cells

(2015) Margarita Villar et al.   MOLECULAR & CELLULAR PROTEOMICS

Differential sialotranscriptomes of unfed and fed Rhipicephalus haemaphysaloides, with particular regard to differentially expressed genes of cysteine proteases

(2015) Xinmao Yu et al.   Parasites & Vectors

Rhipicephalus microplus and Ixodes ovatus cystatins in tick blood digestion and evasion of host immune response

(2015) Luís Parizi et al.   Parasites & Vectors

Targeted silencing of the Aquaporin 2 gene of Rhipicephalus (Boophilus) microplus reduces tick fitness

(2015) Hala E. Hussein et al.   Parasites & Vectors

Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods

(2015) René Feyereisen et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Lessons learned in the analysis of high-dimensional data in vaccinomics

(2015) Ann L. Oberg et al.   VACCINE

Immunoprotective potential of a Rhipicephalus (Boophilus) microplus metalloprotease

(2015) Abid Ali et al.   VETERINARY PARASITOLOGY

Comparative microarray analyses of adult female midgut tissues from feeding Rhipicephalus species

(2015) Willem A. van Zyl et al.   Ticks and Tick-Borne Diseases

Transmembrane proteins – Mining the cattle tick transcriptome

(2015) Sabine A. Richards et al.   Ticks and Tick-Borne Diseases

Identification of 24h Ixodes scapularis immunogenic tick saliva proteins

(2015) Lauren A. Lewis et al.   Ticks and Tick-Borne Diseases

Development of vaccines against Ornithodoros soft ticks: An update

(2015) Verónica Díaz-Martín et al.   Ticks and Tick-Borne Diseases

Tissue- and time-dependent transcription in Ixodes ricinus salivary glands and midguts when blood feeding on the vertebrate host

(2015) Michalis Kotsyfakis et al.   Scientific Reports

Systems Biology of Tissue-Specific Response to Anaplasma phagocytophilum Reveals Differentiated Apoptosis in the Tick Vector Ixodes scapularis

(2015) Nieves Ayllón et al.   PLoS Genetics

A Library of Plasmodium vivax Recombinant Merozoite Proteins Reveals New Vaccine Candidates and Protein-Protein Interactions

(2015) Jessica B. Hostetler et al.   PLoS Neglected Tropical Diseases

Deep Sequencing Analysis of the Ixodes ricinus Haemocytome

(2015) Michalis Kotsyfakis et al.   PLoS Neglected Tropical Diseases

Computational approaches for prediction of pathogen-host protein-protein interactions

(2015) Esmaeil Nourani et al.   Frontiers in Microbiology

Vaccination against Bm86 Homologues in Rabbits Does Not Impair Ixodes ricinus Feeding or Oviposition

(2015) Jeroen Coumou et al.   PLoS One

Identification and Characterization of Anaplasma phagocytophilum Proteins Involved in Infection of the Tick Vector, Ixodes scapularis

(2015) Margarita Villar et al.   PLoS One

Nuclease Tudor-SN Is Involved in Tick dsRNA-Mediated RNA Interference and Feeding but Not in Defense against Flaviviral or Anaplasma phagocytophilum Rickettsial Infection

(2015) Nieves Ayllón et al.   PLoS One

Understanding the evolutionary structural variability and target specificity of tick salivary Kunitz peptides using next generation transcriptome data

(2014) Alexandra Schwarz et al.   BMC EVOLUTIONARY BIOLOGY

Protozoan HSP90-Heterocomplex: Molecular Interaction Network and Biological Significance

(2014) Maria J. Figueras et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

BB0238, a Presumed Tetratricopeptide Repeat-Containing Protein, Is Required during Borrelia burgdorferi Mammalian Infection

(2014) Ashley M. Groshong et al.   INFECTION AND IMMUNITY

Proteomics informed by transcriptomics identifies novel secreted proteins in Dermacentor andersoni saliva

(2014) Lwiindi Mudenda et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

From workstations to workbenches: Towards predicting physicochemically viable protein-protein interactions across a host and a pathogen

(2014) Gayatri Ramakrishnan et al.   IUBMB LIFE

Cutting Edge: Immunity against a "Silent" Salivary Antigen of the Lyme Vector Ixodes scapularis Impairs Its Ability to Feed

(2014) M. Kotsyfakis et al.   JOURNAL OF IMMUNOLOGY

BB0323 and Novel Virulence Determinant BB0238:Borrelia burgdorferiProteins That Interact With and Stabilize Each Other and Are Critical for Infectivity

(2014) Toru Kariu et al.   JOURNAL OF INFECTIOUS DISEASES

Phylogenetic analysis of mitochondrial genome sequences indicates that the cattle tick, Rhipicephalus (Boophilus) microplus, contains a cryptic species

(2014) Thomas D. Burger et al.   MOLECULAR PHYLOGENETICS AND EVOLUTION

The sialotranscriptome of Amblyomma triste, Amblyomma parvum and Amblyomma cajennense ticks, uncovered by 454-based RNA-seq

(2014) Gustavo Garcia et al.   Parasites & Vectors

Evaluation and comparison of the potential of two ferritins as anti-tick vaccines against Haemaphysalis longicornis

(2014) Remil Linggatong Galay et al.   Parasites & Vectors

Tick capillary feeding for the study of proteins involved in tick-pathogen interactions as potential antigens for the control of tick infestation and pathogen infection

(2014) Sandra Antunes et al.   Parasites & Vectors

Two Kinds of Ferritin Protect Ixodid Ticks from Iron Overload and Consequent Oxidative Stress

(2014) Remil Linggatong Galay et al.   PLoS One

Effects of environmental change on zoonotic disease risk: an ecological primer

(2014) Agustín Estrada-Peña et al.   TRENDS IN PARASITOLOGY

Rhipicephalus (Boophilus) microplus tick in vitro feeding methods for functional (dsRNA) and vaccine candidate (antibody) screening

(2014) Ala E. Lew-Tabor et al.   Ticks and Tick-Borne Diseases

Bexsero® chronicle

(2014) George Vernikos et al.   Pathogens and Global Health

Crossing the Interspecies Barrier: Opening the Door to Zoonotic Pathogens

(2014) Christian Gortazar et al.   PLoS Pathogens

Using biological networks to improve our understanding of infectious diseases

(2014) Nicola J. Mulder et al.   Computational and Structural Biotechnology Journal

Reverse vaccinology in the 21st century: improvements over the original design

(2013) Claudio Donati et al.   Annals of the New York Academy of Sciences

Why so many unknown genes? Partitioning orphans from a representative transcriptome of the lone star tick Amblyomma americanum

(2013) Amanda K Gibson et al.   BMC GENOMICS

Multiple ferritins are vital to successful blood feeding and reproduction of the hard tick Haemaphysalis longicornis

(2013) R. L. Galay et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

The lipoprotein La7 contributes to Borrelia burgdorferi persistence in ticks and their transmission to naïve hosts

(2013) Xiuli Yang et al.   MICROBES AND INFECTION

Reciprocal Regulation of NF-kB (Relish) and Subolesin in the Tick Vector, Ixodes scapularis

(2013) Victoria Naranjo et al.   PLoS One

Predicting and Analyzing Interactions between Mycobacterium tuberculosis and Its Human Host

(2013) Holifidy A. Rapanoel et al.   PLoS One

New insights into the machinery of blood digestion by ticks

(2013) Daniel Sojka et al.   TRENDS IN PARASITOLOGY

Vaccinomics, the new road to tick vaccines

(2013) José de la Fuente et al.   VACCINE

Vaccination with proteins involved in tick–pathogen interactions reduces vector infestations and pathogen infection

(2013) Octavio Merino et al.   VACCINE

Sequence characterization and immunogenicity of cystatins from the cattle tick Rhipicephalus (Boophilus) microplus

(2013) Luís F. Parizi et al.   Ticks and Tick-Borne Diseases

Tick vaccines and the control of tick-borne pathogens

(2013) Octavio Merino et al.   Frontiers in Cellular and Infection Microbiology

Systems biology of pathogen-host interaction: Networks of protein-protein interaction within pathogens and pathogen-human interactions in the post-genomic era

(2012) Saliha D. Durmuş Tekir et al.   Biotechnology Journal

Functional genomics studies of Rhipicephalus (Boophilus) annulatus ticks in response to infection with the cattle protozoan parasite, Babesia bigemina

(2012) Sandra Antunes et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Cattle tick vaccines: Many candidate antigens, but will a commercially viable product emerge?

(2012) Felix D. Guerrero et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Evolution of the tissue factor pathway inhibitor-like Kunitz domain-containing protein family in Rhipicephalus microplus

(2012) Elizabeth Louw et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Postgenomic Analyses Reveal Development of Infectious Anaplasma phagocytophilum during Transmission from Ticks to Mice

(2012) J. E. Mastronunzio et al.   JOURNAL OF BACTERIOLOGY

Efficacy of rBm86 against Rhipicephalus (Boophilus) microplus (IVRI-I line) and Hyalomma anatolicum anatolicum (IVRI-II line) infestations on bovine calves

(2012) Binod Kumar et al.   PARASITOLOGY RESEARCH

Gene duplication as a mechanism of genomic adaptation to a changing environment

(2012) F. A. Kondrashov   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Multi-antigenic vaccine against the cattle tick Rhipicephalus (Boophilus) microplus: A field evaluation

(2012) Luís F. Parizi et al.   VACCINE

A systematic, functional genomics, and reverse vaccinology approach to the identification of vaccine candidates in the cattle tick, Rhipicephalus microplus

(2012) Christine Maritz-Olivier et al.   Ticks and Tick-Borne Diseases

The role of cystatins in tick physiology and blood feeding

(2012) Alexandra Schwarz et al.   Ticks and Tick-Borne Diseases

Identification and partial characterization of a gut Rhipicephalus appendiculatus cystatin

(2012) Saiki Imamura et al.   Ticks and Tick-Borne Diseases

Infection Strategies of Bacterial and Viral Pathogens through Pathogen–Human Protein–Protein Interactions

(2012) Saliha Durmuş Tekir et al.   Frontiers in Microbiology

Defining the protein interaction network of human malaria parasite Plasmodium falciparum

(2011) Abhinay Ramaprasad et al.   GENOMICS

Gene expression evidence for off-target effects caused by RNA interference-mediated gene silencing of Ubiquitin-63E in the cattle tick Rhipicephalus microplus

(2011) A.E. Lew-Tabor et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

IrCL1 – The haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus

(2011) Zdenek Franta et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

CattleTickBase: An integrated Internet-based bioinformatics resource for Rhipicephalus (Boophilus) microplus

(2011) Matthew I. Bellgard et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Characterization of Multiprotein Complexes of theBorrelia burgdorferiOuter Membrane Vesicles

(2011) Xiuli Yang et al.   JOURNAL OF PROTEOME RESEARCH

Targeting the tick protective antigen subolesin reduces vector infestations and pathogen infection by Anaplasma marginale and Babesia bigemina

(2011) Octavio Merino et al.   VACCINE

Rhipicephalus (Boophilus) microplus embryo proteins as target for tick vaccine

(2011) Adriana Seixas et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Distinctive amino acid composition profiles in salivary proteins of the tick Ixodes scapularis

(2011) Austin L. Hughes et al.   Ticks and Tick-Borne Diseases

OspA-CD40 dyad: ligand-receptor interaction in the translocation of neuroinvasive Borrelia across the blood-brain barrier

(2011) Lucia Pulzova et al.   Scientific Reports

Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tickOrnithodoros moubata

(2010) Jiří Salát et al.   BIOCHEMICAL JOURNAL

Reverse genetics in eukaryotes

(2010) Serge Hardy et al.   BIOLOGY OF THE CELL

Differential expression of genes in salivary glands of male Rhipicephalus (Boophilus)microplus in response to infection with Anaplasma marginale

(2010) Zorica Zivkovic et al.   BMC GENOMICS

Reassociation kinetics-based approach for partial genome sequencing of the cattle tick, Rhipicephalus (Boophilus) microplus

(2010) Felix D Guerrero et al.   BMC GENOMICS

Two initial vaccinations with the Bm86-based Gavacplus vaccine against Rhipicephalus (Boophilus) microplus induce similar reproductive suppression to three initial vaccinations under production conditions

(2010) Milagros Vargas et al.   BMC Veterinary Research

Predicting Drugs and Proteins in Parasite Infections with Topological Indices of Complex Networks: Theoretical Backgrounds, Applications and Legal Issues

(2010) Humberto Gonzalez-Diaz et al.   CURRENT PHARMACEUTICAL DESIGN

Cross immunity with Haemaphysalis longicornis glutathione S-transferase reduces an experimental Rhipicephalus (Boophilus) microplus infestation

(2010) Luís Fernando Parizi et al.   EXPERIMENTAL PARASITOLOGY

Differential transcription of two highly divergent gut-expressed Bm86 antigen gene homologues in the tick Rhipicephalus appendiculatus (Acari: Ixodida)

(2010) L. Kamau et al.   INSECT MOLECULAR BIOLOGY

Bm86 midgut protein sequence variation in South Texas cattle fever ticks

(2010) Jeanne M Freeman et al.   Parasites & Vectors

Characterization of ferritin 2 for the control of tick infestations

(2010) Ondrej Hajdusek et al.   VACCINE

Microarray analysis of gene expression changes in feeding female and male lone star ticks,Amblyomma americanum(L)

(2009) Majd N. Aljamali et al.   ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY

Vaccination with recombinant Boophilus annulatus Bm86 ortholog protein, Ba86, protects cattle against B. annulatus and B. microplus infestations

(2009) Mario Canales et al.   BMC BIOTECHNOLOGY

Evidence of a tick RNAi pathway by comparative genomics and reverse genetics screen of targets with known loss-of-function phenotypes in Drosophila

(2009) Sebastian Kurscheid et al.   BMC MOLECULAR BIOLOGY

Hemoglobin Digestion in Blood-Feeding Ticks: Mapping a Multipeptidase Pathway by Functional Proteomics

(2009) Martin Horn et al.   CHEMISTRY & BIOLOGY

Effect of vaccination with a recombinant metalloprotease from Haemaphysalis longicornis

(2009) Saiki Imamura et al.   EXPERIMENTAL AND APPLIED ACAROLOGY

Role of an aquaporin in the sheep tick Ixodes ricinus: Assessment as a potential control target☆

(2009) Ewan M. Campbell et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Knockdown of proteins involved in iron metabolism limits tick reproduction and development

(2009) O. Hajdusek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cloning and characterization of Rhipicephalus appendiculatus voraxinα and its effect as anti-tick vaccine

(2009) Shinji Yamada et al.   VACCINE

Identification of a synthetic peptide inducing cross-reactive antibodies binding to Rhipicephalus (Boophilus) decoloratus, Rhipicephalus (Boophilus) microplus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus BM86 homologues

(2009) Nadja Kopp et al.   VACCINE

Suppressive subtractive hybridization analysis of Rhipicephalus (Boophilus) microplus larval and adult transcript expression during attachment and feeding

(2009) Ala E. Lew-Tabor et al.   VETERINARY PARASITOLOGY

Evidence of the role of tick subolesin in gene expression

(2008) José de la Fuente et al.   BMC GENOMICS

A family of putative metalloproteases in the salivary glands of the tick Ixodes ricinus

(2008) Yves Decrem et al.   FEBS Journal

Overview: Ticks as vectors of pathogens that cause disease in humans and animals

(2008) Jose de la Fuente   Frontiers in Bioscience-Landmark

Identification, functional characterization and expression patterns of a water-specific aquaporin in the brown dog tick, Rhipicephalus sanguineus

(2008) Andrew Ball et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Microarray analysis of acaricide-inducible gene expression in the southern cattle tick,Rhipicephalus (Boophilus) microplus

(2008) L. Saldivar et al.   INSECT MOLECULAR BIOLOGY

Invertebrate aquaporins: a review

(2008) Ewan M. Campbell et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

Global trends in emerging infectious diseases

(2008) Kate E. Jones et al.   NATURE

Isolation, Cloning and Structural Characterisation of Boophilin, a Multifunctional Kunitz-Type Proteinase Inhibitor from the Cattle Tick

(2008) Sandra Macedo-Ribeiro et al.   PLoS One

Vaccine potential of a tick vitellin-degrading enzyme (VTDCE)

(2008) Adriana Seixas et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

A Cysteine Protease Is Critical for Babesia spp. Transmission in Haemaphysalis Ticks

(2008) Naotoshi Tsuji et al.   PLoS Pathogens

Synthetic vaccine (SBm7462) against the cattle tick Rhipicephalus (Boophilus) microplus: Preservation of immunogenic determinants in different strains from South America

(2007) A.P. Peconick et al.   EXPERIMENTAL PARASITOLOGY

Comparative sialomics between hard and soft ticks: Implications for the evolution of blood-feeding behavior

(2007) Ben J. Mans et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

The impact of gene knock-down and vaccination against salivary metalloproteases on blood feeding and egg laying by Ixodes ricinus

(2007) Yves Decrem et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY