Review
Biochemistry & Molecular Biology
Durgaramani Sivadasan, Kalaivanan Ramakrishnan, Janani Mahendran, Hariprasad Ranganathan, Arjunan Karuppaiah, Habibur Rahman
Summary: Recent advancements in drug delivery technologies have led to the emergence of nanotechnology as a potential tool in cancer therapeutics. Solid lipid nanoparticles (SLNs) have shown great potential for drug delivery, clinical medicine, and overcoming challenges in cancer therapy. Further research is needed to better understand the biological responses of SLNs and develop therapeutics with reduced side effects. This review focuses on the development, mechanisms, and applications of SLNs in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Kyumin Mo, Ayoung Kim, Soohyun Choe, Miyoung Shin, Hyunho Yoon
Summary: Lipid nanoparticles (LNPs) composed of ionized lipids, helper lipids, and cholesterol have potential for gene therapies and vaccines by facilitating intracellular transport and avoiding endosomal compartments. Solid lipid nanoparticles (SLNs) derived from physiologically acceptable lipids provide high structural stability and biocompatibility, and have been used to enhance drug delivery for cancer treatments. SLNs have shown promising results in breast cancer treatment, improving the therapeutic efficacy of drugs.
Article
Instruments & Instrumentation
Manuela Carvalheiro, Jennifer Vieira, Catarina Faria-Silva, Joana Marto, Sandra Simoes
Summary: Cutaneous leishmaniasis (CL) is a chronic skin disease characterized by skin lesions that may cause permanent scars. This study optimized a deformable lipid vesicle (DLV) for the topical administration of Amphotericin B (AmB) and found it to be effective in reducing parasite viability in skin layers. DLV may represent a cost-effective and safe therapeutic option in CL treatment.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Instruments & Instrumentation
Fereshteh Abdi, Elham Arkan, Mojtaba Eidizadeh, Elahe Valipour, Tahereh Naseriyeh, Younes Hossainy Gamizgy, Kamran Mansouri
Summary: The encapsulation of bevacizumab in lipid-polymer nanoparticles enhances dermal absorption and significantly increases its suppressive effects on cell proliferation and angiogenesis. These findings suggest the potential therapeutic benefits of locally administering bevacizumab using lipid-polymer nanoparticles for angiogenesis-related disorders.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Maryam Akbari, Hossein Heli, Ahmad Oryan, Gholamreza Hatam
Summary: The study found that artemisinin-loaded solid lipid nanoparticles have higher therapeutic efficacy compared to free artemisinin, suggesting them as a new therapeutic strategy for leishmaniasis treatment.
PATHOGENS AND GLOBAL HEALTH
(2023)
Review
Biotechnology & Applied Microbiology
Prakash Kumar, Pawan Kumar, Nidhi Singh, Salil Khajuria, Rahul Patel, Vinod Kumar Rajana, Debabrata Mandal, Ravichandiran Velayutham
Summary: Visceral leishmaniasis is a deadly disease that affects hundreds of thousands of people each year. Current treatment options have limitations, such as drug resistance and toxicity, and are expensive. The development of nanofomulation-based AmB for improved delivery and various AmB nanoformulations have shown promise in overcoming these limitations.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Wenrui Wang, Mengyang Zhou, Yang Xu, Wei Peng, Shiwen Zhang, Rongjie Li, Han Zhang, Hui Zhang, Shumin Cheng, Youjing Wang, Xinyu Wei, Chengxu Yue, Qingling Yang, Changjie Chen
Summary: The study successfully formulated TPGS-Res-SLNs nanoparticles to improve therapeutic efficacy against breast cancer, showing significant anti-tumor activity and promotion of cell apoptosis. It also exhibited significant inhibition of cancer cell invasion and migration. In vivo experiments showed that TPGS-Res-SLNs had higher efficacy in promoting tumor cell apoptosis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Aleksandra Zielinska, Amanda Cano, Tatiana Andreani, Carlos Martins-Gomes, Amelia M. Silva, Marlena Szalata, Ryszard Slomski, Eliana B. Souto
Summary: Lipid nanoparticles are used for targeted drug delivery and lipophilic drug-enriched phospholipid micelles are proposed to overcome biological barriers. These micelles serve as pharmaceutical vehicles with high stability and biocompatibility. This review discusses the use of lipid-drug conjugates as biocompatible carriers for topical application and analyzes the feasibility of using lipids to deliver cannabidiol.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Nicholas Hill, Adam Irwin, Nicolette Graham, Clare Leung, Joshua R. Francis, Nerilee Wall, Clare Nourse
Summary: This article describes four cases of cutaneous leishmaniasis in children in Australia. Treatment of this condition is difficult due to lack of clear guidelines and limited access to traditional treatment methods used in endemic countries. Topical paromomycin or oral fluconazole have been found to be effective first-line treatments in outpatient settings, although the use of topical paromomycin is limited by its high cost for importation or local compounding.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Arman Mokaram Doust Delkhah, Ehsan Karimi, Shirin Farivar
Summary: The study investigated the proapoptotic and anti-metastatic properties of herniarin-loaded solid lipid nanoparticles on human gastric adenocarcinoma, colon adenocarcinoma, and pancreatic carcinoma cell lines, as well as normal human skin fibroblast cell line. The results showed that the nanoparticles had a potent therapeutic target against the pancreatic carcinoma cell line.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Pharmacology & Pharmacy
Gizem Ruya Topal, Maria Meszaros, Gergo Porkolab, Aniko Szecsko, Tamas Ferenc Polgar, Laszlo Siklos, Maria A. Deli, Szilvia Veszelka, Asuman Bozkir
Summary: Targeting ligands on the surface of nanoparticles can improve the delivery of drugs across the blood-brain barrier. In this study, solid lipid nanoparticles labeled with Rhodamine B and loaded with donepezil were targeted with apolipoprotein E to enhance uptake in brain cells. The potential of ApoE as a targeting ligand for CNS drug delivery was demonstrated through increased uptake and permeability across a BBB co-culture model.
Article
Multidisciplinary Sciences
Nowsheen Goonoo, Marie Andrea Laetitia Huet, Itisha Chummun, Nancy Karuri, Kingsley Badu, Fanny Gimie, Jonas Bergrath, Margit Schulze, Mareike Mueller, Archana Bhaw-Luximon
Summary: Nanomedicine strategies have been successfully applied in treating diseases like cancer and diabetes, and could address the unmet needs of diseases such as leishmaniasis. By analyzing current treatment options, nanomedicine strategies aim to achieve scarless wound healing, prevent secondary bacterial infection, and reduce drug toxicity.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Abdul Rahim Ferhan, Soohyun Park, Hyeonjin Park, Hyunhyuk Tae, Joshua A. Jackman, Nam-Joon Cho
Summary: This article focuses on the development of next-generation lipid-based nanoparticles from a nanoarchitectonics perspective, analyzing the design, nucleic acid encapsulation methods, scalable production, and application prospects. It also compares and contrasts different nanoarchitectures, such as traditional lipid nanoparticles, lipoplexes, and bicelles, and evaluates the current development status and possible future directions in overcoming clinical translation challenges and exploring new application opportunities.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Parasitology
Elizabeth M. Coser, Bianca A. Ferreira, Edite H. Yamashiro-Kanashiro, Jose Angelo L. Lindoso, Adriano C. Coelho
Summary: Treatment of tegumentary leishmaniasis in Brazil is currently limited to a few drugs, highlighting the need for expansion of therapeutic options. Paromomycin, an aminoglycoside antibiotic already approved for visceral leishmaniasis, shows promising activity against clinical isolates of tegumentary leishmaniasis in Brazil.
Review
Chemistry, Multidisciplinary
Rumiana Tenchov, Robert Bird, Allison E. Curtze, Qiongqiong Zhou
Summary: Lipid nanoparticles (LNPs) have become promising vehicles in the pharmaceutical industry for delivering various therapeutics, particularly highlighted in the COVID-19 mRNA vaccines. LNPs exhibit versatility and physical stability, allowing for targeted delivery of therapeutic drugs to specific locations within the body. Liposomes, an early version of LNPs, have already been widely applied in medical practice.
Article
Biochemistry & Molecular Biology
Negar Seyed, Sima Rafati
Summary: Leishmaniasis is a global health problem with Th1 response playing a crucial role in disease control. Vaccine formulations aimed at generating long-lived memory Th1 response have not been effective against sand fly transmitted infection except for leishmanization. Recent studies have shown that sand fly dependent factors may compromise pre-existing Th1 memory, while Th1 concomitant immunity has a prominent role in controlling secondary infections delivered by sand fly.
Article
Biochemistry & Molecular Biology
Neda Moazzezy, Elham Rismani, Maryam Rezaei, Mohammad Reza Asadi Karam, Sima Rafati, Saeid Bouzari, Mana Oloomi
Summary: The development of bacterial resistance to antibiotics has led to the attention of antimicrobial peptides (AMPs). This study computationally investigated the interaction between derived peptides and bacterial membrane and found that the derived peptides could exhibit similar antimicrobial effects to HNP-1. Furthermore, chemical modifications improved the physicochemical properties of the peptides and retained similar binding affinity.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Food Science & Technology
Ashraf Hajhosseini, Delaram Doroud, Anousheh Sharifan, Zohreh Eftekhari
Summary: This study investigated the properties of oil-in-water emulsions prepared from Kluyveromyces marxianus mannoprotein (KMM) and compared them with whey protein concentrate (WPC) emulsions. Results showed that KMM was more effective in stabilizing emulsions under various conditions, suggesting its potential as a bioemulsifier.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Obstetrics & Gynecology
Nastaran Vahabi Barzi, Zohre Eftekhari, Delaram Doroud, Akram Eidi
Summary: This study suggests that the continuous use of Chlorpyrifos has a negative impact on pregnancy and may increase the risk of developmental abnormalities in embryos through the mechanism of apoptosis.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Correction
Parasitology
Fatemeh Khadir, Tahereh Taheri, Sima Habibzadeh, Farnaz Zahedifard, Elham Gholami, Maryam Heidari-Kharaji, Ahmad Oryan, Sima Rafati
VETERINARY PARASITOLOGY
(2021)
Article
Parasitology
Atefeh Sadeghi Shermeh, Farnaz Zahedifard, Sima Habibzadeh, Tahereh Taheri, Sima Rafati, Negar Seyed
Summary: The study found that the DC prime-DNA boost vaccine can induce Th1 polarization immune response, but its effectiveness in fighting infection is limited.
EXPERIMENTAL PARASITOLOGY
(2021)
Article
Immunology
Saba Safdarpour, Zohre Eftekhari, Akram Eidi, Delaram Doroud
Summary: This study found that oral consumption of Glycyrrhiza glabra saponin and encapsulated saponin by ferritin nanoparticles has therapeutic effects on mice with pneumonia, reducing inflammation and promoting recovery.
MICROBIAL PATHOGENESIS
(2022)
Correction
Immunology
Mohammad Hassan Pouriayevali, Ali Teimoori, Saber Esmaeili, Asghar Abdoli, Delaram Doroud, Mostafa Salehi-Vaziri, Maryam Shahali, Maryam Kadkhodazadeh, Talieh Sabouni, Mohammad Ali Khosravi, Mohammad Panahi, Fereidoon Khoshroo, Anahita Bahmanjeh, Yury Valdes-Balbin, Dagmar Garcia-Rivera, Vicente Verez-Bencomo, Alireza Biglari, Kazem Baesi
Article
Virology
Rezvan Tavakoli, Pooneh Rahimi, Mojtaba Hamidi-Fard, Sana Eaybpoush, Delaram Doroud, Iraj Ahmadi, Enayat Anvari, Mohammadreza Aghasadeghi, Abolfazl Fateh
Summary: This study evaluated the correlation between the expression of TRIM28 and the severity of COVID-19 infection. The results showed that the downregulation of TRIM28 might be associated with the severity of COVID-19 infection.
Correction
Virology
Rezvan Tavakoli, Pooneh Rahimi, Mojtaba Hamidi-Fard, Sana Eybpoosh, Delaram Doroud, Iraj Ahmadi, Enayat Anvari, Mohammadreza Aghasadeghi, Abolfazl Fateh
Article
Medicine, Research & Experimental
Rezvan Tavakoli, Pooneh Rahimi, Mojtaba Hamidi-Fard, Sana Eybpoosh, Delaram Doroud, Seyed Amir Sadeghi, Mohammadali Zaheri Birgani, Mohammadreza Aghasadeghi, Abolfazl Fateh
Summary: This study analyzed the expression of TRIM5 a and TRIM22 in blood samples of 330 COVID-19 patients. The results showed that the expression of these genes was correlated with the severity of the disease. Lower expression levels of TRIM5 a and TRIM22 were found in severe cases, while higher expression of TRIM22 was observed in mild cases.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Virology
Rezvan Tavakoli, Pooneh Rahimi, Mojtaba Hamidi-Fard, Sana Eybpoosh, Delaram Doroud, Iraj Ahmadi, Enayat Anvari, Mohammadreza Aghasadeghi, Abolfazl Fateh
Summary: Tavakoli et al. discovered a potential association between the TRIM56 gene and severe COVID-19 infections. The study found lower levels of TRIM56 in COVID-19 patients, especially those who were severely ill, suggesting a possible role of TRIM56 in the severity of the disease.
Article
Multidisciplinary Sciences
Maryam Moazami Goodarzi, Reza Jalalirad, Delaram Doroud, Hamidreza Hozouri, Mohammadreza Aghasadeghi, Mahdi Paryan
Summary: In this study, the purification of VLP-based recombinant hepatitis B surface antigen (rHBsAg) was optimized by selecting buffering conditions. The new purification method showed improved protein purity and can be a substitute for the conventional method.
SCIENTIFIC REPORTS
(2023)
Review
Biochemical Research Methods
Yasaman Taslimi, Nasrin Masoudzadeh, Fariborz Bahrami, Sima Rafati
Summary: Cutaneous leishmaniasis (CL) is the most frequent form of leishmaniases, associated with skin inflammation and ulceration. Understanding the interaction of different phagocytic cells in the recognition and uptake of different Leishmania species is critical for controlling the infection.
EXPERT REVIEW OF PROTEOMICS
(2022)
Article
Materials Science, Biomaterials
Fatemeh Rezaei, Hamid Keshvari, Mohammad Ali Shokrgozar, Delaram Doroud, Elham Gholami, Alireza Khabiri, Mehdi Farokhi
Summary: This study utilized silk fibroin nanoparticles as a nano-adjuvant for the delivery of recombinant hepatitis B surface antigen. The physically loaded SFNPs showed higher immunogenicity against HBsAg, preserved native structures, and had better cellular uptake compared to chemically loaded SFNPs.
BIOMATERIALS SCIENCE
(2021)
