Article
Parasitology
Sara Benazzouz, Manel Amri, Junhua Wang, Samia Bouaziz, Fahima Ameur, Sara Djebbara, Karima Achour, Bruno Gottstein, Chafia Touil-Boukoffa
Summary: The laminated layer of Echinococcus granulosus (LL) significantly decreased nitric oxide (NO) production and interferon (IFN-?) mRNA levels in mouse spleen cells in response to lipopolysaccharide (LPS), while also down regulating interleukin 13 (IL-13) levels and upregulating transforming growth factor beta (TGF-β), Foxp3, and interleukin 10 (IL-10) expression. These findings suggest that LL may have potential immuno-regulatory and anti-inflammatory effects in controlling inflammation during inflammatory diseases.
Article
Parasitology
Chan Wang, Song-Hao Yang, Nan Niu, Jia Tao, Xian-Cai Du, Ji-Hui Yang, Ming-Xing Zhu, Ya-Na Wang, Wei Zhao
Summary: Immunization with rEg.P29 downregulated the expression of lncRNA028466, leading to an increased proportion of CD4(+) T cells and a modulation of Th1 and Th2 cytokine expression to mediate the immune response.
PARASITES & VECTORS
(2021)
Article
Immunology
Anabella A. Barrios, Camila Mouhape, Leonard Schreiber, Linyun Zhang, Juliane Nell, Mariana Suarez-Martins, Geraldine Schlapp, Maria Noel Meikle, Ana Paula Mulet, Tsui-Ling Hsu, Shie-Liang Hsieh, Gustavo Mourglia-Ettlin, Carlos Gonzalez, Martina Crispo, Thomas F. E. Barth, Cecilia Casaravilla, Stephen J. Jenkins, Alvaro Diaz
Summary: Cystic echinococcosis is a disease caused by larval stages of cestode parasites of the Echinococcus granulosus species cluster, with E. granulosus sensu stricto being the main infecting species. The parasites form bladder-like structures called hydatids in the internal organs of livestock ungulates and humans. The hydatids are protected by a large acellular laminated layer (LL) composed mainly of mucins. This study found that LL mucins injected into mice are taken up by liver macrophages called Kupffer cells, primarily through a receptor called Clec4F. These findings suggest that Kupffer cells play a role in clearing LL materials from the host.
INFECTION AND IMMUNITY
(2023)
Article
Parasitology
Jianling Bao, Wenjing Qi, Chang Sun, Mengxiao Tian, Hongjie Jiao, Gang Guo, Baoping Guo, Yuan Ren, Huajun Zheng, Yuezhu Wang, Mei Yan, Zhaoxia Zhang, Donald P. McManus, Jun Li, Wenbao Zhang
Summary: This study demonstrates that Echinococcus granulosus infection and antigen B (AgB) can alleviate symptoms and tissue damage in inflammatory bowel disease (IBD) induced by dextran sodium sulfate (DSS). This treatment may improve IBD conditions by inducing an increase in M2-predominant cells and a decrease in type 1 macrophages in the intestinal lamina propria. Additionally, AgB can alter the composition of the gut microbiota and reverse nitric oxide expression.
PARASITES & VECTORS
(2022)
Review
Biochemistry & Molecular Biology
Kevin Bode, Mathias Hauri-Hohl, Vincent Jaquet, Heiko Weyd
Summary: Reactive oxygen species (ROS) have diverse functions within cells and organisms, but their potential to damage biological structures has long been recognized. While phagocytes use ROS to defend against pathogens, regulated release of signaling ROS (sROS) modulates immune responses. This release is primarily attributed to the enzyme NOX2 expressed in myeloid cells. A comprehensive understanding of NOX2 activation and regulation is crucial for pharmaceutical interventions of ROS-related diseases. In this review, recent progress regarding immune regulation by NOX2-derived ROS and the consequences of its deregulation on immune disorders are summarized.
Article
Multidisciplinary Sciences
Lousineh Arakelian, Julien Lion, Guillaume Churlaud, Rezlene Bargui, Briac Thierry, Evelyne Mutabazi, Patrick Bruneval, Antonio Jose Alberdi, Christelle Doliger, Maeva Veyssiere, Jerome Larghero, Nuala Mooney
Summary: Endothelial cells play crucial roles in blood transport, vessel homeostasis, inflammatory responses, transendothelial migration, and blood vessel formation. CD34 is commonly used as an endothelial marker, but its expression and function vary in different organs and pathological conditions. This study investigates the expression and function of CD34 in endothelial cells, revealing that CD34(high) cells have lower proliferation but higher expression of IL-33 and Angiopoietin 2 compared to CD34(low) cells. CD34(high) endothelial cells also enhance the proliferation of regulatory T lymphocytes, suggesting their immunogenic ability and potential role in tolerogenic response.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Francois Anna, Elodie Bole-Richard, Joel LeMaoult, Marie Escande, Martin Lecomte, Jean-Made Certoux, Philippe Souque, Francine Garnache, Olivier Adotevi, Pierre Langlade-Demoyen, Maria Loustau, Julien Caumartin
Summary: CAR-T cell immunotherapy is a breakthrough in treating hematological malignancies, but the lack of tumor-specific antigens and immunosuppressive tumor microenvironments remain major hurdles. A new study shows that HLA-G, acting as both an immune checkpoint and a tumor-specific antigen, could be a promising target for CAR-T cell therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Monika Zaborek-Lyczba, Jakub Lyczba, Paulina Mertowska, Sebastian Mertowski, Anna Hymos, Martyna Podgajna, Paulina Niedzwiedzka-Rystwej, Ewelina Grywalska
Summary: HLA-G, a non-classical MHC class I molecule, has been studied for its relevance in pathological conditions like autoimmune diseases. Current research aims to utilize HLA-G in clinical practice for diagnostics and therapeutic purposes, as it is known for its immunomodulatory role in reducing inflammation and immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Huizhu Tan, Kuirong Mao, Xiuxiu Cong, Yanbao Xin, Feiqi Liu, Jialiang Wang, Xin Wang, Jing Han, Yuning Zhang, Yong-Guang Yang, Tianmeng Sun
Summary: Calcium is essential for the human body, playing a crucial role in intracellular signaling. Recent studies have shown that changes in intracellular calcium concentration can affect immune cell function. This study developed calcium carbonate nanoparticles to modulate calcium concentration and found that they could alter immune cell populations and activate specific immune cells. These nanoparticles also exhibited adjuvant properties without the need for antigenic stimulation. Overall, this research highlights the importance of modulating calcium concentration to regulate immune cell function.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Immunology
Zhicheng Jin, Xuefeng Sun, Yaoyao Wang, Chao Zhou, Haihua Yang, Suna Zhou
Summary: Immunotherapies have revolutionized the treatment of advanced and metastatic tumors, but the immunosuppressed tumor microenvironment (TME) hinders its effectiveness. This review discusses the role of autophagy in converting the immunosuppressive TME to enhance the efficacy and overcome resistance to immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Yasuyuki Matsumoto, Tongzhong Ju
Summary: Glycosylation is a pivotal post-translational modification that plays important roles in various biological processes. In cancers, altered glycosylation known as TACAs has been found to facilitate tumor formation, progression, and metastasis. Recent studies also reveal novel roles of TACAs in modulating the tumor microenvironment. TACAs can serve as potential tumor biomarkers, glycoimmune checkpoints, and therapeutics. This review summarizes the established and promising immunotherapy-targeting TACAs, including monoclonal antibody therapy, CART therapy, and vaccination.
Article
Multidisciplinary Sciences
Bing-Bing Shang, Jun Chen, Zhi-Guo Wang, Hui Liu
Summary: This study revealed the overexpression of HSPA4 in various cancers, its correlation with cancer stage and AFP level in HCC, and its association with poor prognosis. HSPA4 showed high accuracy in tumor diagnosis and has the potential to be a diagnostic and prognostic biomarker as well as a therapeutic target for HCC.
Review
Food Science & Technology
Hao Zou, Hao Wang, Ziye Zhang, Hong Lin, Zhenxing Li
Summary: Food allergies have become a major health concern in recent years due to changes in food resources and the environment. Dairy products fermented by lactic acid bacteria play a crucial role in alleviating allergic diseases. The proteolytic systems of different species of lactic acid bacteria, particularly the correlation between cell envelope proteases (CEPs) and epitopes from milk allergens, are summarized in this paper. Furthermore, the mechanism of immunomodulatory peptide release is also discussed.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Berna Tumoglu, Aidan Keelaghan, Fikri Y. Avci
Summary: Protein-carbohydrate interactions are crucial in maintaining immune homeostasis and regulating immune processes. This review focuses on the immune interactions of macrophage galactose-type lectin (MGL) and Tn carbohydrate antigen, highlighting their role in regulating effector T cells, immune suppression, and pathogen recognition.
Article
Chemistry, Medicinal
Ximena Volpini, Laura Fernanda Ambrosio, Maria Agustina Brajin, Maria Belen Brugo, Maria Pilar Aoki, Hector Walter Rivarola, Fernando Alfonso, Laura Fozzatti, Laura Cervi, Claudia Cristina Motran
Summary: Recent studies have shown the critical role of Wnt signaling pathways in the pathogenesis of Chagas cardiomyopathy. Inhibition of Wnt signaling during T. cruzi infection can control parasite replication, inhibit immune response development, and prevent cardiac abnormalities.
ACS INFECTIOUS DISEASES
(2021)
Article
Immunology
Alvaro Pittini, Cecilia Casaravilla, Judith E. Allen, Alvaro Diaz
INTERNATIONAL IMMUNOPHARMACOLOGY
(2016)
Article
Parasitology
Lucia del Puerto, Romina Rovetta, Marco Navatta, Carolina Fontana, Gerardo Lin, Guillermo Moyna, Sylvia Dematteis, Klaus Brehm, Uriel Koziol, Fernando Ferreira, Alvaro Diaz
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2016)
Article
Parasitology
Martin Cancela, Ileana Corvo, Edileuza da Silva, Aline Teichmann, Leda Roche, Alvaro Diaz, Jose Fransisco Tort, Henrique B. Ferreira, Arnaldo Zaha
Review
Immunology
A. Diaz, C. Sagasti, C. Casaravilla
PARASITE IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Paula I. Seoane, Dominik Ruckerl, Cecilia Casaravilla, Anabella A. Barrios, Alvaro Pittini, Andrew S. MacDonald, Judith E. Allen, Alvaro Diaz
SCIENTIFIC REPORTS
(2016)
Article
Immunology
Anabella A. Barrios, Leticia Grezzi, Sebastian Miles, Mara Mariconti, Gustavo Mourglia-Ettlin, Paula I. Seoane, Alvaro Diaz
Article
Immunology
Alvaro Pittini, Yamila E. Martinez-Acosta, Cecilia Casaravilla, Paula Seoane, Dominik Ruckerl, Celia Quijano, Judith E. Allen, Alvaro Diaz
INFECTION AND IMMUNITY
(2019)
Article
Immunology
Cecilia Casaravilla, Alvaro Pittini, Dominik Ruckerl, Judith E. Allen, Alvaro Diaz
INFECTION AND IMMUNITY
(2020)
Article
Infectious Diseases
Federica Fratini, F. Tamarozzi, G. Macchia, L. Bertuccini, M. Mariconti, C. Birago, A. Iriate, E. Brunetti, C. M. Cretu, O. Akhan, M. Siles-Lucas, A. Diaz, Adriano Casulli
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Biochemistry & Molecular Biology
Camila Sagasti, Cecilia Casaravilla, Cecilia Fernandez, Martin Flo, Alvaro Diaz
Summary: The genus Echinococcus includes important pathogens for humans and livestock, with expansion of monodomain Kunitz proteins observed in transcriptomic and genomic studies. Some family members have evolved from protease inhibition to cation channel blockade functions. Kunitz-type inhibitors from E. granulosus can influence macrophage physiology, potentially serving as immunotherapeutic agents.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
(2021)
Biographical-Item
Virology
Alvaro Diaz
Review
Immunology
Alvaro Diaz, Ignacio Gonzalez-Alayon, Valentina Perez-Torrado, Mariana Suarez-Martins
Summary: The interaction between CD40 and CD154 plays a central role in immunology, involving processes such as DC priming of CD4(+) T cells, CD4(+) T cell help to B cells, and classical macrophage activation. While the role of CD40 and CD154 in Th2 immune responses is still not fully understood, they are crucial for inducing most Th2 responses despite not causing significant up-regulation of CD40 in DC in Th2 systems. Exogenous CD40 ligation can shift Th2-biased systems towards Th1 by enhancing IL-12 production, indicating the importance of these interactions in immune polarization.
SEMINARS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Ana Silva, Diego Simon, Bruno Pannunzio, Cecilia Casaravilla, Alvaro Diaz, Bettina Tassino
Review
Medicine, General & Internal
Alvaro Diaz
BRITISH MEDICAL BULLETIN
(2017)