Article
Surgery
Naziheh Assarzadegan, Elizabeth Thompson, Kevan Salimian, Matthias M. Gaida, Lodewijk A. A. Brosens, Laura Wood, Syed Z. Ali, Ralph H. Hruban
Summary: Informed clinical decisions in the treatment of Intraductal Papillary Mucinous Neoplasms (IPMNs) are based on a deep understanding of the pathology of these lesions, with a focus on balancing the risk of over treatment with the patient's best interests.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Article
Gastroenterology & Hepatology
Hiroyuki Kato, Keisuke Tateishi, Hiroaki Fujiwara, Takuma Nakatsuka, Keisuke Yamamoto, Yotaro Kudo, Yoku Hayakawa, Hayato Nakagawa, Yasuo Tanaka, Hideaki Ijichi, Motoyuki Otsuka, Dosuke Iwadate, Hiroki Oyama, Sachiko Kanai, Kensaku Noguchi, Tatsunori Suzuki, Tatsuya Sato, Ryunosuke Hakuta, Kazunaga Ishigaki, Kei Saito, Tomotaka Saito, Naminatsu Takahara, Takahiro Kishikawa, Tsuyoshi Hamada, Ryota Takahashi, Koji Miyabayashi, Suguru Mizuno, Hirofumi Kogure, Yousuke Nakai, Yoshihiro Hirata, Atsushi Toyoda, Kazuki Ichikawa, Wei Qu, Shinichi Morishita, Junichi Arita, Mariko Tanaka, Tetsuo Ushiku, Kiyoshi Hasegawa, Mitsuhiro Fujishiro, Kazuhiko Koike
Summary: Our study identified the MNX1-HNF1B axis to be biologically significant in IPMN lineages, and this axis is crucial for the regulation of genes such as MYC, SOX9, and OLFM4.
Article
Surgery
Neda Amini, Joseph R. Habib, Alex Blair, Neda Rezaee, Benedict Kinny-Koster, John L. Cameron, Ralph H. Hruban, Matthew J. Weiss, Elliot K. Fishman, Kelly J. Lafaro, Atif Zaheer, Lindsey Manos, William R. Burns, Richard Burkhart, Jin He, Jun Yu, Christopher L. Wolfgang
Summary: There is a risk of progression in the remnant pancreas after resection of noninvasive IPMNs, including both invasive and noninvasive progression. Multifocality and high-grade dysplasia are associated with invasive progression. Patients with high-risk features should be monitored more closely.
Review
Oncology
Beata Jablonska, Pawel Szmigiel, Slawomir Mrowiec
Summary: Intraductal papillary mucinous neoplasms (IPMNs) are a type of pancreatic tumor, accounting for a small percentage of pancreatic neoplasms. They are categorized into different types with varying management strategies based on tumor characteristics and patient factors. There are several guidelines available for diagnosing and managing IPMNs.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Review
Gastroenterology & Hepatology
Thomas R. McCarty, Swathi Paleti, Tarun Rustagi
Summary: The molecular analysis of KRAS and GNAS mutations in EUS-acquired pancreatic cyst fluid shows high sensitivity and specificity, significantly improving diagnostic accuracy for IPMNs and MCLs compared to using CEA alone.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Oncology
Katherine E. Poruk, Armin Shahrokni, Murray F. Brennan
Summary: This study retrospectively analyzed patient outcomes after IPMN resection in older individuals. The results showed that pancreatic resection can be safely performed in selected patients aged 65 and older, with low morbidity and mortality. Further research is needed to determine if the MSKFI score can predict complications in older individuals.
Review
Biology
Masataka Taniuchi, Tetsuya Terada, Ryo Kawata
Summary: Fine-needle aspiration cytology is widely used for preoperative evaluation of parotid tumors, with core needle biopsy and liquid-based cytology improving reliability of immunostaining and molecular testing.
Article
Surgery
Ayako Tsumura, Seiko Hirono, Manabu Kawai, Ken-ichi Okada, Motoki Miyazawa, Yuji Kitahata, Ryohei Kobayashi, Shinya Hayami, Masaki Ueno, Akio Yanagisawa, Hiroki Yamaue
Summary: This retrospective study evaluated predictors of high-grade dysplasia or invasive intraductal papillary mucinous carcinoma in cases of intraductal papillary mucinous neoplasm without mural nodule >= 5 mm. The results suggested that large cysts, positive cytology of pancreatic juice, and high levels of carcinoembryonic antigen may be useful in determining the need for surgery for these cases. More studies are necessary to confirm these findings.
Article
Gastroenterology & Hepatology
Hiroyuki Uehara, Yutaro Abe, Yugo Kai, Ryoji Takada, Takuo Yamai, Tasuku Nakabori, Kenji Ikezawa, Hidenori Takahashi, Kazuyoshi Ohkawa
Summary: Mural nodules of 10 mm or more and positive cytology were independent predictors of malignancy in MD-IPMN.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Computer Science, Artificial Intelligence
Nguyen Thanh Duc, Yong-Moon Lee, Jae Hyun Park, Boreom Lee
Summary: The study utilized artificial intelligence for automated classification of Papillary Thyroid Carcinoma cell clusters, achieving high accuracy and reliability through segmentation of cytological images and deep learning model pre-training and fine-tuning.
EXPERT SYSTEMS WITH APPLICATIONS
(2022)
Article
Oncology
Xiangyi He, Rong Fan, Jing Sun, Yanhao Ren, Xuesong Zhao, Weiwei Rui, Yaozong Yuan, Duowu Zou
Summary: This study developed a predictive model to assess the degree of malignancy in early stage IPMN. The model achieved an accuracy of 99.5% on the training set and 96.0% on the testing set. The top five factors influencing the 3-class classification were mural nodule size, main pancreatic duct diameter, CA19-9 levels, lesion edge, and common bile duct dilation.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Joo Hyung Lee, Hyung Sun Kim, Ji Hyun Park, Joon Seong Park
Summary: This case report presents a rare occurrence of a patient diagnosed with IPNB concurrent with invasive adenocarcinoma post surgery, and subsequently diagnosed with cardiac metastasis 6 months later. The findings suggest the importance of close observation in IPNB patients due to the potential for metastasis.
Article
Multidisciplinary Sciences
Yukiyasu Okamura, Teiichi Sugiura, Takaaki Ito, Yusuke Yamamoto, Ryo Ashida, Katsuhisa Ohgi, Keiko Sasaki, Hiroto Narimatsu, Katsuhiko Uesaka
Summary: This study investigated the role of PNI and CA 19-9 levels as independent predictors of lymph node metastasis in patients with malignant IPMN. A scoring system based on these factors was developed to predict disease outcome.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Devarshi R. Ardeshna, Shiva Rangwani, Troy Cao, Timothy M. Pawlik, Peter P. Stanich, Somashekar G. Krishna
Summary: Hereditary pancreatic cancer accounts for about 10% of pancreatic cancer diagnoses. Early detection of pre-cancerous pancreatic cysts, such as intraductal papillary mucinous cystic neoplasms (IPMNs), has become an important focus to reduce pancreatic cancer incidence and mortality. This review explores the prevalence of IPMNs in patients with hereditary pancreatic cancer and their relatives, and discusses the need for surveillance changes in high-risk individuals.
Article
Gastroenterology & Hepatology
Silvia Carrara, Daoud Rahal, Kareem Khalaf, Tommy Rizkala, Glenn Koleth, Cristiana Bonifacio, Marta Andreozzi, Benedetto Mangiavillano, Francesco Auriemma, Paola Bossi, Monica Balzarotti, Antonio Facciorusso, Teresa Staiano, Elena Maldi, Marco Spadaccini, Matteo Colombo, Alessandro Fugazza, Roberta Maselli, Cesare Hassan, Alessandro Repici
Summary: This study aimed to evaluate the diagnostic accuracy and adverse event rate of EUS-guided fine-needle biopsy sampling (EUS-FNB) in diagnosing lymphadenopathies (LAs). The results showed that EUS-FNB with new end-cutting needles is a valuable and safe method for diagnosing LAs.
GASTROINTESTINAL ENDOSCOPY
(2023)
