Article
Oncology
Najib Ben Khaled, Katharina Hammer, Liangtao Ye, Ahmed Alnatsha, Sebastian A. Widholz, Ignazio Piseddu, Simon Sirtl, Julia Schneider, Stefan Munker, Ujjwal Mukund Mahajan, Juan Jose Montero, Joscha Griger, Julia Mayerle, Florian P. Reiter, Enrico N. De Toni
Summary: Research has identified frequent changes in BRCA genes in pancreatic cancer patients, especially in BRCA2. Pancreatic cancers with alterations in BRCA genes are sensitive to treatment with PARP inhibitors. This study shows that the combination of olaparib and TRAIL can be more effective than olaparib alone in killing pancreatic cancer cells. Furthermore, the combination of olaparib and TRAIL also kills cancer cells without BRCA2 mutations. These findings suggest a potential new combination therapy for pancreatic cancer independent of BRCA2 mutations.
Article
Biochemistry & Molecular Biology
Momoko Gyoten, Yi Luo, Rina Fujiwara-Tani, Shiori Mori, Ruiko Ogata, Shingo Kishi, Hiroki Kuniyasu
Summary: Resistance to anticancer drugs in pancreatic ductal carcinoma (PDAC) is a significant issue. This study found that statins enhance the sensitivity of PDAC cells to gemcitabine by reducing cholesterol rafts, which play a role in drug resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Health Care Sciences & Services
Darren Cowzer, Mohammed Zameer, Michael Conroy, Walter Kolch, Austin G. Duffy
Summary: This article reviews therapeutic innovations targeting RAS signaling in pancreatic cancer from a clinical perspective. Despite the strong resistance of pancreatic cancer to treatment, new approaches such as inhibiting mutated KRAS, KRAS activators, and effectors show promise in breaking this therapeutic deadlock.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
Emily Truong, Stephen Pandol, Christie Jeon
Summary: This review examines the role of pancreatic steatosis in the development of pancreatic cancer through epidemiological studies and experimental animal models. It highlights the prevalence of pancreatic steatosis and its association with pancreatic cancer. The review also explores the cellular mechanisms underlying pancreatic steatosis and its impact on the tumor microenvironment, as well as the effects of bariatric surgery. Additionally, it identifies gaps in current knowledge and proposes future research directions for understanding the mechanisms of other obesity-associated cancers.
Article
Cell Biology
Emir Bozkurt, Heiko Dussmann, Manuela Salvucci, Brenton L. Cavanagh, Sandra Van Schaeybroeck, Daniel B. Longley, Seamus J. Martin, Jochen H. M. Prehn
Summary: The study reveals that TRAIL signaling not only activates apoptosis in colon cancer cells but also induces entosis through TRAIL receptors and the structural presence of caspase-8. The association of TRAIL signaling with cell-in-cell structures is significant in colorectal cancer, especially in the context of patient prognosis. Factors controlling entosis in tumors remain to be elucidated despite the evidence of entosis in cancers.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Abhishek Kumar Das, Uday Hossain, Sumit Ghosh, Sima Biswas, Mullicka Mandal, Bhagirath Mandal, Goutam Brahmachari, Angshuman Bagchi, Parames C. Sil
Summary: This study provides a detailed molecular pathway of lupeol against streptozotocin induced pancreatic damage. The findings suggest that lupeol can regulate hyperglycemic and oxidative stress markers, as well as reverse the expression levels of inflammatory and apoptotic pathway-related molecules.
Article
Medicine, General & Internal
Tawfik Khoury, Wisam Sbeit
Summary: This study found a significant association between fatty pancreas and pancreatic cancer. Fatty pancreas may be an important risk factor for pancreatic cancer. A follow-up plan should be considered for individuals with fatty pancreas.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Anderson Luiz-Ferreira, Teresa Pacifico, Alefe Cardoso Cruz, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: TRAIL is a promising anticancer agent that selectively induces apoptosis in transformed cells, while flavonoids, natural compounds found in plants, have shown competence in enhancing TRAIL-induced apoptosis. However, bioavailability issues are the main limitations for the clinical use of flavonoids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Giulia Di Benedetto, Chiara Burgaletto, Maria Francesca Serapide, Rosario Caltabiano, Antonio Munafo, Carlo Maria Bellanca, Rosaria Di Mauro, Renato Bernardini, Giuseppina Cantarella
Summary: This study demonstrates the significant role of TRAIL-R2 in Aβ-related neurodegeneration and provides further evidence that the TRAIL system is a potential target for innovative AD therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Lokender Kumar, Sanjay Kumar, Kumar Sandeep, Sanjay Kumar Singh Patel
Summary: Cancer poses a significant challenge for effective treatment due to its complex mechanism, different stages of progression, and lack of screening and identification procedures. Pancreatic cancer, with a low survival rate of around 5 years, is ranked seventh globally among mortality-associated cancers. Therefore, it is crucial to develop diagnostic procedures for early detection, understand pancreatic cancer mechanisms, and explore therapeutic strategies. This review highlights recent developments in pancreatic cancer progression, mechanisms, and therapeutic approaches, including molecular techniques and biomedicines for effective cancer treatment.
Article
Biochemistry & Molecular Biology
Jorge Yassen Diaz-Blancas, Ismael Dominguez-Rosado, Carlos Chan-Nunez, Jorge Melendez-Zajgla, Vilma Maldonado
Summary: This study analyzed the effects of platelets on pancreatic cancer cells and found that platelets can increase the proliferation and migration capacity of cancer cells, enhance clonogenicity, and induce higher expression of stem cell markers. Differential expression of microRNAs in platelets from pancreatic cancer patients and healthy subjects was also discovered, with clear differences between the two groups. Furthermore, differences between blood-derived and pancreatic juice-derived platelets in the cancer patients suggest the presence of distinct platelet subpopulations, warranting further analysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
You-Take Oh, Shi-Yong Sun
Summary: The involvement of the TRAIL/death receptor signaling pathway in the regulation of cancer invasion and metastasis is complex, with both positive and negative roles reported. The underlying molecular mechanisms are even more complicated. This review focuses on discussing the current understanding of how TRAIL/death receptor-mediated signaling regulates cancer cell invasion and metastasis.
Article
Gastroenterology & Hepatology
Junjie Huang, Veeleah Lok, Chun Ho Ngai, Lin Zhang, Jinqiu Yuan, Xiang Qian Lao, Kelvin Ng, Charing Chong, Zhi-Jie Zheng, Martin C. S. Wong
Summary: Through data analysis of 48 countries, increasing trends in pancreatic cancer incidence and mortality were observed, especially among women and populations over the age of 50, as well as among younger individuals. More preventive efforts are recommended for these populations.
Article
Surgery
Bradley N. Reames, Alex B. Blair, Robert W. Krell, Vincent P. Groot, Georgios Gemenetzis, James C. Padussis, Sarah P. Thayer, Massimo Falconi, Christopher L. Wolfgang, Matthew J. Weiss, Chandrakanth Are, Jin He
Summary: There is substantial variation in management preferences, perceived contraindications to surgery, and the propensity to consider exploration in LAPC among an international cohort of pancreas surgeons. These results emphasize the importance of a robust and nuanced multidisciplinary discussion for each patient, and suggest an evolving concept of resectability.
Article
Cell Biology
Oliver H. Voss, Daniel Arango, Justin C. Tossey, Miguel A. Villalona Calero, Andrea Doseff
Summary: Apigenin sensitizes primary lung cancer cells to TRAIL-induced apoptosis through reprogramming alternative splicing of key TRAIL/DISC components and directly binding heat shock protein 70 to promote cell death. These findings emphasize the synergies between diet and cancer treatments, providing new avenues for improved cancer therapies.
CELL DEATH & DISEASE
(2021)
Article
Anesthesiology
E. Li
Summary: Surgical patients with peri-operative or recent SARS-CoV-2 infection are at increased risk of postoperative venous thromboembolism compared to those without a history of SARS-CoV-2. However, the optimal prophylaxis and treatment for venous thromboembolism in this patient population remains unknown. Venous thromboembolism is independently associated with 30-day mortality.
Article
Surgery
Georgios Antonios Margonis, Alessandra Pulvirenti, Vicente Morales-Oyarvide, Stefan Buettner, Nikolaos Andreatos, Carsten Kamphues, Katharina Beyer, Jane Wang, Martin E. Kreis, John L. Cameron, Matthew J. Weiss, Kevin Soares, Carlos Fernandez-del Castillo, Peter J. Allen, Christopher L. Wolfgang
Summary: This study validated the applicability of the 7th and 8th editions of the AJCC staging system for IPMN-associated PDAC. The 8th edition introduced T1a sub-staging and a new distinction between N1 and N2, both of which showed mixed results. The findings support the use of the AJCC 8th edition in the IPMN-associated PDAC population, but suggest that certain cutoffs may need to be revisited.
Article
Surgery
Georgios A. Margonis, Thomas Boerner, Jean-Baptiste Bachet, Stefan Buettner, Roberto Moretto, Nikolaos Andreatos, Andrea Sartore-Bianchi, Jane Wang, Carsten Kamphues, Johan Gagniere, Sara Lonardi, Inger M. Loes, Doris Wagner, Andrea Spallanzani, Kazunari Sasaki, Richard Burkhart, Filippo Pietrantonio, Emmanouil Pikoulis, Timothy M. Pawlik, Stephanie Truant, Armando Orlandi, Anastasia Pikouli, Nicoletta Pella, Katharina Beyer, George Poultsides, Hendrik Seeliger, Federico N. Aucejo, Peter Kornprat, Klaus Kaczirek, Per E. Lonning, Martin E. Kreis, Christopher L. Wolfgang, Matthew J. Weiss, Chiara Cremolini, Stephane Benoist, Michael D'Angelica
Summary: This study investigated the clinical implications of BRAF-mutated colorectal liver metastases. The results showed that BRAF V600E mutation was associated with shorter overall survival but not recurrence-free survival. Patients with MSS tumors had shorter recurrence-free survival compared with those with MSI-high tumors. Resection of converted disease resulted in encouraging survival. Second hepatectomy improved outcomes for patients with recurrence.
Article
Gastroenterology & Hepatology
Juliane Glaubitz, Anika Wilden, Fabian Frost, Sabine Ameling, Georg Homuth, Hala Mazloum, Malte Christoph Ruehlemann, Corinna Bang, Ali A. Aghdassi, Christoph Budde, Tilmann Pickartz, Andre Franke, Barbara M. Broeker, Uwe Voelker, Julia Mayerle, Markus M. Lerch, Frank-Ulrich Weiss, Matthias Sendler
Summary: Understanding the role of T-reg/Th17 balance in maintaining intestinal barrier function is important for reducing the risk of severe disease and late death in acute pancreatitis (AP). Depletion of T-reg cells enhances the proinflammatory response and reduces bacterial translocation to the pancreas in a mouse model of AP. Targeting T-regs may help improve the course of the disease.
Article
Biochemistry & Molecular Biology
Florian N. N. Loch, Carsten Kamphues, Katharina Beyer, Christian Schineis, Wael Rayya, Johannes C. C. Lauscher, David Horst, Mihnea P. P. Dragomir, Simon Schallenberg
Summary: Immune checkpoint therapy has shown promise in treating solid tumors, but its role in pancreatic ductal adenocarcinoma is limited. This study aimed to create a profile of immune checkpoint expression and its prognostic relevance in PDAC. The presence of VISTA and PD-L1 significantly correlated with shorter overall survival, suggesting they may be potential targets for ICT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Ioannis Pozios, Nina A. Hering, Emily Guenzler, Marco Arndt, Sefer Elezkurtaj, Thomas Knosel, Christiane J. Bruns, Georgios A. Margonis, Katharina Beyer, Hendrik Seeliger
Summary: The study found that gp130 is expressed in the epithelium of most human PDAC, but is rarely expressed in the stroma. The small molecule gp130 inhibitor SC144 potently inhibits PDAC progression in vitro and may block IL-6 or OSM/gp130/STAT3 signaling. These results suggest gp130 as a potential new drug target for pancreatic cancer therapy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Jasper Max Gebhardt, Neno Werner, Andrea Stroux, Frank Foerster, Ioannis Pozios, Claudia Seifarth, Christian Schineis, Carsten Kamphues, Benjamin Weixler, Katharina Beyer, Johannes Christian Lauscher
Summary: This study compared the outcomes and costs of robotic-assisted and laparoscopic proctectomy with IPAA for UC patients. The results showed no significant differences in postoperative complications between the two surgical methods, but robotic-assisted surgery had a longer operative time and higher costs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Nina A. Hering, Emily Guenzler, Marco Arndt, Miriam Zibell, Johannes C. Lauscher, Martin E. Kreis, Katharina Beyer, Hendrik Seeliger, Ioannis Pozios
Summary: Pancreatic cancer is a leading cause of cancer-related death, and new therapeutic approaches are urgently needed. This study investigates the combined effect of paclitaxel with the inhibitors SC144 and raloxifene in targeting the interleukin-6/gp130 signaling pathway. The results show that both combinations enhance the effectiveness of paclitaxel in inhibiting tumor growth, suggesting the potential to improve treatment outcomes in pancreatic cancer.
Article
Medicine, General & Internal
Johannes Lauscher, Katharina Beyer, Achim Hellinger, Roland S. Croner, Karsten Ridwelski, Christian Krautz, Christine Lim, Paul M. Coplan, Marc Kurepkat, Goran Ribaric
Summary: The study aims to evaluate the impact of a digital operative workflow on complications and mortality in patients undergoing left-sided colorectal resection with primary stapled colorectal anastomosis. The study will be conducted at five certified academic colorectal centers in Germany, with a sample size of 528 cases. The primary endpoint is the overall rate of surgical complications, including death.
Article
Oncology
Ani K. Stoyanova, Arne Sattler, Elisabeth M. Hahn, Nina A. Hering, Marco Arndt, Johannes Christian Lauscher, Fiona Speichinger-Hillenberg, Katja Kotsch, Ann-Kathrin Berg, Katharina Beyer
Summary: This study provides a comprehensive immune profile of TRAIL-deficient mice, indicating a potential role of TRAIL in immune regulation. The results show that T-lymphocytes of TRAIL(-/-) mice have lower proliferation rates, which can be increased by recombinant TRAIL administration, suggesting the importance of TRAIL in immune modulation.
Article
Oncology
Ann-Kathrin Berg, Elisabeth M. Hahn, Fiona Speichinger-Hillenberg, Annemaria Silvana Grube, Nina A. Hering, Ani K. Stoyanova, Katharina Beyer
Summary: Peritonitis and abdominal sepsis are important factors causing sepsis, but their immunological background and molecular mechanism are still unclear, leading to limited treatment options. This study found that apoptosis of neutrophil granulocytes is inhibited in early abdominal sepsis, and TRAIL may have potential as a therapeutic drug.
Article
Radiology, Nuclear Medicine & Medical Imaging
Florian N. Loch, Carsten Kamphues, Katharina Beyer, Christian Schineis, Patrick Asbach, Rolf Reiter, Ingolf Sack, Jurgen Braun
Summary: MRE can assess the viscoelastic properties of small bowel tissue in patients with Crohn's disease (CD) and quantify differences between healthy and CD-affected ileum. The results are an important prerequisite for future studies investigating comprehensive MRE mapping and exact histopathological correlation.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Medicine, Research & Experimental
Lucas D. Lee, Nina A. Hering, Miriam Zibell, Leonard A. Lobbes, Carsten Kamphues, Johannes C. Lauscher, Georgios A. Margonis, Hendrik Seeliger, Katharina Beyer, Benjamin Weixler, Ioannis Pozios
Summary: This study aimed to analyze the role of NIR fluorescence imaging using ICG for pancreatic liver disease in a mouse model. The results showed that ICG-staining failed to visualize liver metastases induced by L3.6pl pancreatic tumor cells and did not increase fluorescence intensity around the liver lesions. Further studies are needed to understand the underlying mechanism for the insufficient ICG uptake in these pancreatic liver metastases.
Article
Gastroenterology & Hepatology
Maria A. Willis, Peter S. Keller, Nils Sommer, Franziska Koch, Joerg-Peter Ritz, Katharina Beyer, Christoph Reissfelder, Julia Hardt, Alexander Herold, Heinz J. Buhr, Klaus Emmanuel, Joerg C. Kalff, Tim O. Vilz
Summary: A survey was conducted among German and Austrian hospitals to assess the implementation of fast track measures in perioperative care. The results showed that there is still room for improvement, especially in the use of abdominal drains and postoperative analgesia. To overcome these issues, the development of an evidence-based guideline for perioperative care, followed by structured education and certification processes, may lead to significant improvements in patient care.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Florian N. Loch, Carsten Kamphues, Katharina Beyer, Christian Schineis, Patrick Asbach, Rolf Reiter, Ingolf Sack, Juergen Braun
Summary: MRE can be used to assess the viscoelastic properties of healthy and CD-affected ileum. The results showed that the penetration rate was lower, and the damping ratio and viscosity parameter were higher in CD-affected tissue compared to healthy tissue. There was no significant difference in shear wave speed between healthy and diseased tissue.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
