Article
Cell Biology
Alfonso Eirin, Yu Meng, Xiang-Yang Zhu, Yongxin Li, Ishran M. Saadiq, Kyra L. Jordan, Hui Tang, Amir Lerman, Andre J. van Wijnen, Lilach O. Lerman
Summary: Obesity alters the miRNA expression profile and size of human adipose mesenchymal stem/stromal cell-derived extracellular vesicles (EVs), reducing their capacity to repair injured cells and modulate important injury pathways in recipient cells. These observations may guide the development of novel strategies to improve healing and repair in obese individuals.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Dongbo Zhao, Weidi Yu, Wangcheng Xie, Zhilong Ma, Zhengyu Hu, Zhenshun Song
Summary: This study investigates whether bone marrow mesenchymal stem cells (BMSCs) can attenuate pancreatic injury in severe acute pancreatitis (SAP) by mediating oxidative stress. The results show that BMSCs transplantation can alleviate pancreatic injury and enhance antioxidant tolerance in SAP, while ML385 administration weakens this efficacy. Furthermore, BMSCs promote Nrf2 nuclear translocation via the PI3K/AKT signaling pathway and reduce inflammatory response by inhibiting the NF-kappa B signaling pathway in SAP.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Cell & Tissue Engineering
Qilin Huang, Xiumei Cheng, Chen Luo, Shuxu Yang, Shuai Li, Bing Wang, Xiaohui Yuan, Yi Yang, Yi Wen, Ruohong Liu, Lijun Tang, Hongyu Sun
Summary: The study demonstrated that placental chorionic plate-derived MSCs can survive in injured tissues of SAP rats, reducing pancreatic injury and systemic inflammation by inducing macrophages to polarize from M1 to M2. The mechanism involves the secretion of TSG-6 by CP-MSCs, which plays a vital role in mitigating pancreatic injury and systemic inflammation in SAP rats.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Pharmacology & Pharmacy
Cong He, Doulathunnisa Jaffar Ali, Smilin Bell G. Aseervatham, Bo Sun, Zhongdang Xiao
Summary: Liver cancer is a highly malignant cancer with poor prognosis, where intracellular mediators and cancer stem cells are believed to play crucial roles in its progression. The phenotypic conversion of tumor cells during epithelial-to-mesenchymal transition and the cell-to-cell communication via secreted microvesicles are key factors in tumor invasion and metastasis. Identifying the interactions between cancer stem cells and microvesicles may provide new insights into targeted anti-cancer therapies.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Ke Pang, Fanyi Kong, Dong Wu
Summary: Mesenchymal stem cell conditioned medium (MSC-CM) shows potential in treating acute pancreatitis by mitigating tissue damage and inflammation. However, further pre-clinical research using large animal models and prolonged observation periods are necessary. The lack of standardization and consensus on isolation processes, quantifications, and purity testing poses challenges for comparing and conducting meta-analyses.
Article
Multidisciplinary Sciences
Ricardo Malvicini, Diego Santa-Cruz, Anna Maria Tolomeo, Maurizio Muraca, Gustavo Yannarelli, Natalia Pacienza
Summary: In this study, we developed a chromatographic, scalable, and clinically compatible method to isolate and concentrate extracellular vesicles (EVs) from conditioned media, while preserving their biological activity. The method is simple, fast, and suitable for clinical production.
Article
Chemistry, Medicinal
Xingcai Zhang, Lifang Ye, Wan Tang, Yiqin Ji, Li Zheng, Yijun Chen, Qidong Ge, Changshun Huang
Summary: The study aimed to investigate the antifibrotic effects of mesenchymal stem cell microvesicles (MSC MVs) in acute respiratory distress syndrome (ARDS) and the underlying mechanisms. The results showed that MSC MVs significantly suppressed pathological progression of ARDS, reversed abnormal expression of epithelial-mesenchymal transition (EMT)-related proteins, and attenuated activation of the Wnt/β-catenin signaling pathway. These findings suggest that MSC MVs have the potential to ameliorate early pulmonary fibrosis associated with ARDS by regulating EMT and the Wnt/β-catenin signaling pathway.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Chemistry, Multidisciplinary
Zhengyu Hu, Dongyan Wang, Jian Gong, Yan Li, Zhilong Ma, Tingyi Luo, Xuyang Jia, Yihai Shi, Zhenshun Song
Summary: The abnormal opening of the mitochondrial permeability transition pore (MPTP) is the central event in acute pancreatitis, and mesenchymal stem cells (MSCs) can deliver functional mitochondria to damaged pancreatic acinar cells (PACs) via extracellular vesicles (EVs). This reverses the metabolic function of PACs, maintains ATP supply, and exhibits an excellent injury-inhibiting effect. These findings reveal the potential of applying mitochondrial therapy to patients with severe acute pancreatitis.
Review
Immunology
Weiqiang Li, Qianqian Liu, Jinchao Shi, Xiang Xu, Jinyi Xu
Summary: Mesenchymal stem cells (MSCs) are pluripotent stem cells with strong immunomodulatory capacity. They rely on microenvironmental factors to stimulate specific cell growth factors, chemokines, immunomodulatory factors, or receptors, or to direct their differentiation into specific tissue cells for tissue regeneration and repair and immunomodulatory functions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Shuang Li, Huijuan Li, Hanjing Zhangdi, Ruiling Xu, Xu Zhang, Jingyang Liu, Ying Hu, Dandan Ning, Shizhu Jin
Summary: This study found that hair follicle-derived mesenchymal stem cell-derived small extracellular vesicles (HF-MSC-sEVs) could treat acute pancreatitis (AP) by alleviating inflammation and pyroptosis levels, providing a new cell-free therapy for AP.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Medicine, Research & Experimental
Allaura S. Cone, Xuegang Yuan, Li Sun, Leanne C. Duke, Michael P. Vreones, Allison N. Carrier, Stephanie M. Kenyon, Spencer R. Carver, Sarah D. Benthem, Alina C. Stimmell, Shawn C. Moseley, David Hike, Samuel C. Grant, Aaron A. Wilber, James M. Olcese, David G. Meckes
Summary: Research has shown that extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have potential therapeutic effects for Alzheimer's disease, slowing down disease progression and improving cognitive function when administered intranasally in mice.
Article
Biochemistry & Molecular Biology
Agnieszka Szyposzynska, Aleksandra Bielawska-Pohl, Marek Murawski, Rafal Sozanski, Grzegorz Chodaczek, Aleksandra Klimczak
Summary: The study demonstrates that HATMSC2 microvesicles can reduce metabolic activity and induce cancer cell death in primary ovarian cancer cells, leading to decreased migratory activity. The anti-cancer effect is likely contributed by the delivery of specific molecules that induce cell cycle arrest and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Nazmul Haque, Darius Widera, Vijayendran Govindasamy, Pratiwi Soesilawati, Noor Hayaty Abu Kasim
Summary: Cell-based regenerative therapies have the potential to treat non-communicable and degenerative diseases. Extracellular vesicles (EVs), which contain miRNAs, mRNAs, and proteins, play a role in intercellular communication. However, the regenerative potential of these molecules is still debated.
CURRENT MOLECULAR MEDICINE
(2022)
Article
Environmental Sciences
Benisio Ferreira Silva Filho, Francisco Filipak Neto, Micheli de Marchi, Erick Laurent Moggio, Izadora Volpato Rossi, Bruna Sabatke, Marcel Ivan Ramirez, Miguel Clodomiro dos Santos Lucena, Adriane Regina Todeschini, Ciro Alberto de Oliveira Ribeiro
Summary: This study investigated the effects of BDE-209 and TCDD on melanoma cells and found that these two pollutants can alter the cell phenotype, leading to increased aggressiveness, including increased cell proliferation and regulation of genes related to metastasis.
ENVIRONMENTAL POLLUTION
(2022)
Review
Biochemistry & Molecular Biology
Sekyung Oh, Sang-Ho Kwon
Summary: This article discusses the challenges of diagnosing acute kidney injury (AKI) and the discovery and application of EVs as biomarkers, as well as the importance of EVs for treating AKI. Future research will focus on addressing the shortcomings of current EV-based AKI diagnosis and therapeutic applications, with the aim of bringing more innovation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Ruling Zhang, Juanjuan Shi, Rulin Zhang, Jianbo Ni, Aida Habtezion, Xingpeng Wang, Guoyong Hu, Jing Xue
JOURNAL OF IMMUNOLOGY
(2019)
Article
Pharmacology & Pharmacy
Xiao Han, Jianbo Ni, Zengkai Wu, Jianghong Wu, Bin Li, Xin Ye, Juanjuan Dai, Congying Chen, Jing Xue, Rong Wan, Li Wen, Xingpeng Wang, Guoyong Hu
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Medicine, Research & Experimental
Jie Xiong, Jianbo Ni, Congying Chen, Kezhou Wang
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Bin Li, Jianghong Wu, Jingpiao Bao, Xiao Han, Shuangjun Shen, Xin Ye, Juanjuan Dai, Zengkai Wu, Mengya Niu, Yan He, Jianbo Ni, Li Wen, Xingpeng Wang, Guoyong Hu
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Medicine, Research & Experimental
Jie Jiang, Jie Xiong, Jianbo Ni, Congying Chen, Kezhou Wang
Summary: LCBE effectively alleviates symptoms of NAFLD in mice by improving body weight, liver function, and blood glucose levels, enhancing intestinal barrier function, modulating gut microbiota composition, and reducing inflammation.
MEDICAL SCIENCE MONITOR
(2021)
Editorial Material
Gastroenterology & Hepatology
Jianbo Ni, Ni Xie, Baiwen Li
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Jian Bo Ni, Mei Ying Zhu, Kai Li, Wei Ming Dai, Lun Gen Lu, Xin Jian Wan, Rong Wan, Xiao Bo Cai
Summary: Using CARAC for ERCP in patients with Roux-en-Y reconstruction after total gastrectomy resulted in a success rate of 68.8% for reaching the papilla and 72.7% for biliary cannulation. Overall clinical success was achieved in 68.8% of patients. Procedure-related mild acute pancreatitis was observed in 25.0% of cases, and mild cholangitis in 18.8%.
JOURNAL OF DIGESTIVE DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Haoran Xie, Qiuyan Zhao, Lanting Yu, Jiawei Lu, Kui Peng, Ni Xie, Jianbo Ni, Baiwen Li
Summary: This study demonstrates that circ_0047744 acts as an anti-oncogene to inhibit PDAC metastasis by regulating the miR-21/SOCS5 axis. Overexpression of circ_0047744 can suppress cell migration and invasion in PDAC.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Jianbo Ni, Kui Peng, Lanting Yu, Haoran Xie, Shengzheng Luo, Kai Xu, Youchen Xia, Ni Xie, Jiawei Lu, Lungen Lu, Duanmin Hu, Xinjian Wan, Baiwen Li
Summary: This study found that combining transpapillary drainage (TPD) with endoscopic transmural drainage (TMD) can reduce the recurrence rate and length of hospital stay of pancreatic fluid collections (PFCs) in patients with disrupted pancreatic duct (PD), compared to using TMD or TPD alone.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Jianbo Ni, Asna Khalid, Yu-Chu Lin, Monique T. Barakat, Jing Wang, Cheng-Yu Tsai, Pasha Reza Shams Azar, Ying Ding, Judy-April Murayi, Thottala Jayaraman, Ronald Poropatich, Rita Bottino, Li Wen, Georgios I. Papachristou, Gayathri Swaminathan, Mang Yu, Sohail Z. Husain
Summary: This study investigated the therapeutic effects of calcineurin inhibitors (CnIs) on post-ERCP pancreatitis (PEP) and its potential toxicities in a preclinical model. The results showed that intraductal administration of CnIs prevented PEP without causing significant hormonal or systemic toxicities, suggesting its clinical utility.
Article
Gastroenterology & Hepatology
Yu-Chu Lin, Jianbo Ni, Gayathri Swaminathan, Asna Khalid, Monique T. Barakat, Adam R. Frymoyer, Cheng-Yu Tsai, Ying Ding, Judy-April Murayi, Thottala Jayaraman, Ronald Poropatich, Rita Bottino, Li Wen, Georgios I. Papachristou, Sunil G. Sheth, Mang Yu, Sohail Z. Husain
Summary: The study demonstrates the effectiveness of rectal administration of tacrolimus (Tac) in mitigating post-ERCP pancreatitis (PEP) and provides clinical utility for PEP prophylaxis.
Article
Gastroenterology & Hepatology
Xiao Han, Jianbo Ni, Bin Li, Jingpiao Bao, Rong Wan, Guoyong Hu, Congying Chen
Summary: This study found that serum RBP levels are associated with the severity of AP and the occurrence of local and systemic complications.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Jianbo Ni, Kui Peng, Lanting Yu, Haoran Xie, Duanmin Hu, Xinjian Wan, Guoyong Hu, Baiwen Li
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Jianbo Ni, Ni Xie, Guoyong Hu, Baiwen Li
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
X. Han, J. B. Ni, Z. K. Wu, L. Wen, X. P. Wang, G. Y. Hu