Article
Biology
Sydney Trask, Jeffrey S. Mogil, Fred J. Helmstetter, Cheryl L. Stucky, Katelyn E. Sadler
Summary: The mechanisms underlying the transition from acute to chronic pain are still unclear, but it may involve the persistence or strengthening of pain memories acquired through associative learning. Recent studies have shown that contextual cues play a critical role in regulating pain memory. Animals and humans exhibit increased pain sensitivity in environments associated with painful experiences. This study suggests that pain perception and activation of endogenous opioid systems can be modified through psychological association with environmental cues.
Article
Anesthesiology
Fabio Carlos Lucas de Oliveira, Camille Cossette, Catherine Mailloux, Timothy H. Wideman, Louis-David Beaulieu, Hugo Masse-Alarie
Summary: The study aimed to assess the reliability of pressure pain threshold (PPT) and temporal summation of pain (TSP) in individuals with chronic low back pain (CLBP), and explore the impact of different measurement sequences on reliability metrics. The results showed excellent relative reliability for PPT and good to excellent reliability for TSP at the low back and hand sites among individuals with CLBP. It is recommended to use 3 measurements for PPT and 2 for TSP to optimize reliability.
CLINICAL JOURNAL OF PAIN
(2023)
Article
Anesthesiology
Yelena Granovsky, Leah Shafran Topaz, Helen Laycock, Rabab Zubiedat, Shoshana Crystal, Chen Buxbaum, Noam Bosak, Rafi Hadad, Erel Domany, Mogher Khamaisi, Elliot Sprecher, David L. Bennett, Andrew Rice, David Yarnitsky
Summary: According to the study, patients with painful diabetic polyneuropathy (DPN) have lower efficiency in conditioned pain modulation (CPM) compared to those with nonpainful DPN. However, these patients demonstrate unexpectedly higher efficiency in thermal CPM. Higher efficiency in thermal CPM is associated with higher levels of clinical pain and greater loss of mechanical sensation. Patients with mechanical hypoesthesia also show higher efficiency in thermal CPM.
Article
Orthopedics
Demario S. Overstreet, Ava N. Michl, Terence M. Penn, Deanna D. Rumble, Edwin N. Aroke, Andrew M. Sims, Annabel L. King, Fariha N. Hasan, Tammie L. Quinn, D. Leann Long, Robert E. Sorge, Burel R. Goodin
Summary: The study found that temporal summation of mechanical pain significantly and prospectively predicted greater movement-evoked pain and poorer physical function in individuals with chronic low back pain. However, neither temporal summation nor conditioned pain modulation were significantly related to self-reported pain severity or pain interference.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Anesthesiology
Madeleine Verriotis, Judy Peters, Clarissa Sorger, Suellen M. Walker
Summary: The study recruited adolescents aged 10-17 with neuropathic pain or complex regional pain syndrome. The results showed that changes in pain symptoms, sensory features, and psychological function were associated with severe pain, decreased quality of life, and emotional distress.
Article
Anesthesiology
Dennis Boye Larsen, Mogens Laursen, Robert R. Edwards, Ole Simonsen, Lars Arendt-Nielsen, Kristian Kjaer Petersen
Summary: The combination of high preoperative clinical pain intensity, high levels of pain catastrophizing thoughts, and impaired conditioned pain modulation may predict long-term postoperative pain 12 months after surgery, explaining approximately 20.5% of variance in follow-up pain.
Article
Anesthesiology
Megan E. McPhee, Thomas Graven-Nielsen
Summary: This study examines the influence of attentional and affective manipulation on conditioned pain modulation among patients with low back pain. The results suggest that attention and positive affect can alleviate the perception of conditioned pain, and patients with recurrent low back pain exhibit less shift in valence during affective processing.
Article
Clinical Neurology
Roi Treister, Liat Honigman, Assaf Berger, Ben Cohen, Israa Asaad, Pora Kuperman, Rotem Tellem, Uri Hochberg, Ido Strauss
Summary: This study evaluated the clinical outcomes of PCC treatment for cancer pain using quantitative sensory testing and found that reduced pain and sensitivity were associated with treatment success. Additionally, the study identified a potential mechanism for the development of contralateral pain post-PCC and suggested temporal summation as a screening tool.
Article
Neurosciences
Jason D. Bao, Morgan A. Rosser, Su Hyoun Park, Anne K. Baker, Katherine T. Martucci
Summary: The impact of long-term opioid therapy on central sensitization is investigated using temporal summation measurement. Hypersensitivity to heat pain in participants taking opioids may influence temporal summation.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Oncology
Burel R. Goodin, Demario S. Overstreet, Terence M. Penn, Rahm Bakshi, Tammie L. Quinn, Andrew Sims, Travis Ptacek, Pamela Jackson, D. Leann Long, Edwin N. Aroke
Summary: This study investigated the relationship between conditioned pain modulation (CPM) and DNA methylation (DNAm) changes in individuals with chronic low back pain (cLBP). The study found differentially methylated CpG sites (DMCs) associated with pain-related genes and pathways. These findings suggest potential therapeutic targets for central sensitization, but further research is needed to confirm the relationship between CPM, central sensitization, and non-specific cLBP.
CLINICAL EPIGENETICS
(2022)
Article
Computer Science, Artificial Intelligence
Yitian Yuan, Lin Ma, Jingwen Wang, Wei Liu, Wenwu Zhu
Summary: Temporal sentence grounding in videos is improved using a novel semantic conditioned dynamic modulation (SCDM) mechanism, which leverages the sentence semantics to improve the correlation between sentence and video. The proposed model is able to localize video segments of various temporal scales and adjust temporal boundaries for more accurate grounding results.
IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE
(2022)
Article
Anesthesiology
Paulo E. P. Teixeira, Kevin Pacheco-Barrios, Elif Uygur-Kucukseymen, Roberto Mathias Machado, Ana Balbuena-Pareja, Stefano Giannoni-Luza, Maria Alejandra Luna-Cuadros, Alejandra Cardenas-Rojas, Paola Gonzalez-Mego, Piero F. Mejia-Pando, Timothy Wagner, Laura Dipietro, Felipe Fregni
Summary: CPM was not significantly correlated with self-reported pain intensity scores. The relative power of EEG in specific brain regions was significantly associated with CPM, while the relative power at certain EEG bands in the central area was significantly correlated with self-reported pain intensity scores.
Article
Orthopedics
Robert R. Edwards, Claudia Campbell, Kristin L. Schreiber, Samantha Meints, Asimina Lazaridou, Marc O. Martel, Marise Cornelius, Xinling Xu, Robert N. Jamison, Jeffrey N. Katz, Junie Carriere, Harpal P. Khanuja, Robert S. Sterling, Michael T. Smith, Jennifer A. Haythornthwaite
Summary: This study highlighted the importance of considering psychosocial factors (especially positively-oriented resilience variables) and sensory profiles, as well as their interaction, in understanding post-surgical pain trajectories.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Clinical Neurology
Soren O'Neill, Liam Holm, Johanne Brinch Filtenborg, Lars Arendt-Nielsen, Casper Glissmann Nim
Summary: The study examined the impact of CPM effect on pain induced by temporal summation and single stimuli in low-back pain patients. The results suggest that repeated pressure pain may be better suited as the CPM test stimuli, and using temporal summation as the test stimulus in a CPM paradigm may be more sensitive.
SCANDINAVIAN JOURNAL OF PAIN
(2021)
Article
Medicine, General & Internal
Elena Sirbu, Roxana Ramona Onofrei, Simona Szasz, Monica Susan
Summary: This study aimed to assess the relationship between pain intensity, catastrophizing components, depression, and disability in patients with chronic low back pain (CLBP). The results showed that age, pain intensity, catastrophizing, and depression can predict the disability level in CLBP patients.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Anesthesiology
Timothy H. Wideman, Robert R. Edwards, David M. Walton, Marc O. Martel, Anne Hudon, David A. Seminowicz
CLINICAL JOURNAL OF PAIN
(2019)
Article
Anesthesiology
Junie S. Carriere, Marc Olivier Martel, Samantha M. Meints, Marise C. Cornelius, Robert R. Edwards
EUROPEAN JOURNAL OF PAIN
(2019)
Article
Clinical Neurology
Marc O. Martel, Kristian Petersen, Marise Cornelius, Lars Arendt-Nielsen, Robert Edwards
Article
Anesthesiology
Samantha M. Meints, Ishtlaq Mawla, Vitaly Napadow, Jian Kong, Jessica Gerber, Suk-Tak Chan, Ajay D. Wasan, Ted J. Kaptchuk, Christina McDonnell, Junie Carriere, Bruce Rosen, Randy L. Gollub, Robert R. Edwards
Article
Clinical Neurology
Hayden E. Hundley, Mark E. Hudson, Ajay D. Wasan, Trent D. Emerick
JOURNAL OF PAIN RESEARCH
(2019)
Article
Anesthesiology
Jieun Kim, Ishtiaq Mawla, Jian Kong, Jeungchan Lee, Jessica Gerber, Ana Ortiz, Hyungjun Kim, Suk-Tak Chan, Marco L. Loggia, Ajay D. Wasan, Robert R. Edwards, Randy L. Gollub, Bruce R. Rosen, Vitaly Napadow
Review
Clinical Neurology
Alex M. Dressler, Andrea G. Gillman, Ajay D. Wasan
JOURNAL OF PAIN RESEARCH
(2019)
Article
Endocrinology & Metabolism
Meghna Nandi, Kristin L. Schreiber, Marc O. Martel, Marise Cornelius, Claudia M. Campbell, Jennifer A. Haythornthwaite, Michael T. Smith, John Wright, Linda S. Aglio, Gary Strichartz, Robert R. Edwards
BIOLOGY OF SEX DIFFERENCES
(2019)
Article
Health Care Sciences & Services
Yannick Tousignant-Laflamme, Chad E. Cook, Annie Mathieu, Florian Naye, Frederic Wellens, Timothy Wideman, Marc-Olivier Martel, Olivier Tri-Trinh Lam
JOURNAL OF EVALUATION IN CLINICAL PRACTICE
(2020)
Review
Clinical Neurology
Alberto Babiloni, Beatrice P. De Koninck, Gabrielle Beetz, Louis De Beaumont, Marc O. Martel, Gilles J. Lavigne
JOURNAL OF NEURAL TRANSMISSION
(2020)
Article
Neurosciences
Hyungjun Kim, Ishtiaq Mawla, Jeungchan Lee, Jessica Gerber, Kathryn Walker, Jieun Kim, Ana Ortiz, Suk-Tak Chan, Marco L. Loggia, Ajay D. Wasan, Robert R. Edwards, Jian Kong, Ted J. Kaptchuk, Randy L. Gollub, Bruce R. Rosen, Vitaly Napadow
Article
Multidisciplinary Sciences
Benedict J. Alter, Nathan P. Anderson, Andrea G. Gillman, Qing Yin, Jong-Hyeon Jeong, Ajay D. Wasan
Summary: This study utilized an algorithmic approach to group patients by pain distribution, finding that pain distribution subgroups were significantly associated with differences in pain intensity, impact, and clinically relevant outcomes.
Editorial Material
Anesthesiology
Connor Richardson, Harry Burke, Zach Frabitore, Ruth Segall, Malcolm Moses-Hampton, Raj Kubendran, Kevin Woeppel, Ajay D. Wasan, Trent Emerick
Article
Anesthesiology
Ajay D. Wasan, Robert R. Edwards, Kevin L. Kraemer, Jong Jeong, Megan Kenney, Kevin Luong, Marise C. Cornelius, Caitlin Mickles, Bhagya Dharmaraj, Essa Sharif, Anita Stoltenberg, Trent Emerick, Jordan F. Karp, Matt J. Bair, Steven Z. George, William M. Hooten
Summary: The study aims to investigate the prevalence of comorbid depression or anxiety disorders in patients with chronic low back pain (CLBP). The presence of negative affect (NA) in CLBP patients is associated with increased pain, worse treatment outcomes, and higher rates of prescription opioid misuse. The SYNNAPTIC protocol is designed to evaluate the effectiveness of antidepressants, fear-avoidance rehabilitation, or their combination in treating CLBP patients with high NA.
Article
Neuroimaging
Wei Shen, Yiheng Tu, Randy L. Gollob, Ana Ortiz, Vitaly Napadow, Siyi Yu, Georgia Wilson, Joel Park, Courtney Lang, Minyoung Jung, Jessica Gerber, Ishtiaq Mawla, Suk-Tak Chan, Ajay D. Wasan, Robert R. Edwards, Ted Kaptchuk, Shasha Li, Bruce Rosen, Jian Kong
NEUROIMAGE-CLINICAL
(2019)