Article
Microbiology
Catarina Gouveia, Ana Subtil, Susana Norte, Joana Arcangelo, Madalena Almeida Santos, Rita Corte-Real, Maria Joao Simoes, Helena Canhao, Delfin Tavares
Summary: The study aimed to distinguish Kingella kingae from pyogenic septic arthritis, and the main predictive factors were age, fever status, and CRP concentration.
Article
Immunology
Ardian Ramadani, Benoit Coulin, Giacomo De Marco, Oscar Vazquez, Anne Tabard-Fougere, Nathaly Gavira, Christina N. Steiger, Romain Dayer, Dimitri Ceroni
Summary: This study aimed to report on the clinical course, biological parameters, and results of microbiological investigations among children with K. kingae-induced septic arthritis of the knee. The Kocher-Caird prediction algorithm is not sensitive enough to effectively detect K. kingae-induced septic arthritis of the knee, and nucleic acid amplification assays on oropharyngeal swabs and joint fluid are necessary to exclude this condition in young children presenting with knee effusion.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Microbiology
Giacomo DeMarco, Moez Chargui, Benoit Coulin, Benoit Borner, Christina Steiger, Romain Dayer, Dimitri Ceroni
Summary: K. kingae is considered the main bacterial cause of osteoarticular infections in children under 48 months, presenting with mild symptoms and moderate inflammatory response. Surgical intervention is often not necessary, as the infections respond well to short antibiotic treatments.
Article
Microbiology
Romain Basmaci, Philippe Bidet, Stephane Bonacorsi
Summary: This narrative review explores the association between Kingella kingae (K. kingae) and viral infections. Symptoms of viral infections often occur concurrently with K. kingae infection, and specific viral syndromes have been described in children with K. kingae infection. Human rhinovirus and coxsackievirus, which belong to the Picornaviridae family, have been frequently identified in patients with K. kingae infection and are known to facilitate bacterial infections. However, the exact role of viral infection in the pathophysiology of K. kingae remains unclear and requires further molecular studies.
Article
Microbiology
Benoit Coulin, Giacomo DeMarco, Oscar Vazquez, Vasiliki Spyropoulou, Nathaly Gavira, Tanguy Vendeuvre, Anne Tabard-Fougere, Romain Dayer, Christina Steiger, Dimitri Ceroni
Summary: Osteoarticular infections in children require prompt diagnosis. A retrospective study was conducted on 335 children, and age, temperature, inflammatory markers were found to be valuable in discriminating between Kingella kingae and Staphylococcus aureus infections. Age, CRP concentration, temperature, and platelet count were the best predictors for K. kingae infections.
Article
Immunology
Catarina Gouveia, Mariana Duarte, Susana Norte, Joana Arcangelo, Margarida Pinto, Cristina Correia, Maria Joao Simoes, Helena Canhao, Delfin Tavares
Summary: The study identified Kingella kingae as the most common causative organism of acute septic arthritis, with a trend towards decreasing antibiotic duration observed. Older children with high inflammatory parameters might be at higher risk of sequelae.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Immunology
Ayelen Ivana Pesce Viglietti, Franco Agustin Sviercz, Cinthya Alicia Marcela Lopez, Rosa Nicole Freiberger, Jorge Quarleri, Maria Victoria Delpino
Summary: Kingella kingae is an emerging pathogen that causes septic arthritis, osteomyelitis, and bacteremia in children aged 6 to 48 months. Infection with K. kingae directly stimulates osteoclastogenesis and indirectly through a potent pro-inflammatory response that drives macrophages to become functional osteoclasts. Additionally, the osteoclastogenic capability of K. kingae is counteracted by their outer membrane vesicles in a concentration-dependent manner.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Laudi Olijve, Lahiru Amarasena, Emma Best, Christopher Blyth, Mirjam van den Boom, Asha Bowen, Penelope A. Bryant, Jim Buttery, Hazel C. Dobinson, Joshua Davis, Joshua Francis, Heidi Goldsmith, Elle Griffiths, Te-Yu Hung, Julie Huynh, Alison Kesson, Andrea Meehan, Brendan McMullan, Clare Nourse, Pamela Palasanthiran, Rushi Penumarthy, Katie Pilkington, Janine Searle, Anya Stephenson, Rachel Webb, Jonathan Williman, Tony Walls
Summary: The study collected information on hospitalized children aged 3-60 months with acute osteoarticular infections in 11 hospitals across Australia and New Zealand from 2012 to 2016. It found that Kingella kingae was the most frequently detected microorganism, while in the majority of cases, no microorganism was detected. The study highlights the need for more widespread use of molecular diagnostic techniques for accurate diagnosis of osteoarticular infections in pre-school aged children.
JOURNAL OF INFECTION
(2021)
Review
Pediatrics
Eric A. Porsch, Kevin A. Hernandez, Daniel P. Morreale, Nina R. Montoya, Taylor A. Yount, Joseph W. St. W. Geme III
Summary: Kingella kingae is an emerging pediatric pathogen known to cause septic arthritis, osteomyelitis, bacteremia, and occasionally endocarditis in young children. The pathogenesis of K. kingae disease involves colonization of the upper respiratory tract, breach of the respiratory epithelial barrier, and hematogenous spread to joints, bones, and endocardium. Surface factors of K. kingae, such as type IV pili, Knh trimeric autotransporter, and surface polysaccharides, play important roles in the pathogenic process of the disease.
FRONTIERS IN PEDIATRICS
(2022)
Review
Microbiology
Eric A. Porsch
Summary: In the past three decades, Kingella kingae has emerged as an important pathogen of pediatric osteoarticular infections, leading to significant research efforts to understand its pathogenicity. The identification of multiple virulence factors has provided potential targets for therapeutic intervention and vaccine antigens.
Article
Pediatrics
Eleftheria Samara, Nicolas Lutz, Pierre-Yves Zambelli
Summary: Kingella kingae is an important cause of primary spinal infections in children, requiring MRI and nucleic acid amplification tests for diagnosis. Most patients respond well to antibiotic treatment, with a benign clinical course and no permanent sequelae.
Article
Orthopedics
M. Khattak, S. Vellathussery Chakkalakumbil, R. A. Stevenson, D. J. Bryson, M. J. Reidy, C. L. Talbot, H. George
Summary: This study found that K. kingae is the most commonly isolated organism in pediatric septic arthritis, with only one third of cases detected on routine cultures. It is crucial to maintain a clinical suspicion for K. kingae infection in young patients presenting atypically. Routine PCR testing is recommended in these patients.
BONE & JOINT JOURNAL
(2021)
Article
Immunology
Madalena Almeida Borges, Sara Silva, Raquel Ferreira, Catarina Martins, Paulo Paixao, Vitoria Rodrigues, Joao Farela Neves
Summary: Kingella kingae is a common cause of osteoarticular infections in young children aged between 6 and 48 months, as well as pediatric bacteremia and endocarditis, but meningitis is rarely associated with it.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Immunology
Aaron Keene, Julie Creighton, Trevor Anderson, Tony Walls
Summary: Kingella kingae infections usually respond well to beta-lactam antibiotics, but we reported a case of treatment failure with high-dose intravenous flucloxacillin in a 3-year-old patient. Despite phenotypic testing and whole-genome sequencing, the mechanism of flucloxacillin resistance remains unknown.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Microbiology
Katerina Filipi, Waheed Ur Rahman, Adriana Osickova, Radim Osicka
Summary: Kingella kingae is a Gram-negative bacterium that is part of the normal flora in the throat of young children. It has recently been recognized as an emerging pathogen that causes skeletal system infections, bacteremia, and severe infective endocarditis. The bacterium secretes an RtxA cytotoxin, which belongs to a growing family of cytolytic toxins secreted by Gram-negative pathogens and is involved in the development of clinical infection.