Article
Pharmacology & Pharmacy
Shengqiang Li, Zhen Lei, Meng Zhao, Yonghao Hou, Di Wang, Xingli Xu, Xiaowen Lin, Jingxin Li, Shuhai Tang, Jingui Yu, Tao Meng
Summary: Propofol can reduce myocardial I/R injury by activating PKC/NRF2 pathway, leading to increased antioxidant enzyme expression and decreased levels of lactate dehydrogenase and creatine kinase-MB.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Yusuf Ayikgoz, Mehmet Salih Aydin, Nazim Kankilic, Ebru Temiz
Summary: During cardiopulmonary bypass, TNF-alpha, Nrf2, and HO-1 gene expressions increase, and these values decrease postoperatively. This indicates that oxidative stress and inflammatory processes start with cardiopulmonary bypass, and antioxidant processes start similarly.
Article
Behavioral Sciences
Cui Li, Tian-yu Yu, Li-rong Gong, Rui Mu, Yuan Zhang, Jian-bo Yu
Summary: Sevoflurane administered immediately after TBI can protect against TBI-induced synaptic and cognitive impairments by promoting the antioxidant Nrf-2/HO-1 pathway, making it a promising anesthetic for patients with TBI.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Tao Xiao, Hongtao Qu, Zhiqing Zeng, Chuanghua Li, Juan Wan
Summary: This study revealed that exosomes derived from M2-polarized macrophages (M2-Exo) exert protective effects against ischemia-reperfusion injury in HT22 neurons, mediated by the activation of the Nrf2/HO-1 signaling pathway.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Hongyan Wu, Toshiyuki Nakamura, Yingnan Guo, Riho Matsumoto, Shintaro Munemasa, Yoshiyuki Murata, Yoshimasa Nakamura
Summary: The present study aimed to quantify the major compounds in brown rice and compare their cytoprotective potential against oxidative stress. The content of hydrophobic compounds in brown rice followed the order of cycloartenyl ferulate (CAF) > alpha-tocopherol (alpha T) > gamma-tocotrienol (gamma T3) > alpha-tocotrienol (alpha T3) > gamma-tocopherol (gamma T). CAF showed significant cytoprotective effect at lower concentration against hydrogen peroxide-induced cytotoxicity compared to alpha T and gamma T.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Agnieszka Loboda, Jozef Dulak
Summary: Skeletal muscles have a robust regenerative capacity. The role of NRF2 in muscle regeneration and its potential therapeutic applications need further investigation.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Gastroenterology & Hepatology
Mushtaq Ahmad Ansari, Mohammad Raish, Yousef A. Bin Jardan, Ajaz Ahmad, Mudassar Shahid, Sheikh Fayaz Ahmad, Nazrul Haq, Mohammad Rashid Khan, Saleh A. Bakheet
Summary: Sinapic acid has hepatoprotective effects against acute liver failure induced by LPS/D-GalN in rats by reducing inflammation and oxidative stress, and regulating Nrf2/HO-1 and NF-kappa B pathways.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Chemistry, Medicinal
Qili Lu, Noha A. Gouda, Guofeng Quan, Hossam Nada, Ahmed Elkamhawy, Dongho Lee, Chang Hoon Lee, Jungsook Cho, Kyeong Lee
Summary: This study reports on the neuroprotective and antioxidant effects of Cudraisoflavone J derivatives, mediated through the Nrf2/HO-1 pathway via phosphorylation of ERK1/2, JNK, or Akt. Compounds 13m and 24 show potential as therapeutic candidates for neuroprotective treatment of Parkinson's disease.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Critical Care Medicine
Jianhang Du, Zhanrong Kang, Libiao Huang, Fei Zhou, Xu Feng, Jianming Huang
Summary: The study aimed to evaluate the protective efficacy of double-doses of hirudin in compartment syndrome and its association with the Nrf2/HO-1 pathway. The results showed that hirudin at a dose of 8 ATU/kg presented the lowest levels of histological damage, fibrosis, W/D ratio, and oxidative stress. Additionally, treatment with hirudin markedly downregulated the level of inflammatory factors. At 72 h after compartment syndrome, hirudin showed a protective effect associated with the nuclear translocation of Nrf2 and an elevated expression of HO-1.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Medicine, Research & Experimental
Qi Pu, Xiao-Xiao Guo, Jing-Jie Hu, Ao-Ling Li, Gui-Gang Li, Xin-Yu Li
Summary: NMN can reverse cell damage, reduce apoptosis, increase cell migration, and restore tight junctions in high-glucose treated corneal epithelial cells through the SIRT1/Nrf2/HO-1 pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Jingying Gao, Lixia Xia, Yuanyuan Wei
Summary: This study investigates the inhibitory effect of oxymatrine on pyroptosis in INS-1 cells and reveals its involvement in glucose metabolism regulation through the suppression of the NF-kappa B pathway and activation of the Nrf2/HO-1 pathway.
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2022)
Article
Immunology
Huimian Jiang, Yan Fang, Yuxin Wang, Ting Li, Hongwei Lin, Jing Lin, Tongtong Pan, Qingxiu Liu, Jiaojian Lv, Dazhi Chen, Yongping Chen
Summary: This study revealed the protective role of fibroblast growth factor 4 (FGF4) in autoimmune hepatitis (AIH) by inhibiting ferroptosis of hepatocytes. The expression of FGF4 was found to be associated with the severity of ferroptosis in AIH liver injury, and treatment with Ferrostatin-1 (Fer-1) effectively reversed this effect. Additionally, exogenous recombinant FGF4 (rFGF4) was shown to mitigate liver damage and ferroptosis, accompanied by the upregulation of CISD3, Nrf2, and HO-1.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Natasha M. Nesbitt, Lisa E. Malone, Zhaoyan Liu, Alexander Jares, Dmitri V. Gnatenko, Yupo Ma, Wei Zhu, Wadie F. Bahou
Summary: The cytoprotective functions of heme oxygenases involve the generation of carbon monoxide, ferrous iron, and bilirubin, with downstream biliverdin reductases playing a key role in cellular protection, especially in stress hematopoiesis. Blvrb is identified as a crucial driver in stress cytoprotection and redox-regulated lineage partitioning in erythroid/megakaryocyte lineage speciation.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Hezhan Shi, Bo Hou, Huifeng Li, Hui Zhou, Bin Du
Summary: CTX can induce ferroptosis through the activation of the NRF2/HMOX-1 pathway, providing a potential strategy for tumor chemotherapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Yanqiong Liu, Qiulian Wu, Fuyong Zhang, Xue Qin
Summary: This study provides evidence for the first time that the NRF2 gene rs6721961 variation is a potential genetic marker for susceptibility to hepatocellular carcinoma (HCC).
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Gustavo Ramirez-Martinez, Luis Armando Jimenez-Alvarez, Alfredo Cruz-Lagunas, Sergio Ignacio-Cortes, Itzel Alejandra Gomez-Garcia, Tatiana Sofia Rodriguez-Reyna, Jose Alberto Choreno-Parra, Joaquin Zuniga
Summary: The costs of COVID-19 are devastating and there is an urgent need for serological biomarkers, antiviral agents, and novel therapies. Previous studies on immunity against other respiratory infections provide reference knowledge to understand the pathogenesis of COVID-19. This review discusses the immune responses and the involvement of matrix metalloproteinases and transforming growth factor-beta in the lungs. Furthermore, it explores the potential implications of these molecules as biomarkers for diagnosis, prognosis, and treatment of COVID-19 patients, including those in the convalescent phase.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Manuel Azaid Ordaz-Arias, Laura Diaz-Alvarez, Joaquin Zuniga, Mariana Esther Martinez-Sanchez, Yalbi Itzel Balderas-Martinez
Summary: This study proposes a regulatory network of cytokines, signaling pathways, and transcription factors to investigate the differentiation, heterogeneity, and plasticity of macrophages. It shows that the network structure can lead to oscillations and that the environment plays a role in macrophage differentiation and plasticity. This provides mechanistic insights into the heterogeneity and plasticity of macrophages in vivo and in vitro.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
F. D. Martinez-Sanchez, A. X. Medina-Urrutia, E. Jorge-Galarza, M. Del Rocio Martinez-Alvarado, J. Reyes-Barrera, H. Osorio-Alonso, A. S. Arellano-Buendia, M. Del Carmen Gonzalez-Salazar, R. Posadas-Sanchez, G. Vargas-Alarcon, C. Posadas-Romero, J. G. Juarez-Rojas
Summary: This study aimed to analyze the composite control of blood pressure, lipids, and glucose in patients with premature coronary artery disease (CAD). The study found that achieving control targets for blood lipids, blood pressure, and blood glucose significantly reduced the risk of recurrent major adverse cardiovascular events (MACE).
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Medicine, General & Internal
Benny Giovanni Cazarin-Santos, Nonanzit Perez-Hernandez, Rosalinda Posadas-Sanchez, Gilberto Vargas-Alarcon, Oscar Perez-Mendez, Juan Rodriguez-Silverio, Bladimir Roque-Ramirez, Veronica Marusa Borgonio-Cuadra, Jose Manuel Rodriguez-Perez
Summary: This study found an association between genetic variants and the development of subclinical atherosclerosis, with the rs3102735 polymorphism showing a protective effect and the GACC haplotype decreasing risk while the GACT haplotype increasing risk.
Article
Microbiology
Mariana Esther Martinez-Sanchez, Jose Alberto Choreno-Parra, Elena R. Alvarez-Buylla, Joaquin Zuniga, Yalbi Itzel Balderas-Martinez
Summary: We used a dynamic and multistable Boolean regulatory network to explain the lymphopenia and dysregulation of CD4+ T cell subsets in COVID-19 and identified potential therapeutic targets. Simulations of cytokine micro-environments in different severity levels of COVID-19 revealed a decrease in antiviral Th1 cells and an increase in Th1-like regulatory and exhausted cells. Addition of TGF-beta and IL-10 cytokines shifted the balance towards Th17 and regulatory subsets by destabilizing the Th1 attractor.
Article
Biochemistry & Molecular Biology
Tristan James Alexander Begg, Axel Schmidt, Arthur Kocher, Maarten H. D. Larmuseau, Goran Runfeldt, Paul Andrew Maier, John D. Wilson, Rodrigo Barquera, Carlo Maj, Andras Szolek, Michael Sager, Stephen Clayton, Alexander Peltzer, Ruoyun Hui, Julia Ronge, Ella Reiter, Caecilia Freund, Marta Burri, Franziska Aron, Anthi Tiliakou, Joanna Osborn, Doron M. Behar, Malte Boecker, Guido Brandt, Isabelle Cleynen, Christian Strassburg, Kay Pruefer, Denise Kuehnert, William Rhea Meredith, Markus M. Noethen, Robert David Attenborough, Toomas Kivisild, Johannes Krause
Summary: Ludwig van Beethoven (1770-1827), a renowned classical music composer, suffered from health problems including hearing loss, gastrointestinal complaints, and liver disease. Through genomic analysis, it was discovered that Beethoven had a genetic predisposition for liver disease and a hepatitis B infection prior to his death. These findings provide plausible explanations for his severe liver disease.
Article
Genetics & Heredity
Esteban Arrieta-Bolanos, Diana Iraiz Hernandez-Zaragoza, Rodrigo Barquera
Summary: HLA frequencies show variation across human populations. Geography has a strong effect on the distribution of HLA class I allele groups, while class II frequencies correlate less clearly to actual geographic location. The study also reveals intra-continental sub-clusters and characteristic HLA allele group patterns.
FRONTIERS IN GENETICS
(2023)
Article
Biology
Qing Li, Jieyi Chen, Pierre Faux, Miguel Eduardo Delgado, Betty Bonfante, Macarena Fuentes-Guajardo, Javier Mendoza-Revilla, J. Camilo Chacon-Duque, Malena Hurtado, Valeria Villegas, Vanessa Granja, Claudia Jaramillo, William Arias, Rodrigo Barquera, Paola Everardo-Martinez, Mirsha Sanchez-Quinto, Jorge Gomez-Valdes, Hugo Villamil-Ramirez, Caio C. Silva de Cerqueira, Tabita Huenemeier, Virginia Ramallo, Sijie Wu, Siyuan Du, Andrea Giardina, Soumya Subhra Paria, Mahfuzur Rahman Khokan, Rolando Gonzalez-Jose, Lavinia Schueler-Faccini, Maria-Catira Bortolini, Victor Acuna-Alonzo, Samuel Canizales-Quinteros, Carla Gallo, Giovanni Poletti, Winston Rojas, Francisco Rothhammer, Nicolas Navarro, Sijia Wang, Kaustubh Adhikari, Andres Ruiz-Linares
Summary: A genome-wide association study and automatic landmarking approach on 2D face photographs of over 6000 Latin Americans reveal novel genomic regions influencing facial features and suggest Neanderthal influence on nasal shape. The study detected significant associations at 42 genome regions, with 33 new regions replicating in East Asians, Europeans, or Africans. The findings provide insights into the genetics of facial features and suggest a simplified method for large-scale studies across populations.
COMMUNICATIONS BIOLOGY
(2023)
Editorial Material
Peripheral Vascular Disease
Carlos A. Hinojosa, Javier E. Anaya-Ayala, Hugo Laparra-Escareno, Lourdes Mena-Hernandez, Rodrigo Barquera, Jose I. Martinez-Quesada, Julio Granados
Summary: Takayasu's arteritis (TA) is a great vessel vasculitis that affects the aorta and its branches, and is associated with the major histocompatibility complex (MHC) genes. Genetic testing of HLA haplotypes in monozygotic twins affected by TA found specific HLA alleles. These results confirm the role of MHC genes in genetic susceptibility to develop TA and the genetic heterogeneity of the disease among populations.
ANNALS OF VASCULAR DISEASES
(2023)
Article
Multidisciplinary Sciences
Maite Rivollat, Adam Benjamin Rohrlach, Harald Ringbauer, Ainash Childebayeva, Fanny Mendisco, Rodrigo Barquera, Andras Szolek, Melie Le Roy, Heidi Colleran, Jonathan Tuke, Franziska Aron, Marie-Helene Pemonge, Ellen Spaeth, Philippe Telouk, Leonie Rey, Gwenaelle Goude, Vincent Balter, Johannes Krause, Stephane Rottier, Marie-France Deguilloux, Wolfgang Haak
Summary: This study uses ancient DNA, isotope, and contextual data to reveal the kinship and social structure of a burial community in France. The findings suggest that the community was composed of two main pedigrees, passed down through generations, with male dominance and exchange of females with neighboring groups. Additionally, the study provides insights into social structure, living conditions, and site occupation. The results indicate that the site was only used for a few decades, shedding light on shifting sedentary farming practices during the European Neolithic.
Article
Multidisciplinary Sciences
Lucy Salazar, Richard Burger, Janine Forst, Rodrigo Barquera, Jason Nesbitt, Jorge Calero, Eden Washburn, John Verano, Kimberly Zhu, Korey Sop, Kalina Kassadjikova, Bebel Ibarra Asencios, Roberta Davidson, Brenda Bradley, Johannes Krause, Lars Fehren-Schmitz
Summary: Machu Picchu was originally a palace of the Inca emperor Pachacuti, built between approximately 1420 and 1532 CE. Little was known about the residents' origins and connections to the inhabitants of Cusco, the Inca capital. By studying the genome-wide data of 34 individuals buried at Machu Picchu and comparing them with 34 individuals from Cusco, it was found that the retainer population at Machu Picchu was highly diverse, with genetic ancestries associated with various regions of the Inca Empire and the Amazon. This suggests a diverse community of retainers at Machu Picchu, where people of different genetic backgrounds lived, reproduced, and were buried together.
Review
Biochemistry & Molecular Biology
Angelica Sarai Jimenez-Osorio, Elizabeth Carreon-Torres, Emmanuel Correa-Solis, Julieta Angel-Garcia, Jose Arias-Rico, Octavio Jimenez-Garza, Lizbeth Morales-Castillejos, Hugo Alexander Diaz-Zuleta, Rosa Maria Baltazar-Tellez, Maria Luisa Sanchez-Padilla, Olga Rocio Flores-Chavez, Diego Estrada-Luna
Summary: Inflammation and oxidative stress play crucial roles in the development of metabolic and chronic diseases. Maintaining a balance between necessary and pathological levels of inflammation and oxidative stress is important during pregnancy. High-density lipoproteins (HDL) are essential for a healthy pregnancy, but in certain conditions, they can lose their protective properties. Bioactive compounds from functional foods can increase the concentration of HDL, TRC, and antioxidant activity.
Article
Pediatrics
Joel Barroso-Santos, Angelina Ingrid Robledo-Martinez, Sara Elva Espinosa-Padilla, Ruben Genaro Hurtado del Angel, Felipe Arteaga-Garcia, Monica Langarica-Bulos, Jose Antonio Madrid-Gomez-Tagle, Beatriz Adriana Sanchez-Reyes, Sarai Eunice Hernandez-Cadena, Jorge Ivan Suarez-Soto, Carolina Delgado-Amezquita, Brenda Godinez-Hernandez, Octavio Otamendi-Canales, Angelica Sarai Jimenez-Osorio
Summary: During August 2020 to December 2021, 52 cases of multisystemic inflammatory syndrome (MIS-C) in pediatric patients were confirmed using World Health Organization criteria. All patients had serologic IgG confirmation of SARS-CoV-2, with a mean age of 7 years and 94% without underlying diseases. In addition to lymphopenia, neutropenia, and thrombocytopenia, elevated D-dimer and ferritin levels were observed in all patients. Clinical improvement was achieved with intravenous gamma globulin and corticosteroid treatment.
Article
Medicine, Research & Experimental
Gilberto Vargas-Alarcon, Oscar Perez-Mendez, Rosalinda Posadas-Sanchez, Hector Gonzalez-Pacheco, Alexandra Arias -Mendoza, Galileo Escobedo, Teresa Juarez-Cedillo, Marva Arellano-Gonzalez, Jose Manuel Fragoso
Summary: This study found that ABO gene polymorphisms are associated with a lower risk of ACS, lower systolic blood pressure, and plasma lipid levels.
BIOMOLECULES AND BIOMEDICINE
(2023)
Article
Medicine, Research & Experimental
Maria Elena Soto, Giovanny Fuentevilla-Alvarez, Solange Gabriela Koretzky, Gilberto Vargas-Alarcon, Yazmin Estela Torres-Paz, Sergio Enrique Meza-Toledo, Israel Perez-Torres, Claudia Huesca-Gomez, Ricardo Gamboa
Summary: Marfan syndrome is an inherited connective tissue disorder associated with spinal deformities. A study found that the SNP rs7755109 of the GPR126 gene is associated with scoliosis in patients with MFS.
BIOMOLECULES AND BIOMEDICINE
(2023)
