Article
Medicine, Research & Experimental
Joon Park, Yongeun Kim, Changho Lee, Yun Tai Kim
Summary: The study found that 3,5-DCQA attenuates inflammation-mediated pain hypersensitivity by enhancing autophagy through inhibition of MCP3-induced JAK2/STAT3 signaling.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Neurosciences
Sachin P. Borikar, Shruti I. Dongare, Kishor R. Danao
Summary: The study aimed to investigate the therapeutic and preventive effects of agmatine on LPS-induced learning and memory impairment in mice. Results showed that agmatine treatment increased exploration to novel objects and reduced escape latency and time spent in the target quadrant in mice with LPS-induced memory deficits. Co-administration of agmatine with LPS also improved discrimination index in NOR test and decreased escape latency and time spent in the target quadrant in MWM test.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Hong Huang, Yiwen Zhang, Caihong Yao, Qinghu He, Fang Chen, Han Yu, Guanghua Lu, Ning Jiang, Xinmin Liu
Summary: This study evaluated the effects of Fresh Gastrodia elata Blume (FG) on cognitive deficits induced by chronic restraint stress (CRS) and found that FG improved learning and memory abilities by regulating mitochondrial apoptosis-related proteins and proinflammatory cytokines.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Camila Andre Cazarin, Ana Paula Dalmagro, Ana Elisa Goncalves, Thaise Boeing, Luisa Mota da Silva, Rogerio Correa, Luiz Carlos Klein-Junior, Bernardo Carlesso Pinto, Thais Savoldi Lorenzett, Thales Uchoa da Costa Sobrinho, Angelo de Fatima, Tiago Coelho de Assis Lage, Sergio Antonio Fernandes, Marcia Maria de Souza
Summary: This study investigated the effects of UA enantiomers on cognitive deficits and neuroinflammation in mice with AD. The results showed that UA improved learning and memory, reduced oxidative stress markers, decreased neuroinflammation, and restored cognitive deficits induced by A beta 1-42 administration in mice.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Martina Janikova, Karolina Mainerova, Iveta Vojtechova, Tomas Petrasek, Jan Svoboda, Ales Stuchlik
Summary: The study examined the impact of using 8-OH-DPAT to simulate OCD behavior on spatial learning, as well as the effects of memantine and riluzole in this model. The results showed that monotherapy with glutamate-modulating agents in the model group did not reduce cognitive symptoms but may exacerbate them.
Article
Immunology
You Zheng, Yan-Min Zhang, Zheng-Shan Tang, Jian-Kui Du, De-Wei Guo, Yong-Jun Xu, Hui Sheng, Jian-Qiang Lu, Xin Ni
Summary: Prenatal exposure to synthetic glucocorticoids increases susceptibility to cognitive and affective disorders in postnatal life, with effects on CRHR1 and CXCL5 in the hippocampus of rats. The study demonstrates that CRHR1 and CXCL5 in the hippocampus are involved in spatial learning and memory deficits caused by prenatal sGC exposure.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Pharmacology & Pharmacy
Lin Zhu, Fangjin Lu, Xiaoran Zhang, Siyuan Liu, Ping Mu
Summary: The study found that Pterostilbene (PTE) in blueberries has neuroprotective properties in the treatment of Alzheimer's disease, improving cognitive dysfunction and neuronal plasticity. Its mechanism may be related to inhibiting mitochondria-dependent apoptosis through the antioxidant effect regulated by SIRT1/Nrf2.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nerea Jimenez-Tellez, Marcus Pehar, Fahad Iqbal, Alberto Casas-Ortiz, Tiffany Rice, Naweed I. Syed
Summary: Anesthetics, specifically sevoflurane, have been found to have cytotoxic effects and impact neuronal growth and connectivity. In this study, the researchers observed learning and memory deficits in animals exposed to sub-clinically used concentrations of sevoflurane, which were accompanied by neuronal cell death and perturbed mitochondrial structure and function. The study also showed that these deficits and cell death could be prevented by pre-treating the animals and cultured neurons with the anesthetic adjuvant dexmedetomidine (DEX). Overall, the findings provide direct evidence for sevoflurane-induced cytotoxic effects on neurons and the negative impact on learning and memory, highlighting the importance of adjuvant agents like DEX to mitigate the harmful effects of commonly used anesthetics.
Article
Biochemistry & Molecular Biology
Pawel Grochecki, Irena Smaga, Paulina Surowka, Marta Marszalek-Grabska, Predrag Kalaba, Vladimir Dragacevic, Patrycja Kotlinska, Malgorzata Filip, Gert Lubec, Jolanta H. Kotlinska
Summary: Maternal separation is a major contributor to neurodevelopmental disorders. This study suggests that dopamine signaling plays a key role in maternal separation-induced learning disabilities. The new dopamine transporter inhibitor, CE-123, can effectively counteract the spatial learning and memory deficit caused by maternal separation in rats, particularly in females. It restores cognitive impairment and dopamine signaling in adolescent rats exposed to maternal separation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Huijuan Shu, Zhongxin Guo, Xiangren Chen, Shuya Qi, Xinxin Xiong, Shuang Xia, Qingyun Huang, Ling Lan, Jiangu Gong, Shaoming Huang, Boning Yang, Guohe Tan
Summary: The study suggests that direct intracerebral transplantation of neural stem cells can improve cognitive function in mice exposed to manganese, possibly by enhancing neurogenesis in the host brain and providing a potential cellular basis for cognitive improvement. This research underscores the potential of treating manganese exposure through NSC transplantation.
Article
Pharmacology & Pharmacy
Nai-You Zhang, Ting-Hsuan Wang, Ching-Hsuan Chou, Kuo-Chen Wu, Chia-Ron Yang, Fan-Lu Kung, Chun-Jung Lin
Summary: Many studies have shown that patients with rheumatoid arthritis (RA) are at a higher risk of cognitive impairment, but long-term use of ibuprofen may reduce the incidence of cognitive impairment. This study investigated the effects of RA on memory function and the potential mechanisms of ibuprofen in improving memory function in rats with collagen-induced arthritis (CIA). The results demonstrated that ibuprofen treatment ameliorated the learning and memory deficits in CIA rats, possibly through normalization of the MAPK and NF-κB pathways and the aberrant glutamatergic system.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Xiaozhen Gu, Nanxi Bi, Tian Wang, Chengqing Huang, Rongrong Wang, Yi Xu, Hui-Li Wang
Summary: Adolescent exposure to lead impairs spatial learning and memory abilities, decreases gut microbiota diversity, and reduces abundance of Lactobacillus. Administration of Lactobacillus rhamnosus GR-1 can reverse lead-induced cognitive deficits by restoring gut microbiota diversity.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Sara K. S. Bengtsson, Jessica Sjostedt, Evgenya Malinina, Roshni Das, Magnus Doverskog, Maja Johansson, David Haage, Torbjorn Backstrom
Summary: Through in vitro and in vivo experiments, it was found that GR3027 has inhibitory effects on GABAA receptors, indicating its potential therapeutic value.
Article
Psychiatry
Lisheng Xia, Ruolei Gu, Yongling Lin, Jianqiang Qin, Wenbo Luo, Yue-jia Luo
Summary: Reversal learning is important for behavioral flexibility, and the association between anxiety and impaired reversal learning ability has been established. This study investigated the underlying mechanisms of this association using a probabilistic reversal learning task with EEG recording. The results showed that individuals with high trait-anxiety had poorer reversal learning performance and lower tendency to shift to the new optimal option after rule reversals. The study also found that the FRN elicited by reversal-shift mediated the relationship between anxiety and the number/reaction time of reversal-shift. This study suggests that abnormalities in belief updating may contribute to impaired reversal learning in anxious individuals.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Basak Bagci, Selin Dusmez, Nabi Zorlu, Gokhan Bahtiyar, Serhan Isikli, Adem Bayrakci, Andreas Heinz, Daniel J. Schad, Miriam Sebold
Summary: This study aimed to investigate the cognitive mechanisms underlying impaired probabilistic reversal learning (PRL) task performance in patients with alcohol use disorder (AUDP) using computational models of reinforcement learning. The findings showed that AUDP exhibited enhanced learning from punishment, decreased learning from positive feedback, and lower choice consistency compared to healthy controls. These results suggest that dysfunctional choice behavior in AUDP is characterized by enhanced negative reinforcement and impaired non-drug-related reward learning.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Food Science & Technology
Seul Ki Yoo, Jin Yong Kang, Uk Lee, Seon Kyeong Park, Jong Min Kim, Hye Ju Han, Dae Ok Kim, Ho Jin Heo
Summary: The study found that EFAL can improve cognitive decline caused by hyperglycemia by reducing oxidative stress and suppressing the decrease of neurotransmitters.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Food Science & Technology
Kwan Joong Kim, Young Sung Jung, Dong Min You, Seung Hyun Lee, Guemsan Lee, Kang-Beom Kwon, Dae-Ok Kim
Summary: In this study, Rhodiola rosea L. rhizome was authenticated and its neuroprotective effects were investigated. The results indicated that Rhodiola rosea L. rhizome and its bioactive compounds showed potential for protecting neuronal cells.
FOOD SCIENCE AND BIOTECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Lei Cao, Yena Park, Sanggil Lee, Dae-Ok Kim
Summary: This review explores the extraction methods and health benefits of blackcurrant anthocyanins, aiming to enhance their utilization in academic and industrial fields.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Min-Jeong Kim, Eun-Sang Hwang, Kwan Joong Kim, Sungho Maeng, Ho Jin Heo, Ji-Ho Park, Dae-Ok Kim
Summary: This study found that EGCG can alleviate scopolamine-induced learning and memory impairments and improve brain function. This may be achieved through mechanisms such as improving cholinergic function and reducing oxidative stress.
Article
Chemistry, Applied
Mi-Seon Kim, Young Sung Jung, Davin Jang, Chi Heung Cho, Sang-Hoon Lee, Nam Soo Han, Dae-Ok Kim
Summary: This study evaluated the antioxidant capacity, bioaccessibility, and bioavailability of 12 soy isoflavones (SIs). The results showed that SIs were stable under gastric digestion conditions but unstable under small intestinal digestion conditions for acetyl and malonyl conjugates. SI aglycones had higher permeability and cellular accumulation than their glucosides. A small amount of intact SI conjugates were found in the cell and in the basolateral side of each Transwell.
Article
Food Science & Technology
Briana M. Nosal, Junichi R. Sakaki, Dae-Ok Kim, Ock K. Chun
Summary: The brewing methods and types of coffee can affect the antioxidant capacity of coffee consumers, with capsule coffee showing higher total phenolic content and antioxidant capacity.
FOOD SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Integrative & Complementary Medicine
Eun-Sang Hwang, Ga-Young Choi, Kwan Joong Kim, Min-Jeong Kim, Seok Lee, Jin-Won Lee, Dae-Ok Kim, Ji-Ho Park
Summary: Vitamin C (VC) can lower blood pressure in spontaneously hypertensive rats (SHRs) by directly targeting ACE I production and may improve endothelial function, with the frequency of administration affecting its effectiveness.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Agriculture, Multidisciplinary
Young Sung Jung, Hyoung-Geun Kim, Seon Min Oh, Dae Young Lee, Cheon-Seok Park, Dae-Ok Kim, Nam-In Baek
Summary: Using amylosucrase from Deinococcus geothermalis, alpha-linked glucosylation of Soybean isoflavone aglycones (SIAs) was achieved, resulting in 13 alpha-linked glucosyl SIAs with confirmed colors in solution. The structures of the compounds were identified using mass spectrometry and multidimensional nuclear magnetic resonance spectroscopy. The study suggests a strategy for the synthesis of bioactive compounds with enhanced water solubility through alpha-linked glucosylation, with the products attached to the C-4 ' of SIAs found to be more water-soluble than those attached to the C-7 and/or beta-linkages.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Kwan Joong Kim, Eun-Sang Hwang, Min-Jeong Kim, Chan-Su Rha, Myoung Chong Song, Sungho Maeng, Ji-Ho Park, Dae-Ok Kim
Summary: The study demonstrated the cognitive-enhancing effect of Pinus densiflora Sieb. et Zucc. bark extract (PBE). PBE improved cognitive impairment in rats through its antioxidant properties and enhancement of long-term potentiation (LTP) induction in organotypic hippocampal slices.
Article
Chemistry, Applied
Chan-Su Rha, Eun Kyu Jang, Jong Suk Lee, Ji-Sung Kim, Min-Ji Ko, Sol Lim, Gun Hwan Park, Dae-Ok Kim
Summary: A study was conducted on the chemical constituents of soybean leaves and their correlations across phenotypes, growing periods, and cultivation areas using targeted metabolomics and machine learning models. The distribution of isoflavones and flavonols was found to be influenced by the growing period and cultivation area, and the neural network model showed the best predictive capacity for the differences in soybean leaves.
Article
Food Science & Technology
Ga-Young Choi, Kwan Joong Kim, Ho-Sub Park, Eun-Sang Hwang, Jae-Min Cho, Hyun-Bum Kim, Dae-Ok Kim, Ji-Ho Park
Summary: The study investigated the potential anti-atopic dermatitis (AD) effects of a herbal combination of Lithospermum erythrorhizon (LE), Houttuynia cordata (HC), and Spirodela polyrhiza (SP). Through ultra-high-pressure liquid chromatography (UHPLC)-Orbitrap mass spectrometer (MS), a total of 42 compounds were identified in LE, HC, SP, and the combined herb extract of LE, HC, and SP (LHS). The LHS showed increased concentration of flavonoid glycosides compared to individual extracts, and effectively inhibited the key characteristics of AD such as epidermal thickness increase, mast cell proliferation, and immunoglobulin E release.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Review
Food Science & Technology
Young Sung Jung, Hyunbin Seong, Nam Soo Han, Dae-Ok Kim
Summary: Soybean is an important crop and a significant dietary source of isoflavones. Understanding the bioaccessibility and bioavailability of soy isoflavones is crucial for comprehending their bioactivities. This review evaluates reports using in vitro methods to study the bioavailability of soy isoflavones and discusses how their molecular structures influence their bioactivities.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Food Science & Technology
Eun-Ha Park, Inil Lee, Gi-Cheol Park, Seung-Ju Lee, Kwan Joong Kim, Jisuk Yun, Dae-Ok Kim
Summary: Canola meal, a by-product of canola oil processing, has antioxidant and skin anti-aging effects. This is due to the bioactive compounds found in canola meal, particularly the antioxidative phenolics present in canola meal extract (CME).
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Young Sung Jung, Hyoung-Geun Kim, Seon Min Oh, Dae Young Lee, Cheon-Seok Park, Dae-Ok Kim, Nam-In Baek
Summary: Soybean isoflavone aglycones (SIAs) have low water solubility in the human body. By glycosylation, SIAs can obtain structural diversity and change their physicochemical properties, including water solubility. The alpha-linked glucosylation of SIAs was achieved using amylosucrase from Deinococcus geothermalis. 13 alpha-linked glucosyl SIAs were obtained and their structures were identified by mass spectrometry and multidimensional nuclear magnetic resonance spectroscopy. The glucosylated SIAs attached to C-4' were found to be more water-soluble than those attached to C-7 and/or beta-linkages.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Min Young Um, Minseok Yoon, Minji Kim, Jonghoon Jung, Seonghui Kim, Dae-Ok Kim, Suengmok Cho
Summary: This study aimed to investigate the effects and underlying mechanisms of curcuminoids and their constituents on the sleep-wake cycle of mice. The results showed that curcuminoids reduced sleep latency and increased sleep duration by interacting with H1R. These findings suggest the potential importance of curcuminoids in treating insomnia.
