Article
Nutrition & Dietetics
Xuefei Li, Zhengjie Lu, Yongjian Qi, Biao Chen, Bin Li
Summary: This study used the Mendelian randomization approach to explore the potential causal relationships between polyunsaturated fatty acids (PUFAs) and osteoarthritis (OA), and found that higher levels of omega-6 fatty acids may reduce the risk of knee OA and hip OA. These results highlight the importance of maintaining optimal levels of PUFAs, especially omega-6 fatty acids, in individuals with a genetic predisposition to OA.
Article
Geriatrics & Gerontology
Roxana Coras, Brian Pedersen, Rekha Narasimhan, Anahy Brandy, Lourdes Mateo, Agueda Prior-Espanol, Arthur Kavanaugh, Aaron M. Armando, Mohit Jain, Oswald Quehenberger, Melania Martinez-Morillo, Monica Guma
Summary: The study revealed that arthritis symptoms in older adults were related to disturbances in serum oxylipins, suggesting that certain oxylipins may be key effectors in arthritis in this population.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Obstetrics & Gynecology
J. Stanhiser, A. M. Z. Jukic, D. R. McConnaughey, A. Z. Steiner
Summary: The study found that self-reported use of omega-3 fatty acid supplements was associated with an increased probability of conceiving.
HUMAN REPRODUCTION
(2022)
Article
Nutrition & Dietetics
Kathleen A. Lee-Sarwar, Kasper Fischer-Rasmussen, Klaus Bonnelykke, Hans Bisgaard, Bo Chawes, Rachel S. Kelly, Jessica Lasky-Su, Robert S. Zeiger, George T. O'Connor, Leonard B. Bacharier, Vincent J. Carey, Nancy Laranjo, Augusto A. Litonjua, Scott T. Weiss
Summary: The association between omega-3 fatty acids (n-3) and allergic diseases varies due to genetic variation. This study aimed to identify and validate genetic variants that modify the relationship between n-3 and childhood asthma or atopy. Results showed that certain SNPs in the DPP10 region interacted with n-3 levels in plasma or diet and were associated with atopy in early childhood and at age 6.
Review
Biochemistry & Molecular Biology
Roberta Cardim Lessa, Fabio de Abreu Alves, Erika Fortunati, Jun Lu
Summary: Oral mucositis (OM) is a painful condition caused by cancer treatments, impacting patients' quality of life and recovery. Current management strategies are insufficient, necessitating a search for new approaches. Utilizing ω-3 fatty acids to manage OM may be an effective strategy based on preliminary evidence.
Article
Nutrition & Dietetics
Marco Ugo Andrea Sartorio, Erica Pendezza, Serena Coppola, Lorella Paparo, Enza D'Auria, Gian Vincenzo Zuccotti, Roberto Berni Canani
Summary: Polyunsaturated fatty acids (PUFAs) may have potential beneficial effects on the prevention and treatment of pediatric food allergy, but there is still a lack of consistent clinical data to determine the optimal timing, dosage, and individuals most likely to benefit.
Article
Agricultural Engineering
Anil Kumar Patel, Ajeet Singh Chauhan, Prashant Kumar, Philippe Michaud, Vijai Kumar Gupta, Jo-Shu Chang, Chiu-Wen Chen, Cheng-Di Dong, Reeta Rani Singhania
Summary: This article provides an update on the production of essential fatty acids from potential microbes and explores novel strategies to promote the accumulation of omega-3 and omega-6 through engineering and omics approaches.
BIORESOURCE TECHNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Anna Wyrostek, Katarzyna Czyz, Ewa Sokola-Wysoczanska, Bozena Patkowska-Sokola, Wieslaw Bielas
Summary: This study examined the effect of supplementation with ethyl esters of linseed oil on the fatty acid profile in blood serum, erythrocyte membranes, and hair sebum of healthy beagle dogs. The results showed that the supplementation decreased the content of saturated fatty acids and increased the level of beneficial unsaturated fatty acids, especially those from the omega-3 family.
Article
Nutrition & Dietetics
Estefania Aparicio, Carla Martin-Grau, Cristina Bedmar, Nuria Serrat Orus, Josep Basora, Victoria Arija
Summary: This study found that factors such as high education levels, older age, consumption of fish and seafood, and non-smoking are significantly associated with serum fatty acid concentrations in pregnant women, leading to a better omega-3 fatty acid profile. Further research is needed to explore the health consequences of these findings.
Article
Nutrition & Dietetics
Masayuki Okuda, Aya Fujiwara, Satoshi Sasaki
Summary: The study found that in Japanese youths, high intake of omega-6 polyunsaturated fatty acids was associated with low levels of low-density-lipoprotein cholesterol, while high intake of saturated fatty acids was associated with high levels of gamma-glutamyl transpeptidase, indicating a close relationship between dietary fatty acid composition and cardiometabolic risk.
Article
Nutrition & Dietetics
Flavia M. S. De Branco, Ana Elisa M. Rinaldi, Jaqueline L. Pereira, Hamilton Roschel, Catarina M. Azeredo, Erick P. De Oliveira
Summary: This study evaluated the association between plasma omega-3 (6)-3 fatty acids and appendicular muscle mass index (AMMI) in adults, taking into account protein intake. The results showed a positive correlation between plasma omega-3 (6)-3 fatty acids and AMMI in individuals with low protein intake, indicating potential benefits of omega-3 (6)-3 fatty acid supplementation for muscle mass when protein intake is inadequate.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Alfonso M. Duran, W. Lawrence Beeson, Anthony Firek, Zaida Cordero-MacIntyre, Marino De Leon
Summary: This study aims to identify the cellular pathways stimulated by dietary omega-3 polyunsaturated fatty acid (PUFA) supplementation in patients with type 2 diabetes mellitus (T2DM) affected by painful diabetic neuropathy (pDN). The results show that supplementation leads to a shift towards an anti-inflammatory state and improved membrane fluidity, which may be responsible for the reduction in adverse symptoms associated with neuroinflammatory diseases and painful neuropathy.
Article
Biochemistry & Molecular Biology
Justin S. Kim, Katiria Soto-Diaz, Tanner W. Bingham, Andrew J. Steelman, Aditi Das
Summary: Epidemiological studies have shown a link between omega-3 fatty acid consumption and improved conditions in neurodegenerative diseases like multiple sclerosis (MS), but the underlying mechanism is not well understood. Recent evidence suggests that these fatty acids are converted into metabolites that directly affect immune responses. In experiments, the metabolite docosahexaenoyl ethanolamide (DHEA) was found to reduce inflammatory T-cell polarization. Additionally, DHEA and related endocannabinoids were found to change during disease progression in a mouse model of MS. Administering DHEA to mice delayed disease onset, reduced relapse rates, and improved clinical scores, indicating its potential as a dietary adjuvant for MS treatment.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Agriculture, Dairy & Animal Science
Mario Francisco Oviedo-Ojeda, Jose Alejandro Roque-Jimenez, Megan Whalin, Hector Aaron Lee-Rangel, Alejandro Enrique Relling
Summary: Supplementing with unsaturated fatty acids during early pregnancy can alter the productive performance and mRNA expression of neuropeptides in offspring, showing that the interaction of different sources of fatty acids and different stages can affect growth in lambs.
JOURNAL OF ANIMAL SCIENCE
(2021)
Review
Cardiac & Cardiovascular Systems
Camila Tureck, Bernardo Paz Barboza, Liliana Paula Bricarello, Anabelle Retondario, Mariane de Almeida Alves, Amanda de Moura Souza, Ricardo Fernandes, Francisco de Assis Guedes de Vasconcelos
Summary: This study conducted a systematic review of the scientific evidence on the oral intake of omega-3 and omega-6 fatty acids and metabolic syndrome in adolescents. The results suggest that oral intake of omega-3 fatty acids may have a decreasing effect on blood pressure, glycemia, and triglycerides, and an increasing effect on HDL cholesterol. However, there is controversy in the scientific evidence due to the heterogeneity between studies and the divergence of results for the same metabolic syndrome component.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Endocrinology & Metabolism
Zhong Wang, Zhouqing Chen, Junjie Yang, Ziying Yang, Jia Yin, Gang Zuo, Xiaochun Duan, Haitao Shen, Haiying Li, Gang Chen
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2017)
Article
Clinical Neurology
Wanchun You, Zhong Wang, Haiying Li, Haitao Shen, Xiang Xu, Genlai Jia, Gang Chen
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2016)
Review
Cell Biology
Li Zhang, Jie Wu, Xiaochun Duan, Xiaodi Tian, Haitao Shen, Qing Sun, Gang Chen
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2016)
Review
Cell Biology
Xiaochun Duan, Zunjia Wen, Haitao Shen, Meifen Shen, Gang Chen
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2016)
Article
Clinical Neurology
Jiang Wu, Yang Zhang, Peng Yang, Budbazar Enkhjargal, Anatol Manaenko, Jiping Tang, William J. Pearce, Richard Hartman, Andre Obenaus, Gang Chen, John H. Zhang
Article
Multidisciplinary Sciences
Junwei Ma, Zhong Wang, Chenglin Liu, Haitao Shen, Zhouqing Chen, Jia Yin, Gang Zuo, Xiaochun Duan, Haiying Li, Gang Chen
SCIENTIFIC REPORTS
(2016)
Review
Pharmacology & Pharmacy
Xiyang Yao, Dapeng Wang, Haiying Li, Haitao Shen, Zhang Shu, Gang Chen
CURRENT DRUG DELIVERY
(2017)
Review
Pharmacology & Pharmacy
Jie Wu, Zhengquan Yu, Gang Chen
CURRENT DRUG DELIVERY
(2017)
Review
Pharmacology & Pharmacy
Xiaodi Tian, Chenglin Liu, Zhang Shu, Gang Chen
CURRENT DRUG DELIVERY
(2017)
Review
Pharmacology & Pharmacy
Yibin Wang, Jiyuan Bu, Haitao Shen, Haiying Li, Zhong Wang, Gang Chen
CURRENT DRUG TARGETS
(2017)
Proceedings Paper
Clinical Neurology
Lingyun Wu, Gang Chen
BRAIN EDEMA XVI: TRANSLATE BASIC SCIENCE INTO CLINICAL PRACTICE
(2016)
Article
Medicine, Research & Experimental
Xiyang Yao, Kai Zhang, Jieyong Bian, Gang Chen
BIOMEDICAL REPORTS
(2016)
Review
Medicine, Research & Experimental
Wei-wei Zhai, Liang Sun, Zheng-quan Yu, Gang Chen
MEDICAL GAS RESEARCH
(2016)
Review
Medicine, Research & Experimental
Yang Dou, Zhong Wang, Gang Chen
MEDICAL GAS RESEARCH
(2016)