Review
Orthopedics
Chuanjian Yuan, Yanchen Liang, Kai Zhu, Wenpeng Xie
Summary: This study compared the efficacy and safety of teriparatide and denosumab with oral bisphosphonates. The results showed that teriparatide and denosumab were superior to bisphosphonates in increasing bone mineral density and preventing vertebral fractures. Therefore, teriparatide and denosumab may be considered as first-line treatments for glucocorticoid-induced osteoporosis.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Endocrinology & Metabolism
A. Atmaca, I. Demirci, C. Haymana, I. Tasci, I. Sahin, E. Cakal, N. Ata, S. Dagdelen, S. Salman, R. Emral, M. Sahin, O. Celik, T. Demir, D. Ertugrul, U. Unluturk, M. Caglayan, I. Satman, A. Sonmez
Summary: This study evaluated the association between the use of anti-osteoporosis drugs in women and COVID-19 outcomes, finding that there was no significant impact on the risk of hospitalization, ICU admission, or mortality. The use of these drugs did not independently influence the outcomes of COVID-19.
OSTEOPOROSIS INTERNATIONAL
(2022)
Review
Medicine, General & Internal
Athanasios D. Anastasilakis, Elena Tsourdi, Gaia Tabacco, Anda Mihaela Naciu, Nicola Napoli, Fabio Vescini, Andrea Palermo
Summary: The study found that there is currently insufficient data to prove the significant impact of bone therapies on glucose metabolism in diabetic patients. It is uncertain whether antiosteoporotic drugs have different effects on fracture incidence between diabetic and nondiabetic patients. More research is needed to address these issues and provide stronger recommendations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Tomaz Kocjan, Antonela Sabati Rajic, Andrej Janez, Gaj Vidmar, Nina Orehek, Janja Marc, Barbara Ostanek
Summary: This retrospective study compared bone mineral density changes in postmenopausal women with severe osteoporosis after stopping teriparatide therapy and receiving denosumab or bisphosphonates treatment for 12 months. The results showed that after 12 months, sequential denosumab treatment appeared to yield higher additional lumbar spine bone mineral density gain compared with bisphosphonates treatment.
ENDOCRINE PRACTICE
(2021)
Article
Rheumatology
Giovanni Adami, Irene Gavioli, Maurizio Rossini, Ombretta Viapiana, Giovanni Orsolini, Camilla Benini, Eugenia Bertoldo, Elena Fracassi, Davide Gatti, Angelo Fassio
Summary: This study investigated the real-life effectiveness of anti-osteoporotic treatments and found that all medications considered were effective in reducing the risk of fracture. However, the effect of bisphosphonates only became apparent after at least one year of treatment.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2022)
Article
Endocrinology & Metabolism
J. Everts-Graber, S. Reichenbach, B. Gahl, H. R. Ziswiler, U. Studer, T. Lehmann
Summary: Patients who received zoledronate after denosumab discontinuation had fewer vertebral fractures, while all subsequent therapies were able to maintain bone mineral density to some extent. Factors such as age, BMI, treatment duration, prior therapy, and BMD gains during denosumab treatment influenced bone mineral density loss, while bone turnover markers correlated with total hip bone loss and treatment duration.
Review
Endocrinology & Metabolism
Elena Tsourdi, M. Carola Zillikens, Christian Meier, Jean-Jacques Body, Elena Gonzalez Rodriguez, Athanasios D. Anastasilakis, Bo Abrahamsen, Eugene McCloskey, Lorenz C. Hofbauer, Nuria Guanabens, Barbara Obermayer-Pietsch, Stuart H. Ralston, Richard Eastell, Jessica Pepe, Andrea Palermo, Bente Langdahl
Summary: Discontinuation of denosumab results in increased bone turnover, rapid bone loss, and risk of multiple vertebral fractures in some patients. Prior bisphosphonate therapy or subsequent antiresorptive treatment may help mitigate the biochemical rebound phenomenon after denosumab discontinuation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Meng Ai Png, Joyce Suang Bee Koh, P. Chandra Mohan, Choong Yin Howe, Tet Sen Howe
Summary: This study observed conservatively managed incomplete atypical femoral fractures (iAFF) and assessed factors influencing their healing and progression, including the effects of bisphosphonates and teriparatide treatment.
JOURNAL OF BONE AND MINERAL METABOLISM
(2023)
Article
Dentistry, Oral Surgery & Medicine
Fernanda Castanheira Goncalves, Bruno Arruda Mascaro, Cassio Rocha Scardueli, Guilherme Jose Pimentel Lopes de Oliveira, Luis Carlos Spolidorio, Rosemary Adriana Chierici Marcantonio
Summary: This study evaluated the effect of strontium ranelate on post-extraction socket healing in rats treated with bisphosphonates. The use of strontium ranelate showed subtle positive effects on connective tissue organization, but had limited impact on bone necrosis and inflammatory infiltration.
Article
Materials Science, Multidisciplinary
Siyu Chen, Rui Zhao, Zhengyi Xing, Tieliang Shang, Xiao Yang, Xiangdong Zhu, Xingdong Zhang
Summary: The study showed that implantation of bioceramics with SrRAN systematic treatment is more effective in promoting new bone formation and osteointegration in repairing critical-sized osteoporotic bone defects compared to pure Sr doping.
APPLIED MATERIALS TODAY
(2021)
Review
Medicine, General & Internal
Yunji Leng, Xian Yu, Yi Yang, Yifan Xia
Summary: This meta-analysis analyzed the efficacy and safety of osteoporosis medications in kidney transplant recipients and patients with chronic kidney disease. The results showed that there is no evidence to support the reduction of fracture risk or improvement in bone mineral density with these medications, and they may increase the incidence of adverse events.
JOURNAL OF INVESTIGATIVE MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Anthony Tucker-Bartley, Daryl J. Selen, Emma Golden, Raquel van Gool, David Ebb, Michael Mannstadt, Jaymin Upadhyay
Summary: Fibrous dysplasia (FD) is a rare non-inherited bone disease caused by a somatic gain-of-function mutation of the GNAS gene. The disease can manifest as a single FD lesion or with extraskeletal features, known as McCune-Albright Syndrome (MAS). Pain is a prominent and challenging aspect of FD/MAS, due to the heterogeneous nature of the disease, variable pain phenotypes, lack of pain mechanism studies, and limited validated analgesic strategies. Current pharmacotherapies, such as bisphosphonates and denosumab, are used to manage skeletal disease activity and pain in FD/MAS. However, there is a need for further research and randomized control trials to identify effective pain treatments and explore new pain pathways in this rare bone disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Joao Andre Correia, Jose Ricardo Ferreira, Miguel Amaral Nunes, Antonio Capelo, Miguel de Araujo Nobre, Francisco Salvado
Summary: VSP and CAD/CAM-customized materials facilitated complete resection of necrotic bone and rigid fixation in MRONJ patients, leading to simplified approach with shorter operative times, reduced morbidity, and predictable results.
APPLIED SCIENCES-BASEL
(2021)
Article
Endocrinology & Metabolism
Elena Tsourdi, Elaine W. Yu, Suzanne M. Jan de Beur, Matthew T. Drake
Summary: The development of COVID-19 vaccines has been rapid and multiple vaccines are now approved for widespread distribution, with a focus on the older population. However, concerns have arisen regarding potential interactions with underlying diseases and treatments for those to be vaccinated.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Editorial Material
Medicine, General & Internal
Kristine E. Ensrud, John T. Schousboe
Summary: Medications used to reduce the risk of osteoporosis-related fractures are classified as antiresorptive agents or anabolic therapies. This article focuses on anabolic medications, including specific drugs like teriparatide, abaloparatide, and romosozumab.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Veterinary Sciences
Ismene A. Dontas, Kenneth Applebee, Martje Fentener van Vlissingen, Viola Galligioni, Katerina Marinou, Kathy Ryder, Johannes Schenkel, Jan-Bas Prins, Anne-Dominique Degryse, David Lewis
Summary: Article 23(2) of the European Union Directive 2010/63/EU requires staff involved in the care and use of animals for scientific purposes to be adequately educated and trained before undertaking any such work. The European Commission developed a common Education and Training Framework to help Member States fulfill their obligations, and an Education & Training Platform for Laboratory Animal Science Working Group was established to further guide the Learning Outcomes and assessment criteria. Adoption of this document will harmonize education and training within the EU and promote mutual recognition of training.
LABORATORY ANIMALS
(2021)
Article
Endocrinology & Metabolism
Kalliopi Lampropoulou-Adamidou, Efthymia Karlafti, Chrysoula Argyrou, Konstantinos Makris, George Trovas, Ismene A. Dontas, Symeon Tournis, Ioannis K. Triantafyllopoulos
Summary: The study demonstrates that supplementation with calcium, vitamin D, and CPs can improve trabecular and cortical bone parameters, prevent a decline in aBMD, and decrease bone turnover in postmenopausal women with osteopenia.
JOURNAL OF CLINICAL DENSITOMETRY
(2022)
Review
Rheumatology
Dimitrios Vasileiadis, Georgios Drosos, Georgios Charitoudis, Ismene Dontas, John Vlamis
Summary: This systematic review suggests that preoperative rehabilitation has a positive effect on reducing pain and improving functional performance after total knee arthroplasty. However, its impact on knee motion and long-term function is limited.
MUSCULOSKELETAL CARE
(2022)
Article
Medicine, Research & Experimental
Anna Aikaterini Neri, Dimitrios Galanis, Antonis Galanos, Angeliki Eirini Pepe, Konstantinos Soultanis, Alexandros Zervas, Spyridon Zoitsis, Stavros K. Kourkoulis, Ermioni D. Pasiou, Argyro Vontzalidou, Dimitris Michailidis, Sofia Mitakou, Efstathios Chronopoulos, Georgios Karamanolis, Ismene A. Dontas, Theodore Karatzas
Summary: This study aimed to investigate the effect of Ceratonia siliqua on bone mineral density (BMD) as a nonpharmaceutical alternative treatment for postmenopausal osteoporosis. The results showed that long-term administration of C. siliqua significantly increased BMD compared to the control group and the ovariectomized group after 3 and 6 months of intervention. Therefore, C. siliqua may be considered a non-pharmaceutical alternative treatment for postmenopausal osteoporosis.
Article
Agriculture, Dairy & Animal Science
Katerina A. Marinou, Ismene A. Dontas
Summary: The Directive 2010/63/EU has been in force for more than a decade, bringing significant improvements and novel requirements for animal welfare and research integrity in scientific experiments. The Directive provides clear provisions for various aspects such as scope, authorization procedures, animal welfare bodies, national committees, cost/benefit analysis, severity classification, retrospective assessment, and statistical reporting. The authors, based on their experience working in this field, have identified indicative areas in existing legislative texts and guidance documents that may impact animal welfare and scientific integrity. They discuss suggested solutions to address these areas through potential future revisions in legislation or other actions to benefit animal welfare, aiming to clarify and simplify these issues for all stakeholders involved.
Article
Biology
Smaragda Koudouna, Dimitrios S. Evangelopoulos, Michail Sarantis, Efstathios Chronopoulos, Ismene A. Dontas, Spiridon Pneumaticos
Summary: This study aims to evaluate prognostic tools for predicting patient recovery after hip fractures and investigate the correlation between pre-fracture motor and functional statuses. The study included 80 patients with hip fractures and evaluated patient history, previous falls, fracture type, and overall survival. The results showed that patients' physical and functional statuses were correlated with their postoperative recovery.
Article
Endocrinology & Metabolism
E. Karlafti, I. Dontas, I. Lambrinoudaki, I. Vlamis, K. Lampropoulou-Adamidou, K. Makris, I. Trifonidi, A. Galanos, G. Trovas, E. Chronopoulos, S. Tournis
Summary: This study aimed to evaluate the impact of Primary Hyperparathyroidism (PHPT) on volumetric Bone Mineral Density (vBMD) and bone geometry. The study found that both trabecular and cortical bone were adversely affected in postmenopausal women with PHPT, with greater effects on cortical bone at the radius compared to the tibia, indicating attenuation of deleterious effects on weight-bearing bone.
Review
Medicine, General & Internal
Smaragda Koudouna, Dimitrios S. Evangelopoulos, Michail Sarantis, Efstathios Chronopoulos, Ismene A. Dontas, Spiros Pneumaticos
Summary: Hip fractures in the elderly are a growing concern, with post-operative rehabilitation being crucial for improved outcomes. However, there is a lack of evidence-based guidelines for the most effective rehabilitation pathways. This review aims to explore these pathways and provide objective evaluation through pre-operative and post-operative scores.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Irena Karabella, Efstathios Chronopoulos, George Panagiotakopoulos, Ismene A. Dontas
Summary: Tuberculosis is a commonly misdiagnosed infectious disease that can mimic bone tumors or metastatic lesions in the spine. In patients with cancer and signs of lymph node involvement and bone lesions, exploring other potential causes is crucial for diagnosis. This case study highlights the importance of maintaining a high level of suspicion, as a lytic lesion initially misdiagnosed as a metastatic lesion turned out to be renal cell carcinoma.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Irena Karabella, Efstathios Chronopoulos, George Panagiotakopoulos, Ismene A. Dontas
Summary: This study retrospectively analyzed the epidemiology, characteristics, and management of bone and joint tuberculosis (BJTB) in Greece. The findings suggest that the treatment outcomes are associated with gender and duration of treatment.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Endocrinology & Metabolism
Mari Muurinen, Fulya Taylan, Symeon Tournis, Jesper Eisfeldt, Alexia Balanika, Heleni Vastardis, Sirpa Ala-Mello, Outi Makitie, Alice Costantini
Summary: Mosaicism, caused by AMER1 and RUNX2 gene variants, was identified using whole-genome sequencing in two clinically diagnosed patients with skeletal disorders. This study sheds light on the importance of considering mosaicism in unresolved cases of skeletal dysplasia.
Article
Neurosciences
Apostolos Tsolakis, Lubna Khaldi, Aliki Rontogianni, Maria Georgaki, Isidora Christopoulou, Ismene A. Dontas
Summary: This study investigated the effect of orthodontic tooth forces on the alveolar bone distal to the loaded teeth in ovariectomized female rats. The results showed reduced bone remodeling in the alveolar bone of ovariectomized rats.
JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS
(2022)
Article
Medicine, General & Internal
Dimitrios Vasileiadis, Georgios Drosos, Georgios Charitoudis, Ismene A. Dontas, John Vlamis
Summary: The purpose of this study was to investigate the efficacy of a six-week supervised high-intensity preoperative training program on muscle strength, functional performance, and patient-reported outcomes in patients undergoing total knee arthroplasty (TKA). The study found that the training program can decrease knee pain, improve knee function, and enhance daily living activities.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Neurosciences
Aliki Rontogianni, Ismene A. Dontas, Demetrios Halazonetis, Konstantinos Tosios, Pavlos Lelovas, Kyriaki Venetsanou, Antonios Galanos, Apostolos I. Tsolakis
Summary: This study aimed to investigate the effect of IUGR on the bone mineral density of the mandible and tibia, as well as the quality of the mandibular and condylar bone in growing rats. The results showed that restricted nutrition during gestation can affect the BMD of the mandible and tibia in offspring animals.
JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS
(2022)
