期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 21, 期 46, 页码 16310-16317出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201502842
关键词
antibiotics; carbohydrates; materials science; nanostructures; supramolecular chemistry
资金
- National Institutes of Health [R01M080295, R21AI109896]
- National Science Foundation [CHE-1112436]
- European Union [289033]
Bacterial infections constitute an increasing problem to human health in response to build-up of resistance to present antibiotics and sluggish development of new pharmaceuticals. However, a means to address this problem is to pinpoint the drug delivery toand intothe bacteria. This results in a high local concentration of the drug, circumventing the increasingly high doses otherwise necessary. Combined with other effectors, such as covalent attachment to carriers, rendering the drugs less degradable, and the combination with efflux inhibitors, old drugs can be revived. In this context, glyconanomaterials offer exceptional potential, since these materials can be tailored to accommodate different effectors. In this Concept article, we describe the different advantages of glyconanomaterials, and point to their potential in antibiotic revitalization.
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