Article
Sport Sciences
Mikel Renee Stiffler-Joachim, Drew Henry Lukes, Stephanie A. Kliethermes, Bryan C. Heiderscheit
Summary: This study investigated asymmetries during running in healthy collegiate athletes, finding that the magnitude of asymmetry varies depending on the variable of interest, with small differences observed in sex and speed which are unlikely to be meaningful.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Multidisciplinary Sciences
Luis Moreira, Joana Figueiredo, Pedro Fonseca, Joao P. Vilas-Boas, Cristina P. Santos
Summary: This study presents a complete dataset of lower limb kinematic, kinetic, and EMG data recorded from sixteen healthy participants at seven controlled speeds, aiming to assist in evaluating human locomotion conditions. The dataset includes raw and processed data, providing valuable information for validating biomechanical gait models and serving as a reference trajectory for personalized control of robotic assistive devices.
Article
Chemistry, Analytical
Marco Bravi, Carlo Massaroni, Fabio Santacaterina, Joshua Di Tocco, Emiliano Schena, Silvia Sterzi, Federica Bressi, Sandra Miccinilli
Summary: The study demonstrated that the WalkerView™ (WV) is a valid tool for analyzing the spatiotemporal parameters of walking and assessing the hip's total range of motion. However, the agreement levels for knee total range of motion and all kinematic peak values were lower, requiring careful evaluation.
Article
Engineering, Biomedical
Yu Rong Mao, Jiang Li Zhao, Min Jie Bian, Wai Leung Ambrose Lo, Yan Leng, Rui Hao Bian, Dong Feng Huang
Summary: This study explored the use of a portable peroneal nerve-targeting electrical stimulator to improve gait ability in patients with chronic stroke. The results showed that using the device led to significant improvements in spatiotemporal gait parameters and ankle-foot angles compared to conventional home rehabilitation.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2022)
Article
Multidisciplinary Sciences
Hristo Dimitrov, Anthony M. J. Bull, Dario Farina
Summary: This study provides a dataset of novel sensor technology for the neuromechanics of human locomotion, which can be used for the development and validation of locomotion mode recognition and control algorithms in various fields.
Article
Computer Science, Artificial Intelligence
M. Amsaprabhaa, Y. Nancy Jane, H. Khanna Nehemiah
Summary: The objective of this study is to develop a Multimodal SpatioTemporal Skeletal Kinematic Gait Feature Fusion classifier for fall detection, using video data. The proposed framework combines features generated by SpatioTemporal Graph Convolution Network and 1D-CNN network model, and achieves high classification accuracy on two fall datasets.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Review
Neurosciences
Mingjie Dong, Hao Fan, Dinglong Yang, Xiaoyu Sun, Chaochao Yan, Yi Feng
Summary: This meta-analysis compares the gait characteristics between total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA) during level walking. The results show that the medial UKA design is superior to TKA design in terms of walking speed, stride length, maximum knee flexion at loading, the first peak and valley of vertical ground reaction force, knee internal rotational moment, knee extension, and KSS Function score.
Article
Clinical Neurology
Bhavuk Garg, Manish Gupta, Nishank Mehta, Rajesh Malhotra
Summary: The study aimed to compare gait variables in scoliosis patients and healthy controls, finding significant differences in certain parameters. However, there was no significant difference between AIS and congenital scoliosis patients.
Article
Chemistry, Multidisciplinary
Chae-Won Kwon, Seong-Ho Yun, Dong-Kyun Koo, Jung-Won Kwon
Summary: The study investigated the biomechanical differences between planned gait termination (PGT) and unplanned gait termination (UGT), aiming to provide therapeutic interventions for individuals struggling with gait termination difficulty. The results showed significant differences in gait termination time and step length between PGT and UGT trials. Ankle range of motion (ROM) and hip, knee, and ankle ROM exhibited significant differences between the conditions. UGT revealed disrupted kinesthetic control, leading to a preference for a hip and knee strategy to absorb force and control the center of mass during gait termination.
APPLIED SCIENCES-BASEL
(2023)
Article
Multidisciplinary Sciences
Jack Dienes, Brody Hicks, Conrad Slater, Kevin D. Janson, George J. Christ, Shawn D. Russell
Summary: This study characterizes the spatiotemporal parameters, ground reaction forces, 3-D joint kinematics, 3-D joint kinetics, and energetics of gait in healthy rats through a comprehensive biomechanical workup. The findings have significant implications for the development and clinical application of improved regenerative therapeutics and rehabilitative therapies for extremity traumas and other musculoskeletal pathologies.
SCIENTIFIC REPORTS
(2022)
Article
Mathematical & Computational Biology
Xin Liu, Chen Zhao, Bin Zheng, Qinwei Guo, Yuanyuan Yu, Dezheng Zhang, Aziguli Wulamu
Summary: This paper introduces a new approach to extract significant features from a small dataset in order to improve computer-assisted diagnosis using deep learning. By utilizing Dual Generative Adversarial Networks and modified Long Short-Term Memory algorithm, the authors were able to augment the training data and enhance the diagnosis of Chronic Ankle Instability patients.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2022)
Article
Neurosciences
Jing Dai, Xin Jin, Jian-xiong Ma, Yan-fei Wu, Bin Lu, Hao-hao Bai, Xin-long Ma
Summary: This study compared the differences in hip, knee, and ankle kinematics and spatiotemporal parameters between patients with knee varus deformity and healthy subjects. The results showed significant differences in gait speed, step length, and double support period between the two groups. There were also significant differences in the range of motion of the knee and hip joints, but not in the ankle joint. Knee varus deformity causes adaptive changes in the kinematic parameters of the hip, knee, and ankle joints to alleviate symptoms and maintain normal activity.
Article
Neurosciences
Gerda Strutzenberger, Lara Leutgeb, Lisa Claussen, Hermann Schwameder
Summary: This study found that walking on a treadmill results in shorter step length and shorter contact time, with increased step frequency compared to walking on a ramp, regardless of slope gradient. Uphill walking on the treadmill increased hip and knee flexion angles, while downhill walking showed a significant decrease in dorsiflexion.
Article
Neurosciences
Petros Ismailidis, Lea Hegglin, Christian Egloff, Geert Pagenstert, Rolf Kernen, Anke Eckardt, Thomas Ilchmann, Corina Nueesch, Annegret Muendermann
Summary: This study utilized the RehaGait (R) system to measure gait parameters in patients with knee OA, revealing significant differences between the affected and unaffected sides as well as between patients and controls. These differences align with known gait alterations measured with camera-based systems.
Article
Multidisciplinary Sciences
Mario Martinez-Zarzuela, Javier Gonzalez-Alonso, Miriam Anton-Rodriguez, Francisco J. Diaz-Pernas, Henning Muller, Cristina Simon-Martinez
Summary: This article introduces the VIDIMU dataset, which aims to provide affordable patient gross motor tracking solutions for daily life activities recognition and kinematic analysis. The dataset is innovative in terms of its clinical relevance, combined utilization of affordable video and custom sensors, and the implementation of state-of-the-art tools for multimodal data processing. The validation confirms that a minimally disturbing acquisition protocol, performed according to real-life conditions, can provide a comprehensive picture of human joint angles during daily life activities.
Article
Engineering, Biomedical
L. Savannah Dewberry, Alexander B. Dru, Maxwell Gravenstine, Brian Nguyen, James Anderson, Sasha Vaziri, Daniel J. Hoh, Kyle D. Allen, Kevin J. Otto
Summary: The study showed that HF block can rapidly reduce tactile sensitivity in a limb with neuropathic injury. No significant increase in gait disability was observed during HF block.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Behavioral Sciences
Peter Le, Charles A. Weisenbach, Emily H. L. Mills, Lanie Monforton, Micah J. Kinney
Summary: This study assessed the impact of helmet, posture, and visual stress on neck muscle activity in a simulated helo-hunch posture. The results suggest that wearing a helmet, adopting an asymmetric posture, and experiencing high visual stress can all alter neck muscle activity. These findings provide valuable insights for designing control measures in the future.
Article
Biophysics
Samuel L. Armington, Yash Y. Shah, Jon Dobson, Kyle D. Allen
Summary: Changes in synovial fluid viscosity can be detected by examining the magnetic deflection of particles flowing through the fluid. The deflection of the magnetic particles showed a strong correlation with glycerol solution viscosity and the amount of ultrasonic degradation of synovial fluid. This principle could be used for point-of-care quantification of synovial fluid mechanics.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2022)
Article
Orthopedics
Kiara M. Chan, Taylor D. Yeater, Kyle D. Allen
Summary: With age, susceptibility to osteoarthritis and OA-related pain and disability increases. This study found that age affects gait changes in rodent OA models, with older animals developing gait compensations that more markedly reduce weight on the injured limb during walking.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Rheumatology
Taylor D. Yeater, Carlos J. Cruz, Yenisel Cruz-Almeida, Kyle D. Allen
Summary: This review discusses the relationship between autonomic dysregulation, osteoarthritis progression, and chronic pain, as well as the potential for new therapies for OA pain through modulation of the autonomic nervous system. Non-pharmacological interventions have shown promise in alleviating joint disease pain, and further research on rebalancing autonomic function may lead to novel therapeutic strategies for treating OA pain.
CURRENT RHEUMATOLOGY REPORTS
(2022)
Article
Anatomy & Morphology
Rebecca A. Wachs, Steven M. Wellman, Stacy L. Porvasnik, Emily H. Lakes, R. Chase Cornelison, Young Hye Song, Kyle D. Allen, Christine E. Schmidt
Summary: Peripheral nerve injury causes loss of motor and sensory function, and autologous nerve grafts are the gold standard for repair. However, there are limitations such as limited tissue supply and size mismatch. Decellularized cadaveric nerve tissue can alleviate some of these limitations. This study compares the utility of apoptosis-decellularized peripheral nerve scaffolds to detergent-decellularized scaffolds and isograft controls, and shows similar functional and histological outcomes.
CELLS TISSUES ORGANS
(2022)
Review
Orthopedics
Kiara M. Chan, Markia T. Bowe, Kyle D. Allen
Summary: Behavioral assays are important in preclinical studies to measure animal pain and disability. Gait analysis is a useful tool to quantify symptoms in rodents with osteoarthritis (OA), but the data analysis can be complex due to confounding variables. Recent advances suggest that measuring dynamic ground reaction forces and accounting for covariates such as velocity are important in interpreting gait data. This review discusses statistical techniques like residualization and linear mixed effects models for analyzing gait data and highlights the future considerations for using rodent gait analysis.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Rheumatology
Carlos J. Cruz, L. Savannah Dewberry, Kevin J. Otto, Kyle D. Allen
Summary: This review discusses the potential of targeting the autonomic nervous system (ANS) for osteoarthritis (OA) treatment and suggests bioelectronic medicine as a novel strategy. Recent studies have shown that OA pathogenesis involves more than joint wear and tear, with the involvement of neuroplastic changes and autonomic dysfunction. Modulating the ANS may modify OA pathogenesis and reduce the impact of OA comorbidities.
CURRENT RHEUMATOLOGY REPORTS
(2023)
Editorial Material
Medicine, General & Internal
Brent Winslow, E. Mills
Summary: Despite investment in early identification of mental and behavioral health disorders in service members, rates of depression, substance abuse, and suicide continue to increase. Objective and persistent measures are needed to address these health issues. The integration of biology, wearables, and artificial intelligence shows potential for accurate and objective monitoring in military settings.
BMJ MILITARY HEALTH
(2023)
Article
Chemistry, Multidisciplinary
Tolulope O. Ajayi, Sitong Liu, Chelsea Rosen, Carlos M. Rinaldi-Ramos, Kyle D. Allen, Blanka Sharma
Summary: Nanoparticles are a promising approach for intra-articular drug delivery and tissue targeting, but tracking and quantifying their concentration in vivo is limited. This study evaluated magnetic particle imaging (MPI) as a method to track nanoparticles in the joint. MPI provided 3D visualization and depth-independent quantification of superparamagnetic iron oxide nanoparticle (SPION) tracers. The study showed that MPI may yield a quantitative and robust method to track nanoparticles following intra-articular injection on an extended timeline.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Orthopedics
Kiara M. Chan, Nat A. Thurlow, Malcolm Maden, Kyle D. Allen
Summary: This study evaluated whether African spiny mice are protected from osteoarthritis (OA)-related joint damage and pain after meniscal injury. The results showed that although the mice developed gait compensations, their hyaline cartilage was not fully protected from OA-related joint damage.
Article
Rheumatology
Taylor D. D. Yeater, Jacob L. L. Griffith, Carlos J. J. Cruz, Folly M. M. Patterson, Jessica L. L. Aldrich, Kyle D. D. Allen
Summary: This study examined the role of the autonomic nervous system in osteoarthritis (OA) in a preclinical model of OA and hypertension. The results showed that hypertension exacerbates OA progression and influences autonomic nervous system function. These findings provide preliminary evidence for further research into the pathogenesis of OA.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Brent D. Winslow, Rebecca Kwasinski, Kyle Whirlow, Emily Mills, Jeffrey Hullfish, Meredith Carroll
Summary: Pain is a common and disabling symptom, but quantifying and monitoring pain objectively is challenging. This study utilized biosensors and machine learning algorithms to develop an algorithm capable of real-time pain detection and quantification. The approach has the potential for clinical and ambulatory use, allowing better identification and mitigation of individual pain.
FRONTIERS IN PAIN RESEARCH
(2022)
Review
Medicine, General & Internal
Jonathan Arias, Kyle W. Scott, J. R. Zaldivar, Denslow A. Trumbull, Blanka Sharma, Kyle Allen, Nikolaus Gravenstein
Summary: Innovation and entrepreneurship programs in medical education are becoming more prevalent, with diverse designs and implementations posing challenges for further development. A review found that most programs integrate faculty leadership with backgrounds in medicine, engineering, and/or business/entrepreneurship, and typically include lecture series and hands-on modules as teaching techniques.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Meeting Abstract
Clinical Neurology
Ken Porche, Savannah Dewberry, Alexander Dru, Kyle Allen
JOURNAL OF NEUROSURGERY
(2021)