Review
Biochemistry & Molecular Biology
Teng Wan, Yi-Lin Wang, Feng-Shi Zhang, Xiao-Meng Zhang, Yi-Chong Zhang, Hao-Ran Jiang, Meng Zhang, Pei-Xun Zhang
Summary: This review discusses the importance of porous structures in peripheral nerve guidance conduits (NGCs) and their impact on physical properties and cellular behavior during peripheral nerve regeneration. It provides an overview of the features and classification of porous structures in NGCs, as well as common methods for constructing them. The review also emphasizes the significance of ideal porous structures in the regeneration of peripheral nerve tissue engineering materials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Shuting Wang, Haotian Lu, Xinchang Kang, Zhenqing Wang, Shengtao Yang, Xuehui Zhang, Xuetao Shi
Summary: The study presents an adhesive, conductive, and immunomodulatory nerve hydrogel bandage that can promote peripheral nerve regeneration and facilitate anatomical and functional recovery of neural tissue.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Cell Biology
Jingxin Zhang, Binjing Zhang, Jinglan Zhang, Weimin Lin, Shiwen Zhang
Summary: Magnesium as a suitable material for promoting peripheral nerve regeneration has both challenges and potentials, but there is currently limited research on this topic, requiring further exploration to address the shortcomings and challenges identified.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Trevor Poitras, Douglas W. Zochodne
Summary: Common mechanisms of peripheral axon regeneration are recruited following diverse forms of damage to peripheral nerve axons. Supporting peripheral axon regrowth could be achieved through direct axon support or manipulation of the inflammatory milieu. Understanding the molecular barriers to regrowth and exploiting the downstream signaling pathways that impact neuron growth are promising approaches for promoting adult peripheral axon regeneration. This review emphasizes intrinsic aspects of adult peripheral axon regeneration and highlights several molecular barriers to regrowth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Lorena R. Lizarraga-Valderrama, Giulia Ronchi, Rinat Nigmatullin, Federica Fregnan, Pooja Basnett, Alexandra Paxinou, Stefano Geuna, Ipsita Roy
Summary: The study demonstrated that PHA-NGCs are highly promising in promoting peripheral nerve regeneration, showing comparable outcomes to autografts in functional evaluation and nerve morphology.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Dong Keon Yon, Yong Jun Kim, Dong Choon Park, Su Young Jung, Sung Soo Kim, Joon Hyung Yeo, Jeongmin Lee, Jae Min Lee, Seung Geun Yeo
Summary: A literature review on the role of autophagy in peripheral nerve injury and regeneration was conducted. The review identified several factors, such as LC3II/I, PI3K, mTOR, Beclin-1, ATG3, ATG5, ATG7, ATG9, and ATG12, that are involved in the process of nerve degeneration and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biotechnology & Applied Microbiology
Xiaolan Li, Xiang Zhang, Ming Hao, Dongxu Wang, Ziping Jiang, Liqun Sun, Yongjian Gao, Ye Jin, Peng Lei, Yue Zhuo
Summary: This review summarizes the importance of collagen in peripheral nerve regeneration, focusing on its characteristics, role, and optimization methods. Collagen, as a biomaterial, plays a crucial role in peripheral nerve repair and can be further optimized by adjusting its structure and physical properties, as well as combining it with bioactive components.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Luke Juckett, Tiam Mana Saffari, Benjamin Ormseth, Jenna-Lynn Senger, Amy M. M. Moore
Summary: Peripheral nerve injuries (PNI) often result in lifelong disability with rare complete functional recovery. Intraoperative electrical stimulation (ES) is a promising surgical adjunct that can augment the intrinsic molecular pathways of nerve regeneration. Clinical trials have shown that ES can be an efficacious therapy to improve patient outcomes following PNIs.
Article
Engineering, Biomedical
Yao Liu, Xiaonong Zhang, Chunsheng Xiao, Bin Liu
Summary: Peripheral nerve injury (PNI) is a complex disease that commonly affects young adults and has limited treatment options and poor clinical outcomes. Tissue-engineered hydrogels have shown promising results in promoting neural tissue regeneration and recovery of impaired neural function. This review discusses recent advances and various therapeutic strategies of hydrogels in peripheral nerve repair, as well as the prospects and challenges in their application for PNI treatment.
MATERIALS TODAY BIO
(2023)
Review
Biochemistry & Molecular Biology
Max Y. Y. Jin, Tristan E. Weaver, Adam Farris, Mayank Gupta, Alaa Abd-Elsayed
Summary: While denervation can occur with aging, peripheral nerve injuries often result in loss of function and neuropathic pain. Neuromodulation has shown promise in enhancing peripheral nerve regeneration, but additional interventions are needed to control the direction of reinnervation. More human studies are required to validate findings from animal studies and optimize neuromodulation for functional restoration.
Article
Chemistry, Multidisciplinary
Yangnan Hu, Zhuoyue Chen, Hongyang Wang, Jiahui Guo, Jiaying Cai, Xiaoyan Chen, Hao Wei, Jieyu Qi, Qiuju Wang, Huisheng Liu, Yuanjin Zhao, Renjie Chai
Summary: Inspired by the structures of peripheral nerves, researchers have developed a conductive topological scaffold for nerve repair using modified butterfly wings. The scaffold showed increased neurite length and guided cellular orientation, and successfully repaired nerve defects in rats.
Article
Engineering, Biomedical
Simon C. Kellaway, Victoria Roberton, Joshua N. Jones, Rabea Loczenski, James B. Phillips, Lisa J. White
Summary: Incorporating dECMh derived from bone, liver, and small intestinal tissues can promote neurite extension and axonal regeneration, providing an alternative to current collagen I hydrogel.
ACTA BIOMATERIALIA
(2023)
Review
Engineering, Biomedical
Woo-Youl Maeng, Wan-Ling Tseng, Song Li, Jahyun Koo, Yuan-Yu Hsueh
Summary: This review examines the potential and challenges of using bioelectronic implantable devices for peripheral nerve regeneration. It summarizes modern fabrication methods and integration techniques to deliver effective and controllable electroceuticals.
Article
Engineering, Biomedical
Elena Stocco, Silvia Barbon, Diego Faccio, Lucia Petrelli, Damiana Incendi, Annj Zamuner, Enrico De Rose, Marta Confalonieri, Francesco Tolomei, Silvia Todros, Cesare Tiengo, Veronica Macchi, Monica Dettin, Raffaele De Caro, Andrea Porzionato
Summary: In severe peripheral nerve injuries, nerve conduits (NCs) based on the new polymer oxidized polyvinyl alcohol (OxPVA) show promising results in a rat model of sciatic nerve neurotmesis. The OxPVA-based devices demonstrate comparable efficacy with Reaxon & REG in sciatic functional index score and gait analysis. Furthermore, OxPVA + EAK-YIGSR stands out for its potential in myelinated axons regeneration and density.
MATERIALS TODAY BIO
(2023)
Article
Biotechnology & Applied Microbiology
Liwei Yan, Ali Entezari, Zhongpu Zhang, Jingxiao Zhong, Jing Liang, Qing Li, Jian Qi
Summary: This study used micro-CT to reconstruct a three-dimensional eECM model sourced from mixed nerves. The microstructural and biomechanical characteristics of eECM were analyzed experimentally and computationally. The findings showed that the eECM model had relatively low permeability and that key microstructural and biomechanical parameters played an important role in scaffold design.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Orthopedics
Dimitrios K. Antonopoulos, Andreas F. Mavrogenis, Panayiotis D. Megaloikonomos, Evanthia Mitsiokapa, George Georgoudis, Christos Th Vottis, George K. Antonopoulos, Panayiotis J. Papagelopoulos, Spyridon Pneumatikos, Sarantis G. Spyridonos
JOURNAL OF HAND THERAPY
(2019)
Article
Orthopedics
Zinon T. Kokkalis, Andreas F. Mavrogenis, Dimitris I. Ntourantonis, Vasilios G. Igoumenou, Thekla Antoniadou, Renos Karamanis, Panayiotis D. Megaloikonomos, Georgios N. Panagopoulos, Dimitrios Giannoulis, Eleftheria Souliotis, Theodosis Saranteas, Panayiotis J. Papagelopoulos, Elias Panagiotopoulos
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2019)
Article
Orthopedics
Panayiotis K. Karampinas, Panayiotis D. Megaloikonomos, Kalliopi Lampropoulou-Adamidou, Eleftherios G. Papadelis, Andreas F. Mavrogenis, John A. Vlamis, Spyros G. Pneumaticos
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2019)
Article
Orthopedics
Christos K. Yiannakopoulos, Panayiotis D. Megaloikonomos, Konstantina Foufa, John Gliatis
SKELETAL RADIOLOGY
(2020)
Article
Orthopedics
Panayiotis D. Megaloikonomos, Martin Thaler, Vasilios G. Igoumenou, Tommaso Bonanzinga, Marko Ostojic, Andre Faria Couto, Jasmin Diallo, Ismail Khosravi
INTERNATIONAL ORTHOPAEDICS
(2020)
Article
Orthopedics
Ioanna K. Bolia, Olga D. Savvidou, Hyunwoo P. Kang, Nikolaos Chatzichristodoulou, Panayiotis D. Megaloikonomos, Evanthia Mitsiokapa, Andreas F. Mavrogenis, Panayiotis J. Papagelopoulos
Summary: The Greek version of both the MSTS for lower extremity and TESS questionnaire demonstrated high reliability and internal consistency in Greek patients with lower extremity sarcoma. The TESS questionnaire showed a stronger correlation with the SF-36 compared to the MSTS for lower extremity, indicating better performance in evaluating global health status postoperatively.
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2021)
Article
Surgery
Panayiotis D. Megaloikonomos, Olga D. Savvidou, Asimina Vlachaki, Vasilios G. Igoumenou, Konstantinos Vlasis, Panayiotis J. Papagelopoulos
Summary: Greece, one of the oldest civilizations in the world, made fundamental contributions to the establishment and evolution of medicine and surgery. The foundations of orthopaedic science can be traced back to antiquity, with Homer's poems and the practices of Hippocrates and Galen playing key roles. Their knowledge of musculoskeletal conditions and treatments laid the groundwork for modern Greek orthopaedics.
SURGICAL INNOVATION
(2021)
Article
Orthopedics
Georgios N. Panagopoulos, Mattia Pugliese, Andreas Leonidou, Faisal Butt, Monketh Jaibaji, Panayiotis D. Megaloikonomos, Paolo Consigliere, Giuseppe Sforza, Ehud Atoun, Ofer Levy
Summary: This study compared the outcomes of RTSA between patients with acute PHFs and those who underwent delayed RTSA for fracture sequelae. Although there were no statistically significant differences, the acute RTSA group showed a significantly shorter time to regaining good pain-free function.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2022)
Article
Orthopedics
Panayiotis D. Megaloikonomos, Christoph Becher, Johan Van der Stok, Turlough O'Donnell
Summary: This study evaluated the clinical outcomes and survival of inlay resurfacing prosthesis for focal femoral condyle chondral and osteochondral defects. The results showed that femoral condyle resurfacing using the HemiCAP(R) device is an effective treatment option, with good to excellent subjective clinical outcomes in the mid- to long-term. The most common mode of failure was osteoarthritis progression, emphasizing the importance of patient selection.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2021)
Article
Surgery
Olga D. Savvidou, Panayiotis D. Megaloikonomos, Asimina Vlachaki, Dimitra Melissaridou, Konstantinos Vlasis, Panayiotis J. Papagelopoulos
Summary: Dr. Marika Daniilidou was born in Asia Minor in 1902 and later forced to immigrate to Greece in 1922. Despite the challenges, she pursued education in Germany and became the first certified female orthopaedic surgeon in Greece. She was a pioneer and role model for future generations of Greek women surgeons.
SURGICAL INNOVATION
(2022)
Article
Orthopedics
Christoph Becher, Panayiotis D. Megaloikonomos, Martin Lind, Karl Eriksson, Mats Brittberg, Johannes Beckmann, Peter Verdonk, Magnus Hogstrom, Lars Konradsen, Johannes Holz, Alois Franz, Matthias J. Feucht, Clemens Kosters, Gerben van Buul, Olof Skoldenberg, Pieter J. Emans, Tarek Boutefnouchet, Dinesh Nathwani, Mike J. McNicholas, Turlough O'Donnell, Tim Spalding, Anders Stalman, Sven Ostermeier, Andreas B. Imhoff, Alexander D. Shearman, Michael Hirschmann
Summary: A group of experts convened to reach consensus on the use of mini-implants for femoral chondral and osteochondral lesions. Among the 25 statements discussed, 18 achieved unanimous agreement, while 7 achieved strong consensus.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Review
Orthopedics
Jim D. D. Georgoulis, Dimitra Melissaridou, Kostas Patras, Panayiotis D. D. Megaloikonomos, Ioannis Trikoupis, Olga D. D. Savvidou, Panayiotis J. J. Papagelopoulos
Summary: This systematic review found that despite ACL reconstruction surgery, there is decreased quadriceps activity and increased hamstrings activity during movement. This muscle activity pattern may serve as a protective mechanism against graft re-injury.
JOURNAL OF EXPERIMENTAL ORTHOPAEDICS
(2023)
Article
Orthopedics
Evangelos Tyrpenou, Panayiotis D. Megaloikonomos, Laura Epure, Olga Huk-Papanastassiou, David Zukor, John Antoniou
Summary: This study compares the complications and readmission rates of patients undergoing simultaneous and staged bilateral total hip arthroplasty (THA) within a year. The results show that both procedures have similar complication and readmission rates. Simultaneous bilateral THA is a safe and effective procedure.
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2023)
Article
Infectious Diseases
Efthymia Giannitsioti, Mauro Jose Salles, Andreas Mavrogenis, Dolors Rodriguez-Pardo, Ibai Los-Arcos, Alba Ribera, Javier Ariza, Maria Dolores del Toro, Sophie Nguyen, Eric Senneville, Eric Bonnet, Monica Chan, Maria Bruna Pasticci, Sabine Petersdorf, Natividad Benito, Nuala O' Connell, Antonio Blanco Garcia, Gabor Skaliczki, Pierre Tattevin, Zeliha Kocak Tufan, Nikolaos Pantazis, Panayiotis D. Megaloikonomos, Panayiotis Papagelopoulos, Alejandro Soriano, Antonios Papadopoulos
Summary: This study aimed to assess the clinical and therapeutic aspects of lower-limb osteosynthesis-associated infection (OAI) caused by multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-negative bacteria (GNB). The research found that only half of the cases treated with antimicrobials and surgery had a successful outcome. Advanced age and multiple surgeries were associated with failure to eradicate the infection.
JOURNAL OF BONE AND JOINT INFECTION
(2022)
Review
Orthopedics
Michael-Alexander Malahias, Lazaros Kostretzis, Panayiotis D. Megaloikonomos, Erwin-Brian Cantiller, Dimitrios Chytas, Hajo Thermann, Christoph Becher
ORTHOPEDIC REVIEWS
(2020)