Review
Chemistry, Multidisciplinary
Kun-Quan Chen, He Sheng, Qiang Liu, Pan-Lin Shao, Xiang-Yu Chen
Summary: In recent years, NHC-catalyzed radical reactions have been gaining attention for their potential to create new activation modes previously inaccessible. Further research and understanding of this emerging area is warranted to explore its synthetic techniques and advantages.
SCIENCE CHINA-CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Tingting Li, Zhichao Jin, Yonggui Robin Chi
Summary: This review discusses N-heterocyclic carbene-catalyzed reactions for the formation of aromatic compounds, categorizing them into 4 types based on activation modes. The achievements, challenges, and future research directions in NHC-catalyzed arene construction processes are summarized. The outlook is based on the authors' opinions and knowledge on the trends of NHC organocatalysis development.
SCIENCE CHINA-CHEMISTRY
(2022)
Article
Biochemical Research Methods
Fady Nahra, Nikolaos Tzouras, Alba Collado, Steven P. Nolan
Summary: N-heterocyclic carbene gold(I) chloride and hydroxide complexes are commonly used as synthetic reagents and efficient catalysts. This study describes a straightforward and practical method for synthesizing mononuclear gold complexes with high yields, as well as the synthesis of a mononuclear gold(I) hydroxide complex and an improved synthesis method for a dinuclear gold(I) hydroxide complex. This methodology offers advantages such as the use of sustainable reaction solvents and commercially available starting materials.
Article
Chemistry, Organic
Min Zhang, Xinghua Wang, Tingting Yang, Yan Qiao, Donghui Wei
Summary: Identifying the special role of N-heterocyclic carbene (NHC) in organocatalysis remains a major challenge. The study proposed a theoretical model for NHC-catalyzed decarboxylation reactions and found that C-H⋯O hydrogen bond interactions significantly contribute to controlling stereoselectivity in these reactions.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Review
Chemistry, Multidisciplinary
Lei Dai, Song Ye
Summary: N-heterocyclic carbene (NHC)-catalyzed reactions involving two-electron and radical pathways have been well-established, with the former more developed than the latter in terms of reaction types and enantioselectivity. In the past decade, several elegant NHC-catalyzed radical reactions have been developed, including oxidation of aldehydes, reductive coupling reactions, and reactions via radical homoenolates.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Thomas P. Nicholls, Zhongfan Jia, Justin M. Chalker
Summary: An electrochemical synthesis method has been developed for the production of gold(I)-N-heterocyclic carbene (Au-NHC) complexes. This method allows for the production of complexes without any by-products, which can be directly used as catalysts without purification.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Physical
Yinli Wang, Akiho Yamauchi, Keiji Hashimoto, Tatsuya Fujiwara, Tsubasa Inokuma, Yuta Mitani, Koichi Ute, Satoru Kuwano, Yousuke Yamaoka, Kiyosei Takasu, Ken-ichi Yamada
Summary: We describe a new method of enhancing molecular recognition through substrate-additive complex formation and catalytic acylation using chiral catalyst. The study demonstrates that the additive forms a hydrogen-bonded complex with the substrate, resulting in improved reaction rate and selectivity. The synthetic applications of the resolved compounds highlight the effectiveness of this method.
Article
Chemistry, Multidisciplinary
Qianqian Deng, Fangjing Mu, Yan Qiao, Donghui Wei
Summary: A computational study was conducted to investigate the stereoselectivity origin of NHC-mediated cyclization reaction between benzoic acid and o-phthalaldehyde. The study found that the formation of C-O bonds is crucial for determining stereoselectivity, with the R-configurational pathway being more energetically favorable than the S-configurational one. Non-covalent interaction (NCI) and atom-in-molecule (AIM) analyses revealed that hydrogen-bond interactions play a key role in controlling the stereoselectivity.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Chemistry, Organic
Killari Satyam, Jakkula Ramarao, Surisetti Suresh
Summary: The NHC-catalyzed intramolecular benzoin condensation-oxidation allows for the expedient synthesis of diverse cyclic 1,2-diketones incorporated in dibenzo-fused seven-membered heterocycles in good to excellent yields under ambient conditions. The transformation appears to proceed through the benzoin intermediate followed by aerobic oxidation.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Constantin Eisen, Jia Min Chin, Michael R. Reithofer
Summary: Solid supported or ligand capped gold nanomaterials (AuNMs) have emerged as versatile and recyclable heterogeneous catalysts for a broad variety of conversions in the ongoing catalytic 'gold rush'. AuNMs, existing at the border of homogeneous and heterogeneous catalysis, have the potential to merge high catalytic activity with significant substrate selectivity. This work summarizes well-defined catalytically active NHC capped AuNMs, including spherical nanoparticles and atom-precise nanoclusters, as well as the important NHC design choices towards activity and (stereo-)selectivity enhancements.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Chemistry, Organic
Kosuke Yasui, Miharu Kamitani, Hayato Fujimoto, Mamoru Tobisu
Summary: This study reports on the N-heterocyclic carbene (NHC)-catalyzed Truce-Smiles rearrangement of aniline derivatives, where an unactivated C(aryl)-N bond is cleaved to form a new C(aryl)-C bond. The key to the success of this reaction lies in the utilization of highly nucleophilic NFIC, which enables the formation of a highly nucleophilic ylide intermediate generated from an alpha,beta-unsaturated amide.
Article
Chemistry, Inorganic & Nuclear
Ximena Zarate, Lucian-Cristian Pop, Manuel Treto-Suarez, Jorge Tapia, Eduardo Schott
Summary: This study investigated the aromatic properties of gold benzimidazole and cycloheptaimidazole N-heterocyclic carbenes through computational calculations, revealing a minor difference between the two families with family 1 being slightly more aromatic. The high stability of the gold atom's molecular orbitals in the complexes resulted in almost no contribution from the metal to the observed UV-Vis transitions.
Review
Chemistry, Multidisciplinary
Yi Zhang, Hui Cai, Xiuhai Gan, Zhichao Jin
Summary: This paper provides a systematic review of N-heterocyclic carbene-catalyzed enantioselective kinetic resolutions, dynamic kinetic resolutions, and desymmetrization reactions. The content is organized based on the activation modes involved in these transformations. Future advances in this highly active research field are also discussed from the authors' perspectives.
SCIENCE CHINA-CHEMISTRY
(2023)
Article
Chemistry, Organic
Qi Zhang, Deb Kumar Das, Shuang Yang, Yao Fu, Xinqiang Fang
Summary: The mechanism of N-heterocyclic carbene-catalyzed umpolung of beta,gamma-unsaturated alpha-diketone was found to be more complicated than originally proposed, involving nucleophilic O-acylated homoenolate and electrophilic alpha,beta-unsaturated acyl azolium intermediates. Both DFT calculations and experimental studies confirmed the existence of these key intermediates, leading to a revised mechanism for product formation.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Shuang-Liang Liu, Xiaoqian Liu, Yang Wang, Donghui Wei
Summary: This study reveals the mechanism and stereo-selectivity origin of NHC-catalyzed annulation of enals and imines through theoretical calculations. The presence of intramolecular hydrogen bond is crucial for the reaction, and non-covalent interaction analysis shows the bonding modes in the lower-energy transition state.
MOLECULAR CATALYSIS
(2022)
Review
Chemistry, Multidisciplinary
R. J. Harris, R. A. Widenhoefer
CHEMICAL SOCIETY REVIEWS
(2016)
Article
Chemistry, Multidisciplinary
Ethan A. Wappes, Kohki M. Nakafuku, David A. Nagib
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Review
Chemistry, Organic
Leah M. Stateman, Kohki M. Nakafuku, David A. Nagib
SYNTHESIS-STUTTGART
(2018)
Article
Chemistry, Multidisciplinary
Kohki M. Nakafuku, Stacy C. Fosu, David A. Nagib
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Article
Chemistry, Physical
Robert J. Harris, Robert G. Carden, Alethea N. Duncan, Ross A. Widenhoefer
Article
Chemistry, Multidisciplinary
Tracy L. McGill, Leah C. Williams, Douglas R. Mulford, Simon B. Blakey, Robert J. Harris, James T. Kindt, David G. Lynn, Patricia A. Marsteller, Frank E. McDonald, Nichole L. Powell
JOURNAL OF CHEMICAL EDUCATION
(2019)
Article
Chemistry, Physical
Jacob S. Burman, Robert J. Harris, Caitlin M. B. Farr, John Bacsa, Simon B. Blakey
Article
Chemistry, Organic
Kohki M. Nakafuku, Raymond K. Twumasi, Avassaya Vanitcha, Ethan A. Wappes, Kayambu Namitharan, Mathieu Bekkaye, David A. Nagib
JOURNAL OF ORGANIC CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Robert J. Harris, Jiyong Park, Taylor A. F. Nelson, Nafees Iqbal, Daniel C. Salgueiro, John Bacsa, Cora E. MacBeth, Mu-Hyun Baik, Simon B. Blakey
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Kohki M. Nakafuku, Zuxiao Zhang, Ethan A. Wappes, Leah M. Stateman, Andrew D. Chen, David A. Nagib
Article
Chemistry, Multidisciplinary
Robert J. Harris, Kohki Nakafuku, Alethea N. Duncan, Robert G. Carden, Jacob C. Timmerman, Ross A. Widenhoefer
Summary: The mechanism of intermolecular hydroamination of 3-methylbuta-1,2-diene with N-methylaniline catalyzed by (IPr)AuOTf has been studied, revealing a complex process involving reversible displacement reactions and the formation of cationic gold complexes.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Robert J. Harris, Kohki Nakafuku, Robert G. Carden, Jacob C. Timmerman, Ross A. Widenhoefer
Summary: The mechanism of hydroamination of enantiomerically enriched, axially chiral (R)-1-aryl-1,2-butadienes with aniline catalyzed by (IPr)AuOTf involves the formation of a gold-x-allene intermediate, leading to the formation of racemic product rac-2, where approximately 30% of rac-2 is formed directly from (R)-1 without the intermediacy of rac-1.
Article
Chemistry, Multidisciplinary
Andrew D. Chen, James H. Herbort, Ethan A. Wappes, Kohki M. Nakafuku, Darsheed N. Mustafa, David A. Nagib
Article
Chemistry, Multidisciplinary
Leah M. Stateman, Ethan A. Wappes, Kohki M. Nakafuku, Kara M. Edwards, David A. Nagib