Article
Chemistry, Medicinal
Yuxiu Ye, Jiaqi Liang, Jianglian She, Xiuping Lin, Junfeng Wang, Yonghong Liu, Dehua Yang, Yanhui Tan, Xiaowei Luo, Xuefeng Zhou
Summary: Marine sponge-derived fungi have been found to produce bioactive natural products, including two new alkaloids (polonimides E and D) and a new butenolide derivative (eutypoid F). In addition, thirteen known compounds were also isolated from the fungus Penicillium sp. SCSIO 41413. The inhibitory effects of the butenolide derivatives on the enzyme PI3K were investigated, and two compounds showed significant binding to the PI3K protein. Furthermore, two compounds exhibited inhibitory activity against LPS-induced NF-kappa B activation in cells.
Article
Plant Sciences
Yi Zhao, Chunxiao Sun, Luyao Huang, Xiao Zhang, Guojian Zhang, Qian Che, Dehai Li, Tianjiao Zhu
Summary: Six new nonadride derivatives were isolated from a fungus derived from Antarctic sponge, with two of them showing selective inhibitory effects against Proteus mirabilis and Vibrio parahemolyticus, suggesting potential pharmaceutical applications.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Plant Sciences
Yi Zhao, Chunxiao Sun, Luyao Huang, Xiao Zhang, Guojian Zhang, Qian Che, Dehai Li, Tianjiao Zhu
Summary: Six new nonadride derivatives, named talarodrides A-F, were isolated from the Antarctic sponge-derived fungus Talaromyces sp. HDN1820200. Talarodride A and talarodride B showed selective inhibitory effects against Proteus mirabilis and Vibrio parahemolyticus.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Chemistry, Multidisciplinary
Cora L. Dieterich, Silke Probst, Reiko Ueoka, Ioana Sandu, Daniel Schaefle, Michael Dal Molin, Hannah A. Minas, Rodrigo Costa, Annette Oxenius, Peter Sander, Joern Piel
Summary: Genome mining and bioactivity studies have identified the sponge-derived bacterium Aquimarina sp. Aq135 as a potential producer of new antibiotics, with the discovery of antibacterial peptides aquimarins. The study also showed that the chlorinations by Fe-II/alpha-ketoglutarate-dependent chlorinase AqmA may not be necessary for antibacterial activity, but can enhance cytotoxicity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Medicinal
Mahmoud F. Elsebai, Clara T. Schoeder, Christa E. Mueller
Summary: The fungus Eurotium sp., derived from the marine sponge Ircinia variabilis, produces a diketopiperazine-indole alkaloid named fintiamin. The structural elucidation of fintiamin was achieved through extensive spectroscopic analysis, revealing its affinity for the cannabinoid CB1 receptor at low micromolar concentrations. Docking studies based on previous X-ray structures provided a plausible binding pose for fintiamin in the orthosteric binding site of the CB1 receptor.
ARCHIV DER PHARMAZIE
(2021)
Article
Chemistry, Medicinal
Peng Jiang, Jinfeng Luo, Yao Jiang, Liping Zhang, Liyuan Jiang, Baorui Teng, Hong Niu, Dan Zhang, Hui Lei
Summary: Five undescribed polyketide derivatives, pestaloketides A-E, were isolated from sponge-derived fungus Pestalotiopsis sp. Pestaloketides A and B exhibited potential anti-inflammatory activity according to preliminary bioactivity evaluations and molecular docking analysis.
Article
Biochemistry & Molecular Biology
Xin Qi, Weihao Chen, Liurong Chen, Yiwei Hu, Xueni Wang, Wenrong Han, Jiao Xiao, Xiaoyan Pang, Xingang Yao, Shuwen Liu, Yong Li, Jie Yang, Junfeng Wang, Yonghong Liu
Summary: Guided by Global Natural Products Social molecular networking, 14 new p-terphenyl derivatives, asperterphenyls A-N (1-14), together with 20 known p-terphenyl derivatives (15-34), were obtained from a sponge derived fungus Aspergillus sp. SCSIO41315. Among them, new compounds 2-8 and 15-17 were ten pairs of enantiomers. Comprehensive methods such as chiral-phase HPLC analysis, ECD calculations and X-ray diffraction analysis were applied to determine the absolute configurations. Asperterphenyls B (2) and C (3) represented the first reported natural p-terphenyl derivatives possessing a dicarboxylic acid system. Asperterphenyl A (1) displayed neuraminidase inhibitory activity with an IC50 value of 1.77 +/- 0.53 mu M and could efficiently inhibit infection of multiple strains of H1N1 with IC50 values from 0.67 +/- 0.28 to 1.48 +/- 0.60 mu M through decreasing viral plaque formation in a dose-dependent manner, which suggested that asperterphenyl A (1) might be exploited as a potential antiviral compound in the pharmaceutical fields.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Jianglian She, Yi Chen, Yuxiu Ye, Xiuping Lin, Bin Yang, Jiao Xiao, Yonghong Liu, Xuefeng Zhou
Summary: New carboxamides and a polyketide were isolated and identified from the sponge-derived fungus Arthrinium sp. SCSIO 41421. Their structures and absolute configurations were determined, and preliminary bioactivity screening showed enzyme inhibitory activities against acetylcholinesterase for some of the compounds.
Article
Biochemistry & Molecular Biology
Elena V. Girich, Phan Thi Hoai Trinh, Liliana E. Nesterenko, Roman S. Popov, Natalya Yu Kim, Anton B. Rasin, Ekaterina S. Menchinskaya, Aleksandra S. Kuzmich, Ekaterina A. Chingizova, Artem S. Minin, Ngo Thi Duy Ngoc, Tran Thi Thanh Van, Ekaterina A. Yurchenko, Anton N. Yurchenko, Dmitry V. Berdyshev
Summary: The metabolic profile of a sponge-associated fungal strain, Aspergillus sp. 1901NT-1.2.2, was investigated using HPLC MS technique. The analysis revealed more than 23 peaks in the HPLC MS chromatogram, with two minor peaks identified as endocrocin and terpene derivative. The main compound, vismione E, was isolated and found to exhibit high cytotoxic activity against human breast cancer MCF-7 cells, with low toxicity for normal human breast MCF-10A cells. Vismione E inhibits MCF-7 cell proliferation, arrests the cell cycle in the G1 phase, and negatively affects cell migration. Molecular docking suggests that vismione E targets the IMPDH2 enzyme.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Organic
Chunxiao Sun, Qianwen Liu, Mudassir Shah, Qian Che, Guojian Zhang, Tianjiao Zhu, Jianfeng Zhou, Xiaozhi Rong, Dehai Li
Summary: A novel Wnt/β-catenin inhibitor talaverrucin A was discovered, which showed inhibitory activity on the Wnt/β-catenin pathway in both in vivo and in vitro experiments. This provides a potential lead for developing new drugs targeting this pathway.
Article
Chemistry, Applied
Zhu Chen, Jianglian She, Juan Liu, Bo Peng, Zhimin Yuan, Xuefeng Zhou
Summary: One new alkaloid and six known natural products were isolated from a marine sponge-derived fungus. Their structures were determined using nuclear magnetic resonance and mass spectroscopy, and the absolute configuration of the new compound was confirmed using theoretical electronic circular dichroism calculation. These natural products demonstrated inhibitory activity against certain fungi and bacteria, with one of them showing significant antibacterial activity against Staphylococcus aureus ATCC 29213.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Phan Thi Hoai Trinh, Anton N. Yurchenko, Olga O. Khmel, Trang Vo Thi Dieu, Ngo Thi Duy Ngoc, Elena Girich, Alexander S. Menshov, Natalya Y. Kim, Ekaterina A. Chingizova, Tran Thi Thanh Van, Jong Seok Lee, Hyi-Seung Lee, Ekaterina A. Yurchenko
Summary: New polyketides lopouzanones A and B, as well as known compounds were isolated from a sponge-derived marine fungus, with their structures determined by NMR and ESIMS techniques. The cytotoxicity and protective effects of these compounds against cancer cells and cardiomyocytes were investigated. Gliorosein showed weak DPPH radical-scavenging activity and in vitro cardioprotective effects.
Article
Microbiology
Yaping Chen, Chuanna Liu, Kaliaperumal Kumaravel, Lihong Nan, Yongqi Tian
Summary: This study investigated three sponge-derived fungal strains to find novel antibacterial compounds. Alternaria sp. SCSIOS02F49, selected for investigation, showed rich metabolites and strong antibacterial activity. Two new dibenzopyrones with rare sulfate group, along with 10 known compounds, were isolated from Alternaria sp. SCSIOS02F49. Almost all compounds showed moderate inhibitory activity against foodborne bacteria.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Tong Xia, Hui Lei, Jianv Wang, Yijing He, Hailan Wang, Lanyang Gao, Tingting Qi, Xia Xiong, Li Liu, Yongxia Zhu
Summary: A study has found that LH-1, a type of ergosterol extracted from marine fungus, has the potential to treat malignant melanoma. The research results show that LH-1 can inhibit the proliferation and migration of melanoma cells, induce cell apoptosis, and suppress melanoma growth. Furthermore, LH-1 does not have significant toxic effects on normal tissues.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Organic
Fu-Rong Jiao, Hong-Rui Zhu, Bin-Bin Gu, Yin Wu, Fan Sun, Shu-Ping Wang, Ao Zhang, Wei-Hua Jiao, Shi-Hai Xu, Hou-Wen Lin
Summary: Two new N-methylated cyclopeptides, asperflomide and asperflosamide, were isolated from the marine sponge-derived fungus Aspergillus flocculosus 16D-1. The structures and configurations of these cyclopeptides were determined using NMR spectroscopy and Marfey's analysis. These cyclopeptides exhibited weak tankyrase1/2 inhibitory activity at a low concentration.
Article
Plant Sciences
Fayrouz El Maddah, Stefan Kehraus, Mamona Nazir, Celso Almeida, Gabriele M. Koenig
JOURNAL OF NATURAL PRODUCTS
(2016)
Article
Plant Sciences
Celso Almeida, Ignacio Perez-Victoria, Victor Gonzalez-Menendez, Nuria de Pedro, Jesus Martin, Gloria Crespo, Thomas Mackenzie, Bastien Cautain, Fernando Reyes, Francisca Vicente, Olga Genilloud
JOURNAL OF NATURAL PRODUCTS
(2018)
Article
Biotechnology & Applied Microbiology
Celso Almeida, Cristina Silva Pereira, Victor Gonzalez-Menendez, Gerald Bills, Javier Pascual, Marina Sanchez-Hidalgo, Stefan Kehraus, Olga Genilloud
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2018)
Article
Biotechnology & Applied Microbiology
Katerina Georgousaki, Nikolaos Tsafantakis, Sentiljana Gumeni, Victor Gonzalez-Menendez, Nuria de Pedro, Jose Ruben Tormo, Celso Almeida, Carole Lambert, Olga Genilloud, Ioannis P. Trougakos, Nikolas Fokialakis
JOURNAL OF BIOTECHNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Mamdouh N. Samy, Geraldine Le Goff, Philippe Lopes, Katerina Georgousaki, Sentiljana Gumeni, Celso Almeida, Ignacio Gonzalez, Olga Genilloud, Ioannis Trougakos, Nikolas Fokialakis, Jamal Ouazzani
Review
Biochemistry & Molecular Biology
Celso Almeida, Margarida D. Amaral
CELLULAR AND MOLECULAR LIFE SCIENCES
(2020)
Article
Chemistry, Applied
Mamdouh Nabil Samy, Geraldine Le Goff, Philippe Lopes, Katerina Georgousaki, Sentiljana Gumeni, Celso Almeida, Victor Gonzalez-Menendez, Olga Genilloud, Ioannis P. Trougakos, Nikolas Fokialakis, Jamal Ouazzani
Summary: Three known compounds were isolated from Virgaria nigra CF-231658, with compound 2 displaying the most potent activity in inhibiting elastase at a concentration of 5 μM. The structures of the compounds were elucidated through spectroscopic analyses, and their abilities to inhibit the enzyme activity were examined using normal human diploid fibroblasts.
NATURAL PRODUCT RESEARCH
(2022)
Review
Environmental Sciences
Celso Almeida
Summary: The endoplasmic reticulum (ER) plays a crucial role in eukaryotic cells by interacting with other organelles and endosymbiotic microorganisms. These interactions, possibly stemming from ancient mechanisms, have implications for both mutualistic endosymbiosis and interactions with pathogens.
ENVIRONMENTAL MICROBIOLOGY REPORTS
(2021)
Article
Chemistry, Organic
Fayrouz El Maddah, Ekaterina Eguereva, Stefan Kehraus, Gabriele M. Koenig
ORGANIC & BIOMOLECULAR CHEMISTRY
(2019)
Article
Microbiology
Katja M. Fisch, Cristina Silva Pereira, Olga Genilloud, Celso Almeida, Till F. Schaeberle
GENOME ANNOUNCEMENTS
(2017)
Article
Biotechnology & Applied Microbiology
Celso Almeida, Gerald Bills, Victor Gonzalez-Menendez, Jesus Martin, Jose R. Tormo, Olga Genilloud
FERMENTATION-BASEL
(2017)
Review
Chemistry, Medicinal
Fayrouz El Maddah, Mamona Nazir, Gabriele M. Koenig
NATURAL PRODUCT COMMUNICATIONS
(2017)