期刊
ORGANIC LETTERS
卷 18, 期 15, 页码 3774-3777出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01787
关键词
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资金
- NSFC [21302057, 21405095]
- Young Talents Joint Fund of Shandong Province [ZR2015JL005]
- Special Funding for Postdoctoral Innovation Project of Shandong Province [201501002]
- Zibo Positive Additive Co., Ltd.
A new type of palladium-catalyzed 6-endo-selective alkyl-Heck reaction of unactivated alkyl iodides has been described. This strategy provides efficient access to a variety of 5-phenyl-1,2,3,6-tetrahydropyridine derivatives, which are important structural motifs for bioactive molecules. This process I displays a broad substrate scope with excellent 6-endo selectivity. Mechanistic investigations reveal that this alkyl-Heck reaction performs via a hybrid palladium-radical process.
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