期刊
ORGANIC LETTERS
卷 18, 期 8, 页码 1792-1795出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b00517
关键词
-
资金
- National Institutes of Health [R01GM063540]
A Pd-catalyzed 1,3-difunctionalization of terminal alkenes using 1,1-disubstituted alkenyl nonaflates and arylboronic acid coupling partners is reported. This transformation affords allylic arene products that are difficult to selectively access using traditional Heck cross-coupling methodologies. The evaluation of seldom employed 1,1-disubstituted alkenyl nonaflate couplingpartners led to the elucidation of subtle mechanistic features of pi-allyl stabilized Pd-intermediates. Good stereo- and regioselectivity for the formation of 1,3-addition products can be accessed through a minimization of steric interactions that emanate from alkenyl nonaflate substitution.
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