期刊
ORGANIC LETTERS
卷 18, 期 19, 页码 4920-4923出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b02401
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资金
- NIGMS NIH HHS [R01 GM083897, R35 GM142869] Funding Source: Medline
An Ir-catalyzed enantioselective hydrogenation of 2-alkyl-pyridines has been developed using ligand MeO-BoQPhos. High levels of enantioselectivities up to 93:7 er were obtained. The resulting enantioenriched piperidines can be readily converted into biologically interesting molecules such as the fused tricyclic structures 5, 6, and 7 in 99:1 er, providing a novel, concise synthetic route to this family of chiral piperidine-containing compounds.
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