期刊
ORGANIC LETTERS
卷 18, 期 10, 页码 2439-2442出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b00971
关键词
-
资金
- National Natural Science Foundation of China [21172142]
- Science and Technology Commission of Shanghai Municipality [15ZR1409200]
A highly efficient copper-catalyzed asymmetric addition of terminal alkynes to isatins has been developed. In the presence of a catalytic amount of copper iodide and a chiral phosphine ligand, the reaction gave the corresponding chiral 3-alkynyl-3-hydroxyindolin-2-ones in high yields with high enantioselectivity. This methodology has a broad substrate scope, and the synthetic utility of the present protocol was further demonstrated by the transformation of chiral alkynylation products.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据