Article
Chemistry, Multidisciplinary
Lazare Saladin, Victor Breton, Ophelie Dal Pra, Andrey S. S. Klymchenko, Lydia Danglot, Pascal Didier, Mayeul Collot
Summary: We introduce a new concept called Directed Photooxidation Induced Conversion (DPIC) to produce dual-color photoconvertible probes. Styryl-coumarins (SCs) with Aromatic Singlet Oxygen Reactive Moieties (ASORMs) have been synthesized to support this mechanism. SC-P, a yellow emitting probe with a pyrrole moiety, can convert to a stable blue emitting coumarin with a 68 nm shift, enabling photoconversion and tracking of lipid droplets in live cells. This novel approach may lead to a new generation of photoconvertible dyes for advanced bioimaging applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Takumi Yamamoto, Sota Kato, Daisuke Aoki, Hideyuki Otsuka
Summary: This study introduces an innovative strategy to detect mechanoradicals visually and quantitatively, using a fluorescent molecular probe that generates relatively stable radicals. Mechanoradicals generated by ball milling of polystyrene samples were successfully detected through this radical chain-transfer mechanism, enabling visualization and quantitative evaluation of mechanoradicals generated by polymer-chain scission.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Inorganic & Nuclear
Wei Quan, Wenhui Song, Qian Zhang, Huawei Huang, Weiying Lin
Summary: The liver, as the metabolic and detoxification center, plays a vital role in various physiological processes. Normal liver function is crucial for maintaining overall health, while abnormal liver function can lead to liver diseases. Early diagnosis of liver diseases is essential for timely treatment. The use of fluorescent probes for detecting biomarkers of liver diseases has provided valuable insights for pathological studies, drug development, and disease diagnosis and treatment in recent years. This review summarizes the progress of fluorescence probes in detecting hepatopathy-related biomarkers and discusses the current challenges and future directions. The development of long wavelength probes, multi-detection probes, quantitative analysis probes, and multi-modal probes is expected to be a popular trend. This review aims to facilitate the development of novel fluorescent probes for disease detection and provide guidance for diagnosis and treatment.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Medicine, Research & Experimental
Xiaoning Zhang, Shasha Li, Huizhen Ma, Hao Wang, Ruiping Zhang, Xiao-Dong Zhang
Summary: NIR-II imaging technology has made significant progress in diagnosing diseases with its high resolution and deep tissue penetration capabilities. Activatable NIR-II fluorescence probes show great potential in reporting pathological changes, exhibiting tunable properties and excellent biocompatibility.
Article
Chemistry, Analytical
Peiyao Xie, Jianfei Liu, Xiaopeng Yang, Weimin Zhu, Yong Ye
Summary: This study developed a novel fluorescent probe, TPA-SO2, which can detect both the polarity and SO2 of lipid droplets. The probe exhibited sensitivity to polarity decrease and SO2 and specifically targeted cellular lipid droplets.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Organic
Jiaxin He, Boyu Yan, Jiangtao Meng, Maogang Ran, Yutong Zhou, Jinfei Deng, Chao-Jun Li, Qiuli Yao
Summary: Rhodamine-based amide derivatives were synthesized for detecting radical intermediates in organic reactions and used as fluorescent probes in various solvents. Mechanistic studies verified the reversible opening and closing of the spirolactam ring. Compound 21 can be employed to support the radical mechanism or for real-time monitoring of radical intermediates.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Na-Eun Choi, Ji-Yu Lee, Eun-Chae Park, Ju-Hee Lee, Jiyoun Lee
Summary: This review summarizes the recent reports on organelle-targeted fluorescent probes, evaluating their strategies and structural features based on their target organelles. The article discusses the advantages of the currently used probes, the potential challenges in their application, and future directions for development.
Review
Chemistry, Inorganic & Nuclear
Lei Feng, Jing Ning, Xiangge Tian, Chao Wang, Zhenlong Yu, Xiaokui Huo, Tian Xie, Baojing Zhang, Tony D. James, Xiaochi Ma
Summary: Cytochrome P450 (CYP) enzymes are haem-containing proteins mainly involved in the oxidative metabolism of various chemicals. Fluorescent probes are useful molecular tools for selectively detecting CYP activity, facilitating important insights into the activity expression of CYP enzymes.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Catalina-Paula Spatarelu, Austin Van Namen, Sidhartha Jandhyala, Geoffrey P. Luke
Summary: This study presents a new phase-changing perfluorocarbon nanodroplet contrast agent that improves sensitivity of fluorescence imaging by externally modulating the signal. The nanodroplets undergo liquid-to-gas phase transition when exposed to an externally applied laser pulse, increasing the fluorescent signal. It also demonstrates the production of ultrasound contrast for multimodal imaging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Yu Zhou, Silvia P. Centeno, Kuan Zhang, Lifei Zheng, Robert Goestl, Andreas Herrmann
Summary: This study reports the development of a series of ratiometric optical force probes (OFPs) based on fluorescent-protein-dye and protein-protein conjugates, and their incorporation into genetically engineered bio-glues. The OFPs efficiently modulate Forster resonance energy transfer upon force application, reporting on force-induced molecular alterations independent of concentration and fluorescence intensity. By fluorescence spectroscopy in solution and in the solid state, as well as fluorescence lifetime imaging microscopy, stress concentrations are visualized and adhesive and cohesive failure in the fracture zone is differentiated.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Analytical
Jinrong Wen, Qianying Hua, Sha Ding, Aokui Sun, Yong Xia
Summary: Zinc is a crucial metal element with wide applications in various fields, and its deficiency can lead to multiple diseases. Selective recognition and effective detection of free zinc ions are highly important. Fluorescent probes, with their high sensitivity, selectivity, real-time monitoring capability, and ease of operation, have been widely used for metal ion detection, including convenient and low-cost methods for Zn2+ detection. This article reviews the latest research advances in fluorescent chemosensors for Zn2+ detection from 2019 to 2023, discussing various mechanisms such as PET, ESIPT, ICT, FRET, CHEF, and AIE. The use of these mechanisms in detecting zinc ions is explored through specific cases, some of which have been validated through theoretical calculations.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xinzhu Wang, Shasha He, Penghui Cheng, Kanyi Pu
Summary: A dual-locked and tandem activatable probe (DTAP) is developed for real-time NIRF imaging of intratumoral pyroptosis during cancer chemo-immunotherapy in living mice. The activated signal of DTAP correlates well with tumor-infiltrating cytotoxic T lymphocytes and tumor growth inhibition, enabling the prediction of cancer therapeutic efficacy. This study provides a non-invasive technique to study the regulatory mechanism of pyroptosis in cancer therapy and optimize cancer chemo-immunotherapies.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Manon Guille-Collignon, Jerome Delacotte, Frederic Lemaitre, Eric Labbe, Olivier Buriez
Summary: Recent works focusing on the modulation of organic fluorescent or fluorogenic molecules by electrochemistry highlight the smart use of known molecules, the design of new ones, and the development of instrumentation providing molecular-level time- and space-resolved information.
Review
Pharmacology & Pharmacy
Elide Zingale, Alessia Romeo, Salvatore Rizzo, Cinzia Cimino, Angela Bonaccorso, Claudia Carbone, Teresa Musumeci, Rosario Pignatello
Summary: This review focuses on the latest advances in ocular routes of drug administration, particularly after topical application. The use of fluorescent nanoparticles for tracking and biodistribution studies is discussed, along with their potential applications in diagnostics and therapeutics.
Article
Chemistry, Applied
Przemyslaw Siarkiewicz, Radoslaw Michalski, Adam Sikora, Renata Smulik-Izydorczyk, Marcin Szala, Aleksandra Grzelakowska, Julia Modrzejewska, Asha Bailey, Jacek E. Nycz, Balaraman Kalyanaraman, Jan Grzegorz Malecki, Jacek Zielonka, Radoslaw Podsiadly
Summary: Recent research focuses on the development of redox probes for in vivo applications, particularly near-infrared fluorescent sensors and tricyanofuran-based fluorophores. The tricyanofuran-based boronate probe forms an adduct with glutathione, decreasing its reactivity towards oxidants, while a modified probe derived from 1-naphthalene boronic acid reacts similarly with peroxynitrite but is not influenced by glutathione, making it suitable for real-time monitoring of peroxynitrite formation.
Article
Chemistry, Multidisciplinary
Vinh X. Truong, Julian Bachmann, Andreas-Neil Unterreiner, James P. Blinco, Christopher Barner-Kowollik
Summary: In this study, we present a wavelength-orthogonal crosslinking method for hydrogel networks using two red-shifted chromophores. The photoreactivity of one chromophore is pH-dependent, and by incorporating a suitable photoacid generator, the activation wavelength of the other chromophore can be selectively controlled. This system was successfully applied to the design of hydrogels with independently tunable stiffness using green or blue light.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Pengfei Han, Cheng Tang, Sarina Sarina, Eric R. Waclawik, Aijun Du, Steven E. Bottle, Yanfen Fang, Yingping Huang, Kun Li, Huai-Yong Zhu
Summary: Research has found that light irradiation can significantly increase the nitrile yield of the ammoxidation reaction of primary aromatic alcohols over supported Pd nanoparticles (NPs). This is achieved through resonance energy transfer and promoting the desorption of nitrile products. This new mechanism provides a means for fine control of catalytic reaction pathways for ecofriendly synthesis.
Article
Chemistry, Multidisciplinary
Xin Liu, Yujian Shi, Yichao Jin, Tana Tana, Erandi Peiris, Xueming Zhang, Feng Xu, Eric R. Waclawik, Steven E. Bottle, Huaiyong Zhu, Sarina Sarina
Summary: This study identifies a surface-plasmon-mediated mechanism for transmetalation, which enables efficient carbon-carbon bond formation reactions driven by visible light without the need for bases or other additives. The reaction pathway can be controlled by switching the excitation wavelength, providing a novel way to optimize product selectivity in organic syntheses.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Organic
Astrid C. R. Larin, Michael C. Pfrunder, Kathleen M. Mullen, Sandra Wiedbrauk, Nathan R. Boase, Kathryn E. Fairfull-Smith
Summary: Neurodegenerative diseases impose a significant burden on global populations. Oxidative stress, caused by an imbalance in pro-oxidant/antioxidant levels, plays a role in these diseases. Manipulating reactive oxygen species (ROS) levels may be a promising treatment option, but effective treatments have not been achieved yet. By combining free radical nitroxide antioxidants with natural antioxidants called flavonoids, a potential multitargeted antioxidant was formed.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Steven C. Gauci, Katharina Ehrmann, Marvin Gernhardt, Bryan Tuten, Eva Blasco, Hendrik Frisch, Vishakya Jayalatharachchi, James P. Blinco, Hannes A. Houck, Christopher Barner-Kowollik
Summary: A photoresist-based on a light-stabilized dynamic material driven by an out-of-equilibrium photo-Diels-Alder reaction is introduced for 3D laser lithography. By adjusting the laser intensity, the postprinting degradation ability can be tuned. The resist's ability to form stable networks that degrade in the dark is transformed into a tunable degradable 3D printing material platform.
ADVANCED MATERIALS
(2023)
Article
Medicine, Research & Experimental
Audrey R. N. Ndukwe, Sophia Hawas, Jilong Qin, Sandra Wiedbrauk, Makrina Totsika, Nathan R. B. Boase, Kathryn E. Fairfull-Smith
Summary: Infectious diseases caused by bacterial pathogens are a major cause of death worldwide. Biofilms, which are difficult to treat bacterial communities, are implicated in persistent infections. Hybridization of antibiotics is considered a promising strategy to combat biofilm infections. This study focused on the synthesis and modification of oxazolidinones, with the aim of extending their useful lifetime and improving their efficacy against MRSA biofilms. The results showed that the modification of antibiotics with a dispersal agent was effective in eradicating MRSA biofilms and overcoming antibiotic resistance.
MOLECULAR PHARMACEUTICS
(2023)
Article
Infectious Diseases
McKenna E. Buckley, Audrey R. N. Ndukwe, Pramod C. Nair, Santu Rana, Kathryn E. Fairfull-Smith, Neha S. Gandhi
Summary: Oxazolidinones are synthetic antibiotics that bind to ribosomes of bacteria. This study evaluated the performance of five molecular docking programs in simulating oxazolidinone-ribosome interactions. Results showed that DOCK 6 performed the best, but could only accurately model the binding in four out of eleven ribosomes due to low structural electron density. The study highlights the need to validate docking protocols for ligand-RNA interactions.
Article
Electrochemistry
Benjamin I. Loomans, Steven E. Bottle, James P. Blinco
Summary: Crossover in non-aqueous redox flow batteries is a challenge that affects the stability of these devices. Bipolar redox-active organic materials (ROM) can help mitigate crossover. In this study, a novel bipolar ROM, NTMIO, derived from an isoindoline nitroxide, was synthesized and found to exhibit good electrochemical properties and excellent cycling performance in both static and flow battery models.
BATTERIES & SUPERCAPS
(2023)
Article
Biochemistry & Molecular Biology
Cassie L. L. Rayner, Steven E. E. Bottle, Alexander P. P. Martyn, Nigel L. L. Barnett
Summary: Oxidative stress plays a major role in progressive neurodegenerative diseases and could be a key target for novel preventative and therapeutic strategies. The antioxidant DCTEIO has shown efficacy in protecting retinal neurocells and reducing inflammation and oxidative stress. These findings suggest that DCTEIO has potential as a neuroprotectant for degenerative diseases of the central nervous system.
NEUROCHEMICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Tana Tana, Pengfei Han, Aidan J. Brock, Xin Mao, Sarina Sarina, Eric R. Waclawik, Aijun Du, Steven E. Bottle, Huai-Yong Zhu
Summary: 5-hydroxymethylfurfural (HMF) is a valuable platform chemical for sustainable fine-chemical and pharmaceutical industry based on biomass. The complex of fulvic acid with Al3+ ions exhibits solar absorption and photocatalytic activity for glucose conversion to HMF in one-pot reaction, offering prospects for new green photocatalytic systems. This mechanism creates the possibility of synthesizing a range of substances that have not previously been considered.
NATURE COMMUNICATIONS
(2023)
Article
Electrochemistry
Benjamin I. Loomans, Steven E. Bottle, James P. Blinco
Summary: This study reports a novel bipolar redox-active organic material (ROM) derived from an isoindoline nitroxide, which exhibits higher stability and oxidation potential. The material shows reversible oxidation and quasi-reversible reduction reactions, with a cell potential of 2.07 V. It demonstrates excellent cycling performance in both static and flow battery models.
BATTERIES & SUPERCAPS
(2023)
Article
Polymer Science
Hope Johnson, Lewis C. Chambers, Joshua O. Holloway, Annastasia Bousgas, Afshin Akhtar-Khavari, James Blinco, Christopher Barner-Kowollik
Summary: Resolving the anonymity of plastic materials is crucial for protecting the environment and human health. Contemporary polymer chemistry, combined with progress in law and governance research, has the potential to significantly impact design standards, consumer behavior, recycling systems, and extended-producer responsibility schemes for plastic waste.
Article
Chemistry, Multidisciplinary
Carl P. Soltau, Zac E. Brown, Aidan J. Brock, Alexander P. Martyn, James P. Blinco, Branka Miljevic, John C. McMurtrie, Steven E. Bottle
Summary: The radical reactions of dimethylsulfoxide (DMSO) and tetrahydrothiophene-1-oxide (THTO) with reactive oxygen species (ROS) were evaluated synthetically and analytically. Fenton-mediated generation of oxygen-centred radicals produced various products, reflecting the fragmentation and ring-opening radical mechanisms of DMSO and THTO. Pollution-derived ROS added to DMSO/THTO solutions generated LC-MS detectable amounts of the same products as the larger-scaled Fenton reactions. These results highlight the complexity surrounding DMSO reactivity and fragmentation, and indicate that THTO produces simpler outcomes for easier analysis.
CHEMICAL COMMUNICATIONS
(2022)
Article
Polymer Science
Susanna Kunz, Cameron M. Cole, Steven C. Gauci, Felicia Zaar, Paul E. Shaw, Chandana Sampath Kumara Ranasinghe, Thomas Baumann, Prashant Sonar, Soniya D. Yambem, Eva Blasco, Christopher Barner-Kowollik, James P. Blinco
Summary: This study introduces solution-processible polymers incorporating a TADF emitter and a host species to adjust charge transport properties. The research shows that a combination of unipolar co-hosts on one polymer chain can produce the same optoelectronic properties as a polymer carrying a corresponding bipolar host molecule.
