Article
Chemistry, Organic
Xueying Bai, Liliang Huang, Bin Qing, Zhicheng Zuo, Huangdi Feng
Summary: The reduction of nitrobenzenes into aniline derivatives was successfully achieved by combining KOH and isopropanol, eliminating the need for a metal catalyst. This reaction is straightforward, chemoselective, and takes place under mild conditions, resulting in good to excellent yields of the desired aminobenzamides.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
James Burrows, Shogo Kamo, Kazunori Koide
Summary: This article presents a Birch reduction method that is simpler, safer, more efficient, and more environmentally friendly, for converting arenes into 1,4-cyclohexadienes. The method is easy to operate, cost-effective, and applicable to various chemical laboratories, making it a new technology with wide application prospects.
Article
Chemistry, Organic
Menghui Song, Hongyan Zhou, Ganggang Wang, Ben Ma, Yajing Jiang, Jingya Yang, Congde Huo, Xi-Cun Wang
Summary: A new visible-light-promoted transfer hydrogenation of azobenzenes has been developed, with the reactions proceeding smoothly in methanol at ambient temperature in the presence of B(2)pin(2). Azobenzenes with diverse functional groups were reduced to hydrazobenzenes with a high yield of up to 96%. Preliminary mechanistic studies suggest that the hydrogen atom comes from the solvent and the transformation occurs via a radical pathway.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Domna Iordanidou, Michael G. Kallitsakis, Marina A. Tzani, Dimitris I. Ioannou, Tryfon Zarganes-Tzitzikas, Constantinos G. Neochoritis, Alexander Domling, Michael A. Terzidis, Ioannis N. Lykakis
Summary: This study reported the synthesis of 3,4-dihydroquinoxalin-2-ones through the selective reduction reaction catalyzed by supported gold nanoparticles. The reaction proceeded through heterogeneous transfer hydrogenation and intramolecular C-N transamidation, resulting in good functional-group tolerance and high yields.
Article
Chemistry, Analytical
Shamsunnahar Suchana, Langping Wu, Elodie Passeport
Summary: Compound-specific isotope analysis (CSIA) is a useful tool for studying the fate of legacy groundwater contaminants, but its application to nonconventional contaminants is still emerging. This study validated CSIA methods for nitro- and amino-substituted chlorobenzenes and developed a solid-phase extraction (SPE) method to minimize matrix interferences. The results showed that the SPE-CSIA procedure had negligible isotope fractionation and can be used to track the environmental fate of these contaminants.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Zhizhao Wang, Guoren Yue, Xiangdong Ji, Hai Song, Penji Yan, Jixing Zhao, Xin Jia
Summary: A tandem Michael addition-cyclization method was developed using phase transfer catalyst, allowing for the synthesis of polysubstituted-[4,5]-dihydrofuran with high yields. The process demonstrated a wide range of substrates and provided a reasonable pathway for denitrating poisonous and explosive nitro-containing compounds. The proposed mechanism was supported by DFT calculations.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Binbin Feng, Rou Guo, Qiulan Cai, Yaping Song, Nan Li, Yanghe Fu, De-Li Chen, Jiangwei Zhang, Weidong Zhu, Fumin Zhang
Summary: This study provides an approach for fabricating isolated nickel single-atom sites catalyst with high performance in catalytic transfer hydrogenation reaction for aniline synthesis. The hollow structure facilitates the enhancement of catalytic performance.
Article
Chemistry, Organic
Linlin Li, Xiaoyu Chen, Congcong Pei, Jingya Li, Dapeng Zou, Yangjie Wu, Yusheng Wu
Summary: A transition metal-free reduction protocol using B(2)pin(2) and N-tert-butanesulfinyl ketimines has been developed, resulting in a series of deuterated secondary amines with high yields and purity when D2O is used as the deuterium source. The method is characterized by mild reaction conditions, operational simplicity, and easy scalability, providing a high yield of cyclopentan-1-d-amine after deprotection of the tert-butanesulfinyl group.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Fuad Othman Abdullah, Leila Behrouzi, Babak Kaboudin
Summary: This study developed a method for synthesizing highly stable PdNPs on AO extract, demonstrating its efficient catalytic activity in the reduction of nitroaromatic compounds. Characterization of the catalyst and investigation of product yields confirmed its practicality and high efficiency in the reaction.
MATERIALS RESEARCH EXPRESS
(2021)
Article
Chemistry, Applied
Piotr Cyganowski, Joanna Wolska
Summary: This study presents a new approach for synthesizing aromatic amines using nitroaromatic compounds (NARs) in contaminated wastewaters. The researchers developed anion exchange membranes with gold nanoparticles (AuNPs) to simultaneously reduce and separate the NARs. The nanocomposite membranes formed using tetrahydrofuran (THF) showed better performance in the reduction and separation process.
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Article
Chemistry, Organic
Wubing Yao, Jiali Wang, Yinpeng Lou, Haijian Wu, Xinxin Qi, Jianguo Yang, Aiguo Zhong
Summary: The study introduced a novel transition-metal-free strategy for chemoselective catalytic reduction of nitro scaffolds to valuable amine functions under mild reaction conditions, which can be readily applied to the preparation of commercially available pharmaceuticals.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Shivendra Singh, Vidhi Agarwal, Tridib K. Sarma, Tushar Kanti Mukherjee
Summary: In this study, we developed a sustainable metal-free photocatalytic oxidative coupling approach for the conversion of arylamines to azoaromatics at the charged aqueous interfaces of micelles. This method showed high yields and selectivity, and demonstrated faster kinetics and a broader substrate scope compared to previously reported catalytic methodologies.
Article
Chemistry, Organic
Shashi Kumar, Sushil K. Maurya
Summary: The hydrogenation of nitro compounds to amines using a heterogeneous and recyclable catalyst under blue LED irradiation at ambient temperature is described. The protocol involves the use of hydrazine hydrate as a reductant and ethanol as a solvent for green, sustainable, and low-cost production. The synthesis of various (hetero)arylamines and pharmaceutically relevant molecules is demonstrated, with key features including catalyst recyclability, green solvent, ambient temperature, and gram-scale reactions.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Breno de S. Bernardes, Thamires M. da Costa, Leticia de O. J. L. da Silva, Ligia S. da S. Pinto, Victor Facchinetti, Marcus Vinicius Nora de Souza, Thatyana R. A. Vasconcelos
Summary: This review discusses the development of sustainable methodologies for the reduction of aromatic nitro compounds from 2017 to 2020, presenting the reaction conditions, reagents, solvents, and catalysts used, as well as the main advantages of these methods.
Article
Chemistry, Organic
Chuanling Chen, Chengrong Lu, Bei Zhao
Summary: This study presents a new catalyst for the reaction of HBPin with nitro compounds, resulting in high yields of N-borylamines. The derivatives of N-borylamines were also obtained through a sequential one-pot method. Moreover, kinetic studies of the reaction were conducted.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
