期刊
ORGANIC LETTERS
卷 18, 期 24, 页码 6280-6283出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b03118
关键词
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资金
- National Institutes of General Medical Sciences [GM038627]
- Harvard University
- Eli Lilly Graduate Fellowship in Chemistry
Sp(3)-rich compounds are underrepresented in libraries for probe- and drug-discovery, despite their promise of extending the range of accessible molecular shapes beyond planar geometries. With this in mind, a collection of single-enantiomer bicyclic, fused cyclopentenones underpinned by a complexity-generating Pauson-Khand cyclization was synthesized. A fingerprint of biological actions of these compounds was determined immediately after synthesis using real-time annotation-a process relying on multiplexed measurements of alterations in cell morphological features.
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