8-lodonaphthalene-1-carbaldehyde: A Versatile Building Block for Diversity-Oriented Synthesis

The scarcely studied 8-halonaphthalene-1-carbaldehyde structure has been converted into the corresponding Ellman's imine and subjected to several transformations, thus achieving an assorted library of polycyclic carbo-and heterocycles. The potential of this scaffold for Diversity-Oriented Synthesis has been shown. Most of these skeletons are unprecedented and, therefore, cover unexplored regions of the chemical space.