期刊
ORGANIC LETTERS
卷 18, 期 7, 页码 1530-1533出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b00183
关键词
-
资金
- Office of Science, Office of Basic Energy Sciences of the US Department of Energy [DE-AC02-05CH11231]
- College of Chemistry
A new transition-metal-free synthetic method for C-O coupling between various aryl halides and alkoxides is described. This type of transformation is typically accomplished using palladium catalysts containing a specialized phosphine ligand. The reactions reported here can be performed under mild, ambient conditions using certain potassium alkoxides and a range of aryl halides; with iodide and bromide derivatives giving the best results. A likely mechanistic pathway involves the in situ generation of an aryne intermediate, and directing groups on the aryl ring inductively control regioselectivity.
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