Metal-Free Remote C-H Bond Amidation of 8-Amidoquinolines on the C5 Position under Mild Conditions

An efficient and facile process was developed for the remote C-H bond amidation of 8-aminoquinoline scaffolds on the C5 position which is geometric. The method only made use of PhI(OAc)(2) as a mediator and showed good tolerance toward numerous dibenzenesulfonimides and amides, giving the corresponding products in moderate to excellent yield.